Toxicity studies of Tithonia diversifolia A. Gray (Asteraceae) in rats

Journal of Ethnopharmacology

Volumn 122, Issue 2, 2009, Pages 410-415

  Elufioye, T O ^a   Alatise, O I ^b   Fakoya, F A ^b   Agbedahunsi, J M ^b   Houghton, P J ^c  

^a UNIVERSITY OF IBADAN   (Nigeria)

^b OBAFEMI AWOLOWO UNIVERSITY   (Nigeria)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Antimalarial; Kidney; Liver; Tithonia diversifolia; Toxicity

Indexed keywords

PLANT EXTRACT; TITHONIA DIVERSIFOLIA EXTRACT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG ISOLATION; HISTOPATHOLOGY; LIVER TOXICITY; NEPHROTOXICITY; NONHUMAN; ORGAN WEIGHT; RAT; TITHONIAN; TOXICOKINETICS;

ANIMALS; ANTIMALARIALS; ASTERACEAE; BRAIN; CELL SIZE; FEMALE; HEART; KIDNEY; LEUKOCYTE COUNT; LIVER; MALE; NIGERIA; ORGAN SIZE; PHYTOTHERAPY; PLANT COMPONENTS, AERIAL; PLANT EXTRACTS; RATS; RATS, WISTAR; SPLEEN;

ANIMALIA; ASTERACEAE; MUS; RATTUS; RATTUS NORVEGICUS; TITHONIA DIVERSIFOLIA;

EID: 60849118633     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2008.12.007     Document Type: Article

References (10)

1. Ben-Ishay Z., and Barak V. Bone marrow stromal dysfunction in mice administered cytosine arabinoside. European Journal of Haematology 66 (2001) 230-237
2. Elufioye T.O., Agbedahunsi J.M., and Adesanya S.A. 8-(2-methlybutanoyl)-3,10 epoxy-, 8-dihydroxyl-4, 11(13)-germacridien-12, 6-olide, a new sesquiterpene lactone from Tithonia diversifolia. Nigerian Journal of Natural Products and Medicine 8 (2004) 74-76
3. Elufioye T.O., and Agbedahunsi J.M. Antimalaria activities of Tithonia diviersifolia (Asteraceae) and Crossopteryx febrifuga (Rubiaceae) on mice in vivo. Journal of Ethnopharmacology 93 (2004) 167-171
4. Goffin E., Ziemons, De Mol P., De Madureira M.D., Martins A.P., Da Cunha A.P., Philippe G., Tits M., Angenot I., and Fredrich M. In vitro antiplasmoidal activity of Tithonia diviersifolia and identification of its main active constituents: tagitinin C. Planta Medica 68 (2002) 543-545
5. Gu J.Q., Gills J.J., Park E.J., Mata-Greenwood E., Hawthorne M.E., Axelrod F., Chavez P.I., Fong H.H., Mehta R.G., Pezzuto J.M., and Kinghorn A.D. Sesquiterpenoids from Tithonia diversifolia with potential cancer chemopreventive activity. Journal of Natural Products 65 (2002) 532-536
6. Huang X., Fan Y., Zhang H., Wang P., Yuan J.P., Li M., and Zhan X. Serum leptin and soluble leptin receptor in non-alcoholic fatty liver disease. World Journal of Gastroenterolology 14 (2008) 2888-2893
7. Kuroda M., Yokosuka A., Kobayashi R., Jitsuno M., Kando H., Nosaka K., Ishii H., Yamori T., and Mimaki Y. Sesquiterpenoids and flavonoids from the aerial parts of Tithonia diversifolia and their cytotoxic activity. Chemical and Pharmaceutical Bulletin 55 (2007) 1240-1244
8. Letteron P., Sutton A., Mansouri A., Fromenty B., and Pessayre D. Inhibition of microsomal triglyceride transfer protein: another mechanism for drug-induced steatosis in mice. Hepatology 38 (2003) 133-140
9. Makinde J.M., Amusan O.O., and Adesogan E.K. The antimalaria activities of Spathodea campanulata stem bark extract on Plasmodium berghei in mice. Planta Medica 54 (1988) 122-125
10. Sheth S.G., Gordon F.D., and Chopra S. Nonalcoholic steatohepatitis. Annals of Internal Medicine 126 (1997) 137-145