Kombucha tea prevents obese mice from developing hepatic steatosis and liver damage

Food Science and Biotechnology

Volumn 25, Issue 3, 2016, Pages 861-866

  Hyun, Jeongeun ^a   Lee, Youngjae ^a   Wang, Sihyung ^a   Kim, Jinnyun ^a   Kim, Jieun ^a   Cha, JaeHo ^a   Seo, Young Su ^a   Jung, Youngmi ^a  

^a Pusan National University   (South Korea)

Author keywords

db db mouse; Kombucha tea; liver protection; nonalcoholic fatty liver disease

Indexed keywords

AMINO ACIDS; BEVERAGES; CELL DEATH; FATTY ACIDS; WATER TREATMENT;

ACTIVE CASPASE-3; DB/DB MOUSE; HEPATIC STEATOSIS; HEPATOCELLULAR; IMMUNOSTAINING; KOMBUCHA TEA; LIPID ACCUMULATIONS; NON-ALCOHOLIC FATTY LIVER DISEASE;

MAMMALS;

EID: 84975830624     PISSN: 12267708     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10068-016-0142-3     Document Type: Article

References (29)

1. Staels B, Rubenstrunk A, Noel B, Rigou G, Delataille P, Millatt LJ, Baron M, Lucas A, Tailleux A, Hum DW, Ratziu V, Cariou B, Hanf R. Hepatoprotective effects of the dual peroxisome proliferator-activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease/ nonalcoholic steatohepatitis. Hepatology 58: 1941–1952 (2013)
2. Syn WK, Teaberry V, Choi SS, Diehl AM. Similarities and differences in the pathogenesis of alcoholic and nonalcoholic steatohepatitis. Semin. Liver Dis. 29: 200–210 (2009)
3. Fon Tacer K, Rozman D. Nonalcoholic Fatty liver disease: Focus on lipoprotein and lipid deregulation. J. Lipids 2011: 783976 (2011)
4. Tolman KG, Dalpiaz AS. Treatment of non-alcoholic fatty liver disease. Ther. Clin. Risk Manag. 3: 1153–1163 (2007)
5. Chitturi S. Treatment options for nonalcoholic fatty liver disease. Therap. Adv. Gastroenterol. 1: 173–189 (2008)
6. Alkhouri N, Dixon LJ, Feldstein AE. Lipotoxicity in nonalcoholic fatty liver disease: Not all lipids are created equal. Expert Rev. Gastroenterol. Hepatol. 3: 445–451 (2009)
7. Musso G, Gambino R, Cassader M. Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD). Prog. Lipid Res. 48: 1–26 (2009)
8. Greco D, Kotronen A, Westerbacka J, Puig O, Arkkila P, Kiviluoto T, Laitinen S, Kolak M, Fisher RM, Hamsten A, Auvinen P, Yki-Jarvinen H. Gene expression in human NAFLD. Am. J. Physiol. Gastrointest. Liver Physiol. 294: G1281–G1287 (2008)
9. Dorn C, Riener MO, Kirovski G, Saugspier M, Steib K, Weiss TS, Gabele E, Kristiansen G, Hartmann A, Hellerbrand C. Expression of fatty acid synthase in nonalcoholic fatty liver disease. Int. J. Clin. Exp. Pathol. 3: 505–514 (2010)
10. Dufresne C, Farnworth E. Tea, Kombucha, and health: A review. Food Res. Int. 33: 409–421 (2000)
11. Bhattacharya S, Gachhui R, Sil PC. Effect of Kombucha, a fermented black tea in attenuating oxidative stress mediated tissue damage in alloxan induced diabetic rats. Food Chem. Toxicol. 60: 328–340 (2013)
12. Chen C, Liu B. Changes in major components of tea fungus metabolites during prolonged fermentation. J. Appl. Microbiol. 89: 834–839 (2000)
13. Ponmurugan P, Muthumani T, Jayabalan R, Swaminathan K. A comparative study on Kombucha tea and black tea. J. Plantation Crops 34: 688–693 (2006)
14. Bhattacharya S, Gachhui R, Sil PC. Hepatoprotective properties of Kombucha tea against TBHP-induced oxidative stress via suppression of mitochondria dependent apoptosis. Pathophysiology 18: 221–234 (2011)
15. Greenwalt CJ, Ledford RA, Steinkraus KH. Determination and characterization of the antimicrobial activity of the fermented tea Kombucha. LWT-Food Sci. Technol. 31: 291–296 (1998)
16. Srihari T, Karthikesan K, Ashokkumar N, Satyanarayana U. Antihyperglycaemic efficacy of kombucha in streptozotocin-induced rats. J. Funct. Foods 5: 1794–1802 (2013)
17. Pauline T, Dipti P, Anju B, Kavimani S, Sharma SK, Kain AK, Sarada SK, Sairam M, Ilavazhagan G, Devendra K, Selvamurthy W. Studies on toxicity, anti-stress and hepato-protective properties of Kombucha tea. Biomed. Environ. Sci. 14: 207–213 (2001)
18. Murugesan GS, Sathishkumar M, Jayabalan R, Binupriya AR, Swaminathan K, Yun SE. Hepatoprotective and curative properties of Kombucha tea against carbon tetrachloride-induced toxicity. J. Microbiol. Biotechn. 19: 397–402 (2009)
19. Sai Ram M, Anju B, Pauline T, Dipti P, Kain AK, Mongia SS, Sharma SK, Singh B, Singh R, Ilavazhagan G, Kumar D, Selvamurthy W. Effect of Kombucha tea on chromate (VI)-induced oxidative stress in albino rats. J. Ethnopharmacol. 71: 235–240 (2000)
20. Jayabalan R, Malbaša RV, Lonèar ES, Vitas JS, Sathishkumar M. A review on Kombucha tea-microbiology, composition, fermentation, beneficial effects, toxicity, and tea fungus. Compr. Rev. Food Sci. F. 13: 538–550 (2014)
21. Wang S, Lee Y, Kim J, Hyun J, Lee K, Kim Y, Jung Y. Potential role of hedgehog pathway in liver response to radiation. PLoS ONE 8: e74141 (2013)
22. Yamaguchi K, Yang L, McCall S, Huang J, Yu XX, Pandey SK, Bhanot S, Monia BP, Li YX, Diehl AM. Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis. Hepatology 45: 1366–1374 (2007)
23. Meissner M, Herrema H, van Dijk TH, Gerding A, Havinga R, Boer T, Müller M, Reijngoud D-J, Groen AK, Kuipers F. Bile acid sequestration reduces plasma glucose levels in db/db mice by increasing its metabolic clearance rate. PLoS ONE 6: e24564 (2011)
24. Takahashi Y, Soejima Y, Fukusato T. Animal Models for Nonalcoholic fatty liver disease. Vol. I, pp. 61-69. In: Integrative Weight Management. Mullin GE, Cheskin LJ, Matarese LE (eds). Springer, New York, NY, USA (2014)
25. Witek RP, Stone WC, Karaca FG, Syn WK, Pereira TA, Agboola KM, Omenetti A, Jung Y, Teaberry V, Choi SS. Pancaspase inhibitor VX166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis. Hepatology 50: 1421–1430 (2009)
26. Xin H-G, Zhang B-B, Wu Z-Q, Hang X-F, Xu W-S, Ni W, Zhang R-Q, Miao X-H. Treatment with baicalein attenuates methionine choline deficient dietinduced non-alcoholic steatohepatitis in rats. Eur. J. Pharmacol. 738: 310–318 (2014)
27. Nagaya T, Tanaka N, Suzuki T, Sano K, Horiuchi A, Komatsu M, Nakajima T, Nishizawa T, Joshita S, Umemura T. Down-regulation of SREBP-1c is associated with the development of burned-out NASH. J. Hepatol. 53: 724–731 (2010)
28. Haque JA, McMahan RS, Campbell JS, Shimizu-Albergine M, Wilson AM, Botta D, Bammler TK, Beyer RP, Montine TJ, Yeh MM. Attenuated progression of diet-induced steatohepatitis in glutathione-deficient mice. Lab. Invest. 90: 1704–1717 (2010)
29. Wang S, Hyun J, Youn B, Jung Y. Hedgehog signaling regulates the repair response in mouse liver damaged by irradiation. Radiat. Res. 179: 69–75 (2012)