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Sigel K, Wisnivesky J, Gordon K, et al. HIV as an independent risk factor for incident lung cancer. AIDS. 2012;26:1017–25. The authors examined a large cohort of 37,294 HIV-infected Veterans compared to 75,750 uninfected Veterans with excellent follow-up to compare the incidence of lung cancer. In models adjusted for smoking and other potential confounding factors, they estimated the adjusted incidence rate ratio of lung cancer associated with HIV to be 1.7 95% CI:(1.5–1.9), suggesting an independent risk of lung cancer in HIV.
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HIV as an independent risk factor for incident lung cancer
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12
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PID: 26829006, The risks and benefits of lung cancer screening were assessed in this single arm trial of chest CT in a subset of HIV-infected smokers in France. Patients were eligible for enrollment if they were older than 40, had a smoking history of at least 20 pack-years and had a CD4 cell count below 350. 442 patients were enrolled and underwent chest CT with ultimate prevalence of lung cancer of 2.03% (95% CI: 0.90-3.80) translating to a number needed to screen of 49 (95% CI: 26-111). No serious adverse events from procedures related to screening were reported. This suggests a possible benefit of screening for lung cancer in a subset of HIV-infected patients
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Makinson A, Eymard-Duvernay S, Raffi F, et al. Feasibility and efficacy of early lung cancer diagnosis with chest computed tomography in HIV-infected smokers. AIDS. 2016;30:573–82. The risks and benefits of lung cancer screening were assessed in this single arm trial of chest CT in a subset of HIV-infected smokers in France. Patients were eligible for enrollment if they were older than 40, had a smoking history of at least 20 pack-years and had a CD4 cell count below 350. 442 patients were enrolled and underwent chest CT with ultimate prevalence of lung cancer of 2.03% (95% CI: 0.90-3.80) translating to a number needed to screen of 49 (95% CI: 26-111). No serious adverse events from procedures related to screening were reported. This suggests a possible benefit of screening for lung cancer in a subset of HIV-infected patients.
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PID: 26077242, This large cohort study, linking HIV/AIDS and cancer registries in 6 states, determined differences in cancer-specific mortality by HIV status. After adjustment for demographic features, cancer stage and diagnosis year, among those with lung cancer the estimated hazard ratio for cancer specific mortality was 1.28 (95% CI 1.17-1.39) comparing HIV-infected to uninfected patients. This suggests higher lung cancer-specific mortality in HIV, although it is unclear if this would persist with finer adjustment for other confounding variables
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Coghill AE, Shiels MS, Suneja G, et al. Elevated cancer-specific mortality among HIV-infected patients in the United States. J Clin Oncol. 2015;33:2376–83. This large cohort study, linking HIV/AIDS and cancer registries in 6 states, determined differences in cancer-specific mortality by HIV status. After adjustment for demographic features, cancer stage and diagnosis year, among those with lung cancer the estimated hazard ratio for cancer specific mortality was 1.28 (95% CI 1.17-1.39) comparing HIV-infected to uninfected patients. This suggests higher lung cancer-specific mortality in HIV, although it is unclear if this would persist with finer adjustment for other confounding variables.
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