HIV-1/Cocaine induced oxidative stress disrupts tight junction protein-1 in human pulmonary microvascular endothelial cells: Role of RAS/ERK1/2 pathway

PLoS ONE

Volumn 9, Issue 1, 2014, Pages

  Dalvi, Pranjali ^a   Wang, Kun ^a   Mermis, Joel ^a   Zeng, Ruoxi ^a   Sanderson, Miles ^a   Johnson, Sara ^a   Dai, Yuqiao ^a   Sharma, Garima ^a   Ladner, Amy O'Brien ^a   Dhillon, Navneet K ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOCYNIN; BETA INTEGRIN; COCAINE; GLYCOPROTEIN GP 91; HYDROGEN PEROXIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; N [2 (3,4 DICHLOROPHENYL)ETHYL] 2 DIMETHYLAMINO N METHYLETHYLAMINE; PROTEIN ZO1; RAF PROTEIN; RAS PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SEMAXANIB; SMALL INTERFERING RNA; SUPEROXIDE; TIGHT JUNCTION PROTEIN; TRANSACTIVATOR PROTEIN;

ARTICLE; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ENDOTHELIUM INJURY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; MICROVASCULAR ENDOTHELIAL CELL; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PATHOGENESIS; PULMONARY HYPERTENSION; RISK FACTOR; WNT SIGNALING PATHWAY;

ANTIOXIDANTS; CAPILLARY PERMEABILITY; COCAINE; ENDOTHELIAL CELLS; GENE KNOCKDOWN TECHNIQUES; HIV-1; HUMANS; LUNG; MAP KINASE SIGNALING SYSTEM; NADPH OXIDASE; OXIDATIVE STRESS; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS P21(RAS); REACTIVE OXYGEN SPECIES; RECEPTORS, SIGMA; TAT GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2; ZONULA OCCLUDENS-1 PROTEIN;

EID: 84896949572     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0085246     Document Type: Article

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