Rare disruptive mutations and their contribution to the heritable risk of colorectal cancer

Nature Communications

Volumn 7, Issue , 2016, Pages

  Chubb, Daniel ^a   Broderick, Peter ^a   Dobbins, Sara E ^a   Frampton, Matthew ^a   Kinnersley, Ben ^a   Penegar, Steven ^a   Price, Amy ^a   Ma, Yussanne P ^a,e   Sherborne, Amy L ^a   Palles, Claire ^b   Timofeeva, Maria N ^c   Bishop, D Timothy ^d   Dunlop, Malcolm G ^c   Tomlinson, Ian ^b   Houlston, Richard S ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

^d ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

^e BRITISH COLUMBIA CANCER AGENCY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; ENZYME; MRE11 PROTEIN; PROTEIN; PROTEIN IL12RB1; PROTEIN LIMK2; PROTEIN POLE2; PROTEIN POT1; UNCLASSIFIED DRUG;

ALLELE; CANCER; GENE EXPRESSION; GENETIC ANALYSIS; HERITABILITY; MUTATION;

ADULT; ARTICLE; CANCER RISK; CANCER SUSCEPTIBILITY; COLORECTAL CANCER; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENE SEQUENCE; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GERMLINE MUTATION; HERITABILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; AGE; ALLELE; CASE CONTROL STUDY; COLORECTAL TUMOR; EXOME; GENETIC PREDISPOSITION; GENETIC VARIATION; GENETICS; MIDDLE AGED; ONSET AGE; PEDIGREE; PHENOTYPE; RISK FACTOR; UNITED KINGDOM;

ADULT; AGE FACTORS; AGE OF ONSET; ALLELES; CASE-CONTROL STUDIES; COLORECTAL NEOPLASMS; EXOME; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GERM-LINE MUTATION; HUMANS; MALE; MIDDLE AGED; PEDIGREE; PHENOTYPE; RISK FACTORS; UNITED KINGDOM;

EID: 84975743169     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms11883     Document Type: Article

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