Specific variants in the MLH1 gene region may drive DNA methylation, loss of protein expression, and MSI-H colorectal cancer

PLoS ONE

Volumn 5, Issue 10, 2010, Pages

  Mrkonjic, Miralem ^a,b   Roslin, Nicole M ^c   Greenwood, Celia M ^c,d   Raptis, Stavroula ^a,b   Pollett, Aaron ^b   Laird, Peter W ^e   Pethe, Vaijayanti V ^b   Chiang, Theodore ^c   Daftary, Darshana ^f   Dicks, Elizabeth ^g   Thibodeau, Stephen N ^h   Gallinger, Steven ^a,b,f   Parfrey, Patrick S ^g   Younghusband, H Banfield ^g   Potter, John D ⁱ   Hudson, Thomas J ^a,j   McLaughlin, John R ^b,d,f   Green, Roger C ^g   Zanke, Brent W ^f,k   Newcomb, Polly A ⁱ   Paterson, Andrew D ^c,d   Bapat, Bharati ^a,b   more..

^a UNIVERSITY OF TORONTO   (Canada)

^b MOUNT SINAI HOSPITAL   (Canada)

^c HOSPITAL FOR SICK CHILDREN   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

^e UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^f CANCER CARE ONTARIO   (Canada)

^g MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

^h MAYO CLINIC   (United States)

ⁱ Fred Hutchinson Cancer Research Center   (United States)

^j ONTARIO INSTITUTE FOR CANCER RESEARCH   (Canada)

^k OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

more..

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN MLH1; MICROSATELLITE DNA; MLH1 PROTEIN, HUMAN; NUCLEAR PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ADULT; ARTICLE; CANADA; CHROMOSOME 3; COLORECTAL CANCER; CONTROLLED STUDY; DNA METHYLATION; FEMALE; GENE EXPRESSION; GENE LINKAGE DISEQUILIBRIUM; GENE SILENCING; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC IDENTIFICATION; GENETIC VARIABILITY; HUMAN; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MICROSATELLITE INSTABILITY; MISMATCH REPAIR; POPULATION BASED CASE CONTROL STUDY; PROMOTER REGION; PROTEIN EXPRESSION; SINGLE NUCLEOTIDE POLYMORPHISM; AGED; COLORECTAL TUMOR; GENETICS; GENOMIC INSTABILITY; METABOLISM; MIDDLE AGED; STATISTICAL MODEL;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AGED; COLORECTAL NEOPLASMS; DNA METHYLATION; FEMALE; GENOMIC INSTABILITY; HUMANS; LOGISTIC MODELS; MALE; MICROSATELLITE REPEATS; MIDDLE AGED; NUCLEAR PROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC;

EID: 78149463044     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0013314     Document Type: Article

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