-
1
-
-
85047691556
-
Activation of mst1 causes dilated cardiomyopathy by stimulating apoptosis without compensatory ventricular myocyte hypertrophy
-
Yamamoto S, et al. Activation of Mst1 causes dilated cardiomyopathy by stimulating apoptosis without compensatory ventricular myocyte hypertrophy. J Clin Invest. 2003;111(10):1463–1474.
-
(2003)
J Clin Invest
, vol.111
, Issue.10
, pp. 1463-1474
-
-
Yamamoto, S.1
-
2
-
-
84894093943
-
The hippo pathway is activated and is a causal mechanism for adipogenesis in arrhythmogenic cardiomyopathy
-
Chen SN, Gurha P, Lombardi R, Ruggiero A, Willerson JT, Marian AJ. The hippo pathway is activated and is a causal mechanism for adipogenesis in arrhythmogenic cardiomyopathy. Circ Res. 2014;114(3):454–468.
-
(2014)
Circ Res
, vol.114
, Issue.3
, pp. 454-468
-
-
Chen, S.N.1
Gurha, P.2
Lombardi, R.3
Ruggiero, A.4
Willerson, J.T.5
Marian, A.J.6
-
3
-
-
84887495190
-
Mst1 inhibits autophagy by promoting the interaction between beclin1 and bcl-2
-
Maejima Y, et al. Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2. Nat Med. 2013;19(11):1478–1488.
-
(2013)
Nat Med
, vol.19
, Issue.11
, pp. 1478-1488
-
-
Maejima, Y.1
-
4
-
-
34248353095
-
Inhibition of endogenous mst1 prevents apoptosis and cardiac dysfunction without affecting cardiac hypertrophy after myocardial infarction
-
Odashima M, et al. Inhibition of endogenous Mst1 prevents apoptosis and cardiac dysfunction without affecting cardiac hypertrophy after myocardial infarction. Circ Res. 2007;100(9):1344–1352.
-
(2007)
Circ Res
, vol.100
, Issue.9
, pp. 1344-1352
-
-
Odashima, M.1
-
5
-
-
77957825772
-
Proapoptotic Rassf1A/Mst1 signaling in cardiac fibroblasts is protective against pressure overload in mice
-
Del Re DP, et al. Proapoptotic Rassf1A/Mst1 signaling in cardiac fibroblasts is protective against pressure overload in mice. J Clin Invest. 2010;120(10):3555–3567.
-
(2010)
J Clin Invest
, vol.120
, Issue.10
, pp. 3555-3567
-
-
Del Re, D.P.1
-
6
-
-
77957883342
-
The hippo signaling pathway in development and cancer
-
Pan D. The hippo signaling pathway in development and cancer. Dev Cell. 2010;19(4):491–505.
-
(2010)
Dev Cell
, vol.19
, Issue.4
, pp. 491-505
-
-
Pan, D.1
-
7
-
-
42449132938
-
A hippo in the ointment: MST signalling beyond the fly
-
Matallanas D, Romano D, Hamilton G, Kolch W, O’Neill E. A Hippo in the ointment: MST signalling beyond the fly. Cell Cycle. 2008;7(7):879–884.
-
(2008)
Cell Cycle
, vol.7
, Issue.7
, pp. 879-884
-
-
Matallanas, D.1
Romano, D.2
Hamilton, G.3
Kolch, W.4
O’Neill, E.5
-
8
-
-
84905575240
-
The hippo signal transduction network in skeletal and cardiac muscle
-
Wackerhage H, Del Re DP, Judson RN, Sudol M, Sadoshima J. The Hippo signal transduction network in skeletal and cardiac muscle. Sci Signal. 2014;7(337):re4.
-
(2014)
Sci Signal
, vol.7
, Issue.337
, pp. re4
-
-
Wackerhage, H.1
Del Re, D.P.2
Judson, R.N.3
Sudol, M.4
Sadoshima, J.5
-
9
-
-
79955405757
-
Hippo pathway inhibits wnt signaling to restrain cardiomyocyte proliferation and heart size
-
Heallen T, et al. Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size. Science. 2011;332(6028):458–461.
-
(2011)
Science
, vol.332
, Issue.6028
, pp. 458-461
-
-
Heallen, T.1
-
10
-
-
76549127712
-
Mammalian mst1 and mst2 kinases play essential roles in organ size control and tumor suppression
-
Song H, et al. Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression. Proc Natl Acad Sci U S A. 2010;107(4):1431–1436.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, Issue.4
, pp. 1431-1436
-
-
Song, H.1
-
11
-
-
84947725512
-
Hippo pathway in organ size control, tissue homeostasis, and cancer
-
Yu FX, Zhao B, Guan KL. Hippo pathway in organ size control, tissue homeostasis, and cancer. Cell. 2015;163(4):811–828.
-
(2015)
Cell
, vol.163
, Issue.4
, pp. 811-828
-
-
Yu, F.X.1
Zhao, B.2
Guan, K.L.3
-
12
-
-
33748308721
-
Association of mammalian sterile twenty kinases, mst1 and mst2, with hsalvador via c-terminal coiled-coil domains, leads to its stabilization and phosphorylation
-
Callus BA, Verhagen AM, Vaux DL. Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation. FEBS J. 2006;273(18):4264–4276.
-
(2006)
FEBS J
, vol.273
, Issue.18
, pp. 4264-4276
-
-
Callus, B.A.1
Verhagen, A.M.2
Vaux, D.L.3
-
13
-
-
16444373346
-
The ste20-like kinase mst2 activates the human large tumor suppressor kinase lats1
-
Chan EH, Nousiainen M, Chalamalasetty RB, Schafer A, Nigg EA, Sillje HH. The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1. Oncogene. 2005;24(12):2076–2086.
-
(2005)
Oncogene
, vol.24
, Issue.12
, pp. 2076-2086
-
-
Chan, E.H.1
Nousiainen, M.2
Chalamalasetty, R.B.3
Schafer, A.4
Nigg, E.A.5
Sillje, H.H.6
-
14
-
-
40149111984
-
MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation
-
Praskova M, Xia F, Avruch J. MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation. Curr Biol. 2008;18(5):311–321.
-
(2008)
Curr Biol
, vol.18
, Issue.5
, pp. 311-321
-
-
Praskova, M.1
Xia, F.2
Avruch, J.3
-
15
-
-
20844449390
-
Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity
-
McPherson JP, et al. Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity. EMBO J. 2004;23(18):3677–3688.
-
(2004)
EMBO J
, vol.23
, Issue.18
, pp. 3677-3688
-
-
McPherson, J.P.1
-
16
-
-
84901229603
-
Mst1 promotes cardiac myocyte apoptosis through phosphorylation and inhibition of Bcl-xL
-
Del Re DP, et al. Mst1 promotes cardiac myocyte apoptosis through phosphorylation and inhibition of Bcl-xL. Mol Cell. 2014;54(4):639–650.
-
(2014)
Mol Cell
, vol.54
, Issue.4
, pp. 639-650
-
-
Del Re, D.P.1
-
17
-
-
84894057702
-
A functional interaction between Hippo-YAP signalling and FoxO1 mediates the oxidative stress response
-
Shao D, et al. A functional interaction between Hippo-YAP signalling and FoxO1 mediates the oxidative stress response. Nat Commun. 2014;5:3315.
-
(2014)
Nat Commun
, vol.5
, pp. 3315
-
-
Shao, D.1
-
18
-
-
0032562796
-
Bax in murine thymus is a soluble monomeric protein that displays differential detergent-induced conformations
-
Hsu YT, Youle RJ. Bax in murine thymus is a soluble monomeric protein that displays differential detergent-induced conformations. J Biol Chem. 1998;273(17):10777–10783.
-
(1998)
J Biol Chem
, vol.273
, Issue.17
, pp. 10777-10783
-
-
Hsu, Y.T.1
Youle, R.J.2
-
19
-
-
0033522391
-
Conformation of the bax c-terminus regulates subcellular location and cell death
-
Nechushtan A, Smith CL, Hsu YT, Youle RJ. Conformation of the Bax C-terminus regulates subcellular location and cell death. EMBO J. 1999;18(9):2330–2341.
-
(1999)
EMBO J
, vol.18
, Issue.9
, pp. 2330-2341
-
-
Nechushtan, A.1
Smith, C.L.2
Hsu, Y.T.3
Youle, R.J.4
-
20
-
-
84890909335
-
Control of apoptosis by the BCL-2 protein family: Implications for physiology and therapy
-
Czabotar PE, Lessene G, Strasser A, Adams JM. Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy. Nat Rev Mol Cell Biol. 2014;15(1):49–63.
-
(2014)
Nat Rev Mol Cell Biol
, vol.15
, Issue.1
, pp. 49-63
-
-
Czabotar, P.E.1
Lessene, G.2
Strasser, A.3
Adams, J.M.4
-
21
-
-
0033535974
-
Signaling pathways in reactive oxygen species-induced cardiomyocyte apoptosis
-
von Harsdorf R, Li PF, Dietz R. Signaling pathways in reactive oxygen species-induced cardiomyocyte apoptosis. Circulation. 1999;99(22):2934–2941.
-
(1999)
Circulation
, vol.99
, Issue.22
, pp. 2934-2941
-
-
von Harsdorf, R.1
Li, P.F.2
Dietz, R.3
-
22
-
-
84994097126
-
Recent progress in research on molecular mechanisms of autophagy in the heart
-
Maejima Y, Chen Y, Isobe M, Gustafsson AB, Kitsis RN, Sadoshima J. Recent progress in research on molecular mechanisms of autophagy in the heart. Am J Physiol Heart Circ Physiol. 2015;308(4):H259–H268.
-
(2015)
Am J Physiol Heart Circ Physiol
, vol.308
, Issue.4
, pp. H259-H268
-
-
Maejima, Y.1
Chen, Y.2
Isobe, M.3
Gustafsson, A.B.4
Kitsis, R.N.5
Sadoshima, J.6
-
23
-
-
0027182438
-
Molecular characterization of angiotensin II — induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts
-
Sadoshima J, Izumo S. Molecular characterization of angiotensin II — induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Circ Res. 1993;73(3):413–423.
-
(1993)
Circ Res
, vol.73
, Issue.3
, pp. 413-423
-
-
Sadoshima, J.1
Izumo, S.2
-
24
-
-
0031007644
-
Nonionic detergents induce dimerization among members of the bcl-2 family
-
Hsu YT, Youle RJ. Nonionic detergents induce dimerization among members of the Bcl-2 family. J Biol Chem. 1997;272(21):13829–13834.
-
(1997)
J Biol Chem
, vol.272
, Issue.21
, pp. 13829-13834
-
-
Hsu, Y.T.1
Youle, R.J.2
-
25
-
-
77951281040
-
Upregulation of nox4 by hypertrophic stimuli promotes apoptosis and mitochondrial dysfunction in cardiac myocytes
-
Ago T, Kuroda J, Pain J, Fu C, Li H, Sadoshima J. Upregulation of Nox4 by hypertrophic stimuli promotes apoptosis and mitochondrial dysfunction in cardiac myocytes. Circ Res. 2010;106(7):1253–1264.
-
(2010)
Circ Res
, vol.106
, Issue.7
, pp. 1253-1264
-
-
Ago, T.1
Kuroda, J.2
Pain, J.3
Fu, C.4
Li, H.5
Sadoshima, J.6
-
26
-
-
84921985434
-
Endogenous drp1 mediates mitochondrial autophagy and protects the heart against energy stress
-
Ikeda Y, et al. Endogenous Drp1 mediates mitochondrial autophagy and protects the heart against energy stress. Circ Res. 2015;116(2):264–278.
-
(2015)
Circ Res
, vol.116
, Issue.2
, pp. 264-278
-
-
Ikeda, Y.1
-
27
-
-
44649184557
-
A redox-dependent pathway for regulating class II HDACs and cardiac hypertrophy
-
Ago T, et al. A redox-dependent pathway for regulating class II HDACs and cardiac hypertrophy. Cell. 2008;133(6):978–993.
-
(2008)
Cell
, vol.133
, Issue.6
, pp. 978-993
-
-
Ago, T.1
|