IL-6 mediates differentiation disorder during spermatogenesis in obesity-associated inflammation by affecting the expression of Zfp637 through the SOCS3/STAT3 pathway

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Huang, Guizhen ^a   Yuan, Miao ^a   Zhang, Jie ^a   Li, Jun ^a   Gong, Di ^a   Li, Yanyan ^a   Lin, Ping ^a   Huang, Lugang ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA-CYANO-(3,4-DIHYDROXY)-N-BENZYLCINNAMIDE; DNA BINDING PROTEIN; INTERLEUKIN 6; LEPTIN; SOCS3 PROTEIN, MOUSE; SOX2 PROTEIN, MOUSE; STAT3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; TRANSCRIPTION FACTOR SOX; TYRPHOSTIN; ZFP637 PROTEIN, MOUSE;

ANIMAL; ANTAGONISTS AND INHIBITORS; BLOOD; CELL LINE; COMPLICATION; CYTOLOGY; DOWN REGULATION; DRUG EFFECTS; GENETICS; INFLAMMATION; MALE; METABOLISM; MOUSE; MOUSE MUTANT; OBESITY; PATHOLOGY; PHOSPHORYLATION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SPERMATOGENESIS; SPERMATOGONIUM; TESTIS;

ANIMALS; CELL LINE; DNA-BINDING PROTEINS; DOWN-REGULATION; INFLAMMATION; INTERLEUKIN-6; LEPTIN; MALE; MICE; MICE, OBESE; OBESITY; PHOSPHORYLATION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SOXB1 TRANSCRIPTION FACTORS; SPERMATOGENESIS; SPERMATOGONIA; STAT3 TRANSCRIPTION FACTOR; SUPPRESSOR OF CYTOKINE SIGNALING 3 PROTEIN; TESTIS; TYRPHOSTINS;

EID: 84975705235     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep28012     Document Type: Article

References (29)

1. Gao, B. et al. Zinc finger protein 637 protects cells against oxidative stress-induced premature senescence by mTERT-mediated telomerase activity and telomere maintenance. Cell Death Dis. Jul 17(5), e1334 (2014).
2. Li, K. et al. A novel zinc finger protein Zfp637 behaves as a repressive regulator in myogenic cellular differentiation. J Cell Biochem. 110, 352-362 (2010).
3. Wagner, I. V. et al. Effects of obesity on human sexual development. Nat Rev Endocrinol. 8, 246-54 (2012).
4. Burt Solorzano, C. M. & McCartney, C. R. Obesity and the pubertal transition in girls and boys. Reproduction. 140, 399-410 (2010).
5. Martins e Silva, B., Rêgo, L. M., Galvão, M. A., Florêncio, T. M. & Cavalcante, J. C. Incidence of sexual dysfunction in patients with obesity and overweight. Rev Col Bras Cir. 40, 196-202 (2013).
6. Geetha, P. et al. Sexual dysfunction (Krcchra Vyavāya) in obesity (Sthaulya): Validation by an observational study. Anc Sci Life. 32, 76-81 (2012).
7. Makki, K., Froguel, P. & Wolowczuk, I. Adipose Tissue in Obesity-Related Inflammation and Insulin Resistance: Cells, Cytokines, and Chemokines. ISRN Inflamm. 22, 139-239 (2013).
8. Mukumoto, H., Takahashi, Y., Ando, M., Nishikawa, M. & Takakura, Y. Expression profile-dependent improvement of insulin sensitivity by gene delivery of interleukin-6 in a mouse model of type II diabetes. Mol Pharm. 10, 3812-3821 (2013).
9. Daniele, G. et al. The inflammatory status score including IL-6, TNF-α, osteopontin, fractalkine, MCP-1 and adiponectin underlies whole-body insulin resistance and hyperglycemia in type 2 diabetes mellitus. Acta Diabetol 51, 123-131 (2014).
10. Białas, M. et al. The role of IL-6, IL-10, TNF-alpha and its receptors TNFR1 and TNFR2 in the local regulatory system of normal and impaired human spermatogenesis. Am J Reprod Immunol. 62, 51-59 (2009).
11. Potashnik, H. et al. Interleukin-6 expression during normal maturation of the mouse testis. Eur Cytokine Netw. 16, 161-165 (2015).
12. Diemer, T., Hales, D. B. & Weidner, W. Immune-endocrine interactions and Leydig cell function: the role of cytokines. Andrologia. 35, 55-63 (2003).
13. Yuan, M. et al. Hyperleptinemia directly affects testicular maturation at different sexual stages in mice, and suppressor of cytokine signaling 3 is involved in thisprocess. Reprod Biol Endocrinol. 6, 12:15[Epub] (2013).
14. Wang, P. et al. Differentiation of spermatogonial stem cell-like cells from murine testicular tissue into haploid male germ cells in vitro. Cytotechnology. 66, 365-372 (2014).
15. Li, K. et al. Cytoplasmic expression, antibody production, and characterization of the novel zinc finger protein 637. Appl Microbiol Biotechnol. 97, 741-749 (2013).
16. Travers, R. L., Motta, A. C., Betts, J. A. & Thompson, D. Adipose tissue metabolic and inflammatory responses to a mixed meal in lean, overweight and obese men. Eur J Nutr. Oct 29 [Epub ahead of print] (2015).
17. Yoshida, S. et al. A combination of interleukin-6 and its soluble receptor impairs sperm motility: implications in infertility associated with endometriosis. Hum Reprod. 19, 1821-1825 (2004).
18. Lachance, C. & Leclerc, P. Mediators of the Jak/STAT signaling pathway in human spermatozoa. Biol Reprod. 85, 1222-1231 (2011).
19. White, C. A. & Nicola, N. A. SOCS3: An essential physiological inhibitor of signaling by interleukin-6 and G-CSF family cytokines. JAKSTAT. Oct 1, 2(4), e25045 (2013).
20. Inagaki-Ohara, K., Kondo, T., Ito, M. & Yoshimura, A. SOCS, inflammation, and cancer. JAKSTAT. Jul 1; 2(3), e24053 (2013).
21. Wunderlich, C. M., Hövelmeyer, N. & Wunderlich, F. T. Mechanisms of chronic JAK-STAT3-SOCS3 signaling in obesity. JAKSTAT. Apr 1, 2(2), e23878 (2013).
22. Nicholson, S. E. et al. Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130. Proc Natl Acad Sci USA 97, 6493-6498 (2000).
23. Matsushita, K. et al. LIF/STAT3/SOCS3 signaling pathway in murine bone marrow stromal cells suppresses osteoblast differentiation. J Cell Biochem. 115, 1262-1268 (2014).
24. Williams, J. J., Munro, K. M. & Palmer, T. M. Role of ubiquitylation in controlling suppressor of cytokine signalling 3 (SOCS3) function and expression. Cells 3, 546-562 (2014).
25. Zhang, H. et al. Interleukin-6 disrupts blood-testis barrier through inhibiting protein degradation or activating phosphorylated ERK in Sertoli cells. Sci Rep. 4, 4260 (2014).
26. Xu, B. et al. Metabolomic profiles reveal key metabolic changes in heat stress-treated mouse Sertoli cells. Toxicol in vitro. 29, 1745-1752 (2015).
27. Winnall, W. R., Muir, J. A. & Hedger, M. P. Differential responses of epithelial Sertoli cells of the rat testis to Toll-like receptor 2 and 4 ligands: implications for studies of testicular inflammation using bacterial lipopolysaccharides. Innate Immun. 17, 123-136 (2011).
28. Aslani, F. et al. Targeting high mobility group box protein 1 ameliorates testicular inflammation in experimental autoimmune orchitis. Hum Reprod. 30, 417-431 (2015).
29. Patra, S. K. et al. First evidence of molecular characterization of rohu carp Sox2 gene being expressed in proliferating spermatogonial cells. Theriogenology. 84, 268-276 (2015).