Lower cerebral blood flow is associated with faster cognitive decline in Alzheimer’s disease

European Radiology

Volumn 27, Issue 3, 2017, Pages 1169-1175

  Benedictus, Marije R ^a   Leeuwis, Annebet E ^a   Binnewijzend, Maja A A ^a   Kuijer, Joost P A ^b   Scheltens, Philip ^a   Barkhof, Frederik ^b   van der Flier, Wiesje M ^a,b   Prins, Niels D ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Alzheimer s disease; dementia; perfusion; prognosis; progression

Indexed keywords

AGED; ALZHEIMER DISEASE; ARTERIAL SPIN LABELING; ARTICLE; BRAIN ATROPHY; BRAIN BLOOD FLOW; BRAIN HEMORRHAGE; BRAIN REGION; BRAIN SIZE; CEREBROSPINAL FLUID; DEMENTIA; DISEASE ASSOCIATION; FEMALE; FOLLOW UP; GRAY MATTER; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDIAL TEMPORAL LOBE; MENTAL DETERIORATION; MINI MENTAL STATE EXAMINATION; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; POSTERIOR CINGULATE; PRECUNEUS; PRIORITY JOURNAL; WHITE MATTER; WHOLE BRAIN RADIOTHERAPY; ATROPHY; BRAIN; BRAIN CIRCULATION; DIAGNOSTIC IMAGING; DISEASE COURSE; LONGITUDINAL STUDY; MIDDLE AGED; NEUROPSYCHOLOGICAL TEST; PATHOLOGY; PSYCHOLOGY; STATISTICAL MODEL; TEMPORAL LOBE; TIME FACTOR;

SPIN LABEL;

AGED; ALZHEIMER DISEASE; ATROPHY; BRAIN; CEREBROVASCULAR CIRCULATION; DISEASE PROGRESSION; FEMALE; GRAY MATTER; HUMANS; LINEAR MODELS; LONGITUDINAL STUDIES; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; SPIN LABELS; TEMPORAL LOBE; TIME FACTORS;

EID: 84975499899     PISSN: 09387994     EISSN: 14321084     Source Type: Journal    
DOI: 10.1007/s00330-016-4450-z     Document Type: Article

References (43)

1. Doody RS, Massman P, Dunn JK (2001) A method for estimating progression rates in Alzheimer disease. Arch Neurol 58:449–454
2. Lam B, Masellis M, Freedman M, Stuss DT, Black SE (2013) Clinical, imaging, and pathological heterogeneity of the Alzheimer's disease syndrome. Alzheimers Res Ther 5:1
3. Sona A, Ellis KA, Ames D (2013) Rapid cognitive decline in Alzheimer's disease: a literature review. Int Rev Psychiatry 25:650–658
4. Sperling RA, Aisen PS, Beckett LA et al (2011) Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 7:280–292
5. Scheltens P, Blennow K, Breteler MM et al (2016) Alzheimer’s disease. Lancet. doi: 10.1016/S0140-6736(15)01124-1
6. Jack CR Jr, Knopman DS, Jagust WJ et al (2013) Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers. Lancet Neurol 12:207–216
7. Alsop DC, Dai W, Grossman M, Detre JA (2010) Arterial spin labeling blood flow MRI: its role in the early characterization of Alzheimer's disease. J Alzheimers Dis 20:871–880
8. Binnewijzend MA, Benedictus MR, Kuijer JP et al. (2015) Cerebral perfusion in the predementia stages of Alzheimer's disease. Eur Radiol 26(2):506–14. doi: 10.1007/s00330-015-3834-9
9. Wolk DA, Detre JA (2012) Arterial spin labeling MRI: an emerging biomarker for Alzheimer's disease and other neurodegenerative conditions. Curr Opin Neurol 25:421–428
10. Chen Y, Wolk DA, Reddin JS et al (2011) Voxel-level comparison of arterial spin-labeled perfusion MRI and FDG-PET in Alzheimer disease. Neurology 77:1977–1985
11. Jueptner M, Weiller C (1995) Review: does measurement of regional cerebral blood flow reflect synaptic activity? Implications for PET and fMRI. Neuroimage 2:148–156
12. Musiek ES, Chen Y, Korczykowski M et al (2012) Direct comparison of fluorodeoxyglucose positron emission tomography and arterial spin labeling magnetic resonance imaging in Alzheimer's disease. Alzheimers Dement 8:51–59
13. Ingelsson M, Fukumoto H, Newell KL et al (2004) Early Abeta accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain. Neurology 62:925–931
14. Landau SM, Mintun MA, Joshi AD et al (2012) Amyloid deposition, hypometabolism, and longitudinal cognitive decline. Ann Neurol 72:578–586
15. Chao LL, Buckley ST, Kornak J et al (2010) ASL perfusion MRI predicts cognitive decline and conversion from MCI to dementia. Alzheimer Dis Assoc Disord 24:19–27
16. Hanyu H, Sato T, Hirao K, Kanetaka H, Iwamoto T, Koizumi K (2010) The progression of cognitive deterioration and regional cerebral blood flow patterns in Alzheimer's disease: a longitudinal SPECT study. J Neurol Sci 290:96–101
17. Nagahama Y, Nabatame H, Okina T et al (2003) Cerebral correlates of the progression rate of the cognitive decline in probable Alzheimer's disease. Eur Neurol 50:1–9
18. Xekardaki A, Rodriguez C, Montandon ML et al (2015) Arterial spin labeling may contribute to the prediction of cognitive deterioration in healthy elderly individuals. Radiology 274:490–499
19. van der Flier WM, Pijnenburg YA, Prins N et al (2014) Optimizing patient care and research: the Amsterdam Dementia Cohort. J Alzheimers Dis 41:313–327
20. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM (1984) Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34:939–944
21. McKhann GM, Knopman DS, Chertkow H et al (2011) The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 7:263–269
22. Verhage F (1964) Intelligence and Age: Study with Dutch People Aged 12–77 [In Dutch]; Van Gorcum, Assen
23. Scheltens P, Launer LJ, Barkhof F, Weinstein HC, van Gool WA (1995) Visual assessment of medial temporal lobe atrophy on magnetic resonance imaging: interobserver reliability. J Neurol 242:557–560
24. Fazekas F, Chawluk JB, Alavi A, Hurtig HI, Zimmerman RA (1987) MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging. AJR Am J Roentgenol 149:351–356
25. Alsop DC, Detre JA, Golay X et al. (2015) Recommended implementation of arterial spin-labeled perfusion MRI for clinical applications: A consensus of the ISMRM perfusion study group and the European consortium for ASL in dementia. Magn Reson Med 73(1):102-16. doi: 10.1002/mrm.25197
26. Dai W, Garcia D, de BC, Alsop DC: Continuous flow-driven inversion for arterial spin labeling using pulsed radio frequency and gradient fields. Magn Reson Med 2008;60:1488-1497
27. Buxton RB, Frank LR, Wong EC, Siewert B, Warach S, Edelman RR (1998) A general kinetic model for quantitative perfusion imaging with arterial spin labeling. Magn Reson Med 40:383–396
28. Smith SM (2002) Fast robust automated brain extraction. Hum Brain Mapp 17:143–155
29. Jenkinson M, Smith S (2001) A global optimisation method for robust affine registration of brain images. Med Image Anal 5:143–156
30. Zhang Y, Brady M, Smith S (2001) Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm. IEEE Trans Med Imaging 20:45–57
31. Binnewijzend MA, Kuijer JP, Benedictus MR et al (2013) Cerebral Blood Flow Measured with 3D Pseudocontinuous Arterial Spin-labeling MR Imaging in Alzheimer Disease and Mild Cognitive Impairment: A Marker for Disease Severity. Radiology 267:221–230
32. Asllani I, Borogovac A, Brown TR (2008) Regression algorithm correcting for partial volume effects in arterial spin labeling MRI. Magn Reson Med 60:1362–1371
33. Folstein MF, Folstein SE, McHugh PR (1975) "Mini-mental state" A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12:189–198
34. de Waal H, Stam CJ, de Haan W et al (2013) Alzheimer's disease patients not carrying the apolipoprotein E epsilon4 allele show more severe slowing of oscillatory brain activity. Neurobiol Aging 34:2158–2163
35. Sluimer JD, van der Flier WM, Karas GB et al (2008) Whole-brain atrophy rate and cognitive decline: longitudinal MR study of memory clinic patients. Radiology 248:590–598
36. Hutton B, Thomas B, Erlandsson K et al (2012) What approach to brain partial volume correction is best for PET/MRI? Nucl Inst Methods Phys Res A 702:29–33
37. Dai W, Lopez OL, Carmichael OT, Becker JT, Kuller LH, Gach HM (2009) Mild cognitive impairment and alzheimer disease: patterns of altered cerebral blood flow at MR imaging. Radiology 250:856–866
38. Terry RD, Masliah E, Salmon DP et al (1991) Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann Neurol 30:572–580
39. Palop JJ, Mucke L (2010) Amyloid-beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks. Nat Neurosci 13:812–818
40. Dennis EL, Thompson PM (2014) Functional brain connectivity using fMRI in aging and Alzheimer's disease. Neuropsychol Rev 24:49–62
41. Viswanathan A, Greenberg SM (2011) Cerebral amyloid angiopathy in the elderly. Ann Neurol 70:871–880
42. Mattsson N, Tosun D, Insel PS et al (2014) Association of brain amyloid-beta with cerebral perfusion and structure in Alzheimer's disease and mild cognitive impairment. Brain 137:1550–1561
43. Stam CJ (2014) Modern network science of neurological disorders. Nat Rev Neurosci 15:683–695