Intraamniotic inflammation and umbilical cord blood interleukin-6 concentrations in pregnancies complicated by preterm prelabor rupture of membranes

Journal of Maternal-Fetal and Neonatal Medicine

Volumn 30, Issue 8, 2017, Pages 900-910

  Musilova, Ivana ^a   Andrys, Ctirad ^a   Drahosova, Marcela ^a   Soucek, Ondrej ^a   Stepan, Martin ^a   Bestvina, Tomas ^a   Spacek, Richard ^b   Jacobsson, Bo ^c,d   Cobo, Teresa ^c,e,f   Kacerovsky, Marian ^a  

^a UNIVERSITY HOSPITAL HRADEC KRALOVE   (Czech Republic)

^b UNIVERSITY OF OSTRAVA   (Czech Republic)

^c UNIVERSITY OF GOTHENBURG   (Sweden)

^d NORWEGIAN INSTITUTE OF PUBLIC HEALTH   (Norway)

^e UNIVERSITY OF BARCELONA   (Spain)

^f CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE ENFERMEDADES RARAS CIBERER   (Spain)

Author keywords

Cytokines; fetal inflammatory response; intraamniotic inflammation; preterm delivery

Indexed keywords

INTERLEUKIN 6; IL6 PROTEIN, HUMAN;

ADULT; AMNION FLUID; ARTICLE; BACTERIUM DETECTION; BLOOD SAMPLING; CHLAMYDIA TRACHOMATIS; COHORT ANALYSIS; CONTROLLED STUDY; ELISA KIT; FEMALE; FETAL INFLAMMATORY RESPONSE SYNDROME; GESTATIONAL AGE; HUMAN; INFECTION; INFLAMMATION; INTRAAMNIOTIC INFLAMMATION; MICROBIAL INVASION OF THE AMNIOTIC CAVITY; MYCOPLASMA HOMINIS; NONHUMAN; PREGNANCY; PREMATURE FETUS MEMBRANE RUPTURE; RETROSPECTIVE STUDY; UMBILICAL CORD BLOOD; UREAPLASMA; VEIN PUNCTURE; BLOOD; CHEMISTRY; CHORIOAMNIONITIS; FETUS BLOOD; METABOLISM; NEWBORN; PREGNANCY COMPLICATION;

ADULT; AMNIOTIC FLUID; CHORIOAMNIONITIS; FEMALE; FETAL BLOOD; FETAL MEMBRANES, PREMATURE RUPTURE; GESTATIONAL AGE; HUMANS; INFANT, NEWBORN; INTERLEUKIN-6; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; RETROSPECTIVE STUDIES;

EID: 84975257588     PISSN: 14767058     EISSN: 14764954     Source Type: Journal    
DOI: 10.1080/14767058.2016.1197900     Document Type: Article

References (43)

1. Mercer BM., Preterm premature rupture of the membranes. Obstet Gynecol 2003;101:178–93
2. Romero R, Espinoza J, Kusanovic JP, et al. The preterm parturition syndrome. BJOG 2006;113:17–42
3. Dutta EH, Behnia F, Boldogh I, et al. Oxidative stress damage-associated molecular signaling pathways differentiate spontaneous preterm birth and preterm premature rupture of the membranes. Mol Hum Reprod 2016;22:143–57
4. Murtha AP, Menon R., Regulation of fetal membrane inflammation:a critical step in reducing adverse pregnancy outcome. Am J Obstet Gynecol 2015;213:447–8
5. Bredeson S, Papaconstantinou J, Deford JH, et al. HMGB1 promotes a p38MAPK associated non-infectious inflammatory response pathway in human fetal membranes. PLoS One 2014;9:e113799
6. Menon R, Boldogh I, Hawkins HK, et al. Histological evidence of oxidative stress and premature senescence in preterm premature rupture of the human fetal membranes recapitulated in vitro. Am J Pathol 2014;184:1740–51
7. Kacerovsky M, Musilova I, Hornychova H, et al. Bedside assessment of amniotic fluid interleukin-6 in preterm prelabor rupture of membranes. Am J Obstet Gynecol 2014;211:385 e381–9
8. Musilova I, Kutova R, Pliskova L, et al. Intraamniotic inflammation in women with preterm prelabor rupture of membranes. PLoS One 2015;10:e0133929
9. Lee J, Romero R, Kim SM, et al. A new antibiotic regimen treats and prevents intra-amniotic inflammation/infection in patients with preterm PROM. J Matern Fetal Neonatal Med 2016;29:2727–37
10. Kim CJ, Romero R, Chaemsaithong P, et al. Acute chorioamnionitis and funisitis:definition, pathologic features, and clinical significance. Am J Obstet Gynecol 2015;213:S29–52
11. Chaemsaithong P, Romero R, Korzeniewski SJ, et al. A point of care test for interleukin-6 in amniotic fluid in preterm prelabor rupture of membranes:a step toward the early treatment of acute intra-amniotic inflammation/infection. J Matern Fetal Neonatal Med 2016;29:360–7
12. Gomez R, Romero R, Ghezzi F, et al. The fetal inflammatory response syndrome. Am J Obstet Gynecol 1998;179:194–202
13. Gotsch F, Romero R, Kusanovic JP, et al. The fetal inflammatory response syndrome. Clin Obstet Gynecol 2007;50:652–83
14. Hofer N, Kothari R, Morris N, et al. The fetal inflammatory response syndrome is a risk factor for morbidity in preterm neonates. Am J Obstet Gynecol 2013;209:542 e541–e511
15. Cobo T, Kacerovsky M, Andrys C, et al. Umbilical cord blood IL-6 as predictor of early-onset neonatal sepsis in women with preterm prelabour rupture of membranes. PLoS One 2013;8:e69341
16. Chiesa C, Pacifico L, Natale F, et al. Fetal and early neonatal interleukin-6 response. Cytokine 2015;76:1–12
17. Buhimschi CS, Buhimschi IA, Abdel-Razeq S, et al. Proteomic biomarkers of intra-amniotic inflammation:relationship with funisitis and early-onset sepsis in the premature neonate. Pediatr Res 2007;61:318–24
18. Kacerovsky M, Cobo T, Andrys C, et al. The fetal inflammatory response in subgroups of women with preterm prelabor rupture of the membranes. J Matern Fetal Neonatal Med 2013;26:795–801
19. Stepan M, Cobo T, Maly J, et al. Neonatal outcomes in subgroups of women with preterm prelabor rupture of membranes before 34 weeks. J Matern Fetal Neonatal Med 2016;29:2373–7
20. Combs CA, Gravett M, Garite TJ, et al. Amniotic fluid infection, inflammation, and colonization in preterm labor with intact membranes. Am J Obstet Gynecol 2014;210:125 e121–e115
21. Romero R, Miranda J, Chaemsaithong P, et al. Sterile and microbial-associated intra-amniotic inflammation in preterm prelabor rupture of membranes. J Matern Fetal Neonatal Med 2015;28:1394–409
22. Romero R, Miranda J, Chaiworapongsa T, et al. Sterile intra-amniotic inflammation in asymptomatic patients with a sonographic short cervix:prevalence and clinical significance. J Matern Fetal Neonatal Med 2014;24:1–17
23. Romero R, Miranda J, Chaiworapongsa T, et al. Prevalence and clinical significance of sterile intra-amniotic inflammation in patients with preterm labor and intact membranes. Am J Reprod Immunol 2014;72:458–74
24. Lee SE, Romero R, Jung H, et al. The intensity of the fetal inflammatory response in intraamniotic inflammation with and without microbial invasion of the amniotic cavity. Am J Obstet Gynecol 2007;197:294 e291–6
25. Pacora P, Chaiworapongsa T, Maymon E, et al. Funisitis and chorionic vasculitis:the histological counterpart of the fetal inflammatory response syndrome. J Matern Fetal Neonatal Med 2002;11:18–25
26. Tambor V, Kacerovsky M, Andrys C, et al. Amniotic fluid cathelicidin in PPROM pregnancies:from proteomic discovery to assessing its potential in inflammatory complications diagnosis. PLoS One 2012;7:e41164
27. Kacerovsky M, Pliskova L, Bolehovska R, et al. The microbial load with genital mycoplasmas correlates with the degree of histologic chorioamnionitis in preterm PROM. Am J Obstet Gynecol 2011;205:213 e211–7
28. Fouhy F, Deane J, Rea MC, et al. The effects of freezing on faecal microbiota as determined using MiSeq sequencing and culture-based investigations. PloS One 2015;10:e0119355
29. Greisen K, Loeffelholz M, Purohit A, Leong D., PCR primers and probes for the 16S rRNA gene of most species of pathogenic bacteria, including bacteria found in cerebrospinal fluid. J Clin Microbiol 1994;32:335–51
30. Chaemsaithong P, Romero R, Korzeniewski SJ, et al. A rapid interleukin-6 bedside test for the identification of intra-amniotic inflammation in preterm labor with intact membranes. J Matern Fetal Neonatal Med 2016;29:349–59
31. Maxwell NC, Davies PL, Kotecha S., Antenatal infection and inflammation:what's new? Curr Opin Infect Dis 2006;19:253–8
32. Bearfield C, Davenport ES, Sivapathasundaram V, Allaker RP., Possible association between amniotic fluid micro-organism infection and microflora in the mouth. BJOG 2002;109:527–33
33. Yoon BH, Romero R, Moon J, et al. Differences in the fetal interleukin-6 response to microbial invasion of the amniotic cavity between term and preterm gestation. J Matern Fetal Neonatal Med 2003;13:32–8
34. Yoon BH, Romero R, Park JS, et al. Microbial invasion of the amniotic cavity with Ureaplasma urealyticum is associated with a robust host response in fetal, amniotic, and maternal compartments. Am J Obstet Gynecol 1998;179:1254–60
35. DiGiulio DB, Romero R, Kusanovic JP, et al. Prevalence and diversity of microbes in the amniotic fluid, the fetal inflammatory response, and pregnancy outcome in women with preterm pre-labor rupture of membranes. Am J Reprod Immunol 2010;64:38–57
36. Oh KJ, Lee KA, Sohn YK, et al. Intraamniotic infection with genital mycoplasmas exhibits a more intense inflammatory response than intraamniotic infection with other microorganisms in patients with preterm premature rupture of membranes. Am J Obstet Gynecol 2010;203:211 e211–8
37. Kacerovsky M, Celec P, Vlkova B, et al. Amniotic fluid protein profiles of intraamniotic inflammatory response to Ureaplasma spp. and other bacteria. PLoS One 2013;8:e60399
38. Jacobsson B, Aaltonen R, Rantakokko-Jalava K, et al. Quantification of Ureaplasma urealyticum DNA in the amniotic fluid from patients in PTL and pPROM and its relation to inflammatory cytokine levels. Acta Obstet Gynecol Scand 2009;88:63–70
39. Kasper DC, Mechtler TP, Reischer GH, et al. The bacterial load of ureaplasma parvum in amniotic fluid is correlated with an increased intrauterine inflammatory response. Diagn Microbiol Infect Dis 2010;67:117–21
40. Kacerovsky M, Pliskova L, Bolehovska R, et al. The impact of the microbial load of genital mycoplasmas and gestational age on the intensity of intraamniotic inflammation. Am J Obstet Gynecol 2012;206:342 e341–8
41. Vaisbuch E, Romero R, Gomez R, et al. An elevated fetal interleukin-6 concentration can be observed in fetuses with anemia due to Rh alloimmunization:implications for the understanding of the fetal inflammatory response syndrome. J Matern Fetal Neona 2011;24:391–6
42. Lee J, Romero R, Lee KA, et al. Meconium aspiration syndrome:a role for fetal systemic inflammation. Am J Obstet Gynecol 2016;214:366 e361–9
43. Matoba N, Yu Y, Mestan K, et al. Differential patterns of 27 cord blood immune biomarkers across gestational age. Pediatrics 2009;123:1320–8