Synthesis of (+)-7,20-Diisocyanoadociane and Liver-Stage Antiplasmodial Activity of the Isocyanoterpene Class

Journal of the American Chemical Society

Volumn 138, Issue 23, 2016, Pages 7268-7271

  Lu, Hai Hua ^a   Pronin, Sergey V ^a,c   Antonova Koch, Yevgeniya ^b   Meister, Stephan ^b   Winzeler, Elizabeth A ^b   Shenvi, Ryan A ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DETOXIFICATION;

ANTIMALARIAL ACTIVITY; ANTIPLASMODIAL ACTIVITY; BUILDING BLOCKES; MECHANISM OF ACTION; SINGLE ENANTIOMERS;

METABOLITES;

7,20 DIISOCYANOADOCIANE; ANTIMALARIAL AGENT; TERPENE DERIVATIVE; UNCLASSIFIED DRUG; DIISOCYANOADOCIANE; HEME; NITRILE; PYRENE DERIVATIVE;

ANTIMALARIAL ACTIVITY; ANTIPLASMODIAL ACTIVITY; ARTICLE; ASYMMETRIC SYNTHESIS; CATALYST; CONTROLLED STUDY; CRYSTALLIZATION; CYCLIZATION; CYCLOADDITION; DECARBOXYLATION; DEOXYGENATION; DIASTEREOISOMER; DIELS ALDER REACTION; DRUG BINDING; DRUG DETOXIFICATION; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG MIXTURE; DRUG POTENCY; DRUG SYNTHESIS; DRUG UPTAKE; ENANTIOMER; HYDROGENATION; HYDROPHOBICITY; IC50; ISOMERIZATION; NONHUMAN; PHARMACOPHORE; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; SCHIZONT; SOLVOLYSIS; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; LIVER; METABOLISM; PARASITOLOGY; STEREOISOMERISM; SYNTHESIS;

ANTIMALARIALS; HEME; LIVER; MOLECULAR STRUCTURE; NITRILES; PLASMODIUM FALCIPARUM; PYRENES; STEREOISOMERISM;

EID: 84975042668     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/jacs.6b03899     Document Type: Article

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