Synthesis and in vitro anti-HIV-1 activity of a series of N-arylsulfonyl-3-propionylindoles

Zeitschrift fur Naturforschung - Section C Journal of Biosciences

Volumn 71, Issue 5-6, 2016, Pages 105-109

  Che, Zhiping ^a   Tian, Yuee ^a   Hu, Zhenjie ^a   Chen, Yingwu ^a   Liu, Shengming ^a   Chen, Genqiang ^a  

^a HENAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

human immunodeficiency virus type 1; inhibitor of virus replication; N Arylsulfonyl 3 propionylindoles

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; INDOLE DERIVATIVE;

CHEMISTRY; DRUG EFFECTS; HIV INFECTIONS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; METABOLISM; PATHOLOGY; PHYSIOLOGY; SYNTHESIS; TUMOR CELL LINE; VIRUS REPLICATION;

ANTI-HIV AGENTS; CELL LINE, TUMOR; HIV INFECTIONS; HIV-1; HUMANS; INDOLES; VIRUS REPLICATION;

EID: 84974794716     PISSN: 09395075     EISSN: None     Source Type: Journal    
DOI: 10.1515/znc-2015-0122     Document Type: Article

References (16)

1. Richman DD. HIV chemotherapy. Nature 2001;410:995-1001.
2. Xu H, Lv M. Developments of indoles as anti-HIV-1 inhibitors. Curr Pharm Des 2009;15:2120-48.
3. Sogolow E, Peersman G, Semaan S, Strouse D, Lyles CM, the HIV/ AIDS Prevention Research Synthesis Project Team. The HIV/AIDS prevention research synthesis project: scope, methods and study classification results. J Acquir Immune Defic Syndr 2002;30:S25-9.
4. Che ZP, Huang N, Yu X, Yang LM, Ran JQ, Zhi XY, et al. Microwaveassisted combinatorial synthesis of 2-alkyl-2-(N-arylsulfonylindol-3-yl)-3-N-acyl-5-aryl-1,3,4-oxadiazolines as anti-HIV-1 agents. Comb Chem High T Scr 2013;16:400-7.
5. Sorensen JL, Copeland AL. Drug abuse treatment as a HIV prevention strategy: A review. Drug Alcohol Depen 2000;59: 17-31.
6. Ran JQ, Huang N, Xu H, Yang LM, Lv M, Zheng YT. Anti HIV-1 agents 5: synthesis and anti-HIV-1 activity of some N-arylsulfonyl-3-acetylindoles in vitro. Bioorg Med Chem Lett 2010;20:3534-6.
7. Che ZP, Liu SM, Tian YE, Hu ZJ, Chen YW, Chen GQ. Design and synthesis of novel N-arylsulfonyl-3-(2-yl-ethanone)-6-methylindole derivatives as inhibitors of HIV-1 replication. Pharmaceuticals 2015;8:221-9.
8. Fan LL, Liu WQ, Xu H, Yang LM, Lv M, Zheng YT. Anti human immunodeficiency virus-1 (HIV-1) agents 3: synthesis and in vitro anti-HIV-1 activity of some N-arylsulfonylindoles. Chem Pharm Bull 2009;57:797-800.
9. Tsai Y, Dukat M, Slassi A, MacLean N, Demchyshyn L, Savage JE, et al. N1-(Benzenesulfonyl)tryptamines as novel 5-HT6 antagonists. Bioorg Med Chem Lett 2000;10:2295-9.
10. Russell MGN, Baker RJ, Barden L, Beer MS, Bristow L, Broughton HB, et al. N-Arylsulfonylindole derivatives as serotonin 5-HT6 receptor ligands. J Med Chem 2001;44:3881-95.
11. Pullagurla M, Siripurapu U, Kolanos R, Bondarev ML, Dukat M, Setola V, et al. Binding of amine-substituted N1-benzenesulfonylindoles at human 5-HT6 serotonin receptors. Bioorg Med Chem Lett 2005;15:5298-302.
12. Che ZP, Zhang SY, Shao YH, Fan LL, Xu H, Yu X, et al. Synthesis and quantitative structure-activity relationship (QSAR) study of novel N-arylsulfonyl-3-acylindole arylcarbonyl hydrazone derivatives as nematicidal agents. J Agric Food Chem 2013;61:5696-705.
13. Reed LJ, Muench H. A simple method of estimating fifty percent end points. Am J Hyg 1938;27:493-7.
14. Zhang GH, Wang Q, Chen JJ, Zhang XM, Tam SC, Zheng YT. The anti-HIV-1 effect of scutellarin. Biochem Biophys Res Commun 2005;334:812-6.
15. Zheng YT, Zhang WF, Ben KL, Wang JH. In vitro immunotoxicity and cytotoxicity of trichosanthin against human normal immunocytes and lekeumia-lymphoma cells. Immunopharmacol Immunotoxicol 1995;17:69-79.
16. Wang Q, Ding ZH, Liu JK, Zheng YT. Xanthohumol, a novel anti-HIV-1 agent purified from hop Humulus lupulus. Antiviral Res 2004;64:189-94.