Activity of compounds from Taxillus sutchuenensis as inhibitors of HCV NS3 serine protease

Natural Product Research

Volumn 31, Issue 4, 2017, Pages 487-491

  Yang, Liyuan ^a,b   Lin, Jun ^b   Zhou, Bin ^b   Liu, Yangang ^a   Zhu, Baoquan ^a,b  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b Shanghai Institute of Pharmaceutical Industry   (China)

Author keywords

Antiviral; HCV NS3 protease; inhibitor; Taxillus sutchuenensis (Lecomte) Danser

Indexed keywords

3 HYDROXY 1,7 BIS(4 HYDROXY PHENYL) HEPTEN 5 ONE; HANNOKINOL; HEPACIVIRIN INHIBITOR; HOMOERIODICTYOL 7 O BETA DEXTRO GLYCOSIDE; ISOSAKURANETIN; KAEMPFEROL 3,7 BISRHAMNOSIDE; MESO HANNOKINOL; OLEANIC ACID; QUERCETIN 3,3',4' TRIMETHYL ETHER; TREMULACIN; UNCLASSIFIED DRUG; VISCUMNEOSIDE I; ANTIVIRUS AGENT; FLAVONOID; NS3 PROTEIN, HEPATITIS C VIRUS; PLANT EXTRACT; SERINE PROTEINASE INHIBITOR; VIRAL PROTEIN;

ANTIVIRAL ACTIVITY; ARTICLE; CHINESE MEDICINE; DRUG STRUCTURE; ELECTROPHILICITY; HEPATITIS C VIRUS; IC50; NONHUMAN; TAXILLUS SUTCHUENENSIS; ANTAGONISTS AND INHIBITORS; CHEMISTRY; LORANTHACEAE;

ANTIVIRAL AGENTS; FLAVONOIDS; LORANTHACEAE; PLANT EXTRACTS; SERINE PROTEINASE INHIBITORS; VIRAL NONSTRUCTURAL PROTEINS;

EID: 84974679343     PISSN: 14786419     EISSN: 14786427     Source Type: Journal    
DOI: 10.1080/14786419.2016.1190719     Document Type: Article

References (27)

1. Au JS, Pockros PJ. 2014. Novel therapeutic approaches for hepatitis C. Clin Pharmacol Ther. 95:78–88.
2. Calland N, Dubuisson J, Rouillé Y, Séron K. 2012. Hepatitis C virus and natural compounds:a new antiviral approach? Viruses. 4:2197–2217.10.3390/v4102197
3. Chen C, Huang N, Wei L, Zhang X. 2015 Apr 1. Traditional Chinese medicine used for treating viral hepatitis comprises Cudrania, Centella asiatica, Hypericum, herba artemisiae scopariae, Polyporus, herba taxilli, Kudzu and Licorice. China patent CN104474023A.
4. De Francesco R, Steinkühler C. 2000. Structure and function of the hepatitis C virus NS3-NS4A serine proteinase. Hepatitis C Viruses. 242:149–169.10.1007/978-3-642-59605-6
5. Duan DL, Li ZQ, Luo HP, Zhang W, Chen LR, Xu XJ. 2004. Antiviral compounds from traditional Chinese medicines Galla Chinese as inhibitors of HCV NS3 protease. Bioorg Med Chem Lett. 14:6041–6044.10.1016/j.bmcl.2004.09.067
6. Hao J, Liu J, Wen X, Sun H. 2013. Synthesis and cytotoxicity evaluation of oleanolic acid derivatives. Bioorg Med Chem Lett. 23:2074–2077.10.1016/j.bmcl.2013.01.129
7. Huang L, Ma WH, Liu YZ, Yang JS, Peng Y, Xiao PG. 2011. Irisdichotins A-C, three new flavonoid glycosides from the rhizomes of Iris dichotoma Pall. J Asian Nat Prod Res. 13:744–748.10.1080/10286020.2011.587806
8. Ishikawa T, Nishigaya K, Takami K, Uchikoshi H, Chen IS, Tsai IL. 2004. Isolation of salicin derivatives from Homalium cochinchinensis and their antiviral activities 1. J Nat Prod. 67:659–663.10.1021/np034052o
9. Jiang L. 2015 May 6. Traditional Chinese medicine composition used for treating spleen deficiency, contains radix Pseudostellaria heterophylla, Cloves, Amomum villosum, Atractylodes macrocephala, Fructus Schisandra, Yam, Radix Puerariae and Coix seeds. China CN104587368-A.
10. Kim JL, Morgenstern KA, Lin C, Fox T, Dwyer MD, Landro JA, Chambers SP, Markland W, Lepre CA, O’Malley ET, et al. 1996. Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide. Cell. 87:343–355.10.1016/S0092-8674(00)81351-3
11. Kim J, Park KS, Lee C, Chong Y. 2007. Synthesis of a complete series of O-methyl analogues of naringenin and apigenin. B KorChem Soc. 28:2527–2530.
12. Kong L, Li S, Liao Q, Zhang Y, Sun R, Zhu X, Zhang Q, Wang J, Wu X, Fang X. 2013. Oleanolic acid and ursolic acid:novel hepatitis C virus antivirals that inhibit NS5B activity. Antiviral Res. 98:44–53.10.1016/j.antiviral.2013.02.003
13. Kong DY, Luo SQ, Li HT, Lei XH. 1987. Studies on the chemical constituents of Viscum coloratum. Chin J Pharm. 18:123–127.
14. Lee G, Lee JH, Ham KK, Lee H, Kim H, Lee H, Hong M, Shin M, Bae H. 2012. Cisplatin induced nephrotoxicity is inhibited by Taxilli Ramulus. Mol Cell Toxicol. 8:311–315.10.1007/s13273-012-0038-0
15. Li MR, Li LQ, Li P. 1987. Flavonoids of Taxillus sutchuenensis (Lecomte) Danser and T. sutchuenensis var. duclouxii (Lecomte) Kiuined. J Tradit Chin Med. 12:34–59.
16. Li YH, Ruan JL, Chen SL, Zhu KX, Zhao MH. 2009. Study on medicinal plants of Loranthaceae resources in China. Mod Tradit Chin Med Mater Med. 11:665–669.
17. Li H, Zhang R, Jiao B. 2015 Apr 8. Traditional Chinese medicinal composition useful for treating liver cancer, prepared using e.g. Ginseng, Tuckahoe, Acanthopanax, Rhizoma coptidis, Selfheal, Cordate houttuynia, herba taxilli, and herba scutellariae barbatae. China CN104491686-A.
18. Lin LC, Tsai TH, Su SC. 2011. A novel 8.O.6’-neolignan from Taxillus theifer. Nat Prod Res. 25:1319–1323.10.1080/14786419.2010.529443
19. Lou Z. 2014 Jul 16. Antihypertensive medicine includes Cortex eucommiae, Selfheal, Cassia seed, Radix scrophulariae, Safflower, Radix codonopsitis, herba taxilli, Barbary wolfberry fruit, Ginseng, Chinese scholartree flower, Dogwood and Cassia twig. China CN103919945-A.
20. Martin TS, Kikuzaki H, Hisamoto M, Nakatani N. 2000. Constituents of Amomum tsao-ko and their radical scavenging and antioxidant activities. J Am Oil Chem Soc. 77:667–673.10.1007/s11746-000-0107-4
21. Urgaonkar S, Shaw JT. 2007. Synthesis of kaempferitrin. J Org Chem. 72:4582–4585.10.1021/jo070502w
22. Wijeratne EMK, Bashyal BP, Liu MX, Rocha DD, Gunaherath GMKB, U’Ren JM, Gunatilaka MK, Arnold AE, Whitesell L, Gunatilaka AAL. 2012. Geopyxins A–E, ent-kaurane diterpenoids from endolichenic fungal strains Geopyxis aff. majalis and Geopyxis sp AZ0066:structure–activity relationships of geopyxins and their analogues(1). J Nat Prod. 75:361–369.10.1021/np200769q
23. Woo KW, Moon E, Kwon OW, Lee SO, Kim SY, Choi SZ, Son MW, Lee KR. 2013. Anti-neuroinflammatory diarylheptanoids from the rhizomes of Dioscorea nipponica. Bioorg Med Chem Lett. 23:3806–3809.10.1016/j.bmcl.2013.04.073
24. Yokosuka A, Mimaki Y, Sakagami H, Sashida Y. 2002. New diarylheptanoids and diarylheptanoid glucosides from the rhizomes of Tacca chantrieri and their cytotoxic activity. J Nat Prod. 65:283–289.10.1021/np010470m
25. Yu Y, Jing JF, Tong XK, He PL, Li YC, Hu YH, Tang W, Zuo JP. 2014. Discovering novel anti-HCV compounds with inhibitory activities toward HCV NS3/4A protease. Acta Pharmacol Sin. 35:1074–1081.10.1038/aps.2014.55
26. Yu F, Wang Q, Zhang Z, Peng Y, Qiu Y, Shi Y, Zheng Y, Xiao S, Wang H, Huang X. 2013. Development of oleanane-type triterpenes as a new class of HCV entry inhibitors. J Med Chem. 56:4300–4319.10.1021/jm301910a
27. Zuo G, Li Z, Chen L, Xu X. 2007. Activity of compounds from Chinese herbal medicine Rhodiola kirilowii (Regel) Maxim against HCV NS3 serine protease. Antiviral Res. 76:86–92.10.1016/j.antiviral.2007.06.001