Applications of magnetic nanoparticles in biomedical separation and purification

Nanotechnology Reviews

Volumn 5, Issue 3, 2016, Pages 331-340

  Yildiz, Ibrahim ^a  

^a KHALIFA UNIVERSITY   (United Arab Emirates)

Author keywords

Biosensor; iron oxide; magnetic separation; nanoparticles; superparamagnetic particles

Indexed keywords

ANTIBODIES; BIOSENSORS; CHEMICAL DETECTION; IRON OXIDES; MAGNETIC MATERIALS; MAGNETIC RESONANCE; MAGNETIC SEPARATION; NANOPARTICLES; NUCLEIC ACIDS; SIGNAL TRANSDUCTION; SUPERPARAMAGNETISM; SURFACE PLASMON RESONANCE; VIRUSES;

COMMERCIALIZED PRODUCTS; IRON OXIDE NANOPARTICLE; MAGNETIC NANO-PARTICLES; NANOPARTICLE FORMULATION; SEPARATION AND PURIFICATION; SIGNAL TRANSDUCTION MECHANISM; SUPERPARAMAGNETIC PARTICLES; SURFACE FUNCTIONALITIES;

NANOMAGNETICS;

EID: 84974663216     PISSN: 21919089     EISSN: 21919097     Source Type: Journal    
DOI: 10.1515/ntrev-2015-0012     Document Type: Review

References (97)

1. Magnetic Nanoparticles. Wiley-VCH Verlag GmbH & Co. KGaA, 2009.
2. Hyeon T. Chemical synthesis of magnetic nanoparticles. Chem. Commun. 2003, 8, 927-934.
3. Lu A-H, Salabas EL, Schüth F. Magnetic nanoparticles: synthesis, protection, functionalization, application. Angew. Chem. Int. Ed. 2007, 46, 1222-1244.
4. Laurent S, Forge D, Port M, Roch A, Robic C, Vander Elst L, Muller RN. Magnetic iron oxide nanoparticles: synthesis, stabilization, vectorization, physicochemical characterizations, biological applications. Chem. Rev. 2008, 108, 2064-2110.
5. Kodama RH. Magnetic nanoparticles. J. Magn. Magn. Mater. 1999, 200, 359-372.
6. Catherine CB, Adam SGC. Functionalisation of magnetic nanoparticles for applications in biomedicine. J. Phys. D: Appl. Phys. 2003, 36, R198.
7. Gao J, Gu H, Xu B. Multifunctional magnetic nanoparticles: design, synthesis, biomedical applications. Acc. Chem. Res. 2009, 42, 1097-1107.
8. Ito A, Shinkai M, Honda H, Kobayashi T. Medical application of functionalized magnetic nanoparticles. J. Biosci. Bioeng. 2005, 100, 1-11.
9. Wu W, He Q, Jiang C. Magnetic iron oxide nanoparticles: synthesis and surface functionalization strategies. Nanoscale Res. Lett. 2008, 3, 397-415.
10. Singh D, McMillan JoEllyn M, Kabanov AV, Sokolsky-Papkov M, Gendelman HE. Bench-to-bedside translation of magnetic nanoparticles. Nanomedicine 2014, 9, 501-516.
11. Na HB, Song IC, Hyeon T. Inorganic nanoparticles for MRI contrast agents. Adv. Mater. 2009, 21, 2133-2148.
12. Laurent S, Saei AA, Behzadi S, Panahifar A, Mahmoudi M. Superparamagnetic iron oxide nanoparticles for delivery of therapeutic agents: opportunities and challenges. Expert Opin. Drug Deliv. 2014, 11, 1449-1470.
13. Safarik I, Safarikova M. Magnetic techniques for the isolation and purification of proteins and peptides. Biomagn. Res. Technol. 2004, 2, 7-7.
14. Chertok B, Moffat BA, David AE, Yu F, Bergemann C, Ross BD, Yang VC. Iron oxide nanoparticles as a drug delivery vehicle for MRI monitored magnetic targeting of brain tumors. Biomaterials 2008, 29, 487-496.
15. Odintsov B, Chun J, Berry S. Whole body MRI and fluorescent microscopy for detection of stem cells labeled with superparamagnetic iron oxide (SPIO) nanoparticles and DiI following intramuscular and systemic delivery. In: Imaging and Tracking Stem Cells, Turksen, K, Ed., vol. 1052, Humana Press: New York, 2013, pp. 177-193.
16. Kievit FM, Stephen ZR, Veiseh O, Arami H, Wang T, Lai VP, Park JO, Ellenbogen RG, Disis ML, Zhang M. Targeting of primary breast cancers and metastases in a transgenic mouse model using rationally designed multifunctional SPIONs. ACS Nano 2012, 6, 2591-2601.
17. Busquets MA, Sabaté R, Estelrich J. Potential applications of magnetic particles to detect and treat Alzheimer's disease. Nanoscale Res. Lett. 2014, 9, 538.
18. Lind K, Kresse M, Debus NP, Müller RH. A novel formulation for superparamagnetic iron oxide (SPIO) particles enhancing MR lymphography: comparison of physicochemical properties and the in vivo behaviour. J. Drug Targeting 2002, 10, 221-230.
19. Weinstein JS, Varallyay CG, Dosa E, Gahramanov S, Hamilton B, Rooney WD, Muldoon LL, Neuwelt EA. Superparamagnetic iron oxide nanoparticles: diagnostic magnetic resonance imaging and potential therapeutic applications in neurooncology and central nervous system inflammatory pathologies, a review. J. Cereb. Blood Flow Metab. 2010, 30, 15-35.
20. Mahmoudi M, Sahraian MA, Shokrgozar MA, Laurent S. Superparamagnetic iron oxide nanoparticles: promises for diagnosis and treatment of multiple sclerosis. ACS Chem. Neurosci. 2011, 2, 118-140.
21. Yang X, Grailer JJ, Rowland IJ, Javadi A, Hurley SA, Matson VZ, Steeber DA, Gong S. Multifunctional stable and pH-responsive polymer vesicles formed by heterofunctional triblock copolymer for targeted anticancer drug delivery and ultrasensitive MR imaging. ACS Nano 2010, 4, 6805-6817.
22. Kievit FM, Veiseh O, Bhattarai N, Fang C, Gunn JW, Lee D, Ellenbogen RG, Olson JM, Zhang M. PEI-PEG-chitosan copolymer coated iron oxide nanoparticles for safe gene delivery: synthesis, complexation, transfection. Adv. Funct. Mater. 2009, 19, 2244-2251.
23. Ren Y, Zhang H, Chen B, Cheng J, Cai X, Liu R, Xia G, Wu W, Wang S, Ding J, Gao C, Wang J, Bao W, Wang L, Tian L, Song H, Wang X. Multifunctional magnetic Fe(3)O(4) nanoparticles combined with chemotherapy and hyperthermia to overcome multidrug resistance. Int. J. Nanomed. 2012, 7, 2261-2269.
24. Obaidat I, Issa B, Haik Y. Magnetic properties of magnetic nanoparticles for efficient hyperthermia. Nanomaterials 2015, 5, 63.
25. Clarke C, Davies S. Immunomagnetic cell separation. In: Metastasis Research Protocols, Brooks, S, Schumacher, U, Eds., vol. 58, Humana Press: New York, 2001, pp. 17-23.
26. Mettler E, Trenkler A, Feilen PJ, Wiegand F, Fottner C, Ehrhart F, Zimmermann H, Hwang YH, Lee DY, Fischer S, Schreiber LM, Weber MM. Magnetic separation of encapsulated islet cells labeled with superparamagnetic iron oxide nano particles. Xenotransplantation 2013, 20, 219-226.
27. Narayanan K, Lin AWH, Zheng Y, Erathodiyil N, Wan ACA, Ying JY. Glucosamine-conjugated nanoparticles for the separation of insulin-secreting beta cells. Adv. Healthcare Mater. 2013, 2, 1198-1203.
28. Sajja VSK, Hanley TR, Gapsis H, Guernsey B, Kennedy DJ, Taylor MJ, Papas KK, Todd PW. Application of magnetic particle tracking velocimetry to quadrupole magnetic sorting of porcine pancreatic islets. Biotechnol. Bioeng. 2011, 108, 2107-2117.
29. Mandal S, Ghosh A, Mandal M. Iron oxide nanoparticle assisted purification and mass spectrometry based proteolytic mapping of intact CD4()T cells from human blood. Prep. Biochem. Biotechnol. 2009, 39, 20-31.
30. Pimpha N, Chaleawlert-umpon S, Chruewkamlow N, Kasinrerk W. Preparation of anti-CD4 monoclonal antibodyconjugated magnetic poly(glycidyl methacrylate) particles and their application on CD4lymphocyte separation. Talanta 2011, 84, 89-97.
31. Cui Y-R, Hong C, Zhou Y-L, Li Y, Gao X-M, Zhang X-X. Synthesis of orientedly bioconjugated core/shell Fe3O4@Au magnetic nanoparticles for cell separation. Talanta 2011, 85, 1246-1252.
32. Bosio A, Huppert V, Donath S, Hennemann P, Malchow M, Heinlein UO. Isolation and enrichment of stem cells. In: Engineering of Stem Cells, Martin, U, Ed., vol. 114, Springer: Berlin Heidelberg, 2009, pp. 23-72.
33. Odaba S, Sayar F, Güven G, Yankkaya-Demirel G, Pikin E. Separation of mesenchymal stem cells with magnetic nanosorbents carrying CD105 and CD73 antibodies in flowthrough and batch systems. J. Chromatogr. B 2008, 861, 74-80.
34. Lui CNP, Tsui YP, Ho ASL, Shum DKY, Chan YS, Wu CT, Li HW, Tsang SCE, Yung KKL. Neural stem cells harvested from live brains by antibody-conjugated magnetic nanoparticles. Angew. Chem. Int. Ed. 2013, 52, 12298-12302.
35. Petri-Fink A, Chastellain M, Juillerat-Jeanneret L, Ferrari A, Hofmann H. Development of functionalized superparamagnetic iron oxide nanoparticles for interaction with human cancer cells. Biomaterials 2005, 26, 2685-2694.
36. Xu H, Aguilar ZP, Yang L, Kuang M, Duan H, Xiong Y, Wei H, Wang A. Antibody conjugated magnetic iron oxide nanoparticles for cancer cell separation in fresh whole blood. Biomaterials 2011, 32, 9758-9765.
37. Kim S, Han S-I, Park M-J, Jeon C-W, Joo Y-D, Choi I-H, Han K-H. Circulating tumor cell microseparator based on lateral magnetophoresis and immunomagnetic nanobeads. Anal. Chem. 2013, 85, 2779-2786.
38. Li F-R, Li Q, Zhou H-X, Qi H, Deng C-Y. Detection of circulating tumor cells in breast cancer with a refined immunomagnetic nanoparticle enriched assay and nested-RT-PCR. Nanomed. Nanotechnol. Biol. Med. 9, 1106-1113.
39. Durgadas CV, Sharma CP, Sreenivasan K. Fluorescent and superparamagnetic hybrid quantum clusters for magnetic separation and imaging of cancer cells from blood. Nanoscale 2011, 3, 4780-4787.
40. Yu X, He R, Li S, Cai B, Zhao L, Liao L, Liu W, Zeng Q, Wang H, Guo S-S, Zhao XZ. Magneto-controllable capture and release of cancer cells by using a micropillar device decorated with graphite oxide-coated magnetic nanoparticles. Small 2013, 9, 3895-3901.
41. Saliba A-E, Saias L, Psychari E, Minc N, Simon D, Bidard F-C, Mathiot C, Pierga J-Y, Fraisier V, Salamero J, Saada V, Farace F, Vielh P, Malaquin L, Viovy J-L. Microfluidic sorting and multimodal typing of cancer cells in self-assembled magnetic arrays. Proc. Natl. Acad. Sci. USA 2010, 107, 14524-14529.
42. Bai L, Du Y, Peng J, Liu Y, Wang Y, Yang Y, Wang C. Peptidebased isolation of circulating tumor cells by magnetic nanoparticles. J. Mater. Chem. B 2014, 2, 4080-4088.
43. Santhosh PB, Ulrih NP. Multifunctional superparamagnetic iron oxide nanoparticles: promising tools in cancer theranostics. Cancer Lett. 2013, 336, 8-17.
44. Li Q, Qi H, Zhou H-X, Deng C-Y, Zhu H, Li J-F, Wang X-L, Li F-R. Detection of micrometastases in peripheral blood of non-small cell lung cancer with a refined immunomagnetic nanoparticle enrichment assay. Int. J. Nanomed. 2011, 6, 2175-2181.
45. Earhart CM, Hughes CE, Gaster RS, Ooi CC, Wilson RJ, Zhou LY, Humke EW, Xu L, Wong DJ, Willingham SB, Schwartz EJ, Weissman IL, Jeffrey SS, Neal JW, Rohatgi R, Wakelee HA, Wang SX. Isolation and mutational analysis of circulating tumor cells from lung cancer patients with magnetic sifters and biochips. Lab Chip 2014, 14, 78-88.
46. Wen C-Y, Wu L-L, Zhang Z-L, Liu Y-L, Wei S-Z, Hu J, Tang M, Sun E-Z, Gong Y-P, Yu J, Pang DW. Quick-response magnetic nanospheres for rapid, efficient capture and sensitive detection of circulating tumor cells. ACS Nano 2013, 8, 941-949.
47. Ersson B, Rydén L, Janson J-C. Introduction to protein purification. In: Protein Purification, John Wiley & Sons, Inc.: New Jersey, 2011, pp. 1-22.
48. Bao J, Chen W, Liu T, Zhu Y, Jin P, Wang L, Liu J, Wei Y, Li Y. Bifunctional Au-Fe3O4 nanoparticles for protein separation. ACS Nano 2007, 1, 293-298.
49. Lin P-C, Yu C-C, Wu H-T, Lu Y-W, Han C-L, Su A-K, Chen Y-J, Lin C-C. A chemically functionalized magnetic nanoplatform for rapid and specific biomolecular recognition and separation. Biomacromolecules 2012, 14, 160-168.
50. Zhang L, Zhu X, Jiao D, Sun Y, Sun H. Efficient purification of His-tagged protein by superparamagnetic Fe3O4/Au-ANTA-Co2 nanoparticles. Mater. Sci. Eng. C Mater Biol Appl. 2013, 33, 1989-1992.
51. Masthoff I-C, David F, Wittmann C, Garnweitner G. Functionalization of magnetic nanoparticles with high-binding capacity for affinity separation of therapeutic proteins. J. Nanopart. Res. 2013, 16, 1-10.
52. Feng G, Hu D, Yang L, Cui Y, Cui X-A, Li H. Immobilized-metal affinity chromatography adsorbent with paramagnetism and its application in purification of histidine-tagged proteins. Sep. Purif. Technol. 2010, 74, 253-260.
53. Liu Y, Li Y, Wei Y. Highly selective isolation and purification of heme proteins in biological samples using multifunctional magnetic nanospheres. J. Sep. Sci. 2014, 37, 3745-3752.
54. Wu J, Zhou L, Zhang H, Guo J, Mei X, Zhang C, Yuan J, Xing X-H. Direct affinity immobilization of recombinant heparinase I fused to maltose binding protein on maltose-coated magnetic nanoparticles. Biochem. Eng. J. 2014, 90, 170-177.
55. Lin Z-A, Zheng J-N, Lin F, Zhang L, Cai Z, Chen G-N. Synthesis of magnetic nanoparticles with immobilized aminophenylboronic acid for selective capture of glycoproteins. J. Mater. Chem. 2011, 21, 518-524.
56. Ayyar BV, Arora S, Murphy C, O'Kennedy R. Affinity chromatography as a tool for antibody purification. Methods 2012, 56, 116-129.
57. Liu X, Guan Y, Yang Y, Ma Z, Wu X, Liu H. Preparation of superparamagnetic immunomicrospheres and application for antibody purification. J. Appl. Polym. Sci. 2004, 94, 2205-2211.
58. Kolotilov SV, Boltovets PN, Snopok BA, Pavlishchuk VV. Nanosized magnetic composite for extraction of-immunoglobulins from biological media. Theor. Exp. Chem. 2006, 42, 211-216.
59. Holschuh K, Schwämmle A. Preparative purification of antibodies with protein A-an alternative to conventional chromatography. J. Magn. Magn. Mater. 2005, 293, 345-348.
60. Chhatre S, Titchener-Hooker NJ, Newcombe AR, Keshavarz-Moore E. Purification of antibodies using the synthetic affinity ligand absorbent MAbsorbent A2P. Nat. Protocols 2007, 2, 1763-1769.
61. Santana SDF, Dhadge VL, Roque ACA. Dextran-coated magnetic supports modified with a biomimetic ligand for IgG purification. ACS Appl. Mater. Interfaces 2012, 4, 5907-5914.
62. Dhadge VL, Hussain A, Azevedo AM, Aires-Barros R, Roque ACA. Boronic acid-modified magnetic materials for antibody purification. J. R. Soc. Interface 2013, 11, 20130875.
63. Borlido L, Moura L, Azevedo AM, Roque ACA, Aires-Barros MR, Farinha JPS. Stimuli-Responsive magnetic nanoparticles for monoclonal antibody purification. Biotechnol. J. 2013, 8, 709-717.
64. Muzard J, Platt M, Lee GU. M13 Bacteriophage-activated superparamagnetic beads for affinity separation. Small 2012, 8, 2403-2411.
65. Nash MA, Waitumbi JN, Hoffman AS, Yager P, Stayton PS. Multiplexed enrichment and detection of malarial biomarkers using a stimuli-responsive iron oxide and gold nanoparticle reagent system. ACS Nano 2012, 6, 6776-6785.
66. Gevaert K, Vandekerckhove J. Protein identification methods in proteomics. Electrophoresis 2000, 21, 1145-1154.
67. Mann M, Jensen ON. Proteomic analysis of post-translational modifications. Nat. Biotech. 2003, 21, 255-261.
68. Li Y-C, Lin Y-S, Tsai P-J, Chen C-T, Chen W-Y, Chen Y-C. Nitrilotriacetic acid-coated magnetic nanoparticles as affinity probes for enrichment of histidine-tagged proteins and phosphorylated peptides. Anal. Chem. 2007, 79, 7519-7525.
69. Lu Z, He L, Yin Y. Superparamagnetic nanocrystal clusters for enrichment of low-abundance peptides and proteins. Chem. Commun. 2010, 46, 6174-6176.
70. Lee A, Yang H-J, Lim E-S, Kim J, Kim Y. Enrichment of phosphopeptides using bare magnetic particles. Rapid Commun. Mass Spectrom. 2008, 22, 2561-2564.
71. Whiteaker JR, Zhao L, Zhang HY, Feng L-C, Piening BD,erson L, Paulovich A. Antibody-based enrichment of peptides on magnetic beads for mass spectrometry-based quantification of serum biomarkers. Anal. Biochem. 2007, 362, 44-54.
72. Yeh C-H, Chen S-H, Li D-T, Lin H-P, Huang H-J, Chang C-I, Shih W-L, Chern C-L, Shi F-K, Hsu J-L. Magnetic bead-based hydrophilic interaction liquid chromatography for glycopeptide enrichments. J. Chromatogr. A 2012, 1224, 70-78.
73. Bland C, Bellanger L, Armengaud J. Magnetic immunoaffinity enrichment for selective capture and MS/MS analysis of N-terminal-TMPP-labeled peptides. J. Proteome Res. 2013, 13, 668-680.
74. Palani A, Lee J-S, Huh J, Kim M, Lee Y-J, Chang JH, Lee K, Lee S-W. Selective enrichment of cysteine-containing peptides using SPDP-functionalized superparamagnetic Fe3O4@SiO2 nanoparticles: application to comprehensive proteomic profiling. J. Proteome Res. 2008, 7, 3591-3596.
75. Choi S, Kim J, Cho K, Park G, Yoon JH, Park S, Yoo JS, Ryu SH, Kim YH, Kim J. Sequential Fe3O4/TiO2 enrichment for phosphopeptide analysis by liquid chromatography/tandem mass spectrometry. Rapid Commun. Mass Spectrom. 2010, 24, 1467-1474.
76. Xiong Z, Zhao L, Wang F, Zhu J, Qin H, Wu Ra, Zhang W, Zou H. Synthesis of branched PEG brushes hybrid hydrophilic magnetic nanoparticles for the selective enrichment of N-linked glycopeptides. Chem. Commun. 2012, 48, 8138-8140.
77. Ma W-F, Zhang Y, Li L-L, You L-J, Zhang P, Zhang Y-T, Li J-M, Yu M, Guo J, Lu H-J, Wang CC. Tailor-made magnetic Fe3O4@mTiO2 microspheres with a tunable mesoporous anatase shell for highly selective and effective enrichment of phosphopeptides. ACS Nano 2012, 6, 3179-3188.
78. Chen Y, Xiong Z, Zhang L, Zhao J, Zhang Q, Peng L, Zhang W, Ye M, Zou H. Facile synthesis of zwitterionic polymer-coated core-shell magnetic nanoparticles for highly specific capture of N-linked glycopeptides. Nanoscale 2015, 7, 3100-3108.
79. Garner I. Isolation of high-molecular-weight DNA from animal cells. In: The Nucleic Acid Protocols Handbook, Rapley, R, Ed., Humana Press: New York, 2000, pp. 3-7.
80. Berensmeier S. Magnetic particles for the separation and purification of nucleic acids. Appl. Microbiol. Biotechnol. 2006, 73, 495-504.
81. Paul T, Basu S, Sarkar K. SPION-mediated soil DNA extraction and comparative analysis with conventional and commercial kit-based protocol. 3 Biotech. 2014, 4, 669-677.
82. Xu S, Song X, Guo J, Wang C. Composite Microspheres for separation of plasmid DNA decorated with MNPs through in situ growth or interfacial immobilization followed by silica coating. ACS Appl. Mater. Interfaces 2012, 4, 4764-4775.
83. Kang K, Choi J, Nam JH, Lee SC, Kim KJ, Lee S-W, Chang JH. Preparation and characterization of chemically functionalized silica-coated magnetic nanoparticles as a DNA separator. J. Phys. Chem. B 2008, 113, 536-543.
84. Nie L-B, Wang X-L, Li S, Chen H. Amplification of fluorescence detection of DNA based on magnetic separation. Anal. Sci. 2009, 25, 1327-1333.
85. Zhang Y, Pilapong C, Guo Y, Ling Z, Cespedes O, Quirke P, Zhou D. Sensitive, simultaneous quantitation of two unlabeled DNA targets using a magnetic nanoparticle-enzyme sandwich assay. Anal. Chem. 2013, 85, 9238-9244.
86. Zhang Y, Guo Y, Quirke P, Zhou D. Ultrasensitive single-nucleotide polymorphism detection using target-recycled ligation, strand displacement and enzymatic amplification. Nanoscale 2013, 5, 5027-5035.
87. Vangala RK, Veeresh SH. Instrument-free, automation and multi-platform ready unmodified iron Oxide based DNA isolation system. J. Biochem. Technol. 2012, 3, 384-388.
88. Ma C, Li C, He N, Wang F, Ma N, Zhang L, Lu Z, Ali Z, Xi Z, Li X, Liang G, Liu H, Deng Y, Xu L, Wang Z. Preparation and characterization of monodisperse core-shell Fe3O4@SiO2 microspheres and its application for magnetic separation of nucleic acids from E. coli BL21. J. Biomed. Nanotechnol. 2012, 8, 1000-1005.
89. Chen GD, Alberts CJ, Rodriguez W, Toner M. Concentration and purification of human immunodeficiency virus Type 1 virions by microfluidic separation of superparamagnetic nanoparticles. Anal. Chem. 2009, 82, 723-728.
90. Wen C-Y, Hu J, Zhang Z-L, Tian Z-Q, Ou G-P, Liao Y-L, Li Y, Xie M, Sun Z-Y, Pang D-W. One-step sensitive detection of Salmonella typhimurium by coupling magnetic capture and fluorescence identification with functional nanospheres. Anal. Chem. 2012, 85, 1223-1230.
91. Huy TQ, Van Chung P, Thuy NT, Blanco-Andujar C, Thanh NnTK. Protein A-conjugated iron oxide nanoparticles for separation of Vibrio cholerae from water samples. Faraday Discuss. 2014, 175, 73-82.
92. Chang W-S, Shang H, Perera RM, Lok S-M, Sedlak D, Kuhn RJ, Lee GU. Rapid detection of dengue virus in serum using magnetic separation and fluorescence detection. Analyst 2008, 133, 233-240.
93. Kell AJ, Stewart G, Ryan S, Peytavi R, Boissinot M, Huletsky A, Bergeron MG, Simard B. Vancomycin-modified nanoparticles for efficient targeting and preconcentration of Gram-positive and Gram-negative bacteria. ACS Nano 2008, 2, 1777-1788.
94. Ran Y-F, Fields C, Muzard J, Liauchuk V, Carr M, Hall W, Lee GU. Rapid, highly sensitive detection of herpes simplex virus-1 using multiple antigenic peptide-coated superparamagnetic beads. Analyst 2014, 139, 6126-6134.
95. Yang K, Jenkins DM, Su WW. Rapid concentration of bacteria using submicron magnetic anion exchangers for improving PCR-based multiplex pathogen detection. J. Microbiol. Methods 2011, 86, 69-77.
96. Lee J-J, Jeong KJ, Hashimoto M, Kwon AH, Rwei A, Shankarappa SA, Tsui JH, Kohane DS. Synthetic ligand-coated magnetic nanoparticles for microfluidic bacterial separation from blood. Nano Lett. 2013, 14, 1-5.
97. El-Boubbou K, Gruden C, Huang X. Magnetic glyco-nanoparticles: a unique tool for rapid pathogen detection, decontamination, strain differentiation. J. Am. Chem. Soc. 2007, 129, 13392-13393.