Efficacy of ascorbic acid (Vitamin C) and/N-acetylcysteine (NAC) supplementation on nutritional and antioxidant status of male chronic obstructive pulmonary disease (COPD) patients

Journal of Nutritional Science and Vitaminology

Volumn 62, Issue 1, 2016, Pages 54-61

  Pirabbasi, Elham ^a   Shahar, Suzana ^a   Manaf, Zahara Abdul ^a   Rajab, Nor Fadilah ^a   Manap, Roslina Abdul ^b  

^a UNIVERSITI KEBANGSAAN MALAYSIA   (Malaysia)

^b DEPARTMENT OF PHARMACOLOGY   (Malaysia)

Author keywords

Antioxidants; Chronic obstructive pulmonary disease; Dietary supplements; Malnutrition; Nutritional support

Indexed keywords

ACETYLCYSTEINE; ALPHA TOCOPHEROL; ASCORBIC ACID; GLUTATHIONE; RETINOL; ANTIOXIDANT; CARBOHYDRATE DIET;

ADULT; ANTHROPOMETRY; ANTIOXIDANT ACTIVITY; ANTIOXIDANT ASSAY; APPETITE; ARTICLE; BLOOD ANALYSIS; BODY MASS; CARBOHYDRATE INTAKE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; DIETARY INTAKE; FORCED EXPIRATORY VOLUME; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; NUTRITIONAL STATUS; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; UNSPECIFIED SIDE EFFECT; ADMINISTRATION AND DOSAGE; AGED; BLOOD; CARBOHYDRATE DIET; DIETARY SUPPLEMENT; DRUG EFFECTS; MALAYSIA; PATHOPHYSIOLOGY; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; TREATMENT OUTCOME;

ACETYLCYSTEINE; ADULT; AGED; ANTIOXIDANTS; ASCORBIC ACID; BODY MASS INDEX; DIETARY CARBOHYDRATES; DIETARY SUPPLEMENTS; GLUTATHIONE; HUMANS; MALAYSIA; MALE; MIDDLE AGED; NUTRITIONAL STATUS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SINGLE-BLIND METHOD; TREATMENT OUTCOME; VITAMIN A;

EID: 84974589104     PISSN: 03014800     EISSN: 18817742     Source Type: Journal    
DOI: 10.3177/jnsv.62.54     Document Type: Article

References (39)

1. World Health Organization, COPD. Fact Sheet No 315. 2011, http://www.who.int/mediacenter/factsheets/fs315/en/index.html
2. Halbert RJ, Isonaka S, George D, Iqbal A. 2003. Interpreting COPD prevalence estimates: What is the true burden of disease? Chest 123: 1684–1692.
3. Tan WC, Seal JP, Charaoenratanakul S, Guia TIPM, Aziah M, Mangunnegoro H, Luh KT, Shim YS, Zhong NS, Schau B. 2003. COPD prevalence in 12 Asia-Pacific countries and regions: projection based on the COPD prevalence estimation model. Respirology 8: 192–198.
4. Sridhar MK. 1999. Nutrition and lung health. Proc Nutr Soc 58: 303–308.
5. MacNee W. 2005. Treatment of stable COPD: antioxidants. Eur Respir Rev 14: 12–22.
6. Paiva SAR, Campana, AO, Godoy I. 2000. Nutrition support for the patient with chronic obstructive pulmonary disease. Nutr Clin Care 3: 44–50.
7. MacNee W. 2000. Oxidants/antioxidants and COPD. Chest 117: 303–317.
8. Stey C, Steurer J, Bachmann S, Medici TC, Tramer MR. 2000. The effect of oral N-acetylcysteine in chronic bronchitis: a quantitative systematic review. Eur Respir J 16: 253–262.
9. Lykkesfeldt J, Christen S, Wallock LM, Chang HH, Jacob RA, Ames BN. 2000. Ascorbate is depleted by smoking and repleted by moderate supplementation: a study in male smokers and nonsmokers with matched dietary antioxidant intakes. Am J Clin Nutr 71: 530–536.
10. Schwartz J, Weiss ST. 1990. Dietary factors and their relation to respiratory symptoms. The Second National Health and Nutrition Examination Survey. Am J Epidemiol 132: 67–76.
11. Schwartz J, Weiss ST. 1994. Relationship between dietary vitamin C intake and pulmonary function in the First National Health and Nutrition Examination Survey (NHANES I). Am J Clin Nutr 59: 110–114.
12. Britton JR, Pavord ID, Richards KA, Knox AJ, Wisniewski AF, Lewis SA, Tattersfield AE, Weiss ST. 1995. Dietary antioxidant vitamin intake and lung function in the general population. Am J Respir Crit Care Med 151: 1383–1387.
13. Tabak C, Feskens EJ, Heederik D, Kromhout D, Menotti A, Blackburn HW. 1998. Fruit and fish consumption: a possible explanation for population differences in COPD mortality (The Seven Countries Study). Eur J Clin Nutr 52: 819–825.
14. Tabak C, Smit HA, Heederik D, Ocké MC, Kromhout D. 2001. Diet and chronic obstructive pulmonary disease: independent beneficial effects of fruits, whole grains, and alcohol (the MORGEN study). Clin Exp Allergy 31: 747–755.
15. American Thoracic Society, 2004. Update 8 September 2005: Standard for the diagnosis and management of patients with COPD. [Online]. Available: htpp://www.thoracic.org/clinical/copd-guidelines/ [accessed July 2008].
16. International Society for the advancement of Kinanthropometry. 2001. International Standard for Anthropometric Assessment (ISAK), 1st ed. National Library of Australia, Underdale.
17. Lee RD, Nieman DC. 2007. Nutritional Assessment, 4th ed. McGraw-Hill, New York.
18. Lohman TG, Roche AF, Martorell R. 1988. Anthropomeric Standardization Reference Manual. Human Kinetics Books, Champaign.
19. Westat, Inc. 1988. National Health and Nutrition Examination Survey (NHANES III). Body measurements (Anthropometry). 20850 (301) 251–1500, Rockville.
20. Wilson MGG, Thomas DR, Rubenstein LZ, Chibnall JT, Andersone S, Baxi A, Diebold MR, Morley JE. 2005. Appetite assessment: simple appetite questionnaire predicts weight loss in community-dwelling adults and nursing home residents. Am J Clin Nutr 82: 1074–1081.
21. Tee ES, Khor SC. 1995. Simultaneous determination of retinol, carotenoids and tocopherol in human serum by high pressure liquid chromatography. Mal J Nutr 1: 151–170.
22. Zhao B, Tham SY, Lu J, Lai MH, Lee LK, Moochhala SM. 2004. Simultaneous determination of vitamin C, E, and -carotene in human plasma by high performance iquid chromatography with photodiode-array detection. J Pharm Pharmaceut Sci 7: 200–204.
23. Benzie FF, Strain JJ. 1999. Ferric reducing/antioxidant power assay: direct measure of total antioxidant activity of biological fluids and modified version for simultaneous measurement of total antioxidant power and ascorbic acid concentration. Methods Enzymol 299: 15–23.
24. Reynolds HY, Newball HH. 1974. Analysis of proteins and respiratory cells obtained from human lungs by bronchial lavage. J Lab Clin Med 84: 559–573.
25. MacNee W. 2005. Treatment of stable COPD: antioxidants. Eur Respir Rev 14(94): 12–22.
26. Suzana S, Hanis MY, Tang SY, Ayieshah R, Roslina AM. 2008. Changes in nutritional, functional status and quality of life of COPD out-patients after a pulmonary rehabilitation programme in HUKM: a pilot study. Malays J Nutr 14: 151–162.
27. Slinde F, Grõnberg A, Engstrõm C, Rossander-Hulthen L, Larsson S. 2002. Individual dietary intervention in patients with COPD during multidisciplinary rehabilitation. Respir Med 96: 330–336.
28. Patrick L. 2000. Nutrients and HIV: part three-N-acetylcysteine, alpha lipoic acid, L-glutamine and L-carnitine. Altern Med Rev 5: 290–305.
29. Agusti AGN. 2005. COPD, a multicomponent disease: implications for management. Respir Med 99: 670–682.
30. Agusti AGN, Noguera A, Sauleda J, Sala E, Pons J, Busquets X. 2003. Systemic effects of chronic obstructive pulmonary disease. Eur Respir J 21: 347–360.
31. Mantovani G, Madeddu C. 2008. Cyclooxygenase-2 inhibitors and antioxidants in the treatment of cachexia. Curr Opin Support Palliat Care 2: 275–281.
32. Mantovani G, Maccio A, Madeddu C, Gramignano G, Serpe R, Massa E, Dessì M, Tanca FM, Sanna E, Deiana L, Panzone F, Contu P, Floris C. 2008. Randomised phase III of five different arms of treatment for patient with cancer cachexia: interim results. Nutrition 24: 305–313.
33. Chun YL, Chao XL, Zia PWX. 2011. Effect of glutamine on nutrition in patients with chronic obstructive pulmonary disease and antioxidant therapy immunomodulatory role. Clinical Medicine Paper, Posted: 2011-1-12.
34. Van der Vliet A, O’Neill CA, Cross CE, Koostra JM, Volz WG, Halliwell B, Louie S. 1999. Determination of low molecular mass antioxidant concentrations in human respiratory tract lining fluids. Am J Physiol 276: 289–296.
35. Jialal I, Vega GL, Grundy SM. 1990. Physiologic levels of ascorbate inhibits the oxidative modification of low density lipoprotein. Atherosclerosis 82: 185–191.
36. Pietri S, Seguin JR, Darbigny PD, Culcasi M. 1994. Ascorbyl free radical a noninvasive marker of oxidative stress in human open heart surgery. Free Radic Biol Med 16: 523–528.
37. Heffner JE, Repine JE. 1989. Pulmonary strategies of antioxidant defense. Am Rev Respir Dis 140: 531–554.
38. De Flora S, Bennicelli C, Camorino A, Serra D, Romano M, Rossi GA, Morelli A, De Floea A. 1985. In vivo effect of N-acetylcysteine on glutathione metabolism and on the biotransformation of carcinogenic and/or mutagenic compounds. Carcinogenesis 6: 1735–1745.
39. Couto N, Malys N, Gaskell SJ, Barber J. 2013. Partition and turnover of glutathione reductase from saccharomyces cerevisiae: a proteomic approach. J Proteome Res 12: 2885–2894.