Red Blood Cell Transfusion in the Emergency Department

Journal of Emergency Medicine

Volumn 51, Issue 2, 2016, Pages 120-130

  Long, Brit ^a   Koyfman, Alex ^b  

^a SAN ANTONIO MILITARY MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

blood product; indications; product age; RBC; transfusion; transfusion reaction

Indexed keywords

HEMOGLOBIN;

ACUTE CORONARY SYNDROME; ANEMIA; ARTICLE; BLOOD; BLOOD TRANSFUSION; BLOOD TRANSFUSION REACTION; CLINICAL TRIAL (TOPIC); COMORBIDITY; CRITICAL ILLNESS; EMERGENCY PHYSICIAN; EMERGENCY WARD; ERYTHROCYTE PRESERVATION; ERYTHROCYTE TRANSFUSION; GASTROINTESTINAL HEMORRHAGE; HEART MUSCLE ISCHEMIA; HEMODYNAMICS; HEMOGLOBIN DETERMINATION; HUMAN; INFECTION COMPLICATION; INJURY; LIBERAL TRANSFUSION THRESHOLD; META ANALYSIS (TOPIC); MORBIDITY; MORTALITY; PHYSIOLOGICAL PROCESS; PRACTICE GUIDELINE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); RESTRICTIVE TRANSFUSION THRESHOLD; RISK BENEFIT ANALYSIS; SEPSIS; SYSTEMATIC REVIEW (TOPIC); TREATMENT INDICATION; ADVERSE EFFECTS; DECISION MAKING; HOSPITAL EMERGENCY SERVICE; INTENSIVE CARE;

ANEMIA; CRITICAL CARE; CRITICAL ILLNESS; DECISION MAKING; EMERGENCY SERVICE, HOSPITAL; ERYTHROCYTE TRANSFUSION; HEMOGLOBINS; HUMANS;

EID: 84973880180     PISSN: 07364679     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jemermed.2016.04.010     Document Type: Article

References (93)

1. 1 US Department of Health and Human Services, The 2009 national blood collection and utilization survey report. 2011, US Department of Health and Human Services, Office of the Assistant Secretary for Health, Washington, DC.
2. 2 Takei, T., Amin, N.A., Schmid, G., Dhingra-Kumar, N., Rugg, D., Progress in global blood safety for HIV. J Acquir Immune Defic Syndr 52:suppl 2 (2009), S127–S131.
3. 3 Emmanuel, J.E., McClelland, B., Page, R., The clinical use of blood in medicine, obstetrics, paediatrics, surgery anaesthesia, trauma and burns. 1997, World Health Organization, Geneva, Switzerland.
4. 4 Corwin, H.L., Surgenor, S.D., Gettinger, A., Transfusion practice in the critically ill. Crit Care Med 31 (2003), S668–S671.
5. 5 Corwin, H.L., Gettinger, A., Pearl, R.G., et al. The CRIT study: anemia and blood transfusion in the critically ill–current clinical practice in the United States. Crit Care Med 32 (2004), 39–52.
6. 6 Walsh, T.S., Saleh, E., Anaemia during critical illness. Br J Anaesth 97 (2006), 278–291.
7. 7 Vincent, J.L., Baron, J.F., Reinhart, K., et al. Anemia and blood transfusion in critically ill patients. JAMA 288 (2002), 1499–1507.
8. 8 Blood Observational Study Investigators of ANZICS-Clinical Trials Group, Westbrook, A., Pettilä, V., et al. Transfusion practice and guidelines in Australian and New Zealand intensive care units. Intensive Care Med 36 (2010), 1138–1146.
9. 9 Balducci, L., Anemia, fatigue and aging. Transfus Clin Biol 17 (2010), 375–381.
10. 10 Terekeci, H.M., Kucukardali, Y., Onem, Y., et al. Relationship between anaemia and cognitive functions in elderly people. Eur J Intern Med 21 (2010), 87–90.
11. 11 Chaves, P.H., Xue, Q.L., Guralnik, J.M., et al. What constitutes normal hemoglobin concentration in community dwelling disabled older women?. J Am Ger Soc 52 (2004), 1811–1816.
12. 12 Musallam, K.M., Tamim, H.M., Richards, T., et al. Preoperative anaemia and postoperative outcomes in non-cardiac surgery: a retrospective cohort study. Lancet 378 (2011), 1396–1407.
13. 13 Sabatine, M.S., Morrow, D.A., Giugliano, R.P., et al. Association of hemoglobin levels with clinical outcomes in acute coronary syndromes. Circulation 111 (2005), 2042–2049.
14. 14 Ripollés Melchor, J., Casans Francés, R., Espinosa, A., et al. Restrictive versus liberal transfusion strategy for red blood cell transfusion in critically ill patients and in patients with acute coronary syndrome: a systematic review, meta-analysis and trial sequential analysis. Minerva Anestesiol, 2015 Jul 22 [Epub ahead of print].
15. 15 Hebert, P.C., Wells, G., Blajchman, M.A., et al. A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group. N Engl J Med 340 (1999), 409–417.
16. 16 Marik, P.E., Corwin, H.L., Efficacy of red blood cell transfusion in the critically ill: a systematic review of the literature. Crit Care Med 36 (2008), 2667–2674.
17. 17 Napolitano, L.M., Kurek, S., Luchette, F.A., et al. Clinical practice guideline: red blood cell transfusion in adult trauma and critical care. Crit Care Med 37 (2009), 3124–3157.
18. 18 Blair, S.D., Janvrin, S.B., McCollum, C.N., Greenhalgh, R.M., Effect of early blood transfusion on gastrointestinal haemorrhage. Br J Surg 73 (1986), 783–785.
19. 19 McIntyre, L., Hebert, P.C., Wells, G., et al. Is a restrictive transfusion strategy safe for resuscitated and critically ill trauma patients?. J Trauma 57 (2004), 563–568.
20. 20 Bracey, A.W., Radovancevic, R., Riggs, S.A., et al. Lowering the hemoglobin threshold for transfusion in coronary artery bypass procedures: effect on patient outcome. Transfusion 39 (1999), 1070–1077.
21. 21 Finch, C.A., Lenfant, C., Oxygen transport in man. N Engl J Med 286 (1972), 407–415.
22. 22 Hameed, S.M., Aird, W.C., Oxygen delivery. Crit Care Med 31 (2003), S658–S667.
23. 23 Liumbruno, G., Bennardello, F., Lattanzio, A., Piccolli, P., Roseetti, G., Recommendations for the transfusion of red blood cells. Blood Transfus 7 (2009), 49–64.
24. 24 National Health and Medical Research Council, Australian Government website. Clinical practice guidelines on the use of blood components (red blood cells, platelets, fresh frozen plasma, cryoprecipitate). Available at: http://www.nhmrc.gov.au/_files_nhmrc/publications/attachments/cp78_cp_blood_components.pdf. Accessed April 29, 2016.
25. 25 American Red Cross website. Practice guidelines for blood transfusion: a compilation from recent peer-reviewed literature. Available at: http://chapters.redcross.org/br/indianaoh/hospitals/transfusion guidelines.htm.re. Accessed April 29, 2016.
26. 26 Elzik, M.E., Dirschl, D.R., Dahners, L.E., Correlation of transfusion volume to change in hematocrit. Am J Hematol 81 (2006), 145–146.
27. 27 Hebert, P.C., Van der Linden, P., Biro, G., Hu, L.Q., Physiologic aspects of anemia. Crit Care Clin 20 (2004), 187–212.
28. 28 Australasian Society of Blood Transfusion Inc website. Topics in transfusion medicine. Guidelines. Irradiated blood products. Leucocyte depletion of blood and blood components. October 1996. Available at: http://www.anzsbt.org.au/publications/documents/1996_Vol3_2.pdf. Accessed April 29, 2016.
29. 29 Council of Europe, Guide to the preparation, use and quality assurance of blood components. Recommendation no R (95) 15 on the preparation, use and quality assurance of blood components. 14th ed., 2008, Council of Europe Press, Strasbourg.
30. 30 Australian and New Zealand Society of Blood Transfusion Inc. website. Guidelines for gamma irradiation of blood components. Revised 2003. Available at: http://www.anzsbt.org.au/publications/documents/ANZSBTguide_May03.pdf. Accessed April 29, 2016.
31. 31 Gorlin, J.B., Minz, P.D., Transfusion-associated graft-vs- host disease. Mintz, P.D., (eds.) Transfusion therapy: clinical principles and practice, 2005, AABB, Bethesda, MD.
32. 32 Vamvakas, E.C., Blajchman, M.A., Transfusion-related immunomodulation (TRIM): an update. Blood Rev 21 (2007), 327–348.
33. 33 Rohde, J.M., Dimcheff, D.E., Blumberg, N., et al. Health care–associated infection after red blood cell transfusion: a systematic review and meta-analysis. JAMA 311 (2014), 1317–1326.
34. 34 Horvath, K.A., Acker, M.A., Chang, H., et al. Blood transfusion and infection after cardiac surgery. Ann Thorac Surg 95 (2013), 2194–2201.
35. 35 Koch, C.G., Li, L., Sessler, D.I., et al. Duration of red-cell storage and complications after cardiac surgery. N Engl J Med 358 (2008), 1229–1239.
36. 36 O'Brien, S.F., Yi, Q.L., Fan, W., et al. Current incidence and estimated residual risk of transfusion-transmitted infections in donations made to Canadian Blood Services. Transfusion 47 (2007), 316–325.
37. 37 Goodnough, L.T., Shander, A., Risks and complications of blood transfusions: optimizing outcomes for patients with chemotherapy-induced anemia. Advanced Studies in Medicine 8 (2008), 357–362.
38. 38 Kitchen, A.D., Barbara, J.A.J., Current information on the infectious risks of allogeneic blood transfusion. Transfusion Alternative in Transfusion Medicine 10 (2008), 102–111.
39. 39 Klein, H.G., Spahn, D.R., Carson, J.L., Red blood cell transfusion in clinical practice. Lancet 370 (2007), 415–426.
40. 40 Zou, S., Stramer, S.L., Notari, E.P., et al. Current incidence and residual risk of hepatitis B infection among blood donors in the United States. Transfusion 49 (2009), 1609–1620.
41. 41 Zou, S., Dorsey, K.A., Notari, E.P., et al. Prevalence, incidence, and residual risk of human immunodeficiency virus and hepatitis C virus infections among United States blood donors since the introduction of nucleic acid testing. Transfusion 50 (2010), 1495–1504.
42. 42 Pineda, A.A., Taswell, H.F., Transfusion reactions associated with anti-IgA antibodies: report of four cases and review of the literature. Transfusion 15 (1975), 10–15.
43. 43 Finlay, H.E., Cassorla, L., Feiner, J., Toy, P., Designing and testing a computer-based screening system for transfusion-related acute lung injury. Am J Clin Pathol, 124, 2005, 601.
44. 44 Toy, P., Gajic, O., Bacchetti, P., et al. Transfusion-related acute lung injury: incidence and risk factors. Blood 119 (2012), 1757–1767.
45. 45 Tinmouth, A., Fergusson, D., Yee, I.C., Hebert, P.C., Clinical consequences of red cell storage in the critically ill. Transfusion 46 (2006), 2014–2027.
46. 46 Chin-Yee, I., Arya, N., d'Almeida, M.S., The red cell storage lesion and its implication for transfusion. Transfus Sci 18 (1997), 447–458.
47. 47 Card, R.T., Mohandas, N., Perkins, H.A., Shohet, S.B., Deformability of stored red blood cells. Relationship to degree of packing. Transfusion 22 (1982), 96–101.
48. 48 Karam, O., Tucci, M., Toledano, B.J., et al. Length of storage and in vitro immunomodulation induced by prestorage leukoreduced red blood cells. Transfusion 49 (2009), 2326–2334.
49. 49 Rana, R., Fernandez-Perez, E.R., Kahn, S.A., et al. Transfusion-related acute lung injury and pulmonary edema in critically ill patients: a retrospective study. Transfusion 46 (2006), 1478–1483.
50. 50 Li, G., Daniels, C.E., Kojicic, M., et al. The accuracy of natriuretic peptides in the differentiation between transfusion-related acute lung injury and transfusion-related circulatory overload in the critically ill. Transfusion 49 (2009), 13–20.
51. 51 Skeate, R.C., Easlung, T., Distinguishing between transfusion-related acute lung injury and transfusion-associated circulatory overload. Curr Opin Hematol 14 (2007), 682–687.
52. 52 Ho, J., Sibbald, W.J., Chin-Yee, I.H., Effects of storage on efficacy of red cell transfusion: when is it not safe?. Crit Care Med 31:12 suppl (2003), S687–S697.
53. 53 Almac, E., Ince, C., The impact of storage of red cell function in blood transfusion. Best Pract Res Clin Anaesthesiol 21 (2007), 195–208.
54. 54 Offner, P.J., Age of blood: does it make a difference?. Crit Care 8:suppl 2 (2004), S24–S26.
55. 55 Wang, D., Sun, J., Solomon, S.B., Klein, H.G., Natanson, C., Transfusion of older stored blood and risk of death: a meta-analysis. Transfusion 52 (2012), 1184–1195.
56. 56 Shimmer, C., Hamouda, K., Özkur, M., et al. Influence of storage time and amount of red blood cell transfusion on postoperative renal function: an observational cohort study. Heart Lung Vessel 5 (2013), 148–157.
57. 57 Steiner, M.E., Ness, P.M., Assmann, S.F., et al. Effects of red-cell storage duration on patients undergoing cardiac surgery. N Engl J Med 372 (2015), 1419–1429.
58. 58 Kor, D.J., Kashyap, R., Weiskopf, R.B., et al. Fresh red blood cell transfusion and short-term pulmonary, immunologic, and coagulation status: a randomized clinical trial. Am J Respir Crit Care Med 185 (2012), 842–850.
59. 59 Lacroix, J., Hébert, P.C., Fergusson, D.A., et al. Age of transfused blood in critically ill adults. N Engl J Med 372 (2015), 1410–1418.
60. 60 Brunskill, S.J., Wilkinson, K.L., Doree, C., Trivella, M., Stanworth, S., Transfusion of fresher versus older red blood cells for all conditions. Cochrane Database Syst Rev, 5, 2015, CD010801.
61. 61 Aubron, C., Nichol, A., Cooper, D.J., Bellomo, R., Age of red blood cells and transfusion in critically ill patients. Ann Intensive Care, 3, 2013, 2.
62. 62 Practice guidelines for blood component therapy: a report by the American Society of Anesthesiologists Task Force on Blood Component Therapy. Anesthesiology 84 (1996), 732–747.
63. 63 Murphy, M.F., Wallington, T.B., Kelsey, P., et al. Guidelines for the clinical use of red cell transfusions. Br J Haematol 113 (2001), 24–31.
64. 64 National Health and Medical Research Council/Australasian Society of Blood Transfusion, Clinical practice guidelines: appropriate use of red blood cells. 2001, National Health and Medical Research Council/Australasian Society of Blood Transfusion, Sydney, Australia.
65. 65 Bassand, J.P., Hamm, C.W., Ardissino, D., et al. Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes. Eur Heart J 28 (2007), 1598–1660.
66. 66 Carson, J.L., Grossman, B.J., Kleinman, S., et al. Clinical Transfusion Medicine Committee of the AABB. Red blood cell transfusion: a clinical practice guideline from the AABB. Ann Intern Med 157 (2012), 49–58.
67. 67 Carson, J.L., Terrin, M.L., Noveck, H., et al. Liberal or restrictive transfusion in high-risk patients after hip surgery. N Engl J Med 365 (2011), 2453–2462.
68. 68 Carson, J.L., Carless, P.A., Hebert, P.C., Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion. Cochrane Database Syst Rev, 4, 2012, CD002042.
69. 69 Carless, P.A., Henry, D.A., Carson, J.L., et al. Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion. Cochrane Database Syst Rev, 10, 2010, CD002042.
70. 70 Salpeter, S.R., Buckley, J.S., Chatterjee, S., Impact of more restrictive blood transfusion strategies on clinical outcomes: a meta-analysis and systematic review. Am J Med 127 (2014), 124–131.e3.
71. 71 Holst, L.B., Petersen, M.W., Haase, N., Perner, A., Wetterslev, J., Restrictive versus liberal transfusion strategy for red blood cell transfusion: systematic review of randomised trials with meta-analysis and trial sequential analysis. BMJ, 350, 2015, h1354.
72. 72 Rivers, E., Nguyen, B., Havstad, S., et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 345 (2001), 1368–1377.
73. 73 Holst, L.B., Haase, N., Wetterslev, J., et al. Lower versus higher hemoglobin threshold for transfusion in septic shock. N Engl J Med 371 (2014), 1381–1391.
74. 74 The ProCESS Investigators, A randomized trial of protocol-based care for early septic shock. N Engl J Med 370 (2014), 1683–1693.
75. 75 The ARISE Investigators and the ANZICS Clinical Trials Group. Goal-directed resuscitation for patients with early septic shock. N Engl J Med 371 (2014), 1496–1506.
76. 76 Villanueva, C., Colomo, A., Bosch, A., et al. Transfusion strategies for acute upper gastrointestinal bleeding. N Engl J Med 368 (2013), 11–21.
77. 77 Restellini, S., Kherad, O., Jairath, V., Martel, M., Barkun, A.N., Red blood cell transfusion is associated with increased rebleeding in patients with nonvariceal upper gastrointestinal bleeding. Aliment Pharmacol Ther 37 (2013), 316–322.
78. 78 Jairath, V., Kahan, B.C., Gray, A., et al. Restrictive versus liberal blood transfusion for acute upper gastrointestinal bleeding (TRIGGER): a pragmatic, open-label, cluster randomised feasibility trial. Lancet 386 (2015), 137–144.
79. 79 Wang, J., Bao, Y.-X., Bai, M., Zhang, Y.-G., Xu, W.-D., Qi, X.-S., Restrictive vs liberal transfusion for upper gastrointestinal bleeding: A meta-analysis of randomized controlled trials. World J Gastroenterol 19 (2013), 6919–6927.
80. 80 Levy, P.S., Kim, S.J., Eckel, P.K., et al. Limit to cardiac compensation during acute isovolemic hemodilution: influence of coronary stenosis. Am J Physiol 265 (1993), H340–H349.
81. 81 Carson, J.L., Brooks, M.M., Abbott, J.D., et al. Liberal versus restrictive transfusion thresholds for patients with symptomatic coronary artery disease. Am Heart J 165 (2013), 964–971.e1.
82. 82 Cooper, H.A., Rao, S.V., Greenberg, M.D., et al. Conservative vs liberal red cell transfusion in acute myocardial infarction (the CRIT Randomized Pilot Study). Am J Cardiol 108 (2011), 1108–1111.
83. 83 Rao, S.V., Jollis, J.G., Harrington, R.A., et al. Relationship of blood transfusion and clinical outcomes in patients with acute coronary syndromes. JAMA 292 (2004), 1555–1562.
84. 84 Chatterjee, S., Wetterslev, J., Sharma, A., Lichstein, E., Mukherjee, D., Association of blood transfusion with increased mortality in myocardial infarction: a meta-analysis and diversity-adjusted study sequential analysis. JAMA Intern Med 173 (2013), 132–139.
85. 85 Baraniuk, S., Tilley, B.C., del Junco, D.J., et al. Pragmatic Randomized Optimal Platelet and Plasma Ratios (PROPPR) trial: design, rationale and implementation. Injury 45 (2014), 1287–1295.
86. 86 Brakenridge, S.C., Phelan, H.A., Henley, S.S., et al. Early blood product and crystalloid volume resuscitation: risk association with multiple organ dysfunction after severe blunt traumatic injury. J Trauma 71 (2011), 299–305.
87. 87 Johnson, J.L., Moore, E.E., Kashuk, J.L., et al. Effect of blood products transfusion on the development of postinjury multiple organ failure. Arch Surg 145 (2010), 973–977.
88. 88 Bochicchio, G.V., Napolitano, L., Joshi, M., et al. Outcome analysis of blood product transfusion in trauma patients: a prospective, risk-adjusted study. World J Surg 32 (2008), 2185–2189.
89. 89 LeRoux, P., Haemoglobin management in acute brain injury. Curr Opin Crit Care 19 (2013), 83–91.
90. 90 Diedler, J., Sykora, M., Hahn, P., et al. Low hemoglobin is associated with poor functional outcome after non-traumatic, supratentorial intracerebral hemorrhage. Crit Care, 14, 2010, R63.
91. 91 Oddo, M., Milby, A., Chen, I., et al. Hemoglobin concentration and cerebral metabolism in patients with aneurysmal subarachnoid hemorrhage. Stroke 40 (2009), 1275–1281.
92. 92 McIntyre, L.A., Fergusson, D.A., Hutchison, J.S., et al. Effect of a liberal versus restrictive transfusion strategy on mortality in patients with moderate to severe head injury. Neurocrit Care 5 (2006), 4–9.
93. 93 Boutin, A., Chassé, M., Shemilt, M., et al. Red blood cell transfusion in patients with traumatic brain injury: a systematic review and meta-analysis. Transfus Med Rev 30 (2016), 15–24.