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Volumn 7, Issue 4, 2014, Pages S2-S7

Novel therapies in development for metastatic colorectal cancer

Author keywords

[No Author keywords available]

Indexed keywords

AFLIBERCEPT; ALPELISIB; B RAF KINASE; BEVACIZUMAB; BINIMETINIB; BMS 936559; CAPECITABINE PLUS OXALIPLATIN; CETUXIMAB; COBIMETINIB; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; DABRAFENIB; DULIGOTUZUMAB; ENCORAFENIB; EPIDERMAL GROWTH FACTOR RECEPTOR; FLUOROPYRIMIDINE; FLUOROURACIL; FOLINIC ACID; FUTUXIMAB; IPILIMUMAB; IRINOTECAN; LEFITOLIMOD; MITOGEN ACTIVATED PROTEIN KINASE KINASE; NIVOLUMAB; PANITUMUMAB; PEMBROLIZUMAB; PHOSPHATIDYLINOSITOL 3 KINASE; TICILIMUMAB; TRAMETINIB; UNINDEXED DRUG; VEMURAFENIB;

EID: 84973875608     PISSN: 19347820     EISSN: 19347987     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (4)

References (73)
  • 1
    • 84973876134 scopus 로고    scopus 로고
    • Accessed 2014
    • SEER Cancer Statistics Review, 1975-2011. National Cancer Institute, 2014. Available at http://seer.cancer.gov/csr/1975_2011. Accessed 2014.
    • (2014) 1975-2011. National Cancer Institute
  • 2
    • 68949094312 scopus 로고    scopus 로고
    • Improved survival in metastatic colorectal cancer is associated with adoption of hepatic resection and improved chemotherapy
    • Kopetz S, Chang GJ, Overman MJ, et al: Improved survival in metastatic colorectal cancer is associated with adoption of hepatic resection and improved chemotherapy. J Clin Oncol 27: 3677-3683, 2009
    • (2009) J Clin Oncol , vol.27 , pp. 3677-3683
    • Kopetz, S.1    Chang, G.J.2    Overman, M.J.3
  • 3
    • 84907027361 scopus 로고    scopus 로고
    • CALGB/SWOG 80405: Phase III trial of irinote-can/5-FU/leucovorin (FOLFIRI) or oxaliplatin/5-FU/leucovorin (mFOLFOX6) with bevacizumab (BV) or cetuximab (CET) for patients (pts) with KRAS wild-type (wt) untreated metastatic ade-nocarcinoma of the colon or rectum (MCRC)
    • (abstr LBA3)
    • Venook AP, Niedzwiecki D, Lenz H-J, et al: CALGB/SWOG 80405: Phase III trial of irinote-can/5-FU/leucovorin (FOLFIRI) or oxaliplatin/5-FU/leucovorin (mFOLFOX6) with bevacizumab (BV) or cetuximab (CET) for patients (pts) with KRAS wild-type (wt) untreated metastatic ade-nocarcinoma of the colon or rectum (MCRC). J Clin Oncol 32:3677-5S, 2014 (abstr LBA3)
    • (2014) J Clin Oncol , vol.32 , pp. 3677S-3755S
    • Venook, A.P.1    Niedzwiecki, D.2    Lenz, H.-J.3
  • 4
    • 79956298812 scopus 로고    scopus 로고
    • Cetuximab plus irinotecan, fluorouracil, and leuco-vorin as first-line treatment for metastatic colorectal cancer: Updated analysis of overall survival according to tumor KRAS and BRAF mutation status
    • Van Cutsem E, Kohne CH, Lang I, et al: Cetuximab plus irinotecan, fluorouracil, and leuco-vorin as first-line treatment for metastatic colorectal cancer: updated analysis of overall survival according to tumor KRAS and BRAF mutation status. J Clin Oncol 29:2011-2019, 2011
    • (2011) J Clin Oncol , vol.29 , pp. 2011-2019
    • Van Cutsem, E.1    Kohne, C.H.2    Lang, I.3
  • 5
    • 63849088630 scopus 로고    scopus 로고
    • Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer
    • Van Cutsem E, Kohne CH, Hitre E, et al: Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N Engl J Med 360: 1408-1417, 2009
    • (2009) N Engl J Med , vol.360 , pp. 1408-1417
    • Van Cutsem, E.1    Kohne, C.H.2    Hitre, E.3
  • 6
    • 54949085398 scopus 로고    scopus 로고
    • K-ras mutations and benefit from cetuximab in advanced colorectal cancer
    • Karapetis CS, Khambata-Ford S, Jonker DJ, et al: K-ras mutations and benefit from cetuximab in advanced colorectal cancer. N Engl J Med 359:1757-1765, 2008
    • (2008) N Engl J Med , vol.359 , pp. 1757-1765
    • Karapetis, C.S.1    Khambata-Ford, S.2    Jonker, D.J.3
  • 7
    • 3242720345 scopus 로고    scopus 로고
    • Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
    • Cunningham D, Humblet Y, Siena S, et al: Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med 351:337-345, 2004
    • (2004) N Engl J Med , vol.351 , pp. 337-345
    • Cunningham, D.1    Humblet, Y.2    Siena, S.3
  • 8
    • 84883680951 scopus 로고    scopus 로고
    • Panitu-mumab-FOLFOX4 treatment and RAS mutations in colorectal cancer
    • Douillard JY, Oliner KS, Siena S, et al: Panitu-mumab-FOLFOX4 treatment and RAS mutations in colorectal cancer. N Engl J Med 369: 1023-1034, 2013
    • (2013) N Engl J Med , vol.369 , pp. 1023-1034
    • Douillard, J.Y.1    Oliner, K.S.2    Siena, S.3
  • 9
    • 34147103678 scopus 로고    scopus 로고
    • Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer
    • Van Cutsem E, Peeters M, Siena S, et al: Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer. J Clin Oncol 25:1658-1664, 2007
    • (2007) J Clin Oncol , vol.25 , pp. 1658-1664
    • Van Cutsem, E.1    Peeters, M.2    Siena, S.3
  • 10
    • 76549085643 scopus 로고    scopus 로고
    • Sym004: A novel synergistic anti-epidermal growth factor receptor antibody mixture with superior anticancer efficacy
    • Pedersen MW, Jacobsen HJ, Koefoed K, et al: Sym004: a novel synergistic anti-epidermal growth factor receptor antibody mixture with superior anticancer efficacy. Cancer Res 70: 588-597, 2010
    • (2010) Cancer Res , vol.70 , pp. 588-597
    • Pedersen, M.W.1    Jacobsen, H.J.2    Koefoed, K.3
  • 11
    • 85027537515 scopus 로고    scopus 로고
    • Phase 1 study of biweekly (Q2W) anti-EGFR monoclonal antibody (mAb) mixture Sym004 in patients (pts) with metastatic colorectal cancer (mCRC) resistant to previous anti-EGFR treat-ment
    • (abstr 3551)
    • Argilés G, Dienstmann R, Viñuales MB, et al: Phase 1 study of biweekly (Q2W) anti-EGFR monoclonal antibody (mAb) mixture Sym004 in patients (pts) with metastatic colorectal cancer (mCRC) resistant to previous anti-EGFR treat-ment. J Clin Oncol 32:588-5S, 2014 (abstr 3551)
    • (2014) J Clin Oncol , vol.32 , pp. 588S-658S
    • Argilés, G.1    Dienstmann, R.2    Viñuales, M.B.3
  • 12
    • 80054765331 scopus 로고    scopus 로고
    • A two-in-one antibody against HER3 and EGFR has superior inhibitory activity compared with monospecific antibodies
    • Schaefer G, Haber L, Crocker LM, et al: A two-in-one antibody against HER3 and EGFR has superior inhibitory activity compared with monospecific antibodies. Cancer Cell 20:472-486, 2011
    • (2011) Cancer Cell , vol.20 , pp. 472-486
    • Schaefer, G.1    Haber, L.2    Crocker, L.M.3
  • 13
    • 0033009389 scopus 로고    scopus 로고
    • Binding specificities and affinities of egf domains for ErbB receptors
    • Jones JT, Akita RW, Sliwkowski MX: Binding specificities and affinities of egf domains for ErbB receptors. FEBS Lett 447:227-231, 1999
    • (1999) FEBS Lett , vol.447 , pp. 227-231
    • Jones, J.T.1    Akita, R.W.2    Sliwkowski, M.X.3
  • 14
    • 0028302018 scopus 로고
    • ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor
    • Soltoff SP, Carraway KL 3rd, Prigent SA, et al: ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor. Mol Cell Biol 14:3550-3558, 1994
    • (1994) Mol Cell Biol , vol.14 , pp. 3550-3558
    • Soltoff, S.P.1    Carraway, K.L.2    Prigent, S.A.3
  • 15
    • 33748361817 scopus 로고    scopus 로고
    • Inactivation of Akt by the epidermal growth factor receptor inhibitor erlotinib is mediated by HER-3 in pancreatic and colorectal tumor cell lines and contributes to erlotinib sensitivity
    • Buck E, Eyzaguirre A, Haley JD, et al: Inactivation of Akt by the epidermal growth factor receptor inhibitor erlotinib is mediated by HER-3 in pancreatic and colorectal tumor cell lines and contributes to erlotinib sensitivity. Mol Cancer Ther 5:2051-2059, 2006
    • (2006) Mol Cancer Ther , vol.5 , pp. 2051-2059
    • Buck, E.1    Eyzaguirre, A.2    Haley, J.D.3
  • 16
    • 84874541055 scopus 로고    scopus 로고
    • A phase I study of MEHD7945A (MEHD), a first-in-class HER3/EGFR dual-action antibody, in patients (pts) with refractory/recurrent epithelial tumors: Expansion cohorts
    • (abstr 2568)
    • Cervantes-Ruiperez A, Juric D, Hidalgo M, et al: A phase I study of MEHD7945A (MEHD), a first-in-class HER3/EGFR dual-action antibody, in patients (pts) with refractory/recurrent epithelial tumors: expansion cohorts. J Clin Oncol 30(suppl), 2012 (abstr 2568)
    • (2012) J Clin Oncol , vol.30
    • Cervantes-Ruiperez, A.1    Juric, D.2    Hidalgo, M.3
  • 17
    • 58749102224 scopus 로고    scopus 로고
    • High concordance of KRAS status between primary colorectal tumors and related metastatic sites: Implications for clinical practice
    • Santini D, Loupakis F, Vincenzi B, et al: High concordance of KRAS status between primary colorectal tumors and related metastatic sites: implications for clinical practice. Oncologist 13: 1270-1275, 2008
    • (2008) Oncologist , vol.13 , pp. 1270-1275
    • Santini, D.1    Loupakis, F.2    Vincenzi, B.3
  • 18
    • 84863000299 scopus 로고    scopus 로고
    • The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers
    • Diaz LA Jr., Williams RT, Wu J, et al: The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers. Nature 486:537-540, 2012
    • (2012) Nature , vol.486 , pp. 537-540
    • Diaz, L.A.1    Williams, R.T.2    Wu, J.3
  • 19
    • 84862999938 scopus 로고    scopus 로고
    • Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer
    • Misale S, Yaeger R, Hobor S, et al: Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer. Nature 486:532-536, 2012
    • (2012) Nature , vol.486 , pp. 532-536
    • Misale, S.1    Yaeger, R.2    Hobor, S.3
  • 20
    • 84866633148 scopus 로고    scopus 로고
    • Clinical activity of the oral MEK1/MEK2 inhibitor GSK1120212 in pancreatic and colorectal cancer
    • (abstr 246)
    • Messersmith WA, Falchook GS, Fecher LA, et al: Clinical activity of the oral MEK1/MEK2 inhibitor GSK1120212 in pancreatic and colorectal cancer. J Clin Oncol 29, 2011 (abstr 246)
    • (2011) J Clin Oncol , vol.29
    • Messersmith, W.A.1    Falchook, G.S.2    Fecher, L.A.3
  • 21
    • 84855487013 scopus 로고    scopus 로고
    • A Phase II, open-label, randomised study to assess the efficacy and safety of the MEK1/2 inhibitor AZD6244 (ARRY-142886) vs. Capecit-abine monotherapy in patients with colorectal cancer who have failed one or two prior chemo-therapeutic regimens
    • Bennouna J, Lang I, Valladares-Ayerbes M, et al: A Phase II, open-label, randomised study to assess the efficacy and safety of the MEK1/2 inhibitor AZD6244 (ARRY-142886) vs. capecit-abine monotherapy in patients with colorectal cancer who have failed one or two prior chemo-therapeutic regimens. Investig New Drugs 29: 1021-1028, 2011
    • (2011) Investig New Drugs , vol.29 , pp. 1021-1028
    • Bennouna, J.1    Lang, I.2    Valladares-Ayerbes, M.3
  • 22
    • 84904388268 scopus 로고    scopus 로고
    • Primary and acquired resistance of colorectal cancer cells to anti-EGFR antibodies converge on MEK/ERK pathway activation and can be over-come by combined MEK/EGFR inhibition
    • Troiani T, Napolitano S, Vitagliano D, et al: Primary and acquired resistance of colorectal cancer cells to anti-EGFR antibodies converge on MEK/ERK pathway activation and can be over-come by combined MEK/EGFR inhibition. Clin Cancer Res 20:3775-3786, 2014
    • (2014) Clin Cancer Res , vol.20 , pp. 3775-3786
    • Troiani, T.1    Napolitano, S.2    Vitagliano, D.3
  • 23
    • 84896078397 scopus 로고    scopus 로고
    • Blockade of EGFR and MEK intercepts heterogeneous mechanisms of acquired resistance to anti-EGFR therapies in colorectal cancer
    • 224ra26
    • Misale S, Arena S, Lamba S, et al: Blockade of EGFR and MEK intercepts heterogeneous mechanisms of acquired resistance to anti-EGFR therapies in colorectal cancer. Sci Trans-lat Med 6:224ra26, 2014
    • (2014) Sci Trans-Lat Med , vol.6
    • Misale, S.1    Arena, S.2    Lamba, S.3
  • 24
    • 84863922124 scopus 로고    scopus 로고
    • Comprehensive molecular characterization of human colon and rectal cancer
    • The Cancer Genome Atlas Network: Comprehensive molecular characterization of human colon and rectal cancer. Nature 487:330-337, 2012
    • (2012) Nature , vol.487 , pp. 330-337
  • 25
    • 84862026304 scopus 로고    scopus 로고
    • Addition of cetuximab to chemotherapy as first-line treatment for KRAS wild-type metastatic colorectal cancer: Pooled analysis of the CRYS-TAL and OPUS randomised clinical trials
    • Bokemeyer C, Van Cutsem E, Rougier P, et al: Addition of cetuximab to chemotherapy as first-line treatment for KRAS wild-type metastatic colorectal cancer: pooled analysis of the CRYS-TAL and OPUS randomised clinical trials. Eur J Cancer 48:1466-1475, 2012
    • (2012) Eur J Cancer , vol.48 , pp. 1466-1475
    • Bokemeyer, C.1    Van Cutsem, E.2    Rougier, P.3
  • 26
    • 84861083983 scopus 로고    scopus 로고
    • Dab-rafenib in patients with melanoma, untreated brain metastases, and other solid tumours: A phase 1 dose-escalation trial
    • Falchook GS, Long GV, Kurzrock R, et al: Dab-rafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial. Lancet 379:1893-1901, 2012
    • (2012) Lancet , vol.379 , pp. 1893-1901
    • Falchook, G.S.1    Long, G.V.2    Kurzrock, R.3
  • 27
    • 78649723255 scopus 로고    scopus 로고
    • PLX4032 in metastatic colorectal cancer patients with mutant BRAF tumors
    • (abstr 3534)
    • Kopetz S, Desai J, Chan E, et al: PLX4032 in metastatic colorectal cancer patients with mutant BRAF tumors. J Clin Oncol 28:1893-15S, 2010 (abstr 3534)
    • (2010) J Clin Oncol , vol.28 , pp. 1893S-2153S
    • Kopetz, S.1    Desai, J.2    Chan, E.3
  • 28
    • 84863230465 scopus 로고    scopus 로고
    • Unrespon-siveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR
    • Prahallad A, Sun C, Huang S, et al: Unrespon-siveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR. Nature 483:100-103, 2012
    • (2012) Nature , vol.483 , pp. 100-103
    • Prahallad, A.1    Sun, C.2    Huang, S.3
  • 29
    • 84861863158 scopus 로고    scopus 로고
    • EGFR-mediated re-activation of MAPK signaling contributes to insensitivity of BRAF mutant colorectal cancers to RAF inhibition with vemurafenib
    • Corcoran RB, Ebi H, Turke AB, et al: EGFR-mediated re-activation of MAPK signaling contributes to insensitivity of BRAF mutant colorectal cancers to RAF inhibition with vemurafenib. Cancer Discov 2:227-235, 2012
    • (2012) Cancer Discov , vol.2 , pp. 227-235
    • Corcoran, R.B.1    Ebi, H.2    Turke, A.B.3
  • 30
    • 84919393400 scopus 로고    scopus 로고
    • Phase I study of the selective BRAFV600 inhibitor encorafenib (LGX818) combined with cetuximab and with or without the α-specific PI3K inhibitor BYL719 in patients with advanced BRAF-mutant colorectal cancer
    • (abstr 3514)
    • Van Geel R, Elez E, Bendell JC, et al: Phase I study of the selective BRAFV600 inhibitor encorafenib (LGX818) combined with cetuximab and with or without the α-specific PI3K inhibitor BYL719 in patients with advanced BRAF-mutant colorectal cancer. J Clin Oncol 32:227-5S, 2014 (abstr 3514)
    • (2014) J Clin Oncol , vol.32 , pp. 227S-257S
    • Van Geel, R.1    Elez, E.2    Bendell, J.C.3
  • 31
    • 84923100781 scopus 로고    scopus 로고
    • Efficacy and tolerability in an open-label phase I/II study of MEK inhibitor trametinib (T), BRAF inhibitor dabrafenib (D), and anti-EGFR antibody panitu-mumab (P) in combination in patients (pts) with BRAF V600E mutated colorectal cancer (CRC)
    • (abstr 3515)
    • Bendell JC, Atreya CE, André T, et al: Efficacy and tolerability in an open-label phase I/II study of MEK inhibitor trametinib (T), BRAF inhibitor dabrafenib (D), and anti-EGFR antibody panitu-mumab (P) in combination in patients (pts) with BRAF V600E mutated colorectal cancer (CRC). J Clin Oncol 32:227-5S, 2014 (abstr 3515)
    • (2014) J Clin Oncol , vol.32 , pp. 227S-257S
    • Bendell, J.C.1    Atreya, C.E.2    Ré, T.3
  • 32
    • 84925133542 scopus 로고    scopus 로고
    • VE-BASKET, a Simon 2-stage adaptive design, phase II, histology-independent study in non-melanoma solid tumors harboring BRAF V600 mutations (V600m): Activity of vemurafenib (VEM) with or without cetuximab (CTX) in colo-rectal cancer (CRC)
    • (abstr 3518)
    • Tabernero J, Chan E, Baselga J, et al: VE-BASKET, a Simon 2-stage adaptive design, phase II, histology-independent study in non-melanoma solid tumors harboring BRAF V600 mutations (V600m): activity of vemurafenib (VEM) with or without cetuximab (CTX) in colo-rectal cancer (CRC). J Clin Oncol 32:227-5S, 2014 (abstr 3518)
    • (2014) J Clin Oncol , vol.32 , pp. 227S-257S
    • Tabernero, J.1    Chan, E.2    Baselga, J.3
  • 33
    • 84922636156 scopus 로고    scopus 로고
    • Phase 1-2 trial of the BRAF inhibitor dabrafenib (D) plus MEK inhibitor trametinib (T) in BRAF V600 mutant colorectal cancer (CRC): Updated efficacy and biomarker analysis
    • (abstr 3517)
    • Corcoran RB, Atreya CE, Falchook GS, et al: Phase 1-2 trial of the BRAF inhibitor dabrafenib (D) plus MEK inhibitor trametinib (T) in BRAF V600 mutant colorectal cancer (CRC): Updated efficacy and biomarker analysis. J Clin Oncol 227-325S, 2014 (abstr 3517)
    • (2014) J Clin Oncol , pp. 227S-325S
    • Corcoran, R.B.1    Atreya, C.E.2    Falchook, G.S.3
  • 34
    • 84925134597 scopus 로고    scopus 로고
    • Phase 1B study of vemurafenib in combination with irinotecan and cetuximab in patients with BRAF-mutated advanced cancers and metastatic colorectal cancer
    • (abstr 3516)
    • Hong DS, Morris VK, Fu S, et al: Phase 1B study of vemurafenib in combination with irinotecan and cetuximab in patients with BRAF-mutated advanced cancers and metastatic colorectal cancer. J Clin Oncol 32:5S, 2014 (abstr 3516)
    • (2014) J Clin Oncol , vol.32
    • Hong, D.S.1    Morris, V.K.2    Fu, S.3
  • 35
    • 79960403316 scopus 로고    scopus 로고
    • Cytotoxic T-lymphocyte-associated antigen-4
    • Salama AK, Hodi FS: Cytotoxic T-lymphocyte-associated antigen-4. Clin Cancer Res 17: 4622-4628, 2011
    • (2011) Clin Cancer Res , vol.17 , pp. 4622-4628
    • Salama, A.K.1    Hodi, F.S.2
  • 36
    • 84859158384 scopus 로고    scopus 로고
    • Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity
    • Topalian SL, Drake CG, Pardoll DM: Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity. Curr Opin Immunol 24:207-212, 2012
    • (2012) Curr Opin Immunol , vol.24 , pp. 207-212
    • Topalian, S.L.1    Drake, C.G.2    Pardoll, D.M.3
  • 37
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • Hodi FS, O’Day SJ, McDermott DF, et al: Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 363:711-723, 2010
    • (2010) N Engl J Med , vol.363 , pp. 711-723
    • Hodi, F.S.1    O’Day, S.J.2    McDermott, D.F.3
  • 38
    • 84879777241 scopus 로고    scopus 로고
    • Niv-olumab plus ipilimumab in advanced melanoma
    • Wolchok JD, Kluger H, Callahan MK, et al: Niv-olumab plus ipilimumab in advanced melanoma. N Engl J Med 369:122-133, 2013
    • (2013) N Engl J Med , vol.369 , pp. 122-133
    • Wolchok, J.D.1    Kluger, H.2    Callahan, M.K.3
  • 39
    • 79959772576 scopus 로고    scopus 로고
    • Ipilimumab plus dacarbazine for previously un-treated metastatic melanoma
    • Robert C, Thomas L, Bondarenko I, et al: Ipilimumab plus dacarbazine for previously un-treated metastatic melanoma. N Engl J Med 364:2517-2526, 2011
    • (2011) N Engl J Med , vol.364 , pp. 2517-2526
    • Robert, C.1    Thomas, L.2    Bondarenko, I.3
  • 40
    • 84925622262 scopus 로고    scopus 로고
    • LBA3_PR: A phase 3 randomized, open-label study of nivolumab (anti-PD-1; BMS-936558; ONO-4538) vs. Investigator’s choice chemo-therapy (ICC) in patients with advanced mela-noma after prior anti-CTLA-4 therapy
    • (abstr 1-41)
    • Weber JS, Minor DR, D’Angelo SP, et al: LBA3_PR: a phase 3 randomized, open-label study of nivolumab (anti-PD-1; BMS-936558; ONO-4538) vs. investigator’s choice chemo-therapy (ICC) in patients with advanced mela-noma after prior anti-CTLA-4 therapy. Ann Oncol 25, 2014 (abstr 1-41)
    • (2014) Ann Oncol , vol.25
    • Weber, J.S.1    Minor, D.R.2    D’Angelo, S.P.3
  • 41
    • 84908354848 scopus 로고    scopus 로고
    • Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: A randomised dose-compar-ison cohort of a phase 1 trial
    • Robert C, Ribas A, Wolchok JD, et al: Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: a randomised dose-compar-ison cohort of a phase 1 trial. Lancet 384:1109-1117, 2014
    • (2014) Lancet , vol.384 , pp. 1109-1117
    • Robert, C.1    Ribas, A.2    Wolchok, J.D.3
  • 42
    • 84908233609 scopus 로고    scopus 로고
    • Getting personal with neoantigen-based therapeutic cancer vaccines
    • Hacohen N, Fritsch EF, Carter TA, et al: Getting personal with neoantigen-based therapeutic cancer vaccines. Cancer Immunol Res 1:11-15, 2013
    • (2013) Cancer Immunol Res , vol.1 , pp. 11-15
    • Hacohen, N.1    Fritsch, E.F.2    Carter, T.A.3
  • 43
    • 77955292303 scopus 로고    scopus 로고
    • Phase II study of the anti-cytotoxic T-lymphocyte-associated antigen 4 monoclonal antibody, tremelimumab, in patients with refractory metastatic colorectal cancer
    • Chung KY, Gore I, Fong L, et al: Phase II study of the anti-cytotoxic T-lymphocyte-associated antigen 4 monoclonal antibody, tremelimumab, in patients with refractory metastatic colorectal cancer. J Clin Oncol 28:3485-3490, 2010
    • (2010) J Clin Oncol , vol.28 , pp. 3485-3490
    • Chung, K.Y.1    Gore, I.2    Fong, L.3
  • 44
    • 84862903106 scopus 로고    scopus 로고
    • Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
    • Brahmer JR, Tykodi SS, Chow LQ, et al: Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med 366:2455-2465, 2012
    • (2012) N Engl J Med , vol.366 , pp. 2455-2465
    • Brahmer, J.R.1    Tykodi, S.S.2    Chow, L.Q.3
  • 45
    • 77954899030 scopus 로고    scopus 로고
    • Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: Safety, clinical activity, pharmacodynamics, and immu-nologic correlates
    • Brahmer JR, Drake CG, Wollner I, et al: Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immu-nologic correlates. J Clin Oncol 28:3167-3175, 2010
    • (2010) J Clin Oncol , vol.28 , pp. 3167-3175
    • Brahmer, J.R.1    Drake, C.G.2    Wollner, I.3
  • 46
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • Topalian SL, Hodi FS, Brahmer JR, et al: Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med 366:2443-2454, 2012
    • (2012) N Engl J Med , vol.366 , pp. 2443-2454
    • Topalian, S.L.1    Hodi, F.S.2    Brahmer, J.R.3
  • 47
    • 69549111048 scopus 로고    scopus 로고
    • Tumor-infiltrating lymphocytes in colorectal cancers with microsatellite instability are correlated with the number and spectrum of frame-shift mutations
    • Tougeron D, Fauquembergue E, Rouquette A, et al: Tumor-infiltrating lymphocytes in colorectal cancers with microsatellite instability are correlated with the number and spectrum of frame-shift mutations. Mod Pathol 22:1186-1195, 2009
    • (2009) Mod Pathol , vol.22 , pp. 1186-1195
    • Tougeron, D.1    Fauquembergue, E.2    Rouquette, A.3
  • 48
    • 84904024273 scopus 로고    scopus 로고
    • Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with re-sponse to Anti-PD-1 therapy
    • Taube JM, Klein A, Brahmer JR, et al: Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with re-sponse to Anti-PD-1 therapy. Clin Cancer Res 20:5064-5074, 2014
    • (2014) Clin Cancer Res , vol.20 , pp. 5064-5074
    • Taube, J.M.1    Klein, A.2    Brahmer, J.R.3
  • 49
    • 84982184242 scopus 로고    scopus 로고
    • Programmed death 1 (PD-1) lymphocytes and ligand (PD-L1) in colorectal cancer and their relationship to microsatellite instability status
    • (abstr 3625)
    • Gatalica Z, Snyder CL, Yeatts K, et al: Programmed death 1 (PD-1) lymphocytes and ligand (PD-L1) in colorectal cancer and their relationship to microsatellite instability status. J Clin Oncol 32:5064-5S, 2014 (abstr 3625)
    • (2014) J Clin Oncol , vol.32 , pp. 5064S-5154S
    • Gatalica, Z.1    Snyder, C.L.2    Yeatts, K.3
  • 50
    • 85065005056 scopus 로고    scopus 로고
    • The vigorous immune microenvironment of microsatellite in-stable colon cancer is balanced by multiple counter-inhibitory checkpoints
    • (in press)
    • Llosa NJ, Cruise M, Tam A, et al: The vigorous immune microenvironment of microsatellite in-stable colon cancer is balanced by multiple counter-inhibitory checkpoints. Cancer Discov (in press)
    • Cancer Discov
    • Llosa, N.J.1    Cruise, M.2    Tam, A.3
  • 51
    • 84875189381 scopus 로고    scopus 로고
    • Molecular pathways: Toll-like receptors in the tumor microenvironment: Poor prognosis or new therapeutic opportunity
    • Ridnour LA, Cheng RY, Switzer CH, et al: Molecular pathways: toll-like receptors in the tumor microenvironment: poor prognosis or new therapeutic opportunity. Clin Cancer Res 19:1340-1346, 2013
    • (2013) Clin Cancer Res , vol.19 , pp. 1340-1346
    • Ridnour, L.A.1    Cheng, R.Y.2    Switzer, C.H.3
  • 52
    • 34249677845 scopus 로고    scopus 로고
    • Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists
    • Kanzler H, Barrat FJ, Hessel EM, et al: Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists. Nature Med 13:552-559, 2007
    • (2007) Nature Med , vol.13 , pp. 552-559
    • Kanzler, H.1    Barrat, F.J.2    Hessel, E.M.3
  • 53
    • 84902676837 scopus 로고    scopus 로고
    • Maintenance treatment with the immunomodulator MGN1703, a Toll-like receptor 9 (TLR9) agonist, in patients with metastatic colorectal carcinoma and disease control after chemotherapy: A ran-domised, double-blind, placebo-controlled trial
    • Schmoll HJ, Wittig B, Arnold D, et al: Maintenance treatment with the immunomodulator MGN1703, a Toll-like receptor 9 (TLR9) agonist, in patients with metastatic colorectal carcinoma and disease control after chemotherapy: a ran-domised, double-blind, placebo-controlled trial. J Cancer Res Clin Oncol 140:1615-1624, 2014
    • (2014) J Cancer Res Clin Oncol , vol.140 , pp. 1615-1624
    • Schmoll, H.J.1    Wittig, B.2    Arnold, D.3
  • 54
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H, Fehrenbacher L, Novotny W, et al: Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 350:2335-2342, 2004
    • (2004) N Engl J Med , vol.350 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3
  • 55
    • 84884552646 scopus 로고    scopus 로고
    • Efficacy and safety of bevacizumab in meta-static colorectal cancer: Pooled analysis from seven randomized controlled trials
    • Hurwitz HI, Tebbutt NC, Kabbinavar F, et al: Efficacy and safety of bevacizumab in meta-static colorectal cancer: pooled analysis from seven randomized controlled trials. Oncologist 18:1004-1012, 2013
    • (2013) Oncologist , vol.18 , pp. 1004-1012
    • Hurwitz, H.I.1    Tebbutt, N.C.2    Kabbinavar, F.3
  • 56
    • 75749096309 scopus 로고    scopus 로고
    • Phase II trial of infusional fluorouracil, irinotecan, and bevaci-zumab for metastatic colorectal cancer: Efficacy and circulating angiogenic biomarkers associated with therapeutic resistance
    • Kopetz S, Hoff PM, Morris JS, et al: Phase II trial of infusional fluorouracil, irinotecan, and bevaci-zumab for metastatic colorectal cancer: efficacy and circulating angiogenic biomarkers associated with therapeutic resistance. J Clin Oncol 28:453-459, 2010
    • (2010) J Clin Oncol , vol.28 , pp. 453-459
    • Kopetz, S.1    Hoff, P.M.2    Morris, J.S.3
  • 57
    • 84867047384 scopus 로고    scopus 로고
    • Addition of aflibercept to fluorouracil, leuco-vorin, and irinotecan improves survival in a phase III randomized trial in patients with metastatic colorectal cancer previously treated with an oxaliplatin-based regimen
    • Van Cutsem E, Tabernero J, Lakomy R, et al: Addition of aflibercept to fluorouracil, leuco-vorin, and irinotecan improves survival in a phase III randomized trial in patients with metastatic colorectal cancer previously treated with an oxaliplatin-based regimen. J Clin Oncol 30: 3499-3506, 2012
    • (2012) J Clin Oncol , vol.30 , pp. 3499-3506
    • Van Cutsem, E.1    Tabernero, J.2    Lakomy, R.3
  • 58
    • 84875222627 scopus 로고    scopus 로고
    • Cediranib with mFOLFOX6 vs. Bevacizumab with mFOLFOX6 in previously treated metastatic colorectal cancer
    • Cunningham D, Wong RP, D’Haens G, et al: Cediranib with mFOLFOX6 vs. bevacizumab with mFOLFOX6 in previously treated metastatic colorectal cancer. Br J Cancer 108:493-502, 2013
    • (2013) Br J Cancer , vol.108 , pp. 493-502
    • Cunningham, D.1    Wong, R.P.2    D’Haens, G.3
  • 59
    • 84867115561 scopus 로고    scopus 로고
    • Cediranib with mFOLFOX6 vs. Bevacizumab with mFOLFOX6 as first-line treatment for patients with advanced colorectal cancer: A double-blind, randomized phase III study (HORI-ZON III)
    • Schmoll HJ, Cunningham D, Sobrero A, et al: Cediranib with mFOLFOX6 vs. bevacizumab with mFOLFOX6 as first-line treatment for patients with advanced colorectal cancer: a double-blind, randomized phase III study (HORI-ZON III). J Clin Oncol 30:3588-3595, 2012
    • (2012) J Clin Oncol , vol.30 , pp. 3588-3595
    • Schmoll, H.J.1    Cunningham, D.2    Sobrero, A.3
  • 60
    • 84867602281 scopus 로고    scopus 로고
    • Cediranib plus FOLFOX/CAPOX vs. Placebo plus FOLFOX/CAPOX in patients with previously un-treated metastatic colorectal cancer: A random-ized, double-blind, phase III study (HORIZON II)
    • Hoff PM, Hochhaus A, Pestalozzi BC, et al: Cediranib plus FOLFOX/CAPOX vs. placebo plus FOLFOX/CAPOX in patients with previously un-treated metastatic colorectal cancer: a random-ized, double-blind, phase III study (HORIZON II). J Clin Oncol 30:3596-3603, 2012
    • (2012) J Clin Oncol , vol.30 , pp. 3596-3603
    • Hoff, P.M.1    Hochhaus, A.2    Pestalozzi, B.C.3
  • 61
    • 79956334386 scopus 로고    scopus 로고
    • Randomized, placebo-controlled, phase III study of first-line oxaliplatin-based chemotherapy plus PTK787/ZK 222584, an oral vascular endothelial growth factor receptor inhibitor, in patients with metastatic colorectal adenocarcinoma
    • Hecht JR, Trarbach T, Hainsworth JD, et al: Randomized, placebo-controlled, phase III study of first-line oxaliplatin-based chemotherapy plus PTK787/ZK 222584, an oral vascular endothelial growth factor receptor inhibitor, in patients with metastatic colorectal adenocarcinoma. J Clin Oncol 29:1997-2003, 2011
    • (2011) J Clin Oncol , vol.29 , pp. 1997-2003
    • Hecht, J.R.1    Trarbach, T.2    Hainsworth, J.D.3
  • 62
    • 79956297102 scopus 로고    scopus 로고
    • Randomized, placebo-controlled, phase III study of ox-aliplatin, fluorouracil, and leucovorin with or without PTK787/ZK 222584 in patients with previously treated metastatic colorectal adeno-carcinoma
    • Van Cutsem E, Bajetta E, Valle J, et al: Randomized, placebo-controlled, phase III study of ox-aliplatin, fluorouracil, and leucovorin with or without PTK787/ZK 222584 in patients with previously treated metastatic colorectal adeno-carcinoma. J Clin Oncol 29:2004-2010, 2011
    • (2011) J Clin Oncol , vol.29 , pp. 2004-2010
    • Van Cutsem, E.1    Bajetta, E.2    Valle, J.3
  • 63
    • 84883074556 scopus 로고    scopus 로고
    • Phase III randomized, placebo-controlled study of cetuximab plus brivanib alaninate vs. Cetuximab plus placebo in patients with metastatic, chemotherapy-refractory, wild-type K-RAS colorectal carcinoma: The NCIC Clinical Trials Group and AGITG CO.20 Trial
    • Siu LL, Shapiro JD, Jonker DJ, et al: Phase III randomized, placebo-controlled study of cetuximab plus brivanib alaninate vs. cetuximab plus placebo in patients with metastatic, chemotherapy-refractory, wild-type K-RAS colorectal carcinoma: the NCIC Clinical Trials Group and AGITG CO.20 Trial. J Clin Oncol 31:2477-2484, 2013
    • (2013) J Clin Oncol , vol.31 , pp. 2477-2484
    • Siu, L.L.1    Shapiro, J.D.2    Jonker, D.J.3
  • 64
    • 49649123154 scopus 로고    scopus 로고
    • BIBF 1120: Triple angiokinase inhibitor with sustained re-ceptor blockade and good antitumor efficacy
    • Hilberg F, Roth GJ, Krssak M, et al: BIBF 1120: triple angiokinase inhibitor with sustained re-ceptor blockade and good antitumor efficacy. Cancer Res 68:4774-4782, 2008
    • (2008) Cancer Res , vol.68 , pp. 4774-4782
    • Hilberg, F.1    Roth, G.J.2    Krssak, M.3
  • 65
    • 84872600553 scopus 로고    scopus 로고
    • A Phase l/lI, open-label, randomised study of BIBF 1120 plus mFOLFOX6 compared to bev-acizumab plus mFOLFOX6 in patients with met-astatic colorectal cancer
    • (abstr)
    • Van Cutsem E, Prenen H, Guillen-Ponce C, et al: A Phase l/lI, open-label, randomised study of BIBF 1120 plus mFOLFOX6 compared to bev-acizumab plus mFOLFOX6 in patients with met-astatic colorectal cancer. Eur J Cancer 47:8-9, 2011 (abstr)
    • (2011) Eur J Cancer , vol.47 , pp. 8-9
    • Van Cutsem, E.1    Prenen, H.2    Guillen-Ponce, C.3
  • 66
    • 79956334138 scopus 로고    scopus 로고
    • Vatalanib in advanced colorectal cancer: Two studies with identical results
    • Sobrero AF, Bruzzi P: Vatalanib in advanced colorectal cancer: two studies with identical results. J Clin Oncol 29:1938-1940, 2011
    • (2011) J Clin Oncol , vol.29 , pp. 1938-1940
    • Sobrero, A.F.1    Bruzzi, P.2
  • 67
    • 84875133981 scopus 로고    scopus 로고
    • HORIZON I: Is there a future for oral anti-angiogenics on the horizon of colorectal cancer therapy?
    • Hochster HS. HORIZON I: is there a future for oral anti-angiogenics on the horizon of colorectal cancer therapy? Br J Cancer 108:477-478, 2013
    • (2013) Br J Cancer , vol.108 , pp. 477-478
    • Hochster, H.S.1
  • 68
    • 79954499886 scopus 로고    scopus 로고
    • Rego-rafenib (BAY 73-4506): A new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity
    • Wilhelm SM, Dumas J, Adnane L, et al: Rego-rafenib (BAY 73-4506): a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity. Intl J Cancer 129:245-255, 2011
    • (2011) Intl J Cancer , vol.129 , pp. 245-255
    • Wilhelm, S.M.1    Dumas, J.2    Adnane, L.3
  • 69
    • 84872921660 scopus 로고    scopus 로고
    • Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): An in-ternational, multicentre, randomised, placebo-controlled, phase 3 trial
    • Grothey A, Van Cutsem E, Sobrero A, et al: Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an in-ternational, multicentre, randomised, placebo-controlled, phase 3 trial. Lancet 381:303-312, 2013
    • (2013) Lancet , vol.381 , pp. 303-312
    • Grothey, A.1    Van Cutsem, E.2    Sobrero, A.3
  • 70
    • 84904074017 scopus 로고    scopus 로고
    • Vascular effects, efficacy and safety of nintedanib in patients with advanced, refractory colorectal cancer: A prospective phase I subanalysis
    • Mross K, Buchert M, Frost A, et al: Vascular effects, efficacy and safety of nintedanib in patients with advanced, refractory colorectal cancer: a prospective phase I subanalysis. BMC Cancer 14:303-510, 2014
    • (2014) BMC Cancer , vol.14 , pp. 303-510
    • Mross, K.1    Buchert, M.2    Frost, A.3
  • 71
    • 85027535751 scopus 로고    scopus 로고
    • LUME-COLON 1: Double-blind, randomized phase III study of nintedanib (BIBF 1120) plus best supportive care (BSC) vs. Placebo plus BSC in patients (pts) with refractory colorectal cancer
    • Van Cutsem E, Tabernero J, Yoshino T, et al: LUME-COLON 1: double-blind, randomized phase III study of nintedanib (BIBF 1120) plus best supportive care (BSC) vs. placebo plus BSC in patients (pts) with refractory colorectal cancer. Ann Oncol 25:303-iv208, 2014
    • (2014) Ann Oncol , vol.25 , pp. iv208-iv303
    • Van Cutsem, E.1    Tabernero, J.2    Yoshino, T.3
  • 72
    • 84866925889 scopus 로고    scopus 로고
    • TAS-102 monotherapy for pretreated metastatic colorectal cancer: A double-blind, randomised, placebo-controlled phase 2 trial
    • Yoshino T, Mizunuma N, Yamazaki K, et al: TAS-102 monotherapy for pretreated metastatic colorectal cancer: a double-blind, randomised, placebo-controlled phase 2 trial. Lancet Oncol 13:993-1001, 2012
    • (2012) Lancet Oncol , vol.13 , pp. 993-1001
    • Yoshino, T.1    Mizunuma, N.2    Yamazaki, K.3
  • 73
    • 84955757927 scopus 로고    scopus 로고
    • Phase III RECOURSE trial of TAS-102 vs. Placebo, with best supportive care (BSC), in patients (pts) with metastatic colorectal cancer (mCRC) refractory to standard therapies
    • (abstr LBA13)
    • Van Cutsem E, Ohtsu A, Falcone A, et al: Phase III RECOURSE trial of TAS-102 vs. placebo, with best supportive care (BSC), in patients (pts) with metastatic colorectal cancer (mCRC) refractory to standard therapies. Ann Oncol 2014; 25-4 (abstr LBA13)
    • (2014) Ann Oncol , pp. 25-34
    • Van Cutsem, E.1    Ohtsu, A.2    Falcone, A.3


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