Enhancing detection sensitivity in gradient liquid chromatography via post-column refocusing and strong-solvent remobilization

Journal of Chromatography A

Volumn 1455, Issue , 2016, Pages 86-92

  De Vos, Jelle ^a   Desmet, Gert ^a   Eeltink, Sebastiaan ^a  

^a VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

Author keywords

Antibiotics; Impurity profiling; Metabolites; Peak compression; Solvent switch

Indexed keywords

ACETONITRILE; ANTIBIOTICS; CHROMATOGRAPHY; COLUMN CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; METABOLITES; SIGNAL DETECTION; SOLVENTS; VISCOSITY;

ANALYTICAL SEPARATIONS; DETECTION SENSITIVITY; GRADIENT LIQUID CHROMATOGRAPHY; GRADIENT SEPARATIONS; IMPURITY PROFILING; ISOCRATIC SEPARATION; PEAK COMPRESSION; VISCOSITY CALIBRATIONS;

ORGANIC SOLVENTS;

2 PROPANOL; ACETONITRILE; ANTIBIOTIC AGENT; CEFRADINE; CIPROFLOXACIN; DRUG METABOLITE; FENBENDAZOLE; FURAZOLIDONE; NORFLOXACIN; SILICON DIOXIDE; SOLVENT; SULFADIAZINE; SULFAGUANIDINE; TETRACYCLINE; TILMICOSIN; ACETONITRILE DERIVATIVE; ANTIINFECTIVE AGENT; WATER;

ANALYTICAL EQUIPMENT; ARTICLE; CALIBRATION; CHEMICAL ANALYSIS; CHEMICAL COMPOSITION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DETECTION SENSITIVITY; DISPERSION; FLOW RATE; GRADIENT LIQUID CHROMATOGRAPHY; LABORATORY TEST; LIQUID CHROMATOGRAPHY; MATHEMATICAL PARAMETERS; POSTCOLUMN REFOCUSING; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; STRONG SOLVENT REMOBILIZATION; VAN DEEMTER FLOW RATE; VISCOSITY; CHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOLATION AND PURIFICATION; METABOLISM; PROCEDURES;

ACETONITRILES; ANTI-BACTERIAL AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; SILICON DIOXIDE; SOLVENTS; VISCOSITY; WATER;

EID: 84973548076     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2016.05.046     Document Type: Article

References (23)

1. Görög S., Babják M., Balogh G., Brlik J., Csehi A., Dravecz F., Gazdag M., Horváth P., Laukó A., Varga K. Drug impurity profiling strategies. Talanta 1997, 44:1517-1526.
2. Singh S., Handa T., Narayanam M., sahu A., Junwal M., Shap R.P. A critical review on the use of modern sophisticated hyphenated tools in the characterization of impurities and degradation products. J. Biopharm. Biomed. Anal. 2012, 69:148-173.
3. Carlet J., Jarlier V., Harbarth S., Voss A., Goossens H., Pittet D. Ready for a world without antibiotics? The pensières antibiotic resistance call to action. Antimicrob. Resist. Infect. Control 2012, 1:1-13.
4. Phillips I., Casewell M., Cox T., De Groot B., Friis C., Jones R., Waddell J. Does the use of antibiotics in food animals pose a risk to human health? A critical review of published data. J. Antimicrob. Chemotherapy 2004, 35:28-52.
5. Filippini M., Ortiz J.G.G., Masiero G. Assessing the impact of national antibiotic campaigns in Europe. Eur. J. Health Econ. 2003, 14:587-599.
6. Vass M., Hruska K., Franek M. Nitrofuran antibiotics: a review on the application, prohibition and residual analysis. Vet. Med. (Praha) 2008, 9:469-500.
7. Kennedy D.G., McCracken R.J., Cannavan A., Hewitt S.A. Use of liquid chromatography-mass spectrometry in the analysis of residues of antibiotics in meat and milk. J. Chromatogr. A 1998, 812:77-98.
8. Niessen W.M.A. Analysis of antibiotics by liquid chromatography-mass spectrometr. J. Chromatogr. A 1998, 812:53-75.
9. Grzelak E.M., Choma I.M. Stability of cefacetrile in milk samples with various fat content. Eur. Food Res. Technol. 2013, 237:673-678.
10. Karger B.L., Martin M., Guiochon G. Role of column parameters and injection volume on detection limits in liquid chromatography. Anal. Chem. 1974, 46:1640-1647.
11. Busetti F., Backe W.J., Bendixen N., Maier U., Place B., Giger W., Field J.A. Trace analysis of environmental matrices by large-volume injection and liquid chromatography-mass spectrometry. Anal. Bioanal. Chem. 2012, 402:175-186.
12. Gilar M., McDonald T.S., Roman G., Johnson J.S., Murphy J.P., Jorgenson J.W. Repetitive injection method: a tool for investigation of injection zone formation and its compression in microfluidic liquid chromatography. J. Chromatogr. A 2015, 1381:110-117.
13. Gilar M., McDonald T.S., Johnson J.S., Murphy J.P., Jorgenson J.W. Wide injection zone compression in gradient reversed-phase liquid chromatography. J. Chromatogr. A 2015, 1390:86-94.
14. Layne J., Farcas T., Rustamov I., Ahmed F. Volume-load capacity in fast-gradient liquid chromatography effect of sample solvent composition and injection volume on chromatographic performance. J. Chromatogr. A 2001, 913:233-242.
15. Schlotterbeck G., Ceccarelli S.M. LC-SPE-NMR-MS: a total analysis system for bioanalysis. Bioanalysis 2009, 1:549-559.
16. Djukovic D., Liu S., Henry I., Tobias B., Raftery D. Signal enhancement in HPLC/microcoil NMR using automated column trapping. Anal. Chem. 2006, 78:7154-7160.
17. Wilson S.R., Malerød H., Petersen D., Rise F., Lundanes E., Greibrokk T. An alternative multiple-trapping LC-SPE-NMR system. J. Sep. Sci. 2007, 30:322-328.
18. Vonk R.J., Gargano A.F.G., Davydova E., Dekker H.L., Eeltink S., de Koning L.J., Schoenmakers P.J. Comprehensive two-dimensional liquid chromatography with stationary-phase-assisted modulation coupled to high-resolution mass spectrometry applied to proteome analysis of Saccharomyces cerevisiae. Anal. Chem. 2015, 87:5387-5394.
19. De Vos J., Desmet G., Eeltink S. A generic approach to post-column refocusing in liquid chromatography. J. Chromatogr. A 2014, 1360:164-171.
20. De Vos J., Eeltink S., Desmet G. Peak refocusing using subsequent retentive trapping and strong eluent remobilization in liquid chromatography: a theoretical optimization study. J. Chromatogr. A 2015, 1381:74-86.
21. Billen J., Broeckhoven K., Liekens A., Choikhet K., Rozing G., Desmet G. Influence of pressure and temperature on the physico-chemical properties of mobile phase mixtures commonly used in high-performance liquid chromatography. J. Chromatogr. A 2008, 1210:30-44.
22. Guillarme D., Heinisch S., Rocca J.L. Effect of temperature in reversed phase liquid chromatography. J. Chromatogr. A 2004, 1052:39-51.
23. Snyder L.R. Classification of the solvent properties of common liquids. J. Chromatogr. A 1974, 92:223-230.