Amino acid metabolism is altered in adolescents with nonalcoholic fatty liver disease - An untargeted, high resolution metabolomics study

Journal of Pediatrics

Volumn 172, Issue , 2016, Pages 14-19.e5

  Jin, Ran ^a   Banton, Sophia ^a   Tran, Vilinh T ^a   Konomi, Juna V ^a   Li, Shuzhao ^a   Jones, Dean P ^a   Vos, Miriam B ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TYROSINE; AMINO ACID;

ADOLESCENCE; ADOLESCENT; ADOLESCENT OBESITY; AMINO ACID METABOLISM; ARTICLE; CASE CONTROL STUDY; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HISPANIC; HUMAN; LIPID METABOLISM; MALE; MASS SPECTROMETER; MASS SPECTROMETRY; METABOLIC DISORDER; METABOLITE; METABOLOMICS; NONALCOHOLIC FATTY LIVER; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PLASMA; PRIORITY JOURNAL; PROSPECTIVE STUDY; REVERSED PHASE LIQUID CHROMATOGRAPHY; SCHOOL CHILD; COMPLICATION; LIVER; METABOLISM; OBESITY; PATHOLOGY; PROCEDURES;

ADOLESCENT; AMINO ACIDS; CASE-CONTROL STUDIES; CHILD; FEMALE; HUMANS; LIVER; MAGNETIC RESONANCE SPECTROSCOPY; MALE; METABOLOMICS; NON-ALCOHOLIC FATTY LIVER DISEASE; OBESITY; PROSPECTIVE STUDIES;

EID: 84973414833     PISSN: 00223476     EISSN: 10976833     Source Type: Journal    
DOI: 10.1016/j.jpeds.2016.01.026     Document Type: Article

References (33)

1. J.A. Welsh, S. Karpen, and M.B. Vos Increasing prevalence of nonalcoholic fatty liver disease among United States adolescents, 1988-1994 to 2007-2010 J Pediatr 162 2013 496 500.e1
2. R. Loomba, and A.J. Sanyal The global NAFLD epidemic Nat Rev Gastroenterol Hepatol 10 2013 686 690
3. A.L. Schneider, M. Lazo, E. Selvin, and J.M. Clark Racial differences in nonalcoholic fatty liver disease in the US population Obesity (Silver Spring) 22 2014 292 299
4. M.I. Goran, R. Walker, and H. Allayee Genetic-related and carbohydrate-related factors affecting liver fat accumulation Curr Opin Clin Nutr Metab Care 15 2012 392 396
5. M.B. Vos, J.E. Kimmons, C. Gillespie, J. Welsh, and H.M. Blanck Dietary fructose consumption among US children and adults: the Third National Health and Nutrition Examination Survey Medscape J Med 10 2008 160
6. A.M. Fitzpatrick, Y. Park, L.A. Brown, and D.P. Jones Children with severe asthma have unique oxidative stress-associated metabolomic profiles J Allergy Clin Immunol 133 2014 258 261.e1-8
7. S.K. Cribbs, Y. Park, D.M. Guidot, G.S. Martin, L.A. Brown, J. Lennox, and et al. Metabolomics of bronchoalveolar lavage differentiate healthy HIV-1-infected subjects from controls AIDS Res Hum Retroviruses 30 2014 579 585
8. K. Uppal, Q.A. Soltow, F.H. Strobel, W.S. Pittard, K.M. Gernert, T. Yu, and et al. xMSanalyzer: automated pipeline for improved feature detection and downstream analysis of large-scale, nontargeted metabolomics data BMC Bioinformatics 14 2013 15
9. D.P. Jones, Y. Park, and T.R. Ziegler Nutritional metabolomics: progress in addressing complexity in diet and health Annu Rev Nutr 32 2012 183 202
10. S. Li, Y. Park, S. Duraisingham, F.H. Strobel, N. Khan, Q.A. Soltow, and et al. Predicting network activity from high throughput metabolomics PLoS Comput Biol 9 2013 e1003123
11. R. Jin, N.A. Le, R. Cleeton, X. Sun, J. Cruz Munos, J. Otvos, and et al. Amount of hepatic fat predicts cardiovascular risk independent of insulin resistance among Hispanic-American adolescents Lipids Health Dis 14 2015 39
12. E.P. Ralli, S.H. Rubin, and S. Rinzler The liver lipids in normal human livers and in cased of cirrhosis and fatty infiltration of the liver J Clin Invest 20 1941 93 97
13. M.J. Lee, P. Bagci, J. Kong, M.B. Vos, P. Sharma, B. Kalb, and et al. Liver steatosis assessment: correlations among pathology, radiology, clinical data and automated image analysis software Pathol Res Pract 209 2013 371 379
14. N. Pineda, P. Sharma, Q. Xu, X. Hu, M. Vos, and D.R. Martin Measurement of hepatic lipid: high-speed T2-corrected multiecho acquisition at 1H MR spectroscopy - a rapid and accurate technique Radiology 252 2009 568 576
15. Q.A. Soltow, F.H. Strobel, K.G. Mansfield, L. Wachtman, Y. Park, and D.P. Jones High-performance metabolic profiling with dual chromatography-Fourier-transform mass spectrometry (DC-FTMS) for study of the exposome Metabolomics 9 2013 132 143
16. T. Yu, Y. Park, J.M. Johnson, and D.P. Jones apLCMS - adaptive processing of high-resolution LC/MS data Bioinformatics 25 2009 1930 1936
17. Y. Benjamini, and Y. Hochberg Controlling the false discovery rate: a practical and powerful approach to multiple testing J R Statist Soc B 57 1995 289 300
18. P. Puri, M.M. Wiest, O. Cheung, F. Mirshahi, C. Sargeant, H.K. Min, and et al. The plasma lipidomic signature of nonalcoholic steatohepatitis Hepatology 50 2009 1827 1838
19. J.E. Lambert, M.A. Ramos-Roman, J.D. Browning, and E.J. Parks Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic fatty liver disease Gastroenterology 146 2014 726 735
20. P. Wurtz, M. Tiainen, V.P. Makinen, A.J. Kangas, P. Soininen, J. Saltevo, and et al. Circulating metabolite predictors of glycemia in middle-aged men and women Diabetes Care 35 2012 1749 1756
21. P. Wurtz, P. Soininen, A.J. Kangas, T. Ronnemaa, T. Lehtimaki, M. Kahonen, and et al. Branched-chain and aromatic amino acids are predictors of insulin resistance in young adults Diabetes Care 36 2013 648 655
22. P. Wurtz, V.P. Makinen, P. Soininen, A.J. Kangas, T. Tukiainen, J. Kettunen, and et al. Metabolic signatures of insulin resistance in 7,098 young adults Diabetes 61 2012 1372 1380
23. P.K. Wiklund, S. Pekkala, R. Autio, E. Munukka, L. Xu, J. Saltevo, and et al. Serum metabolic profiles in overweight and obese women with and without metabolic syndrome Diabetol Metab Syndr 6 2014 40
24. T.J. Wang, M.G. Larson, R.S. Vasan, S. Cheng, E.P. Rhee, E. McCabe, and et al. Metabolite profiles and the risk of developing diabetes Nat Med 17 2011 448 453
25. A.D. Lake, P. Novak, P. Shipkova, N. Aranibar, D.G. Robertson, M.D. Reily, and et al. Branched chain amino acid metabolism profiles in progressive human nonalcoholic fatty liver disease Amino Acids 47 2015 603 615
26. S. Michail, M. Lin, M.R. Frey, R. Fanter, O. Paliy, B. Hilbush, and et al. Altered gut microbial energy and metabolism in children with non-alcoholic fatty liver disease FEMS Microbiol Ecol 91 2015 1 9
27. M.B. Vos Nutrition, nonalcoholic fatty liver disease and the microbiome: recent progress in the field Curr Opin Lipidol 25 2014 61 66
28. X. Zheng, G. Xie, A. Zhao, L. Zhao, C. Yao, N.H. Chiu, and et al. The footprints of gut microbial-mammalian co-metabolism J Proteome Res 10 2011 5512 5522
29. Z. Lin, J.R. Roede, C. He, D.P. Jones, and N.M. Filipov Short-term oral atrazine exposure alters the plasma metabolome of male C57BL/6 mice and disrupts alpha-linolenate, tryptophan, tyrosine and other major metabolic pathways Toxicology 326 2014 130 141
30. D.D. Wei, J.S. Wang, P.R. Wang, M.H. Li, M.H. Yang, and L.Y. Kong Toxic effects of chronic low-dose exposure of thioacetamide on rats based on NMR metabolic profiling J Pharm Biomed Anal 98 2014 334 338
31. M. Arciello, M. Gori, R. Maggio, B. Barbaro, M. Tarocchi, A. Galli, and et al. Environmental pollution: a tangible risk for NAFLD pathogenesis Int J Mol Sci 14 2013 22052 22066
32. S.C. Kalhan, L. Guo, J. Edmison, S. Dasarathy, A.J. McCullough, R.W. Hanson, and et al. Plasma metabolomic profile in nonalcoholic fatty liver disease Metabolism 60 2011 404 413
33. S. Cheng, P. Wiklund, R. Autio, R. Borra, X. Ojanen, L. Xu, and et al. Adipose tissue dysfunction and altered systemic amino acid metabolism are associated with nonalcoholic fatty liver disease PLoS One 10 2015 e0138889