Large-Effect Beneficial Synonymous Mutations Mediate Rapid and Parallel Adaptation in a Bacterium

Molecular Biology and Evolution

Volumn 33, Issue 6, 2016, Pages 1542-1553

  Agashe, Deepa ^a,b   Sane, Mrudula ^a   Phalnikar, Kruttika ^a   Diwan, Gaurav D ^a,c   Habibullah, Alefiyah ^a   Martinez Gomez, Norma Cecilia ^d   Sahasrabuddhe, Vinaya ^a   Polachek, William ^b   Wang, Jue ^b,e   Chubiz, Lon M ^b   Marx, Christopher J ^b,f,g  

^a TATA INSTITUTE OF FUNDAMENTAL RESEARCH   (India)

^b HARVARD UNIVERSITY   (United States)

^c SASTRA UNIVERSITY   (India)

^d Michigan State University ^*  (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

^f HARVARD UNIVERSITY   (United States)

^g UNIVERSITY OF IDAHO   (United States)

Author keywords

Codon use; Epistasis; Fitness; mRNA folding; Shine Dalgarno sequence

Indexed keywords

MESSENGER RNA; METHYLAMINE; BACTERIAL PROTEIN; CODON; FAE PROTEIN, METHYLOBACTERIUM EXTORQUENS; LIGASE;

ADAPTATION; ARTICLE; BACTERIAL GENE; BACTERIAL GROWTH; ENZYME ACTIVITY; ENZYME SYNTHESIS; FAE GENE; METHYLOBACTERIUM EXTORQUENS; NONHUMAN; PLEIOTROPY; POINT MUTATION; SINGLE NUCLEOTIDE POLYMORPHISM; START CODON; CODON; ENZYMOLOGY; EPISTASIS; EVOLUTION; GENETIC SELECTION; GENETICS; METABOLISM; MOLECULAR EVOLUTION; MUTATION; PROTEIN SYNTHESIS; REPRODUCTIVE FITNESS; RIBOSOME; SILENT MUTATION;

ADAPTATION, PHYSIOLOGICAL; BACTERIAL PROTEINS; BIOLOGICAL EVOLUTION; CARBON-NITROGEN LIGASES; CODON; EPISTASIS, GENETIC; EVOLUTION, MOLECULAR; GENETIC FITNESS; METHYLOBACTERIUM EXTORQUENS; MUTATION; PROTEIN BIOSYNTHESIS; RIBOSOMES; RNA, MESSENGER; SELECTION, GENETIC; SILENT MUTATION;

EID: 84973352161     PISSN: 07374038     EISSN: 15371719     Source Type: Journal    
DOI: 10.1093/molbev/msw035     Document Type: Article

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