Antimicrobial activity of plumbagin, a naturally occurring naphthoquinone from Plumbago rosea, against Staphylococcus aureus and Candida albicans

International Journal of Medical Microbiology

Volumn 306, Issue 4, 2016, Pages 237-248

  Nair, Sweatha V ^a   Baranwal, Gaurav ^a   Chatterjee, Maitrayee ^a   Sachu, Arun ^a   Vasudevan, Anil Kumar ^a   Bose, Chinchu ^b   Banerji, Asoke ^b   Biswas, Raja ^a  

^a AMRITA INSTITUTE OF MEDICAL SCIENCES   (India)

^b AMRITA UNIVERSITY   (India)

Author keywords

Bacteria; Biofilm; Fungus; Phytochemicals; Plumbagin

Indexed keywords

AMPICILLIN; ANGELICIN; ANTIBIOTIC AGENT; ANTIFUNGAL AGENT; ANTIINFECTIVE AGENT; AYURVEDIC DRUG; CARDOL; CURCUMIN; ECDYSTERONE; EMBELIN; FLUCONAZOLE; GALLIC ACID; GOSSYPETIN; LAWSONE; NAPHTHOQUINONE; PLUMBAGIN; QUERCETAGETIN; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; PLANT MEDICINAL PRODUCT;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIFUNGAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; AYURVEDA; BACILLUS SUBTILIS; BACTERIAL GROWTH; BACTERIAL LOAD; BIOFILM; CANDIDA ALBICANS; CANDIDIASIS; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; DRUG DOSE INCREASE; EXPERIMENTAL PIG; FEMALE; FUNGUS GROWTH; KLEBSIELLA PNEUMONIAE; MEDICINAL PLANT; MINIMUM INHIBITORY CONCENTRATION; MIXED INFECTION; MYCOBACTERIUM FORTUITUM; NONHUMAN; PATHOGEN LOAD; PLUMBAGO ROSEA; PSEUDOMONAS AERUGINOSA; SALMONELLA ENTERICA SEROVAR PARATYPHI A; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION; STREPTOCOCCUS PNEUMONIAE; ANIMAL; CHEMISTRY; DISEASE MODEL; DRUG EFFECTS; ISOLATION AND PURIFICATION; MICROBIAL SENSITIVITY TEST; PHYSIOLOGY; PLUMBAGINACEAE; STAPHYLOCOCCAL INFECTIONS; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

ANIMALS; ANTI-INFECTIVE AGENTS; BIOFILMS; CANDIDA ALBICANS; CANDIDIASIS; DISEASE MODELS, ANIMAL; DROSOPHILA MELANOGASTER; FEMALE; MICROBIAL SENSITIVITY TESTS; NAPHTHOQUINONES; PHYTOCHEMICALS; PLUMBAGINACEAE; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

EID: 84973101031     PISSN: 14384221     EISSN: 16180607     Source Type: Journal    
DOI: 10.1016/j.ijmm.2016.05.004     Document Type: Article

References (57)

1. Achkar J.M., Fries B.C. Candida infections of the genitourinary tract. Clin. Microbiol. Rev. 2010, 23:253-273.
2. Al-Fattani M.A., Douglas L.J. Penetration of Candida biofilms by antifungal agents. Antimicrob. Agents. Chemother. 2004, 48:3291-3297.
3. Asche C. Antitumour quinones. Mini Rev. Med. Chem. 2005, 5:449-467.
4. Beg A.Z., Ahmad I. Effect of Plumbago zeylanica extract and certain curing agents on multidrug resistant bacteria of clinical origin. World J. Microbiol. Biotechnol. 2000, 16:841-844.
5. Bhattacharya A., Jindal B., Singh P., Datta A., Panda D. Plumbagin inhibits cytokinesis in Bacillus subtilis by inhibiting FtsZ assembly-a mechanistic study of its antibacterial activity. FEBS J. 2013, 280:4585-4599.
6. Biswas R., Voggu L., Simon U.K., Hentschel P., Thumm G., Gotz F. Activity of the major staphylococcal autolysin Atl. FEMS Microbiol. Lett. 2006, 259:260-268.
7. Chellan G., Shivaprakash S., Karimassery Ramaiyar S., Varma A.K., Varma N., Thekkeparambil Sukumaran M., Rohinivilasam Vasukutty J., Bal A., Kumar H. Spectrum and prevalence of fungi infecting deep tissues of lower-limb wounds in patients with type 2 diabetes. J. Clin. Microbiol. 2010, 48:2097-2102.
8. Chugani S.A., Whiteley M., Lee K.M., D'Argenio D., Manoil C., Greenberg E.P. QscR: a modulator of quorum-sensing signal synthesis and virulence in Pseudomonas aeruginosa. Proc. Natl. Acad. Sci. U. S. A. 2001, 98:2752-2757.
9. Cragg G.M., Newman D.J. Natural products: a continuing source of novel drug leads. Biochim. Biophys. Acta 2013, 1830:3670-3695.
10. Durga R., Sridhar P., Polasa H. Effects of plumbagin on antibiotic resistance in bacteria. Indian J. Med. Res. 1990, 91:18-20.
11. Dzoyem J.P., Tangmouo J.G., Lontsi D., Etoa F.X., Lohoue P.J. In vitro antifungal activity of extract and plumbagin from the stem bark of Diospyros crassiflora Hiern (Ebenaceae). Phytother. Res. 2007, 21:671-674.
12. Ferry L.L., Argentieri G., Lochner D.H. The comparative histology of porcine and guinea pig skin with respect to iontophoretic drug delivery. Pharm. Acta. Helv. 1995, 70:43-56.
13. Fortis A.A., Lianou P.E., Papavassilliou J.T. Adherence of Staphylococcus aureus, Klebsiella pneumoniae and Candida albicans to human buccal epithelial cells, from healthy persons and HIV carriers, under the influence of Broncho Vaxom in vitro and ascorbic acid in vivo. APMIS 1998, 106:441-448.
14. Fournet A., Barrios A.A., Munoz V., Hocquemiller R., Cave A. Effect of natural naphthoquinones in BALB/c mice infected with Leishmania amazonensis and L. venezuelensis. Trop. Med. Parasitol 1992, 43:219-222.
15. Gotz F. Staphylococcus and biofilms. Mol. Microbiol. 2002, 43:1367-1378.
16. Hachem R., Reitzel R., Borne A., Jiang Y., Tinkey P., Uthamanthil R., Chandra J., Ghannoum M., Raad I. Novel antiseptic urinary catheters for prevention of urinary tract infections: correlation of in vivo and in vitro test results. Antimicrob. Agents Chemother. 2009, 53:5145-5149.
17. Harriott M.M., Noverr M.C. Candida albicans and Staphylococcus aureus form polymicrobial biofilms: effects on antimicrobial resistance. Antimicrob. Agents. Chemother. 2009, 53:3914-3922.
18. Heilmann C., Gerke C., Perdreau-Remington F., Gotz F. Characterization of Tn917 insertion mutants of Staphylococcus epidermidis affected in biofilm formation. Infect. Immun 1996, 64:277-282.
19. Jenkins S.G., Schuetz A.N. Current concepts in laboratory testing to guide antimicrobial therapy. Mayo Clin. Proc. 2012, 87:290-308.
20. Kaewbumrung S., Panichayupakaranant P. Antibacterial activity of plumbagin derivative-rich Plumbago indica root extracts and chemical stability. Nat. Prod. Res. 2014, 28:835-837.
21. Kanafani Z.A., Perfect J.R. Antimicrobial resistance: resistance to antifungal agents: mechanisms and clinical impact. Clin. Infect. Dis. 2008, 46:120-128.
22. Kojic E.M., Darouiche R.O. Candida infections of medical devices. Clin. Microbiol. Rev. 2004, 17:255-267.
23. Kwasny S.M., Opperman T.J. Static biofilm cultures of Gram-positive pathogens grown in a microtiter format used for anti-biofilm drug discovery. Curr. Protoc. Pharmacol. 2010, 18. (Chapter 13, Unit 13A).
24. Lboutounne H., Chaulet J.F., Ploton C., Falson F., Pirot F. Sustained ex vivo skin antiseptic activity of chlorhexidine in poly(epsilon-caprolactone) nanocapsule encapsulated form and as a digluconate. J. Control Release 2002, 82:319-334.
25. Lee J.H., Yeon J.H., Kim H., Roh W., Chae J., Park H.O., Kim D.M. The natural anticancer agent plumbagin induces potent cytotoxicity in MCF-7 human breast cancer cells by inhibiting a PI-5 kinase for ROS generation. PLoS One 2012, 7:e45023.
26. Mabona U., Viljoen A., Shikanga E., Marston A., Van Vuuren S. Antimicrobial activity of southern African medicinal plants with dermatological relevance: from an ethnopharmacological screening approach, to combination studies and the isolation of a bioactive compound. J. Ethnopharmacol. 2013, 148:45-55.
27. Mermel L.A., Allon M., Bouza E., Craven D.E., Flynn P., O'Grady N.P., Raad I.I., Rijnders B.J., Sherertz R.J., Warren D.K. Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection: 2009 update by the Infectious Diseases Society of America. Clin. Infect. Di.s 2009, 49:1-45.
28. Nair N., Biswas R., Gotz F., Biswas L. Impact of Staphylococcus aureus on pathogenesis in polymicrobial infections. Infect. Immunol. 2014, 82:2162-2169.
29. Nair N., Vinod V., Suresh M.K., Vijayrajratnam S., Biswas L., Peethambaran R., Vasudevan A.K., Biswas R. Amidase a cell wall hydrolase, elicits protective immunity against Staphylococcus aureus and S. epidermidis. Int. J. Biol. Macromol. 2015, 77:314-321.
30. 2 nanoparticles and nanowires in ex vivo porcine skin model. J. Biomed. Nanotechnol. 2014, 10:864-870.
31. Needham A.J., Kibart M., Crossley H., Ingham P.W., Foster S.J. Drosophila melanogaster as a model host for Staphylococcus aureus infection. Microbiology 2004, 150:2347-2355.
32. Padhye S., Dandawate P., Yusufi M., Ahmad A., Sarkar F.H. Perspectives on medicinal properties of plumbagin and its analogs. Med. Res. Rev. 2012, 32:1131-1158.
33. Panayidou S., Ioannidou E., Apidianakis Y. Human pathogenic bacteria, fungi, and viruses in Drosophila: disease modeling, lessons, and shortcomings. Virulence 2014, 5:253-269.
34. Pearl R. A synthetic food medium for the cultivation of Drosophila: preliminary note. J. Gen. Physiol. 1926, 9:513-519.
35. Peters B.M., Noverr M.C. Candida albicans-Staphylococcus aureus polymicrobial peritonitis modulates host innate immunity. Infect. Immunol. 2013, 81:2178-2189.
36. Peters B.M., Ovchinnikova E.S., Krom B.P., Schlecht L.M., Zhou H., Hoyer L.L., Busscher H.J., van der Mei H.C., Jabra-Rizk M.A., Shirtliff M.E. Staphylococcus aureusadherence to Candida albicans hyphae is mediated by the hyphal adhesin Als3p. Microbiology 2012, 158:2975-2986.
37. Raad I., Darouiche R., Hachem R., Mansouri M., Bodey G.P. The broad-spectrum activity and efficacy of catheters coated with minocycline and rifampin. J. Infect. Dis. 1996, 173:418-424.
38. Rastogi R.P., Singh S.P., Hader D.P., Sinha R.P. Detection of reactive oxygen species (ROS) by the oxidant-sensing probe 2',7'-dichlorodihydrofluorescein diacetate in the cyanobacterium Anabaena variabilis PCC 7937. Biochem. Biophys. Res. Commun. 2010, 397:603-607.
39. Rondevaldova J., Novy P., Kokoska L. In vitro combinatory antimicrobial effect of plumbagin with oxacillin and tetracycline against Staphylococcus aureus. Phytother. Res. 2015, 29:144-147.
40. Saising J., Dube L., Ziebandt A.K., Voravuthikunchai S.P., Nega M., Gotz F. Activity of gallidermin on Staphylococcus aureus and Staphylococcus epidermidis biofilms. Antimicrob. Agents. Chemother. 2012, 56:5804-5810.
41. Simon G.A., Maibach H.I. The pig as an experimental animal model of percutaneous permeation in man: qualitative and quantitative observations-an overview. Skin Pharmacol. Appl. Skin Physiol. 2000, 13:229-234.
42. Singh R., Ray P., Das A., Sharma M. Penetration of antibiotics through Staphylococcus aureus and Staphylococcus epidermidis biofilms. J. Antimicrob. Chemother. 2010, 65:1955-1958.
43. Slobbe L., El Barzouhi A., Boersma E., Rijnders B.J. Comparison of the roll plate method to the sonication method to diagnose catheter colonization and bacteremia in patients with long-term tunnelled catheters: a randomized prospective study. J. Clin. Microbiol. 2009, 47:885-888.
44. Srinivas P., Gopinath G., Banerji A., Dinakar A., Srinivas G. Plumbagin induces reactive oxygen species: which mediate apoptosis in human cervical cancer cells. Mol. Carcinog. 2004, 40:201-211.
45. Srinivas P., Patra C.R., Bhattacharya S., Mukhopadhyay D. Cytotoxicity of naphthoquinones and their capacity to generate reactive oxygen species is quenched when conjugated with gold nanoparticles. Int. J. Nanomed. 2011, 6:2113-2122.
46. Subramaniya B.R., Srinivasan G., Sadullah S.S., Davis N., Subhadara L.B., Halagowder D., Sivasitambaram N.D. Apoptosis inducing effect of plumbagin on colonic cancer cells depends on expression of COX-2. PLoS One 2011, 6:e18695.
47. Summerfield A., Meurens F., Ricklin M.E. The immunology of the porcine skin and its value as a model for human skin. Mol. Immunol. 2015, 66:14-21.
48. Sumsakul l.W., Plengsuriyakar n.T., Chaijaroenku l.W., Viyanan t.V., Karbwan g.J., Na-Bangchan g.K. Antimalarial activity of plumbagin in vitro and in animal models. BMC Complement. Altern. Med. 2014, 14:15.
49. Talpaert M.J., Balfour A., Stevens S., Baker M., Muhlschlegel F.A., Gourlay C.W. Candida biofilm formation on voice prostheses. J. Med. Microbiol. 2015, 64:199-208.
50. Tarai B., Das P., Kumar D. Recurrent challenges for clinicians: emergence of methicillin-Resistant Staphylococcus aureus, vancomycin resistance, and current treatment options. J. Lab. Physicians 2013, 5:71-78.
51. Tavares A.F., Teixeira M., Romao C.C., Seixas J.D., Nobre L.S., Saraiva L.M. Reactive oxygen species mediate bactericidal killing elicited by carbon monoxide-releasing molecules. J. Biol. Chem. 2011, 286:26708-26717.
52. Tegos G., Stermitz F.R., Lomovskaya O., Lewis K. Multidrug pump inhibitors uncover remarkable activity of plant antimicrobials. Antimicrob. Agents Chemother. 2002, 46:3133-3141.
53. Varma P., Nisha N., Dinesh K.R., Kumar A.V., Biswas R. Anti-infective properties of Lactobacillus fermentum against Staphylococcus aureus and Pseudomonas aeruginosa. J. Mol. Microbiol. Biotechnol. 2011, 20:137-143.
54. Vecchio G., Galeone A., Brunetti V., Maiorano G., Sabella S., Cingolani R., Pompa P.P. Concentration-dependent, size-independent toxicity of citrate capped AuNPs in Drosophila melanogaster. PLoS One 2012, 7:e29980.
55. Weidenmaier C., Kokai-Kun J.F., Kristian S.A., Chanturiya T., Kalbacher H., Gross M., Nicholson G., Neumeister B., Mond J.J., Peschel A. Role of teichoic acids in Staphylococcus aureus nasal colonization, a major risk factor in nosocomial infections. Nat. Med. 2004, 10:243-245.
56. Wu K., Conly J., Surette M., Sibley C., Elsayed S., Zhang K. Assessment of virulence diversity of methicillin-resistant Staphylococcus aureus strains with a Drosophila melanogaster infection model. BMC Microbiol. 2012, 12:274.
57. de Paiva S.R., Figueiredo M.R., Aragao T.V., Kaplan M.A. Antimicrobial activity in vitro of plumbagin isolated from Plumbago species. Mem. Inst. Oswaldo. Cruz. 2003, 98:959-961.