Ligand-induced Ordering of the C-terminal Tail Primes STING for Phosphorylation by TBK1

EBioMedicine

Volumn 9, Issue , 2016, Pages 87-96

  Tsuchiya, Yuko ^a,b   Jounai, Nao ^a   Takeshita, Fumihiko ^a   Ishii, Ken J ^a   Mizuguchi, Kenji ^a  

^a NATIONAL INSTITUTE OF BIOMEDICAL INNOVATION   (Japan)

^b OSAKA UNIVERSITY   (Japan)

Author keywords

cGAMP.; Molecular dynamics simulation; STING C terminal tail; TBK1; Type I IFNs

Indexed keywords

BETA INTERFERON; CYCLIC GMP; INTERFERON REGULATORY FACTOR 3; CYCLIC AMP; LIGAND; MEMBRANE PROTEIN; MPYS PROTEIN, HUMAN; PROTEIN BINDING; PROTEIN SERINE THREONINE KINASE; TBK1 PROTEIN, HUMAN;

ARTICLE; CHEMICAL PHENOMENA; CRYSTALLOGRAPHY; GENE; GENE EXPRESSION; HUMAN; IMMUNOBLOTTING; IMMUNOPRECIPITATION; LIGAND BINDING; LUCIFERASE ASSAY; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PLASMID; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SCREENING; SITE DIRECTED MUTAGENESIS; STIMULATOR OF INTERFERON GENE; BINDING SITE; CHEMISTRY; GENETICS; HEK293 CELL LINE; METABOLISM; PHOSPHORYLATION; PROMOTER REGION; PROTEIN DOMAIN;

BINDING SITES; CYCLIC AMP; CYCLIC GMP; HEK293 CELLS; HUMANS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; INTERFERON-BETA; LIGANDS; MEMBRANE PROTEINS; MOLECULAR DYNAMICS SIMULATION; MUTAGENESIS, SITE-DIRECTED; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTEIN DOMAINS; PROTEIN-SERINE-THREONINE KINASES;

EID: 84971667795     PISSN: None     EISSN: 23523964     Source Type: Journal    
DOI: 10.1016/j.ebiom.2016.05.039     Document Type: Article

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