Differential changes in gene expression in human neutrophils following TNF-α stimulation: Up-regulation of anti-apoptotic proteins and down-regulation of proteins involved in death receptor signaling

Immunity, Inflammation and Disease

Volumn 4, Issue 1, 2016, Pages 35-44

  Chiewchengchol, Direkrit ^a,b   Wright, Helen L ^a   Thomas, Huw B ^a   Lam, Connie W ^a   Roberts, Kate J ^a   Hirankarn, Nattiya ^b   Beresford, Michael W ^a   Moots, Robert J ^a   Edwards, Steven W ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b CHULALONGKORN UNIVERSITY   (Thailand)

Author keywords

Death receptor signaling; Neutrophils; TNF receptors

Indexed keywords

EID: 84971661329     PISSN: None     EISSN: 20504527     Source Type: Journal    
DOI: 10.1002/iid3.90     Document Type: Article

References (45)

1. Cabal-Hierro L., and Lazo P. S., 2012. Signal transduction by tumor necrosis factor receptors. Cell Signal. 24:1297-1305.
2. Hayden M. S., and Ghosh S., 2008. Shared principles in NF-κB signaling. Cell 132:344-362.
3. Rauert H., Stühmer T., Bargou R., Wajant H., and Siegmund D., 2011. TNFR1 and TNFR2 regulate the extrinsic apoptotic pathway in myeloma cells by multiple mechanisms. Cell Death Dis. 2:e194.
4. Fisher C. J. Jr., Agosti J. M., Opal S. M., Lowry S. F., Balk R. A., Sadoff J. C., Abraham E., Schein R. M., and Benjamin E., 1996. Treatment of septic shock with the tumor necrosis factor receptor:Fc fusion protein. The Soluble TNF Receptor Sepsis Study Group. N. Engl. J. Med. 334:1697-1702.
5. Qiu P., Cui X., Barochia A., Li Y., Natanson C., and Eichacker P. Q., 2011. The evolving experience with therapeutic TNF inhibition in sepsis: considering the potential influence of risk of death. Expert Opin. Investig. Drugs 20:1555-1564.
6. Roberts-Thomson I. C., Fon J., Uylaki W., Cummins A. G., and Barry S., 2011. Cells and cytokines and inflammatory bowel disease: a clinical perspective. Expert Rev. Gastroenterol. Hepatol. 5:703-716.
7. Postal M., and Appenzeller S., 2011. The role of Tumor Necrosis Factor-α (TNF-α) in the pathogenesis of systemic lupus erythematosus. Cytokine 56:537-543.
8. Choy E. 2012. Understanding the dynamics: pathways involved in the pathogenesis of rheumatoid arthritis. Rheumatology (Oxford) 51(Suppl 5):v3-11.
9. Wright H. L., Bucknall R. C., Moots R. J., and Edwards S. W., 2012. Analysis of SF and plasma cytokines provides insights into the mechanisms of inflammatory arthritis and may predict response to therapy. Rheumatology (Oxford) 51:451-459.
10. Moots R. J., and Naisbett-Groet B., 2012. The efficacy of biologic agents in patients with rheumatoid arthritis and an inadequate response to tumour necrosis factor inhibitors: a systematic review. Rheumatology (Oxford) 51:2252-2261.
11. Beresford M. W. 2011. Juvenile idiopathic arthritis: new insights into classification, measures of outcome, and pharmacotherapy. Paediatr. Drugs 13:161-173.
12. Croft M., Duan W., Choi H., Eun S.-Y., Madireddi S., and Mehta A., 2012. TNF superfamily in inflammatory disease: translating basic insights. Trends Immunol. 33:144-152.
13. Silva I., and Branco J. C., 2011. Rank/Rankl/opg: literature review. Acta Reum Port 36:209-218.
14. Hehlgans T., and Pfeffer K., 2005. The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games. Immunology 115:1-20.
15. So T., Lee S.-W., and Croft M., 2006. Tumor necrosis factor/tumor necrosis factor receptor family members that positively regulate immunity. Int. J. Hematol. 83:1-11.
16. Micheau O., and Tschopp J., 2003. Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell 114:181-190.
17. Lee T. H., Shank J., Cusson N., and Kelliher M. A., 2004. The kinase activity of Rip1 is not required for tumor necrosis factor-α-induced IκB kinase or p38 MAP kinase activation or for the ubiquitination of Rip1 by Traf2. J. Biol. Chem. 279:33185-33191.
18. Varfolomeev E., Goncharov T., Fedorova A. V., Dynek J. N., Zobel K., Deshayes K., Fairbrother W. J., and Vucic D., 2008. C-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor α(TNFα)-induced NF-κB activation. J. Biol. Chem. 283:24295-24299.
19. Ea C-.K., Deng L., Xia Z-.P., Pineda G., and Chen Z. J., 2006. Activation of IKK by TNFα requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO. Mol. Cell. 22:245-257.
20. Wang C. Y., Mayo M. W., Korneluk R. G., Goeddel D. V., and Baldwin A. S., 1998. NF-κB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science 281:1680-1683.
21. Dewas C., Dang P. M. -C., Gougerot-Pocidalo M.-A., and El-Benna J., 2003. TNF-α induces phosphorylation of p47(phox) in human neutrophils: partial phosphorylation of p47phox is a common event of priming of human neutrophils by TNF-α and granulocyte-macrophage colony-stimulating factor. J. Immunol. 171:4392-4398.
22. Ginis I., and Tauber A. I., 1990. Activation mechanisms of adherent human neutrophils. Blood 76:1233-1239.
23. Fujishima S., Hoffman A. R., Vu T., Kim K. J., Zheng H., Daniel D., Kim Y., Wallace E. F., Larrick J. W., and Raffin T. A., 1993. Regulation of neutrophil interleukin 8 gene expression and protein secretion by LPS, TNF-α, and IL-1 β. J. Cell Physiol. 154:478-485.
24. McColl S. R., Paquin R., Ménard C., and Beaulieu A. D., 1992. Human neutrophils produce high levels of the interleukin 1 receptor antagonist in response to granulocyte/macrophage colony-stimulating factor and tumor necrosis factor α. J. Exp. Med. 176:593-598.
25. Van den Berg J. M., Weyer S., Weening J. J., Roos D., and Kuijpers T. W., 2001. Divergent effects of tumor necrosis factor αon apoptosis of human neutrophils. J. Leukoc. Biol. 69:467-473.
26. Salamone G., Trevani A., Martínez D., Vermeulen M., Gamberale R., Fernández-Calotti P., Raiden S., Giordano M., and Geffner J., 2004. Analysis of the mechanisms involved in the stimulation of neutrophil apoptosis by tumour necrosis factor-α. Immunology 113:355-362.
27. Cross A., Moots R. J., and Edwards S. W., 2008. The dual effects of TNFα on neutrophil apoptosis are mediated via differential effects on expression of Mcl-1 and Bfl-1. Blood 111:878-874.
28. Wright H. L., Chikura B., Bucknall R. C., Moots R. J., and Edwards S. W., 2011. Changes in expression of membrane TNF, NF-κB activation and neutrophil apoptosis during active and resolved inflammation. Ann. Rheum. Dis. 70:537-543.
29. Kato T., and Kitagawa S., 2006. Regulation of neutrophil functions by proinflammatory cytokines. Int. J. Hematol. 84:205-209.
30. Pfaffl M. W. 2001. A new mathematical model for relative quantification in real-time RT-PCR. Nucl. Acids Res. 29:2002-2007.
31. Trapnell C., Pachter L., and Salzberg S. L., 2009. TopHat: discovering splice junctions with RNA-Seq. Bioinformatics 25:1105-1111.
32. Trapnell C., Roberts A., Goff L., Pertea G., Kim D., Kelley D. R., Pimentel H., Salzberg S. L., Rinn J. L., and Pachter L., 2012. Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks. Nat. Protoc. 7:562-578.
33. Trapnell C., Williams B. A., Pertea G., Mortazavi A., Kwan G., van Baren M. J., Salzberg S.l L., Wold B. J., and Pachter L., 2010. Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. Nat. Biotechnol. 28:511-515.
34. Fadeel B., Ahlin A., Henter J. I., Orrenius S., and Hampton M. B., 1998. Involvement of caspases in neutrophil apoptosis: regulation by reactive oxygen species. Blood 92:4808-4818.
35. Khwaja A., and Tatton L., 1999. Caspase-mediated proteolysis and activation of protein kinase Cδ plays a central role in neutrophil apoptosis. Blood 94:291-301.
36. Wright H. L., Thomas H. B., Moots R. J., and Edwards S. W., 2013. RNA-seq reveals activation of both common and cytokine-specific pathways following neutrophil priming. PLoS. One. 8:e58598.
37. Kamata N., Kutsuna H., Hato F., Kato T., Oshitani N., Arakawa T., and Kitagawa S., 2004. Activation of human neutrophils by granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, and tumor necrosis factor α: role of phosphatidylinositol 3-kinase. Int. J. Hematol. 80:421-427.
38. Suzuki K., Hino M., Hato F., Tatsumi N., and Kitagawa S., 1999. Cytokine-specific activation of distinct mitogen-activated protein kinase subtype cascades in human neutrophils stimulated by granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, and tumor necrosis factor-α. Blood 93:341-349.
39. Nathan C., and Sanchez E., 1990. Tumor necrosis factor and CD11/CD18 (β2) integrins act synergistically to lower cAMP in human neutrophils. J. Cell Biol. 111:2171-2181.
40. Takeda Y., Watanabe H., Yonehara S., Yamashita T., Saito S., and Sendo F., 1993. Rapid acceleration of neutrophil apoptosis by tumor necrosis factor-α. Int. Immunol. 5:691-694.
41. Murray J., Barbara J. A., Dunkley S. A., Lopez A. F., Van Ostade X., Condliffe A. M., Dransfield I., Haslett C., and Chilvers E. R., 1997. Regulation of neutrophil apoptosis by tumor necrosis factor-α: requirement for TNFR55 and TNFR75 for induction of apoptosis in vitro. Blood 90:2772-2783.
42. Kettritz R., Gaido M. L., Haller H., Luft F. C., Jennette C. J., and Falk R. J., 1998. Interleukin-8 delays spontaneous and tumor necrosis factor-α-mediated apoptosis of human neutrophils. Kidney Int. 53:84-91.
43. Kettritz R., Scheumann J., Xu Y., Luft F. C., and Haller H., 2002. TNF-α-accelerated apoptosis abrogates ANCA-mediated neutrophil respiratory burst by a caspase-dependent mechanism. Kidney Int. 61:502-515.
44. Dri P., Gasparini C., Menegazzi R., Cramer R., Albéri L., Presani G., Garbisa S., and Patriarca P., 2000. TNF-Induced shedding of TNF receptors in human polymorphonuclear leukocytes: role of the 55-kDa TNF receptor and involvement of a membrane-bound and non-matrix metalloproteinase. J. Immunol. 165:2165-2172.
45. Porteu F., and Hieblot C., 1994. Tumor necrosis factor induces a selective shedding of its p75 receptor from human neutrophils. J. Biol. Chem. 269:2834-2840.