Dynein, kinesin and morphological changes in optic nerve axons in a rat model with cerebrospinal fluid pressure reduction: The Beijing Intracranial and Intraocular Pressure (iCOP) study

Acta Ophthalmologica

Volumn 94, Issue 3, 2016, Pages 266-275

  Zhang, Zheng ^a   Wu, Shen ^a   Jonas, Jost B ^a,b   Zhang, Jingxue ^a   Liu, Kegao ^a   Lu, Qingjun ^a   Wang, Ningli ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

axonal transport; cerebrospinal fluid pressure; dynein; glaucoma; intraocular pressure; kinesin; optic neuropathy

Indexed keywords

DYNEIN ADENOSINE TRIPHOSPHATASE; KINESIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CEREBROSPINAL FLUID PRESSURE; CONTROLLED STUDY; ENZYME ANALYSIS; HISTOLOGY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INTRAOCULAR PRESSURE; MALE; NONHUMAN; OPTIC NERVE FIBER; OPTIC NERVE LESION; PRIORITY JOURNAL; RAT; RETINA GANGLION CELL; ANIMAL; AXON; DISEASE MODEL; METABOLISM; NERVE FIBER TRANSPORT; NUCLEAR MAGNETIC RESONANCE IMAGING; OPTIC NERVE; PATHOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT; TUNEL ASSAY; WESTERN BLOTTING;

ANIMALS; AXONAL TRANSPORT; AXONS; BLOTTING, WESTERN; CEREBROSPINAL FLUID PRESSURE; DISEASE MODELS, ANIMAL; DYNEINS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; INTRAOCULAR PRESSURE; KINESIN; MAGNETIC RESONANCE IMAGING; MALE; OPTIC NERVE; RATS; RATS, SPRAGUE-DAWLEY; RETINAL GANGLION CELLS;

EID: 84971641038     PISSN: 1755375X     EISSN: 17553768     Source Type: Journal    
DOI: 10.1111/aos.12768     Document Type: Article

References (44)

1. Abbott CJ, Choe TE, Lusardi TA, Burgoyne CF, Wang L, &, Fortune B, (2014): Evaluation of retinal nerve fiber layer thickness and axonal transport 1 and 2 weeks after 8 hr of acute intraocular pressure elevation in rats. Invest Ophthalmol Vis Sci 55: 674-687.
2. Anderson DR, &, Hendrickson A, (1974): Effect of intraocular pressure on rapid axoplasmic transport in monkey optic nerve. Invest Ophthalmol 13: 771-783.
3. Balaratnasingam C, Morgan WH, Bass L, Matich G, Cringle SJ, &, Yu DY, (2007): Axonal transport and cytoskeletal changes in the laminar regions after elevated intraocular pressure. Invest Ophthalmol Vis Sci 48: 3632-3644.
4. Bellezza AJ, Rintalan CJ, Thompson HW, Downs JC, Hart RT, &, Burgoyne CF, (2003): Deformation of the lamina cribrosa and anterior scleral canal wall in early experimental glaucoma. Invest Ophthalmol Vis Sci 44: 623-637.
5. Berdahl JP, Allingham RR, &, Johnson DH, (2008a): Cerebrospinal fluid pressure is decreased in primary open-angle glaucoma. Ophthalmology 115: 763-768.
6. Berdahl JP, Fautsch MP, Stinnett SS, &, Allingham RR, (2008b): Intracranial pressure in primary open angle glaucoma, normal tension glaucoma, and ocular hypertension: a case-control study. Invest Ophthalmol Vis Sci 49: 5412-5418.
7. Bourne RR, Stevens GA, White RA, et al., (2013): Causes of vision loss worldwide, 1990-2010: a systematic analysis. Lancet Glob Health 1: e339-e349.
8. Chidlow G, Ebneter A, Wood JP, &, Casson RJ, (2011): The optic nerve head is the site of axonal transport disruption, axonal cytoskeleton damage and putative axonal regeneration failure in a rat model of glaucoma. Acta Neuropathol 121: 737-751.
9. Dandona L, Hendrickson A, &, Quigley HA, (1991): Selective effects of experimental glaucoma on axonal transport by retinal ganglion cells to the dorsal lateral geniculate nucleus. Invest Ophthalmol Vis Sci 32: 1593-1599.
10. Dolma K, Iacobucci GJ, Hong Zheng K, Shandilya J, Toska E, White JA 2nd, Spina E, &, Gunawardena S, (2014): Presenilin influences glycogen synthase kinase-3 beta (GSK-3beta) for kinesin-1 and dynein function during axonal transport. Hum Mol Genet 23: 1121-1133.
11. Fleischman D, Berdahl J, Stinnett SS, Fautsch MP, &, Allingham RR, (2014): Cerebrospinal fluid pressure trends in diseases associated with primary open-angle glaucoma. Acta Ophthalmol 93: 234-236.
12. Gaasterland D, Tanishima T, &, Kuwabara T, (1978): Axoplasmic flow during chronic experimental glaucoma. 1. Light and electron microscopic studies of the monkey optic nervehead during development of glaucomatous cupping. Invest Ophthalmol Vis Sci 17: 838-846.
13. Gunawardena S, &, Goldstein LS, (2004): Cargo-carrying motor vehicles on the neuronal highway: transport pathways and neurodegenerative disease. J Neurobiol 58: 258-271.
14. Johansson JO, (1986): Retrograde axoplasmic transport in rat optic nerve in vivo. What causes blockage at increased intraocular pressure?. Exp Eye Res 43: 653-660.
15. Johansson JO, (1988): Inhibition and recovery of retrograde axoplasmic transport in rat optic nerve during and after elevated IOP in vivo. Exp Eye Res 46: 223-227.
16. Jonas JB, Berenshtein E, &, Holbach L, (2003): Anatomic relationship between lamina cribrosa, intraocular space, and cerebrospinal fluid space. Invest Ophthalmol Vis Sci 44: 5189-5195.
17. Jonas JB, Nangia V, Wang N, et al., (2013): Trans-lamina cribrosa pressure difference and open-angle glaucoma. The central India eye and medical study. PLoS ONE 8: e82284.
18. Jonas JB, Wang N, Wang YX, You QS, Xie X, Yang D, &, Xu L, (2014a): Body height, estimated cerebrospinal fluid pressure and open-angle glaucoma. The Beijing Eye Study 2011. PLoS ONE 9: e86678.
19. Jonas JB, Wang NL, Wang YX, You QS, Xie XB, Yang DY, &, Xu L, (2014b): Estimated trans-lamina cribrosa pressure difference versus intraocular pressure as biomarker for open-angle glaucoma. The Beijing Eye Study 2011. Acta Ophthalmol 93: 7-13.
20. Lampert PW, Vogel MH, &, Zimmerman LE, (1968): Pathology of the optic nerve in experimental acute glaucoma. Electron microscopic studies. Invest Ophthalmol 7: 199-213.
21. Martin KR, Quigley HA, Valenta D, Kielczewski J, &, Pease ME, (2006): Optic nerve dynein motor protein distribution changes with intraocular pressure elevation in a rat model of glaucoma. Exp Eye Res 83: 255-262.
22. Minckler DS, Bunt AH, &, Johanson GW, (1977): Orthograde and retrograde axoplasmic transport during acute ocular hypertension in the monkey. Invest Ophthalmol Vis Sci 16: 426-441.
23. Minckler DS, Bunt AH, &, Klock IB, (1978): Radioautographic and cytochemical ultrastructural studies of axoplasmic transport in the monkey optic nerve head. Invest Ophthalmol Vis Sci 17: 33-50.
24. Morfini GA, You YM, Pollema SL, et al., (2009): Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin. Nat Neurosci 12: 864-871.
25. Morgan WH, Yu DY, Cooper RL, Alder VA, Cringle SJ, &, Constable IJ, (1995): The influence of cerebrospinal fluid pressure on the lamina cribrosa tissue pressure gradient. Invest Ophthalmol Vis Sci 36: 1163-1172.
26. Morgan WH, Chauhan BC, Yu DY, Cringle SJ, Alder VA, &, Phillip HH, (2002): Optic disc movement with variations in intraocular and cerebrospinal fluid pressure. Invest Ophthalmol Vis Sci 43: 7.
27. Morgan WH, Yu DY, &, Balaratnasingam C, (2008): The role of cerebrospinal fluid pressure in glaucoma pathophysiology: the dark side of the optic disc. J Glaucoma 17: 408-413.
28. Park HY, Jeon SH, &, Park CK, (2012): Enhanced depth imaging detects lamina cribrosa thickness differences in normal tension glaucoma and primary open-angle glaucoma. Ophthalmology 119: 10-20.
29. Pease ME, McKinnon SJ, Quigley HA, Kerrigan-Baumrind LA, &, Zack DJ, (2000): Obstructed axonal transport of BDNF and its receptor TrkB in experimental glaucoma. Invest Ophthalmol Vis Sci 41: 764-774.
30. Quigley H, &, Anderson DR, (1976): The dynamics and location of axonal transport blockade by acute intraocular pressure elevation in primate optic nerve. Invest Ophthalmol 15: 606-616.
31. Quigley HA, &, Anderson DR, (1977): Distribution of axonal transport blockade by acute intraocular pressure elevation in the primate optic nerve head. Invest Ophthalmol Vis Sci 16: 640-644.
32. Quigley HA, &, Addicks EM, (1980): Chronic experimental glaucoma in primates. II. Effect of extended intraocular pressure elevation on optic nerve head and axonal transport. Invest Ophthalmol Vis Sci 19: 137-152.
33. Quigley HA, Guy J, &, Anderson DR, (1979): Blockade of rapid axonal transport. Effect of intraocular pressure elevation in primate optic nerve. Arch Ophthalmol 97: 525-531.
34. Quigley HA, McKinnon SJ, Zack DJ, Pease ME, Kerrigan-Baumrind LA, Kerrigan DF, &, Mitcbell RS, (2000): Retrograde axonal transport of BDNF in retinal ganglion cells is blocked by acute IOP elevation in rats. Invest Ophthalmol Vis Sci 41: 3460-3466.
35. Radius RL, &, Anderson DR, (1981a): Rapid axonal transport in primate optic nerve. Distribution of pressure-induced interruption. Arch Ophthalmol 99: 650-654.
36. Radius RL, &, Anderson DR, (1981b): Reversibility of optic nerve damage in primate eyes subjected to intraocular pressure above systolic blood pressure. Br J Ophthalmol 65: 661-672.
37. Ren R, Jonas JB, Tian G, (2010): Cerebrospinal fluid pressure in glaucoma: a prospective study. Ophthalmology 117: 259-266.
38. Ren R, Wang N, Zhang X, Cui T, &, Jonas JB, (2011): Trans-lamina cribrosa pressure difference correlated with neuroretinal rim area in glaucoma. Graefes Arch Clin Exp Ophthalmol 249: 1057-1063.
39. Salinas-Navarro M, Alarcon-Martinez L, Valiente-Soriano FJ, Jimenez-Lopez M, Mayor-Torroglosa S, Aviles-Trigueros M, Villegas-Perez MP, &, Vidal-Sanz, (2010): Ocular hypertension impairs optic nerve axonal transport leading to progressive retinal ganglion cell degeneration. Exp Eye Res 90: 168-183.
40. Siaudvytyte L, Januleviciene I, Ragauskas A, Bartusis L, Siesky B, &, Harris A, (2014): Update in intracranial pressure evaluation methods and translaminar pressure gradient role in glaucoma. Acta Ophthalmol 93: 9-15.
41. Vaughan PS, Leszyk JD, &, Vaughan KT, (2001): Cytoplasmic dynein intermediate chain phosphorylation regulates binding to dynactin. J Biol Chem 276: 26171-26179.
42. Wang N, Xie X, Yang D, et al., (2012): Orbital cerebrospinal fluid space in glaucoma: the Beijing intracranial and intraocular pressure (iCOP) study. Ophthalmology 119: 2065-2073.
43. Yang D, Fu J, Hou R, et al., (2014): Optic Neuropathy Induced by Experimentally Reduced Cerebrospinal Fluid Pressure in Monkeys. Invest Ophthalmol Vis Sci 55: 3067-3073.
44. Zhang Z, Wang X, Jonas JB, et al., (2014): Valsalva manoeuver, intra-ocular pressure, cerebrospinal fluid pressure, optic disc topography: Beijing intracranial and intra-ocular pressure study. Acta Ophthalmol 92: e475-e480.