-
1
-
-
81255177676
-
The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation
-
Ahmed, N., M. Zeng, I. Sinha, L. Polin, W. Z. Wei, C. Rathinam, et al. 2011. The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation. Nat. Immunol. 12:1176–1183. doi: 1110.1038/ni.2157
-
(2011)
Nat. Immunol.
, vol.12
, pp. 1176-1183
-
-
Ahmed, N.1
Zeng, M.2
Sinha, I.3
Polin, L.4
Wei, W.Z.5
Rathinam, C.6
-
2
-
-
55549089660
-
Accurate whole human genome sequencing using reversible terminator chemistry
-
Bentley, D. R., S. Balasubramanian, H. P. Swerdlow, G. P. Smith, J. Milton, C. G. Brown, et al. 2008. Accurate whole human genome sequencing using reversible terminator chemistry. Nature 456:53–59. doi: 10.1038/nature07517
-
(2008)
Nature
, vol.456
, pp. 53-59
-
-
Bentley, D.R.1
Balasubramanian, S.2
Swerdlow, H.P.3
Smith, G.P.4
Milton, J.5
Brown, C.G.6
-
3
-
-
84872585155
-
Genome and transcriptome sequencing in prospective metastatic triple-negative breast cancer uncovers therapeutic vulnerabilities
-
Craig, D.W., J.A.O’ Shaughnessy, J.A. Kiefer, J. Aldrich, S. Sinari, S. Sinari, et al. 2013. Genome and transcriptome sequencing in prospective metastatic triple-negative breast cancer uncovers therapeutic vulnerabilities. Mol. Cancer Ther. 12:104–116. doi: 110. 1158/1535-7163.MCT-1112-0781
-
(2013)
Mol. Cancer Ther
, vol.12
, pp. 104-116
-
-
Craig, D.W.1
Shaughnessy, J.A.O.’.2
Kiefer, J.A.3
Aldrich, J.4
Sinari, S.5
Sinari, S.6
-
4
-
-
33646468938
-
Cutting edge: Monovalency of CD28 maintains the antigen dependence of T cell costimulatory responses
-
Dennehy, K. M., F. Elias, G. Zeder-Lutz, X. Ding, D. Altschuh, F. Luhder, et al. 2006. Cutting edge: monovalency of CD28 maintains the antigen dependence of T cell costimulatory responses. J. Immunol. 176:5725–5729.
-
(2006)
J. Immunol.
, vol.176
, pp. 5725-5729
-
-
Dennehy, K.M.1
Elias, F.2
Zeder-Lutz, G.3
Ding, X.4
Altschuh, D.5
Luhder, F.6
-
5
-
-
77952544480
-
CTLA-4 (CD152) inhibits T cell function by activating the ubiquitin ligase Itch
-
Hoff, H., P. Kolar, A. Ambach, A. Radbruch, and M. C. Brunner-Weinzierl. 2010. CTLA-4 (CD152) inhibits T cell function by activating the ubiquitin ligase Itch. Mol. Immunol. 47:1875–1881. doi: 10.1016/j.molimm.2010.03.017
-
(2010)
Mol. Immunol.
, vol.47
, pp. 1875-1881
-
-
Hoff, H.1
Kolar, P.2
Ambach, A.3
Radbruch, A.4
Brunner-Weinzierl, M.C.5
-
6
-
-
0033563265
-
Lymphoproliferative disorder in CTLA-4 knockout mice is characterized by CD28-regulated activation of Th2 responses
-
Khattri, R., J. A. Auger, M. D. Griffin, A. H. Sharpe, and J. A. Bluestone. 1999. Lymphoproliferative disorder in CTLA-4 knockout mice is characterized by CD28-regulated activation of Th2 responses. J. Immunol. 162:5784–5791.
-
(1999)
J. Immunol.
, vol.162
, pp. 5784-5791
-
-
Khattri, R.1
Auger, J.A.2
Griffin, M.D.3
Sharpe, A.H.4
Bluestone, J.A.5
-
7
-
-
0029120245
-
CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation
-
Krummel, M. F., and J. P. Allison. 1995. CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J. Exp. Med. 182:459–465.
-
(1995)
J. Exp. Med.
, vol.182
, pp. 459-465
-
-
Krummel, M.F.1
Allison, J.P.2
-
8
-
-
33751237384
-
Wapl controls the dynamic association of cohesin with chromatin
-
Kueng, S., B. Hegemann, B. H. Peters, J. J. Lipp, A. Schleiffer, K. Mechtler, et al. 2006. Wapl controls the dynamic association of cohesin with chromatin. Cell 127:955–967.
-
(2006)
Cell
, vol.127
, pp. 955-967
-
-
Kueng, S.1
Hegemann, B.2
Peters, B.H.3
Lipp, J.J.4
Schleiffer, A.5
Mechtler, K.6
-
9
-
-
77950517259
-
CDKN2A-CDKN2B deletion defines an aggressive subset of cutaneous T-cell lymphoma
-
Laharanne, E., E. Chevret, Y. Idrissi, C. Gentil, M. Longy, J. Ferrer, et al. 2010. CDKN2A-CDKN2B deletion defines an aggressive subset of cutaneous T-cell lymphoma. Mod. Pathol. 23:547–558.
-
(2010)
Mod. Pathol.
, vol.23
, pp. 547-558
-
-
Laharanne, E.1
Chevret, E.2
Idrissi, Y.3
Gentil, C.4
Longy, M.5
Ferrer, J.6
-
10
-
-
84859544145
-
Management of cutaneous T cell lymphoma: New and emerging targets and treatment options
-
Li, J. Y., S. Horwitz, A. Moskowitz, P. L. Myskowski, M. Pulitzer, and C. Querfeld. 2012. Management of cutaneous T cell lymphoma: new and emerging targets and treatment options. Cancer Manag. Res. 4:75–89.
-
(2012)
Cancer Manag. Res.
, vol.4
, pp. 75-89
-
-
Li, J.Y.1
Horwitz, S.2
Moskowitz, A.3
Myskowski, P.L.4
Pulitzer, M.5
Querfeld, C.6
-
11
-
-
77953801296
-
Genetic determinants at the interface of cancer and neurodegenerative disease
-
Morris, L. G., S. Veeriah, and T. A. Chan. 2010. Genetic determinants at the interface of cancer and neurodegenerative disease. Oncogene 29:3453–3464.
-
(2010)
Oncogene
, vol.29
, pp. 3453-3464
-
-
Morris, L.G.1
Veeriah, S.2
Chan, T.A.3
-
12
-
-
67349128620
-
Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins
-
Mund, T., and H. R. Pelham. 2009. Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins. EMBO Rep. 10:501–507.
-
(2009)
EMBO Rep
, vol.10
, pp. 501-507
-
-
Mund, T.1
Pelham, H.R.2
-
13
-
-
77954914419
-
Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2
-
Mund, T., and H. R. Pelham. 2010. Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2. Proc. Natl. Acad. Sci. USA 107:11429–11434.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 11429-11434
-
-
Mund, T.1
Pelham, H.R.2
-
14
-
-
33947693781
-
Unscheduled overexpression of human WAPL promotes chromosomal instability
-
Ohbayashi, T., K. Oikawa, K. Yamada, C. Nishida-Umehara, Y. Matsuda, H. Satoh, et al. 2007. Unscheduled overexpression of human WAPL promotes chromosomal instability. Biochem. Biophys. Res. Commun. 356:699–704.
-
(2007)
Biochem. Biophys. Res. Commun.
, vol.356
, pp. 699-704
-
-
Ohbayashi, T.1
Oikawa, K.2
Yamada, K.3
Nishida-Umehara, C.4
Matsuda, Y.5
Satoh, H.6
-
15
-
-
33845386442
-
Ndfip1 protein promotes the function of itch ubiquitin ligase to prevent T cell activation and T helper 2 cell-mediated inflammation
-
Oliver, P. M., X. Cao, G. S. Worthen, P. Shi, N. Briones, M. MacLeod, et al. 2006. Ndfip1 protein promotes the function of itch ubiquitin ligase to prevent T cell activation and T helper 2 cell-mediated inflammation. Immunity 25:929–940.
-
(2006)
Immunity
, vol.25
, pp. 929-940
-
-
Oliver, P.M.1
Cao, X.2
Worthen, G.S.3
Shi, P.4
Briones, N.5
Macleod, M.6
-
16
-
-
78751571254
-
Sezary syndrome: Immunopathogenesis, literature review of therapeutic options, and recommendations for therapy by the United States Cutaneous Lymphoma Consortium (USCLC)
-
Olsen, E. A., A. H. Rook, J. Zic, Y. Kim, P. Porcu, C. Querfeld, et al. 2011. Sezary syndrome: immunopathogenesis, literature review of therapeutic options, and recommendations for therapy by the United States Cutaneous Lymphoma Consortium (USCLC). J. Am. Acad. Dermatol. 64:352–404.
-
(2011)
J. Am. Acad. Dermatol.
, vol.64
, pp. 352-404
-
-
Olsen, E.A.1
Rook, A.H.2
Zic, J.3
Kim, Y.4
Porcu, P.5
Querfeld, C.6
-
17
-
-
0031915677
-
The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in 18H mice
-
Perry, W. L., C. M. Hustad, D. A. Swing, T. N. O’Sullivan, N. A. Jenkins, and N. G. Copeland. 1998. The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in 18H mice. Nat. Genet. 18:143–146.
-
(1998)
Nat. Genet.
, vol.18
, pp. 143-146
-
-
Perry, W.L.1
Hustad, C.M.2
Swing, D.A.3
O’Sullivan, T.N.4
Jenkins, N.A.5
Copeland, N.G.6
-
18
-
-
77956990244
-
PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice
-
Poulogiannis, G., R. E. McIntyre, M. Dimitriadi, J. R. Apps, C. H. Wilson, K. Ichimura, et al. 2010. PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice. Proc. Natl. Acad. Sci. USA 107:15145–15150. doi: 15110. 11073/pnas.1009941107
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 15145-15150
-
-
Poulogiannis, G.1
McIntyre, R.E.2
Dimitriadi, M.3
Apps, J.R.4
Wilson, C.H.5
Ichimura, K.6
-
19
-
-
79960036578
-
Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia
-
Puente, X. S., M. Pinyol, V. Quesada, L. Conde, G. R. Ordonez, N. Villamor, et al. 2011. Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia. Nature 475:101–105. doi: 110.1038/nature10113
-
(2011)
Nature
, vol.475
, pp. 101-105
-
-
Puente, X.S.1
Pinyol, M.2
Quesada, V.3
Conde, L.4
Ordonez, G.R.5
Villamor, N.6
-
20
-
-
39449083378
-
The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20
-
Shembade, N., N. S. Harhaj, K. Parvatiyar, N. G. Copeland, N. A. Jenkins, L. E. Matesic, et al. 2008. The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20. Nat. Immunol. 9:254–262.
-
(2008)
Nat. Immunol.
, vol.9
, pp. 254-262
-
-
Shembade, N.1
Harhaj, N.S.2
Parvatiyar, K.3
Copeland, N.G.4
Jenkins, N.A.5
Matesic, L.E.6
-
21
-
-
84861576201
-
The landscape of cancer genes and mutational processes in breast cancer
-
Stephens, P. J., P. S. Tarpey, H. Davies, P. Van Loo, C. Greenman, D. C. Wedge, et al. 2012. The landscape of cancer genes and mutational processes in breast cancer. Nature 486:400–404. doi: 410.1038/nature11017
-
(2012)
Nature
, vol.486
, pp. 400-404
-
-
Stephens, P.J.1
Tarpey, P.S.2
Davies, H.3
van Loo, P.4
Greenman, C.5
Wedge, D.C.6
-
22
-
-
0037707487
-
Strategy for randomised clinical trials in rare cancers
-
Tan, S. B., K. B. Dear, P. Bruzzi, and D. Machin. 2003. Strategy for randomised clinical trials in rare cancers. BMJ 327:47–49.
-
(2003)
BMJ
, vol.327
, pp. 47-49
-
-
Tan, S.B.1
Dear, K.B.2
Bruzzi, P.3
Machin, D.4
-
23
-
-
79959293462
-
BRAF mutations in hairy-cell leukemia
-
Tiacci, E., V. Trifonov, G. Schiavoni, A. Holmes, W. Kern, M. P. Martelli, et al. 2011. BRAF mutations in hairy-cell leukemia. N. Engl. J. Med. 364:2305–2315. doi: 2310.1056/NEJMoa1014209
-
(2011)
N. Engl. J. Med.
, vol.364
, pp. 2305-2315
-
-
Tiacci, E.1
Trifonov, V.2
Schiavoni, G.3
Holmes, A.4
Kern, W.5
Martelli, M.P.6
-
24
-
-
65449136284
-
TopHat: Discovering splice junctions with RNA-Seq
-
Trapnell, C., L. Pachter, and S. L. Salzberg. 2009. TopHat: discovering splice junctions with RNA-Seq. Bioinformatics 25:1105–1111.
-
(2009)
Bioinformatics
, vol.25
, pp. 1105-1111
-
-
Trapnell, C.1
Pachter, L.2
Salzberg, S.L.3
-
25
-
-
77952123055
-
Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation
-
Trapnell, C., B. A. Williams, G. Pertea, A. Mortazavi, G. Kwan, M. J. van Baren et al. 2010. Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. Nat. Biotechnol. 28:511–515.
-
(2010)
Nat. Biotechnol.
, vol.28
, pp. 511-515
-
-
Trapnell, C.1
Williams, B.A.2
Pertea, G.3
Mortazavi, A.4
Kwan, G.5
van Baren, M.J.6
-
26
-
-
73349125417
-
Somatic mutations of the Parkinson’s disease-associated gene PARK2 in glioblastoma and other human malignancies
-
Veeriah, S., B. S. Taylor, S. Meng, F. Fang, E. Yilmaz, I. Vivanco, et al. 2010. Somatic mutations of the Parkinson’s disease-associated gene PARK2 in glioblastoma and other human malignancies. Nat. Genet. 42:77–82. doi: 10.1038/ng. 1491
-
(2010)
Nat. Genet.
, vol.42
, pp. 77-82
-
-
Veeriah, S.1
Taylor, B.S.2
Meng, S.3
Fang, F.4
Yilmaz, E.5
Vivanco, I.6
-
27
-
-
0037245125
-
Short cytoplasmic SDYMNM segment of CD28 is sufficient to convert CTLA-4 to a positive signaling receptor
-
Yin, L., H. Schneider, and C. E. Rudd. 2003. Short cytoplasmic SDYMNM segment of CD28 is sufficient to convert CTLA-4 to a positive signaling receptor. J. Leukoc. Biol. 73:178–182.
-
(2003)
J. Leukoc. Biol.
, vol.73
, pp. 178-182
-
-
Yin, L.1
Schneider, H.2
Rudd, C.E.3
|