메뉴 건너뛰기




Volumn 11, Issue 5, 2016, Pages 698-701

TFP5/TP5 peptide provides neuroprotection in the MPTP model of Parkinson’s disease

Author keywords

Cyclin dependent kinase 5; MPTP; Neurodegeneration; Parkinson s disease; Therapeutic target; TP5 TFP5 TP5 peptide

Indexed keywords

CASPASE 3; CYCLIN DEPENDENT KINASE 5; CYTOCHROME C; INTERLEUKIN 1BETA; PROTEIN BCL 2; PROTEIN P25; THYMOPENTIN; TUMOR NECROSIS FACTOR ALPHA;

EID: 84971475305     PISSN: 16735374     EISSN: 18767958     Source Type: Journal    
DOI: 10.4103/1673-5374.182681     Document Type: Review
Times cited : (12)

References (40)
  • 1
    • 33644809553 scopus 로고    scopus 로고
    • Inhibition of the cdk5/p25 fragment formation may explain the antiapoptotic effects of melatonin in an experimental model of Parkinson's disease
    • Alvira D, Tajes M, Verdaguer E, Acuña-Castroviejo D, Folch J, Camins A, Pallas M (2006) Inhibition of the cdk5/p25 fragment formation may explain the antiapoptotic effects of melatonin in an experimental model of Parkinson's disease. J Pineal Res 40: 251-258.
    • (2006) J Pineal Res , vol.40 , pp. 251-258
    • Alvira, D.1    Tajes, M.2    Verdaguer, E.3    Acuña-Castroviejo, D.4    Folch, J.5    Camins, A.6    Pallas, M.7
  • 2
    • 0036470547 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 5 (cdk5) activation requires interaction with three domains of p35
    • Amin ND, Albers W and Pant HC (2002) Cyclin-dependent kinase 5 (cdk5) activation requires interaction with three domains of p35. J Neurosci Res 67: 354-362.
    • (2002) J Neurosci Res , vol.67 , pp. 354-362
    • Amin, N.D.1    Albers, W.2    Pant, H.C.3
  • 3
    • 34250344611 scopus 로고    scopus 로고
    • Phosphorylation of parkin by the cyclin-dependent kinase 5 at the linker region modulates the E3 ubiquitin-ligase activity and parkin aggregation
    • Avraham E, Rott R, Liani E, Szargel R, Engelender S (2007) Phosphorylation of parkin by the cyclin-dependent kinase 5 at the linker region modulates the E3 ubiquitin-ligase activity and parkin aggregation. J Biol Chem 282: 12842-12850.
    • (2007) J Biol Chem , vol.282 , pp. 12842-12850
    • Avraham, E.1    Rott, R.2    Liani, E.3    Szargel, R.4    Engelender, S.5
  • 4
    • 0032571148 scopus 로고    scopus 로고
    • Cyclin-dependent kinase-5 is associated with lipofuscin in motor neurones in amyotrophic lateral sclerosis
    • Bajaj NP, Al-Sarraj ST, Anderson V, Kibble M (1998) Cyclin-dependent kinase-5 is associated with lipofuscin in motor neurones in amyotrophic lateral sclerosis. Neurosci Lett 245: 45-48.
    • (1998) Neurosci Lett , vol.245 , pp. 45-48
    • Bajaj, N.P.1    Al-Sarraj, S.T.2    Anderson, V.3    Kibble, M.4
  • 5
    • 0033167050 scopus 로고    scopus 로고
    • Cyclin dependent kinase-5 (CDK-5) phosphorylates neurofilaments heavy (NF-H) chain to generate epitopes for antibodies that label neurofilament accumulations in amyotrophic lateral sclerosis (ALS) and is present in affected motor neurones in ALS
    • Bajaj NP, al-Sarraj ST, Leigh PN, Anderson V, Miller CC (1999) Cyclin dependent kinase-5 (CDK-5) phosphorylates neurofilaments heavy (NF-H) chain to generate epitopes for antibodies that label neurofilament accumulations in amyotrophic lateral sclerosis (ALS) and is present in affected motor neurones in ALS. Prog Neuropsychopharmacol Biol Psychiatry 23: 833-850.
    • (1999) Prog Neuropsychopharmacol Biol Psychiatry , vol.23 , pp. 833-850
    • Bajaj, N.P.1    Al-Sarraj, S.T.2    Leigh, P.N.3    Anderson, V.4    Miller, C.C.5
  • 6
    • 84949058159 scopus 로고    scopus 로고
    • Peptide (TFP5/TP5), derived from Cdk5 activator P35, provides neuroprotection in the MPTP model of Parkinson's disease
    • Binukumar B, Shukla V, Amin ND, Grant P, Bhaskar M, Skuntz S, Steiner J, Pant HC (2015) Peptide (TFP5/TP5), derived from Cdk5 activator P35, provides neuroprotection in the MPTP model of Parkinson's disease. Mol Biol Cell 26: 4478-4491
    • (2015) Mol Biol Cell , vol.26 , pp. 4478-4491
    • Binukumar, B.1    Shukla, V.2    Amin, N.D.3    Grant, P.4    Bhaskar, M.5    Skuntz, S.6    Steiner, J.7    Pant, H.C.8
  • 7
    • 0028828550 scopus 로고
    • Cortical and brainstem-type Lewy bodies are immunoreactive for the cyclin-dependent kinase 5
    • Brion JP, Couck AM (1995) Cortical and brainstem-type Lewy bodies are immunoreactive for the cyclin-dependent kinase 5. Am J Pathol 147: 1465-1476.
    • (1995) Am J Pathol , vol.147 , pp. 1465-1476
    • Brion, J.P.1    Couck, A.M.2
  • 8
    • 77955504380 scopus 로고    scopus 로고
    • Paroxetine prevents loss of nigrostriatal dopaminergic neurons by inhibiting brain inflammation and oxidative stress in an experimental model of Parkinson's disease
    • Chung YC, Kim SR, Jin BK (2010) Paroxetine prevents loss of nigrostriatal dopaminergic neurons by inhibiting brain inflammation and oxidative stress in an experimental model of Parkinson's disease. J Immunol 185: 1230-1237.
    • (2010) J Immunol , vol.185 , pp. 1230-1237
    • Chung, Y.C.1    Kim, S.R.2    Jin, B.K.3
  • 9
    • 83755178512 scopus 로고    scopus 로고
    • Cannabinoid receptor type 1 protects nigrostriatal dopaminergic neurons against MPTP neurotoxicity by inhibiting microglial activation
    • Chung YC, Bok E, Huh SH, Park JY, Yoon SH, Kim SR, Kim YS, Maeng S, Park SH, Jin BK (2011) Cannabinoid receptor type 1 protects nigrostriatal dopaminergic neurons against MPTP neurotoxicity by inhibiting microglial activation. J Immunol 187: 6508-6517.
    • (2011) J Immunol , vol.187 , pp. 6508-6517
    • Chung, Y.C.1    Bok, E.2    Huh, S.H.3    Park, J.Y.4    Yoon, S.H.5    Kim, S.R.6    Kim, Y.S.7    Maeng, S.8    Park, S.H.9    Jin, B.K.10
  • 10
    • 27344438938 scopus 로고    scopus 로고
    • Microglial inflammation in the parkinsonian substantia nigra: Relationship to alpha-synuclein deposition
    • Croisier E, Moran LB, Dexter DT, Pearce RK, Graeber MB (2005) Microglial inflammation in the parkinsonian substantia nigra: relationship to alpha-synuclein deposition. J Neuroinflammation 2: 14.
    • (2005) J Neuroinflammation , vol.2 , pp. 14
    • Croisier, E.1    Moran, L.B.2    Dexter, D.T.3    Pearce, R.K.4    Graeber, M.B.5
  • 11
    • 0025906420 scopus 로고
    • Principal neurofilament-associated protein kinase in squid axoplasm is related to casein kinase I
    • Floyd CC, Grant P, Gallant PE, Pant HC (1991) Principal neurofilament-associated protein kinase in squid axoplasm is related to casein kinase I. J Biol Chem 266: 4987-4994.
    • (1991) J Biol Chem , vol.266 , pp. 4987-4994
    • Floyd, C.C.1    Grant, P.2    Gallant, P.E.3    Pant, H.C.4
  • 12
    • 1342281018 scopus 로고    scopus 로고
    • Topographic regulation of phosphorylation in giant neurons of the squid, Loligo pealei: Role of phosphatases
    • Grant P, Pant HC (2004) Topographic regulation of phosphorylation in giant neurons of the squid, Loligo pealei: role of phosphatases. J Neurobiol 58: 514-528.
    • (2004) J Neurobiol , vol.58 , pp. 514-528
    • Grant, P.1    Pant, H.C.2
  • 13
    • 0025807172 scopus 로고
    • Epitopes located in spatially separate domains of each neurofilaments subunit are present in Parkinson's disease Lewy bodies
    • Hill WD, Lee VM, Hurtig HI, Murray JM, Trojanowski JQ (1991) Epitopes located in spatially separate domains of each neurofilaments subunit are present in Parkinson's disease Lewy bodies. J Comp Neurol 309: 150-160.
    • (1991) J Comp Neurol , vol.309 , pp. 150-160
    • Hill, W.D.1    Lee, V.M.2    Hurtig, H.I.3    Murray, J.M.4    Trojanowski, J.Q.5
  • 14
    • 0026619472 scopus 로고
    • Phosphorylationsites on tau by tau proteinkinaseI, a bovine derived kinase generating an epitope of paired helical filaments
    • Ishiguro K, Omori A, Takamatsu M, Sato K, Arioka M, Uchida T (1992) Phosphorylationsites on tau by tau proteinkinaseI, a bovine derived kinase generating an epitope of paired helical filaments. Neurosci Lett 148: 202-206.
    • (1992) Neurosci Lett , vol.148 , pp. 202-206
    • Ishiguro, K.1    Omori, A.2    Takamatsu, M.3    Sato, K.4    Arioka, M.5    Uchida, T.6
  • 15
    • 17744368458 scopus 로고    scopus 로고
    • Deregulation of Cdk5 in a mouse model of ALS: Toxicity alleviated by perikaryal neurofilament inclusions
    • Julien JP (2001) Deregulation of Cdk5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofilament inclusions. Neuron 30: 135-147.
    • (2001) Neuron , vol.30 , pp. 135-147
    • Julien, J.P.1
  • 16
    • 34548480683 scopus 로고    scopus 로고
    • Peptides derived from Cdk5 activator p35, specifically inhibit deregulated activity of Cdk5
    • Kesavapany S, Zheng YL, Amin N, Pant HC (2007) Peptides derived from Cdk5 activator p35, specifically inhibit deregulated activity of Cdk5. Biotechnol J 2: 978-987.
    • (2007) Biotechnol J , vol.2 , pp. 978-987
    • Kesavapany, S.1    Zheng, Y.L.2    Amin, N.3    Pant, H.C.4
  • 17
    • 0026680802 scopus 로고
    • Purification and characterization of a novel proline-directed protein kinase from bovine brain
    • Lew J, Beaudette K, Litwin CM, Wang JH (1992) Purification and characterization of a novel proline-directed protein kinase from bovine brain. J Biol Chem 267: 13383-13390.
    • (1992) J Biol Chem , vol.267 , pp. 13383-13390
    • Lew, J.1    Beaudette, K.2    Litwin, C.M.3    Wang, J.H.4
  • 19
    • 0030749732 scopus 로고    scopus 로고
    • P35nck5a and cyclin-dependent kinase 5 colocalize in Lewy bodies of brains with Parkinson's disease
    • Nakamura S, Kawamoto Y, Nakano S, Akiguchi I, Kimura J (1997) p35nck5a and cyclin-dependent kinase 5 colocalize in Lewy bodies of brains with Parkinson's disease. Acta Neuropathol 94: 153-157.
    • (1997) Acta Neuropathol , vol.94 , pp. 153-157
    • Nakamura, S.1    Kawamoto, Y.2    Nakano, S.3    Akiguchi, I.4    Kimura, J.5
  • 21
  • 23
    • 0032492651 scopus 로고    scopus 로고
    • Site-specific phosphorylation of Lys-Ser-Pro repeat peptides from neurofilament H by cyclindependent kinase 5: Structural basis for substrate recognition
    • Sharma P, Barchi JJ, Jr Huang X, Amin ND, Jaffe H, Pant HC (1998) Site-specific phosphorylation of Lys-Ser-Pro repeat peptides from neurofilament H by cyclindependent kinase 5: structural basis for substrate recognition. Biochemistry 37: 4759-4766.
    • (1998) Biochemistry , vol.37 , pp. 4759-4766
    • Sharma, P.1    Barchi, J.J.2    Jr Huang, X.3    Amin, N.D.4    Jaffe, H.5    Pant, H.C.6
  • 24
    • 0027165323 scopus 로고
    • Cdc2-like kinase from rat spinal cord specifically phosphorylates KSPXK motifs in neurofilament proteins: Isolation and characterization
    • Shetty KT, Link WT, Pant HC (1993) cdc2-like kinase from rat spinal cord specifically phosphorylates KSPXK motifs in neurofilament proteins: isolation and characterization. Proc Natl Acad Sci U S A 90: 6844-6848.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 6844-6848
    • Shetty, K.T.1    Link, W.T.2    Pant, H.C.3
  • 26
    • 0344823864 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease
    • Smith PD, Crocker SJ, Jackson-Lewis V, Jordan-Sciutto KL (2003) Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease. Proc Natl Acad Sci U S A 100: 13650-13655.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 13650-13655
    • Smith, P.D.1    Crocker, S.J.2    Jackson-Lewis, V.3    Jordan-Sciutto, K.L.4
  • 27
    • 32544441845 scopus 로고    scopus 로고
    • Calpain-regulated p35/cdk5 plays a central role in dopaminergic neuron death through modulation of the transcription factor myocyte enhancer factor 2
    • Smith PD, Mount MP, Shree R, Callaghan, Park DS (2006) Calpain-regulated p35/cdk5 plays a central role in dopaminergic neuron death through modulation of the transcription factor myocyte enhancer factor 2. J Neurosci 26: 440-447.
    • (2006) J Neurosci , vol.26 , pp. 440-447
    • Smith, P.D.1    Mount, M.P.2    Shree, R.3    Callaghan4    Park, D.S.5
  • 29
    • 0036719568 scopus 로고    scopus 로고
    • Mice deficient in TNF receptors are protected against dopaminergic neurotoxicity: Implications for Parkinson's disease
    • Sriram K, Matheson JM, Benkovic SA, Miller DB, Luster MI, O'Callaghan JP (2002). Mice deficient in TNF receptors are protected against dopaminergic neurotoxicity: implications for Parkinson's disease. FASEB J 16: 1474-1476.
    • (2002) FASEB J , vol.16 , pp. 1474-1476
    • Sriram, K.1    Matheson, J.M.2    Benkovic, S.A.3    Miller, D.B.4    Luster, M.I.5    O'Callaghan, J.P.6
  • 31
    • 0028981152 scopus 로고
    • P13suc1 associates with a cdc2-like kinase in a multimeric cytoskeletal complex in squid axoplasm
    • Takahashi M, Amin N, Grant P, Pant HC (1995) P13suc1 associates with a cdc2-like kinase in a multimeric cytoskeletal complex in squid axoplasm. J Neurosci 15: 6222-6229.
    • (1995) J Neurosci , vol.15 , pp. 6222-6229
    • Takahashi, M.1    Amin, N.2    Grant, P.3    Pant, H.C.4
  • 32
    • 0037125209 scopus 로고    scopus 로고
    • A survey of Cdk5 activator p35 and p25 levels in Alzheimer's disease brains
    • Tseng HC, Zhou Y, Shen Y, Tsai LH (2002) A survey of Cdk5 activator p35 and p25 levels in Alzheimer's disease brains. FEBS Lett 523: 58-62.
    • (2002) FEBS Lett , vol.523 , pp. 58-62
    • Tseng, H.C.1    Zhou, Y.2    Shen, Y.3    Tsai, L.H.4
  • 33
    • 0034728574 scopus 로고    scopus 로고
    • Cdk5 and MAPK are associated with complexes of cytoskeletal proteins in rat brain
    • Veeranna, Shetty KT, Takahashi M, Grant P, Pant HC (2000) Cdk5 and MAPK are associated with complexes of cytoskeletal proteins in rat brain. Brain Res Mol Brain Res 76: 229-236.
    • (2000) Brain Res Mol Brain Res , vol.76 , pp. 229-236
    • Veeranna1    Shetty, K.T.2    Takahashi, M.3    Grant, P.4    Pant, H.C.5
  • 34
    • 0032100631 scopus 로고    scopus 로고
    • Mitogen activated protein kinases (Erk1, 2) phosphorylate Lys-Ser-Pro (KSP) repeats in neurofilament proteins NF-H and NF-M
    • Veeranna, Amin ND, Ahn NG, Jaffe H, Winters CA, Grant P, Pant HC (1998) Mitogen activated protein kinases (Erk1, 2) phosphorylate Lys-Ser-Pro (KSP) repeats in neurofilament proteins NF-H and NF-M. J Neurosci 18: 4008-4021.
    • (1998) J Neurosci , vol.18 , pp. 4008-4021
    • Veeranna1    Amin, N.D.2    Ahn, N.G.3    Jaffe, H.4    Winters, C.A.5    Grant, P.6    Pant, H.C.7
  • 35
    • 34447328426 scopus 로고    scopus 로고
    • Neuroinflammation in Parkinson's patients and MPTP-treated mice is not restricted to the nigrostriatal system: Microgliosis and differential expression of interleukin-1 receptors in the olfactory bulb
    • Vroon A, Drukarch B, Bol JG, Cras P, Breve JJ, Allan SM, Relton JK, Hoogland PV, Van Dam AM (2007) Neuroinflammation in Parkinson's patients and MPTP-treated mice is not restricted to the nigrostriatal system: microgliosis and differential expression of interleukin-1 receptors in the olfactory bulb. Exp Gerontol 42: 762-771.
    • (2007) Exp Gerontol , vol.42 , pp. 762-771
    • Vroon, A.1    Drukarch, B.2    Bol, J.G.3    Cras, P.4    Breve, J.J.5    Allan, S.M.6    Relton, J.K.7    Hoogland, P.V.8    Van Dam, A.M.9
  • 38
    • 0036379174 scopus 로고    scopus 로고
    • A peptide derived from cyclindependent kinase activator (p35) specifically inhibits Cdk5 activity and phosphorylation of tau protein in transfected cells
    • Zheng YL, Li BS, Amin ND, Albers W, Pant HC (2002) A peptide derived from cyclindependent kinase activator (p35) specifically inhibits Cdk5 activity and phosphorylation of tau protein in transfected cells. Eur J Biochem 269: 4427-4434.
    • (2002) Eur J Biochem , vol.269 , pp. 4427-4434
    • Zheng, Y.L.1    Li, B.S.2    Amin, N.D.3    Albers, W.4    Pant, H.C.5
  • 40
    • 77958594810 scopus 로고    scopus 로고
    • A 24-residue peptide (p5), derived from p35, the Cdk5 neuronal activator, specifically inhibits Cdk5-p25 hyperactivity and tau hyperphosphorylation
    • Zheng YL, Amin ND, Hu YF, Rudrabhatla P, Shukla V, Kanungo J, Kesavapany S, Grant P, Albers W, Pant HC (2010) A 24-residue peptide (p5), derived from p35, the Cdk5 neuronal activator, specifically inhibits Cdk5-p25 hyperactivity and tau hyperphosphorylation. J Biol Chem 285: 34202-34212.
    • (2010) J Biol Chem , vol.285 , pp. 34202-34212
    • Zheng, Y.L.1    Amin, N.D.2    Hu, Y.F.3    Rudrabhatla, P.4    Shukla, V.5    Kanungo, J.6    Kesavapany, S.7    Grant, P.8    Albers, W.9    Pant, H.C.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.