Cyclin-dependent kinase-5 is associated with lipofuscin in motor neurones in amyotrophic lateral sclerosis

Neuroscience Letters

Volumn 245, Issue 1, 1998, Pages 45-48

  Bajaj, Narinder P S ^a   Al Sarraj, Safa T ^a   Anderson, Valerie ^a   Kibble, Mavis ^a   Leigh, Nigel ^a   Miller, Christopher C J ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Amyotrophic lateral sclerosis; Apoptosis; Cyclin dependent kinase 5; Lipofuscin; Motor neurone disease; Neurofilaments

Indexed keywords

CYCLIN DEPENDENT KINASE; LIPOFUSCIN;

ADULT; AGED; AMYOTROPHIC LATERAL SCLEROSIS; APOPTOSIS; ARTICLE; CLINICAL ARTICLE; FEMALE; HUMAN; MALE; NERVE DEGENERATION; NEUROFILAMENT; OXIDATIVE STRESS; PRIORITY JOURNAL;

ADULT; AGED; AGED, 80 AND OVER; AMYOTROPHIC LATERAL SCLEROSIS; CYCLIN-DEPENDENT KINASE 5; CYCLIN-DEPENDENT KINASES; HUMANS; IMMUNOHISTOCHEMISTRY; LIPOFUSCIN; MIDDLE AGED; MOTOR NEURONS; PROTEIN-SERINE-THREONINE KINASES; SUPEROXIDE DISMUTASE;

EID: 0032571148     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(98)00176-1     Document Type: Article

References (20)

1. Bajaj N.P.S., Miller C.C.J. Phosphorylation of neurofilament heavy-chain side-arm fragments by cyclin-dependent kinase-5 and glycogen synthase kinase-3α in transfected cells. J. Neurochem. 69:1997;737-743.
2. Brion J.P., Couck A.M. Cortical and brainstem-type Lewy bodies are immunoreactive for the cyclin-dependent kinase 5. Am. J. Pathol. 147:1995;1465-1476.
3. Brunk U.T., Jone C.B., Sohal R.S. A novel hypothesis of lipofuscinogenesis and cellular ageing based upon interactions between oxidative stress and autophagocytosis. Mutation Res. 275:1992;395-403.
4. Greenlund L.J.S., Deckwerth T.L., Johnson E.M. Jr. Superoxide dismutase delays neuronal apoptosis: a role for reactive oxygen species in programmed neuronal death. Neuron. 14:1995;303-315.
5. Guidato S., Tsai L.-H., Woodgett J., Miller C.C.J. Differential cellular phosphorylation of neurofilament heavy side-arms by glycogen synthase kinase-3 and cyclin-dependent kinase-5. J. Neurochem. 66:1996;1698-1706.
6. Henchcliffe C., Burke R.E. Increased expression of cyclin-dependent kinase 5 in induced apoptotic neuron death in rat substantia nigra. Neurosci. Lett. 230:1997;41-44.
7. Leigh, P.N. and Garafolo, O., The molecular pathology of motor neurone disease. In M. Swash and P.N. Leigh (Eds.), Motor Neurone Disease, Springer Verlag, London, 1995.
8. Migheli A., Cavalla P., Piva R., Giordana M.T., Sciffer D. bcl-2 protein expression in aged brain and neurodegenerative diseases. NeuroReport. 5:1994;1906-1908.
9. Miller C.C.J., Brion J.P., Calvert R., Chin T.K., Eagles P.A.M., Downes M.J., Haugh M., Kahn J., Probst A., Ulrich J., Anderton B.H. Alzheimer's paired helical filaments share epitopes with neurofilament side arms. EMBO J. 5:1986;269-276.
10. Miyasaka H., Okabe S., Ishiguro K., Uchida T., Hirokawa N. Interaction of the tail domain of high molecular weight subunits of neurofilaments with the COOH-terminal region of tubulin and its regulation by τ protein kinase II. J. Biol. Chem. 268:1993;22695-22702.
11. Mu X., He J., Anderson D.W., Tojanowski J.Q., Springer J.E. Altered expression of bcl-2 and bax mRNA in amyotrophic lateral sclerosis spinal cord motor neurones. Ann. Neurol. 40:1996;379-386.
12. Nakamura S., Kawamoto Y., Nakano S., Akiguchi I., Kimura J. Cyclin dependent kinase-5 in Lewy body-like inclusions in anterior horn cells of a patient with sporadic amyotrophic lateral sclerosis. Neurology. 48:1997;267-270.
13. nck5a and cyclin-dependent kinase 5 colocalise in Lewy bodies of brains with Parkinson's disease. Acta Neuropathol. (Berl.). 94:1997;153-157.
14. Rabizadeh S., Gralla E.B., Borchelt D.R., Gwinn R., Valentine J.S., Sisodia S., Wong P., Lee M., Hahn H., Bredesen D.E. Mutations associated with amyotrophic lateral sclerosis convert superoxide dismutase from an antiapoptotic gene to a proapoptotic gene: studies in yeast and neural cells. Proc. Natl. Acad. Sci. USA. 92:1995;3024-3028.
15. Rosen D.R., Siddique T., Patterson D., Figlewicz D.A., Sapp P., Hentati A., Donaldson D., Goto J., O'Regan J.P., Deng H.X., Brown R. Mutations in the Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature. 362:1993;59-62.
16. Shetty K.T., Link W.T., Pant H.C. cdc2-like kinase from rat spinal cord specifically phosphorylates KSPXK motifs in neurofilament proteins: isolation and characterization. Proc. Natl. Acad. Sci. USA. 90:1993;6844-6848.
17. Sun D., Leung C.L., Liem R.K.H. Phosphorylation of the high molecular weight neurofilament protein (NF-H) by cdk-5 and p35. J. Biol. Chem. 271:1996;14245-14251.
18. Tsai L.-H., Takahashi T., Caviness V.S. Jr., Harlow E. Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system. Development. 119:1993;1029-1040.
19. Tu P.H., Gurney M.E., Julien J.P., Lee V.M.Y., Trojanowski J.Q. Oxidative stress, mutant SOD1, and neurofilament pathology in transgenic mouse models of human motor neuron disease. Lab. Invest. 76:1997;441-456.
20. Zhang Q., Ahuja H.S., Zakeri Z.F., Wolgemuth D.J. Cyclin-dependent kinase 5 is associated with apoptotic cell death during development and tissue remodelling. Dev. Biol. 183:1997;222-233.