Intrathecal baclofen trials: Complications and positive yield in a pediatric cohort

Journal of Neurosurgery: Pediatrics

Volumn 17, Issue 2, 2016, Pages 240-245

  Sayer, Charlotte ^a   Lumsden, Daniel E ^a   Perides, Sarah ^a   Tustin, Kylee ^a   Bassi, Sanj ^b   Lin, Jean Pierre ^a   Kaminska, Margaret ^a  

^a EVELINA LONDON CHILDREN S HOSPITAL   (United Kingdom)

^b KING S COLLEGE HOSPITAL   (United Kingdom)

Author keywords

Baclofen; Children; Complications; Dystonia; Functional neurosurgery; Intrathecal

Indexed keywords

BACLOFEN;

ADOLESCENT; ARTICLE; BACKACHE; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL (TOPIC); DEEP SEDATION; DEHYDRATION; DIZZINESS; DROWSINESS; DYSTONIA; FEMALE; GROSS MOTOR FUNCTION CLASSIFICATION SYSTEM; HEADACHE; HUMAN; HYPOTENSION; IMPLANTABLE PUMP; INFECTION; INTRATHECAL CATHETER; LIQUORRHEA; LUMBAR PUNCTURE; MALE; MENINGITIS; MUSCLE HYPERTONIA; PEDIATRICS; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SPASTICITY; TREATMENT OUTCOME; TREATMENT RESPONSE; VOMITING;

EID: 84971378251     PISSN: 19330707     EISSN: 19330715     Source Type: Journal    
DOI: 10.3171/2015.5.PEDS14587     Document Type: Article

References (29)

1. Albright AL: Intrathecal baclofen for childhood hypertonia. Childs Nerv Syst 23:971-979, 2007
2. Albright AL, Barron WB, Fasick MP, Polinko P, Janosky J: Continuous intrathecal baclofen infusion for spasticity of cerebral origin. JAMA 270:2475-2477, 1993
3. Albright AL, Cervi A, Singletary J: Intrathecal baclofen for spasticity in cerebral palsy. JAMA 265:1418-1422, 1991
4. Albright AL, Ferson SS: Intrathecal baclofen therapy in children. Neurosurg Focus 21(2):e3, 2006
5. Albright AL, Shultz BL: Plasma baclofen levels in children receiving continuous intrathecal baclofen infusion. J Child Neurol 14:408-409, 1999
6. Bleyenheuft C, Filipetti P, Caldas C, Lejeune T: Experience with external pump trial prior to implantation for intrathecal baclofen in ambulatory patients with spastic cerebral palsy. Neurophysiol Clin 37:23-28, 2007
7. Bohannon RW, Smith MB: Interrater reliability of a modified Ashworth scale of muscle spasticity. Phys Ther 67:206-207, 1987
8. Bonouvrié LA, van Schie PE, Becher JG, van Ouwerkerk WJ, Reeuwijk A, Jeroen Vermeulen R: Effects of intrathecal baclofen on daily care in children with secondary generalized dystonia: a pilot study. Eur J Paediatr Neurol 15:539-543, 2011
9. Brochard S, Remy-Neris O, Filipetti P, Bussel B: Intrathecal baclofen infusion for ambulant children with cerebral palsy. Pediatr Neurol 40:265-270, 2009
10. Brogden RN, Speight TM, Avery GS: Baclofen: a preliminary report of its pharmacological properties and therapeutic efficacy in spasticity. Drugs 8:1-14, 1974
11. Butler C, Campbell S: Evidence of the effects of intrathecal baclofen for spastic and dystonic cerebral palsy. Dev Med Child Neurol 42:634-645, 2000
12. Carda S, Cazzaniga M, Taiana C, Pozzi R: Intrathecal baclofen bolus complicated by deep vein thrombosis and pulmonary embolism. A case report. Eur J Phys Rehabil Med 44:87-88, 2008
13. Dan B, Motta F, Vles JS, Vloeberghs M, Becher JG, Eunson P, et al: Consensus on the appropriate use of intrathecal baclofen (ITB) therapy in paediatric spasticity. Eur J Paediatr Neurol 14:19-28, 2010
14. Flückiger B, Knecht H, Grossmann S, Felleiter P: Devicerelated complications of long-term intrathecal drug therapy via implanted pumps. Spinal Cord 46:639-643, 2008
15. Gimeno H, Gordon A, Tustin K, Lin JP: Functional priorities in daily life for children and young people with dystonic movement disorders and their families. Eur J Paediatr Neurol 17:161-168, 2013
16. Gray N, Morton RE, Brimlow K, Keetley R, Vloeberghs M: Goals and outcomes for non ambulant children receiving continuous infusion of intrathecal baclofen. Eur J Paediatr Neurol 16:443-448, 2012
17. Hoving MA, van Raak EP, Spincemaille GH, Palmans LJ, Sleypen FA, Vles JS: Intrathecal baclofen in children with spastic cerebral palsy: a double-blind, randomized, placebocontrolled, dose-finding study. Dev Med Child Neurol 49:654-659, 2007
18. Hoving MA, van Raak EP, Spincemaille GH, van Kranen-Mastenbroek VH, van Kleef M, Gorter JW, et al: Safety and one-year efficacy of intrathecal baclofen therapy in children with intractable spastic cerebral palsy. Eur J Paediatr Neurol 13:247-256, 2009
19. Kolaski K, Logan LR: A review of the complications of intrathecal baclofen in patients with cerebral palsy. NeuroRehabilitation 22:383-395, 2007
20. Motta F, Antonello CE: Analysis of complications in 430 consecutive pediatric patients treated with intrathecal baclofen therapy: 14-year experience. J Neurosurg Pediatr 13:301-306, 2014
21. Motta F, Buonaguro V, Stignani C: The use of intrathecal baclofen pump implants in children and adolescents: safety and complications in 200 consecutive cases. J Neurosurg 107 (1 Suppl):32-35, 2007
22. Murphy NA, Irwin MC, Hoff C: Intrathecal baclofen therapy in children with cerebral palsy: efficacy and complications. Arch Phys Med Rehabil 83:1721-1725, 2002
23. Natale M, Mirone G, Rotondo M, Moraci A: Intrathecal baclofen therapy for severe spasticity: analysis on a series of 112 consecutive patients and future prospectives. Clin Neurol Neurosurg 114:321-325, 2012
24. Nielsen JF, Hansen HJ, Sunde N, Christensen JJ: Evidence of tolerance to baclofen in treatment of severe spasticity with intrathecal baclofen. Clin Neurol Neurosurg 104:142-145, 2002
25. Palisano R, Rosenbaum P, Walter S, Russell D, Wood E, Galuppi B: Development and reliability of a system to classify gross motor function in children with cerebral palsy. Dev Med Child Neurol 39:214-223, 1997
26. Sanger TD, Delgado MR, Gaebler-Spira D, Hallett M, Mink JW: Classification and definition of disorders causing hypertonia in childhood. Pediatrics 111:e89-e97, 2003
27. Specchio N, Carotenuto A, Trivisano M, Cappelletti S, Vigevano F, Fusco L: Prolonged episode of dystonia and dyskinesia resembling status epilepticus following acute intrathecal baclofen withdrawal. Epilepsy Behav 21:321-323, 2011
28. van Hilten JJ, Hoff JI, Thang MC, van de Meerakker MM, Voormolen JH, Delhaas EM: Clinimetric issues of screening for responsiveness to intrathecal baclofen in dystonia. J Neural Transm 106:931-941, 1999
29. Vloeberghs M, Keetley R, Morton R: Intrathecal baclofen in the management of spasticity due to cerebral palsy. Pediatr Rehabil 8:172-179, 2005