A review of the complications of intrathecal baclofen in patients with cerebral palsy

NeuroRehabilitation

Volumn 22, Issue 5, 2007, Pages 383-395

  Kolaski, Kat ^a   Logan, Lynne Romeiser ^b  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b SUNY UPSTATE MEDICAL UNIVERSITY   (United States)

Author keywords

Cerebral palsy; Complications; Intrathecal baclofen; Outcomes; Spasticity

Indexed keywords

BACLOFEN;

ASPIRATION PNEUMONIA; BEHAVIOR DISORDER; BRADYCARDIA; CEREBRAL PALSY; COGNITION; CONSTIPATION; CONTINUOUS INFUSION; DECUBITUS; DEEP VEIN THROMBOSIS; DROWSINESS; DRUG EFFICACY; DRUG SAFETY; GASTROINTESTINAL SYMPTOM; HEADACHE; HEART FUNCTION; HIGH RISK PATIENT; HUMAN; HYPERSALIVATION; LETHARGY; MENINGITIS; MENTAL HEALTH; MORBIDITY; MUSCLE HYPOTONIA; MUSCLE SPASM; NAUSEA; PERSONALITY; PSYCHOSIS; RELIABILITY; RESPIRATION DEPRESSION; REVIEW; RISK BENEFIT ANALYSIS; SEDATION; SEIZURE; SIDE EFFECT; TREATMENT OUTCOME; URINE RETENTION; VOMITING;

EID: 37549025860     PISSN: 10538135     EISSN: None     Source Type: Journal    
DOI: 10.3233/nre-2007-22505     Document Type: Review

References (77)

1. A.L. Albright, M.J. Barry, D.H. Shafton and S.S. Ferson, Intrathecal baclofen for generalized dystonia, Developmental Medicine & Child Neurology 43 (2001), 652-657.
2. A.L. Albright, R. Gilmartin, D. Swift, L.E. Krach, C.B. Ivanhoe and J.F. McLaughlin, Long-term intrathecal baclofen therapy for severe spasticity of cerebral origin, Journal of Neurosurgery 98 (2003), 291-295.
3. A.L. Albright, Y. Awaad, M. Muhonen, W.R. Boydston, R. Gilmartin, L.E. Krach, M. Turner, K.A. Zidek, E. Wright, D. Swift and K. Bloom, Performance and complications associated with the synchromed 10-ml infusion pump for intrathecal baclofen administration in children, Journal of Neurosurgery 101 (2004), 64-68.
4. A.L. Albright, S. Ferson and S. Carlos, Occult hydrocephalus in children with cerebral palsy, [see comment], Neurosurgery 56 (2005), 93-96.
5. A.L. Albright and S.S. Ferson, Intrathecal baclofen therapy in children, Neurosurgical Focus 21 (2006), e3.
6. A.L. Albright, M. Turner and J.V. Pattisapu, Best-practice surgical techniques for intrathecal baclofen therapy, Journal of Neurosurgery 104 (2006), 233-239.
7. T.D. Alden, R.A. Lytle, T.S. Park, M.J. Noetzel and J.G. Ojemann, Intrathecal baclofen withdrawal: A case report and review of the literature, Childs Nervous System 18 (2002), 522-525.
8. K.J. Anderson, J.P. Farmer and K. Brown, Reversible coma in children after improper baclofen pump insertion. [see comment], Paediatric Anaesthesia 12 (2002), 454-460.
9. R.W. Armstrong, Intrathecal baclofen and spasticity: What do we know and what do we need to know? Developmental Medicine & Child Neurology 34 (1992), 739-745.
10. Y. Awaad, H. Tayem, S. Munoz, S. Ham, A.M. Michon and R. Awaad, Functional assessment following intrathecal baclofen therapy in children with spastic cerebral palsy, Journal of Child Neurology 18 (2003 Jan), 26-34.
11. M.J. Barry, A.L. Albright and B.L. Shultz, Intrathecal baclofen therapy and the role of the physical therapist, Pediatric Physical Therapy 12 (2000), 77-86.
12. K.F. Bjornson, J.F. McLaughlin, J.D. Loeser, K.M. Nowak-Cooperman, M. Russel, K.A. Bader and S.A. Desmond, Oral motor, communication, and nutritional status of children during intrathecal baclofen therapy: A descriptive pilot study, Archives of Physical Medicine & Rehabilitation 84 (2003 Apr), 500-506.
13. C. Bleyenheuft, P. Filipetti, C. Caldas and T. Lejeune, Experience with external pump trial prior to implantation for intrathecal baclofen in ambulatory patients with spastic cerebral palsy, Clinical Neurophysiology 10 (2007).
14. V. Buonaguro, B. Scelsa, D. Curci, S. Monforte, T. Iuorno and F. Motta, Epilepsy and intrathecal baclofen therapy in children with cerebral palsy, Pediatric Neurology 33 (2005), 110-113.
15. C. Butler and S. Campbell, Evidence of the effects of intrathecal baclofen for spastic and dystonic cerebral palsy, AACPDM treatment outcomes committee review panel, Developmental Medicine & Child Neurology 42 (2000), 634-645.
16. W.M. Campbell, A. Ferrel, J.F. McLaughlin, G.A. Grant, J.D. Loeser, C. Graubert and K. Bjornson, Long-term safety and efficacy of continuous intrathecal baclofen, Developmental Medicine & Child Neurology 44 (2002), 660-665.
17. R.J. Coffey, T.S. Edgar, G.E. Francisco, V. Graziani, J.M. Meythaler, P.M. Ridgely, S.A. Sadiq and M.S. Turner, Abrupt withdrawal from intrathecal baclofen: Recognition and management of a potentially life-threatening syndrome. [erratum appears in arch phys med rehabil 2002 oct;83(10):1479], Archives of Physical Medicine & Rehabilitation 83 (2002), 735-741.
18. B. Dachy and B. Dan, Electrophysiological assessment of the effect of intrathecal baclofen in spastic children, Clinical Neurophysiology 113 (2002), 336-340.
19. B. Dachy and B. Dan, Electrophysiological assessment of the effect of intrathecal baclofen in dystonic children, Clinical Neurophysiology 115 (2004), 774-778.
20. F.P. Darbari, J.J. Melvin, J.H. Piatt Jr, T.A. Adirim and S.V. Kothare, Intrathecal baclofen overdose followed by withdrawal: Clinical and EEG features, Pediatric Neurology 33 (2005), 373-377.
21. R.D. Dickerman and S.J. Schneider, Recurrent intrathecal baclofen pump catheter leakage: A surgical observation with recommendations, Journal of Pediatric Surgery 37 (2002), E17.
22. FDA. 2002 03/02. Lioresal intrathecal (baclofen) injection. 〈www.fda.gov/medWatch/SAFETY/2002/mar02.htm#liores〉. Accessed 2006 11/07.
23. J.J. Fitzgerald, M. Tsegaye and M.H. Vloeberghs, Treatment of childhood spasticity of cerebral origin with intrathecal baclofen: A series of 52 cases, British Journal of Neurosurgery 18 (2004), 240-245.
24. P.J. Flett, Rehabilitation of spasticity and related problems in childhood cerebral palsy, Journal of Paediatrics & Child Health 39 (2003), 6-14.
25. D. Fulkerson, Boaz JC and Luerssen TG, Interaction of ventriculoperitoneal shunt and baclofen pump, Childs Nerv Syst 3/16/07.
26. J.L. Gooch, W.A. Oberg, B. Grams, L.A. Ward and M.L. Walker, Complications of intrathecal baclofen pumps in children, Pediatric Neurosurgery 39 (2003), 1-6.
27. J.L. Gooch, W.A. Oberg, B. Grams, L.A. Ward and M.L. Walker, Care provider assessment of intrathecal baclofen in children, Developmental Medicine & Child Neurology 46 (2004), 548-552.
28. D. Guillaume, A. Van Havenbergh, M. Vloeberghs, J. Vidal and G. Roeste, A clinical study of intrathecal baclofen using a programmable pump for intractable spasticity, Archives of Physical Medicine & Rehabilitation 86 (2005), 2165-2171.
29. G. Hagglund, S. Andersson, H. Duppe, H. Lauge-Pedersen, E. Nordmark and L. Westbom, Prevention of dislocation of the hip in children with cerebral palsy. the first ten years of a population-based prevention programme, Journal of Bone & Joint Surgery - British Volume 87 (2005), 95-101.
30. G. Hagglund, S. Andersson, H. Duppe, H. Lauge-Pedersen, E. Nordmark and L. Westbom, Prevention of severe contractures might replace multilevel surgery in cerebral palsy: Results of a population-based health care programme and new techniques to reduce spasticity. [erratum appears in J Pediatr Orthop B. 2005 sep;14(5):388 note: Pedertsen, Henrik Lauge [corrected to Lauge-Pedersen, Henrik]], Journal of Pediatric Orthopaedics, Part B 14 (2005), 269-273.
31. C. Hemingway, J. McGrogan and J.M. Freeman, Energy requirements of spasticity. [see comment], Developmental Medicine & Child Neurology 43 (2001), 277-278.
32. M.A. Hoving, N.M. Smulders, B. Abdul Fatah, M.J. van Kroonenburgh, E.P. van Raak, G.H. Spincemaille and J.S. Vles, The use of an indium111 DTPA flow study in the evaluation of a lumbar swelling in a girl with a baclofen pump, Neuropediatrics 37 (2006), 99-101.
33. M.A. Hoving, V.H. van Kranen-Mastenbroek, E.P. van Raak, G.H. Spincemaille, E.L. Hardy and J.S. Vles, On Behalf Of The Dutch Study Group On Child, Spasticity, Placebo controlled utility and feasibility study of the H-reflex and flexor reflex in spastic children treated with intrathecal baclofen, Clinical Neurophysiology 117 (2006), 1508-1517.
34. H.A. Huraibi, J. Phillips, R.J. Rose, H. Pallatroni, H. Westbrook and G.J. Fanciullo, Intrathecal baclofen pump implantation complicated by epidural lipomatosis, Anesthesia & Analgesia 91 (2000), 429-431.
35. C.B. Ivanhoe, A.H. Tilton and G.E. Francisco, Intrathecal baclofen therapy for spastic hypertonia, Physical Medicine & Rehabilitation Clinics of North America 12 (2001), 923-938.
36. K. Kolaski, Complications of ITB: Overdosage and withdrawal, in: Management of Spasticity in Cerebral Play: The Role of Intrathecal Baclofen, L.A. Koman and B.P. Smith, eds, DataTrace Publishing Company, Towson, MD, 2005.
37. K. Kolaski, The ITB management team, in: Management of Spasticity in Cerebral Palsy: The Role of Intrathecal Baclofen, L.A. Koman and B.P. Smith, eds, DataTrace Publishing Company, Towson, MD, 2005.
38. K. Kolaski and L.R. Logan, Intrathecal baclofen in cerebral palsy: A decade of treatment outcomes, Journal of Pediatric Rehabilitation Medicine 1 (2007), 3-32.
39. B.H. Kopell, D. Sala, W.K. Doyle, D.S. Feldman, J.H. Wisoff and H.L. Weiner, Subfascial implantation of intrathecal baclofen pumps in children: Technical note, Neurosurgery 49 (2001), 753-756.
40. L.E. Krach, R.L. Kriel, R.C. Gilmartin, D.M. Swift, B.B. Storrs, R. Abbott, J.D. Ward, K.K. Bloom, W.H. Brooks, J.R. Madsen, J.F. McLaughlin and J.M. Nadell, Hip status in cerebral palsy after one year of continuous intrathecal baclofen infusion, Pediatric Neurology 30 (2004), 163-168.
41. L.E. Krach, R.L. Kriel, R.C. Gilmartin, D.M. Swift, B.B. Storrs, R. Abbott, J.D. Ward, K.K. Bloom, W.H. Brooks, J.R. Madsen, J.F. McLaughlin and J.M. Nadell, GMFM 1 year after continuous intrathecal baclofen infusion, Pediatric Rehabilitation 8 (2005), 207-213.
42. L.E. Krach, A. Nettleton and B. Klempka, Satisfaction of individuals treated long-term with continuous infusion of intrathecal baclofen by implanted programmable pump, Pediatric Rehabilitation 9 (2006), 219-218.
43. S.M. Leary, P. Gilpin, L. Lockley, L. Rodriguez, L. Jarrett and V.L. Stevenson, Intrathecal baclofen therapy improves functional intelligibility of speech in cerebral palsy, Clinical Rehabilitation 20 (2006), 228-231.
44. S.M. Lew, E.L. Psaty and R. Abbott, An unusual cause of overdose after baclofen pump implantation: Case report, Neurosurgery 56 (2005), E624.
45. J.K. Liu and M.L. Walker, Posterior cervical approach for intrathecal baclofen pump insertion in children with previous spinal fusions: technical note, Journal of Neurosurgery 102 (2005), 119-122.
46. T.D. McCall and J.D. MacDonald, Cervical catheter tip placement for intrathecal baclofen administration, Neurosurgery 59 (2006), 634-640.
47. S.F. McCarty, D. Gaebler-Spira and R.L. Harvey, Improvement of sleep apnea in a patient with cerebral palsy, American Journal of Physical Medicine & Rehabilitation 80 (2001), 540-542.
48. A.A. McCoy, M.A. Fox, D.E. Schaubel and R.N. Ayyangar, Weight gain in children with hypertonia of cerebral origin receiving intrathecal baclofen therapy, Archives of Physical Medicine & Rehabilitation 87 (2006), 1503-1508.
49. J.M. Meythaler, S. Guin-Renfroe, C. Law, P. Grabb and M.N. Hadley, Continuously infused intrathecal baclofen over 12 months for spastic hypertonia in adolescents and adults with cerebral palsy, Archives of Physical Medicine & Rehabilitation 82 (2001), 155-161.
50. N.A. Murphy, Deep venous thrombosis as a result of hypotonia secondary to intrathecal baclofen therapy: A case report, Archives of Physical Medicine & Rehabilitation 83 (2002), 1311-1312.
51. N.A. Murphy, M.C. Irwin and C. Hoff, Intrathecal baclofen therapy in children with cerebral palsy: Efficacy and complications. [see comment], Archives of Physical Medicine & Rehabilitation 83 (2002), 1721-1725.
52. M. O'Donnnell, J. Darrah, R. Adams, C. Butler, L. Roxbourough and D.L. Damiano, 2004 AACPDM methodology to develop systematic reviews of treatment interventions. 〈www.aacpdm.org/resources/systematicReviewsMethodology. pdf〉. Accessed 2006 9/29.
53. D.R. Patel and O. Soyode, Pharmacologic interventions for reducing spasticity in cerebral palsy, Indian Journal of Pediatrics 72 (2005), 869-872.
54. P.K. Rawlins, Intrathecal baclofen therapy over 10 years, Journal of Neuroscience Nursing 36 (2004), 322-327.
55. B. Ridley and P. K. Rawlins, Intrathecal baclofen therapy: Ten steps toward best practice, Journal of Neuroscience Nursing 38 (2006), 72-82.
56. D.A. Ross, C. Byers and T. Hall, A novel approach to prevent repeated catheter migration in a patient with a baclofen pump: A case report, Archives of Physical Medicine & Rehabilitation 86 (2005), 1060-1061.
57. F.C. Sampson, A. Hayward, G. Evans, R. Morton and B. Collett, Functional benefits and cost/benefit analysis of continuous intrathecal baclofen infusion for the management of severe spasticity, Journal of Neurosurgery 96 (2002), 1052-1057.
58. L. Samson-Fang, J. Gooch and C. Norlin, Intrathecal baclofen withdrawal simulating neuroepileptic malignant syndrome in a child with cerebral palsy, Developmental Medicine & Child Neurology 42 (2000), 561-565.
59. J.M. Sansone, D. Mann, K. Noonan, D. Mcleish, M. Ward and B.J. Iskandar, Rapid progression of scoliosis following insertion of intrathecal baclofen pump, Journal of Pediatric Orthopedics 26 (2006), 125-128.
60. A. Scheinberg, S. O'Flaherty, R. Chaseling and M. Dexter, Continuous intrathecal baclofen infusion for children with cerebral palsy: A pilot study, Journal of Paediatrics & Child Health 37 (2001), 283-288.
61. B.D. Schmit and D. Gaebler-Spira, Mechanical measurements of the effects of intrathecal baclofen dosage adjustments in cerebral palsy: A pilot study, American Journal of Physical Medicine & Rehabilitation 83 (2004), 33-41.
62. L.S. Segal, D.M. Wallach and P.M. Kanev, Potential complications of posterior spine fusion and instrumentation in patients with cerebral palsy treated with intrathecal baclofen infusion, Spine 30 (2005), E219-E224.
63. S. Sgouros and S. Seri, The effect of intrathecal baclofen on muscle co-contraction in children with spasticity of cerebral origin, Pediatric Neurosurgery 37 (2002), 225-230.
64. D. Sharan, Recent advances in management of cerebral palsy, Indian Journal of Pediatrics 72 (2005), 969-973.
65. K.W. Shirley, S. Kothare, J.H. Piatt Jr and T.A. Adirim, Intrathecal baclofen overdose and withdrawal, Pediatric Emergency Care 22 (2006), 258-261.
66. C. Staal, A. Arends and S. Ho, Aself-report of quality of life of patients receiving intrathecal baclofen therapy, Rehabilitation Nursing 28 (2003), 159-163.
67. P. Steinbok and M. O'Donnnell, Baclofen infusion for spastic cerebral palsy, Clinical Neurosurgery 47 (2000), 440-457.
68. L. Stempien and T. Tsai, Intrathecal baclofen pump use for spasticity: A clinical survey, American Journal of Physical Medicine & Rehabilitation 79 (2000), 536-541.
69. A.H. Tilton, Therapeutic interventions for tone abnormalities in cerebral palsy, NeuroRx 3 (2006), 217-224.
70. J.R. Vender, S. Hester, J.L. Waller, A. Rekito and M.R. Lee, Identification and management of intrathecal baclofen pump complications: A comparison of pediatric and adult patients, Journal of Neurosurgery 104 (2006), 9-15.
71. A. Verrotti and R. Greco, Pharmacotherapy of spasticity in children with cerebral palsy, Pediatric Neurology 34 (2006), 1-6.
72. M. Vloeberghs, R. Keetley and R. Morton, Intrathecal baclofen in the management of spasticity due to cerebral palsy, Pediatric Rehabilitation 8 (2005), 172-179.
73. C.S. von Koch, T.S. Park, P. Steinbok, M. Smyth and W.J. Peacock, Selective posterior rhizotomy and intrathecal baclofen for the treatment of spasticity. [see comment], Pediatric Neurosurgery 35 (2001), 57-65.
74. L.A. Ward, Spasticity in kids. An intrathecal option, RN 64 (2001), 39-41.
75. C.A. Wunderlich and L.E. Krach, Gram-negative meningitis and infections in individuals treated with intrathecal baclofen for spasticity: A retrospective study, Developmental Medicine & Child Neurology 48 (2006), 450-455.
76. R.N. Yeh, M.M. Nypaver, T.J. Deegan and R. Ayyangar, Baclofen toxicity in an 8-year-old with an intrathecal baclofen pump, Journal of Emergency Medicine 26 (2004 Feb), 163-167.
77. N.S. Zuckerbraun, S.S. Ferson, A.L. Albright and E. Vogeley, Intrathecal baclofen withdrawal: Emergent recognition and management, Pediatric Emergency Care 20 (2004), 759-764.