메뉴 건너뛰기




Volumn 6, Issue , 2016, Pages

Hepatitis B virus inhibits intrinsic RIG-I and RIG-G immune signaling via inducing miR146a

Author keywords

[No Author keywords available]

Indexed keywords

DDX58 PROTEIN, HUMAN; IFIT3 PROTEIN, HUMAN; MICRORNA; MIRN146 MICRORNA, HUMAN; RETINOIC ACID INDUCIBLE PROTEIN I; SIGNAL PEPTIDE;

EID: 84971350180     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep26150     Document Type: Article
Times cited : (40)

References (41)
  • 1
    • 69749087855 scopus 로고    scopus 로고
    • New concepts in the immunopathogenesis of chronic hepatitis B: The importance of the innate immune response
    • Ratnam, D. & Visvanathan, K. New concepts in the immunopathogenesis of chronic hepatitis B: the importance of the innate immune response. Hepatol Int 2, 12-18 (2008).
    • (2008) Hepatol Int , vol.2 , pp. 12-18
    • Ratnam, D.1    Visvanathan, K.2
  • 2
    • 84872378173 scopus 로고    scopus 로고
    • The role of innate immunity in HBV infection
    • Han, Q., Zhang, C., Zhang, J. & Tian, Z. The role of innate immunity in HBV infection. Semin Immunopathol 35, 23-38 (2013).
    • (2013) Semin Immunopathol , vol.35 , pp. 23-38
    • Han, Q.1    Zhang, C.2    Zhang, J.3    Tian, Z.4
  • 3
    • 58149517671 scopus 로고    scopus 로고
    • Activation of pattern recognition receptor-mediated innate immunity inhibits the replication of hepatitis B virus in human hepatocyte-derived cells
    • Guo, H. et al. Activation of pattern recognition receptor-mediated innate immunity inhibits the replication of hepatitis B virus in human hepatocyte-derived cells. J Virol 83, 847-858 (2009).
    • (2009) J Virol , vol.83 , pp. 847-858
    • Guo, H.1
  • 4
    • 18744399291 scopus 로고    scopus 로고
    • Toll-like receptor signaling inhibits hepatitis B virus replication in vivo
    • Isogawa, M., Robek, M. D., Furuichi, Y. & Chisari, F. V. Toll-like receptor signaling inhibits hepatitis B virus replication in vivo. J Virol 79, 7269-7272 (2005).
    • (2005) J Virol , vol.79 , pp. 7269-7272
    • Isogawa, M.1    Robek, M.D.2    Furuichi, Y.3    Chisari, F.V.4
  • 5
    • 0030067167 scopus 로고    scopus 로고
    • Hepatitis B virus transgenic mice: Models of viral immunobiology and pathogenesis
    • Chisari, F. V. Hepatitis B virus transgenic mice: models of viral immunobiology and pathogenesis. Curr Top Microbiol Immunol 206, 149-173 (1996).
    • (1996) Curr Top Microbiol Immunol , vol.206 , pp. 149-173
    • Chisari, F.V.1
  • 6
    • 80053330165 scopus 로고    scopus 로고
    • Reversal of hepatitis B virus-induced immune tolerance by an immunostimulatory 3p-HBxsiRNAs in a retinoic acid inducible gene I-dependent manner
    • Han, Q., Zhang, C., Zhang, J. & Tian, Z. Reversal of hepatitis B virus-induced immune tolerance by an immunostimulatory 3p-HBxsiRNAs in a retinoic acid inducible gene I-dependent manner. Hepatology 54, 1179-1189 (2011).
    • (2011) Hepatology , vol.54 , pp. 1179-1189
    • Han, Q.1    Zhang, C.2    Zhang, J.3    Tian, Z.4
  • 7
    • 77955290279 scopus 로고    scopus 로고
    • Hepatitis B virus polymerase inhibits RIG-I-and Toll-like receptor 3-mediated beta interferon induction in human hepatocytes through interference with interferon regulatory factor 3 activation and dampening of the interaction between TBK1/IKKepsilon and DDX3
    • Yu, S. et al. Hepatitis B virus polymerase inhibits RIG-I-and Toll-like receptor 3-mediated beta interferon induction in human hepatocytes through interference with interferon regulatory factor 3 activation and dampening of the interaction between TBK1/IKKepsilon and DDX3. J Gen Virol 91, 2080-2090 (2010).
    • (2010) J Gen Virol , vol.91 , pp. 2080-2090
    • Yu, S.1
  • 8
    • 78650645590 scopus 로고    scopus 로고
    • Hepatitis B virus regulatory HBx protein binds to adaptor protein IPS-1 and inhibits the activation of beta interferon
    • Kumar, M. et al. Hepatitis B virus regulatory HBx protein binds to adaptor protein IPS-1 and inhibits the activation of beta interferon. J Virol 85, 987-995 (2011).
    • (2011) J Virol , vol.85 , pp. 987-995
    • Kumar, M.1
  • 9
    • 77957679632 scopus 로고    scopus 로고
    • Hepatitis B virus X protein suppresses virus-triggered IRF3 activation and IFN-beta induction by disrupting the VISA-associated complex
    • Wang, X. et al. Hepatitis B virus X protein suppresses virus-triggered IRF3 activation and IFN-beta induction by disrupting the VISA-associated complex. Cell Mol Immunol 7, 341-348 (2010).
    • (2010) Cell Mol Immunol , vol.7 , pp. 341-348
    • Wang, X.1
  • 10
    • 79953137779 scopus 로고    scopus 로고
    • Mechanism of inhibiting type i interferon induction by hepatitis B virus X protein
    • Jiang, J. & Tang, H. Mechanism of inhibiting type I interferon induction by hepatitis B virus X protein. Protein Cell 1, 1106-1117 (2010).
    • (2010) Protein Cell , vol.1 , pp. 1106-1117
    • Jiang, J.1    Tang, H.2
  • 11
    • 84928984522 scopus 로고    scopus 로고
    • Host cellular microRNA involvement in the control of hepatitis B virus gene expression and replication
    • Mizuguchi, Y., Takizawa, T. & Uchida, E. Host cellular microRNA involvement in the control of hepatitis B virus gene expression and replication. World J Hepatol 7, 696-702 (2015).
    • (2015) World J Hepatol , vol.7 , pp. 696-702
    • Mizuguchi, Y.1    Takizawa, T.2    Uchida, E.3
  • 12
    • 84891166169 scopus 로고    scopus 로고
    • Regulation of hepatitis B virus replication by epigenetic mechanisms and microRNAs
    • Zhang, X., Hou, J. & Lu, M. Regulation of hepatitis B virus replication by epigenetic mechanisms and microRNAs. Front Genet 4, 202 (2013).
    • (2013) Front Genet , vol.4 , pp. 202
    • Zhang, X.1    Hou, J.2    Lu, M.3
  • 13
    • 84918840017 scopus 로고    scopus 로고
    • Immuno-miRs: Critical regulators of T-cell development, function and ageing
    • Kroesen, B. J. et al. Immuno-miRs: critical regulators of T-cell development, function and ageing. Immunology 144, 1-10 (2015).
    • (2015) Immunology , vol.144 , pp. 1-10
    • Kroesen, B.J.1
  • 14
    • 68149165370 scopus 로고    scopus 로고
    • MicroRNA-146a feedback inhibits RIG-I-dependent Type i IFN production in macrophages by targeting TRAF6, IRAK1, and IRAK2
    • Hou, J. et al. MicroRNA-146a feedback inhibits RIG-I-dependent Type I IFN production in macrophages by targeting TRAF6, IRAK1, and IRAK2. J Immunol 183, 2150-2158 (2009).
    • (2009) J Immunol , vol.183 , pp. 2150-2158
    • Hou, J.1
  • 15
    • 60649100708 scopus 로고    scopus 로고
    • Altered expression profiles of microRNAs in a stable hepatitis B virus-expressing cell line
    • Liu, Y. et al. Altered expression profiles of microRNAs in a stable hepatitis B virus-expressing cell line. Chin Med J (Engl) 122, 10-14 (2009).
    • (2009) Chin Med J (Engl) , vol.122 , pp. 10-14
    • Liu, Y.1
  • 16
    • 80052102854 scopus 로고    scopus 로고
    • Hepatitis B virus and hepatocellular carcinoma at the miRNA level
    • Zhang, Z. Z. et al. Hepatitis B virus and hepatocellular carcinoma at the miRNA level. World J Gastroenterol 17, 3353-3358 (2011).
    • (2011) World J Gastroenterol , vol.17 , pp. 3353-3358
    • Zhang, Z.Z.1
  • 17
    • 80052026310 scopus 로고    scopus 로고
    • MicroRNAs-372/373 promote the expression of hepatitis B virus through the targeting of nuclear factor I/B
    • Guo, H. et al. MicroRNAs-372/373 promote the expression of hepatitis B virus through the targeting of nuclear factor I/B. Hepatology 54, 808-819 (2011).
    • (2011) Hepatology , vol.54 , pp. 808-819
    • Guo, H.1
  • 18
    • 84879629826 scopus 로고    scopus 로고
    • MicroRNA-146a feedback suppresses T cell immune function by targeting Stat1 in patients with chronic hepatitis B
    • Wang, S. et al. MicroRNA-146a feedback suppresses T cell immune function by targeting Stat1 in patients with chronic hepatitis B. J Immunol 191, 293-301 (2013).
    • (2013) J Immunol , vol.191 , pp. 293-301
    • Wang, S.1
  • 19
    • 84890128358 scopus 로고    scopus 로고
    • MiR146a impairs the IFN-induced anti-HBV immune response by downregulating STAT1 in hepatocytes
    • Hou, Z. H. et al. miR146a impairs the IFN-induced anti-HBV immune response by downregulating STAT1 in hepatocytes. Liver Int 34, 58-68 (2014).
    • (2014) Liver Int , vol.34 , pp. 58-68
    • Hou, Z.H.1
  • 20
    • 79959377900 scopus 로고    scopus 로고
    • IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA
    • Pichlmair, A. et al. IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA. Nat Immunol 12, 624-630 (2011).
    • (2011) Nat Immunol , vol.12 , pp. 624-630
    • Pichlmair, A.1
  • 21
    • 80052675864 scopus 로고    scopus 로고
    • IFN-induced TPR protein IFIT3 potentiates antiviral signaling by bridging MAVS and TBK1
    • Liu, X. Y. et al. IFN-induced TPR protein IFIT3 potentiates antiviral signaling by bridging MAVS and TBK1. J Immunol 187, 2559-2568 (2011).
    • (2011) J Immunol , vol.187 , pp. 2559-2568
    • Liu, X.Y.1
  • 22
    • 33947591977 scopus 로고    scopus 로고
    • TLR3 signaling in a hepatoma cell line is skewed towards apoptosis
    • Khvalevsky, E. et al. TLR3 signaling in a hepatoma cell line is skewed towards apoptosis. J Cell Biochem 100, 1301-1312 (2007).
    • (2007) J Cell Biochem , vol.100 , pp. 1301-1312
    • Khvalevsky, E.1
  • 23
    • 79958759913 scopus 로고    scopus 로고
    • Effects of hepatitis B virus infection on the interferon response in immunodeficient human hepatocyte chimeric mice
    • Tsuge, M. et al. Effects of hepatitis B virus infection on the interferon response in immunodeficient human hepatocyte chimeric mice. J Infect Dis 204, 224-228 (2011).
    • (2011) J Infect Dis , vol.204 , pp. 224-228
    • Tsuge, M.1
  • 24
    • 20944450160 scopus 로고    scopus 로고
    • Combinatorial microRNA target predictions
    • Krek, A. et al. Combinatorial microRNA target predictions. Nat Genet 37, 495-500 (2005).
    • (2005) Nat Genet , vol.37 , pp. 495-500
    • Krek, A.1
  • 25
    • 11844278458 scopus 로고    scopus 로고
    • Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
    • Lewis, B. P., Burge, C. B. & Bartel, D. P. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 120, 15-20 (2005).
    • (2005) Cell , vol.120 , pp. 15-20
    • Lewis, B.P.1    Burge, C.B.2    Bartel, D.P.3
  • 26
    • 4644237189 scopus 로고    scopus 로고
    • Fast and effective prediction of microRNA/target duplexes
    • Rehmsmeier, M. Fast and effective prediction of microRNA/target duplexes. Rna 10, 1507-1517 (2004).
    • (2004) Rna , vol.10 , pp. 1507-1517
    • Rehmsmeier, M.1
  • 27
    • 14044251458 scopus 로고    scopus 로고
    • Human microRNA targets
    • John, B. et al. Human MicroRNA Targets. Plos Biology 2, e363 (2004).
    • (2004) Plos Biology , vol.2 , pp. e363
    • John, B.1
  • 28
    • 38849160013 scopus 로고    scopus 로고
    • Epstein-Barr virus latent membrane protein 1 induces cellular MicroRNA miR-146a, a modulator of lymphocyte signaling pathways
    • Cameron, J. E. et al. Epstein-Barr virus latent membrane protein 1 induces cellular MicroRNA miR-146a, a modulator of lymphocyte signaling pathways. J Virol 82, 1946-1958 (2008).
    • (2008) J Virol , vol.82 , pp. 1946-1958
    • Cameron, J.E.1
  • 29
    • 2342588229 scopus 로고    scopus 로고
    • Genomic analysis of the host response to hepatitis B virus infection
    • Wieland, S., Thimme, R., Purcell, R. H. & Chisari, F. V. Genomic analysis of the host response to hepatitis B virus infection. Proc Natl Acad Sci USA 101, 6669-6674 (2004).
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 6669-6674
    • Wieland, S.1    Thimme, R.2    Purcell, R.H.3    Chisari, F.V.4
  • 30
    • 84865567558 scopus 로고    scopus 로고
    • Transcriptomic analysis of the woodchuck model of chronic hepatitis B
    • Fletcher, S. P. et al. Transcriptomic analysis of the woodchuck model of chronic hepatitis B. Hepatology 56, 820-830 (2012).
    • (2012) Hepatology , vol.56 , pp. 820-830
    • Fletcher, S.P.1
  • 31
    • 84927517067 scopus 로고    scopus 로고
    • MiR-33a levels in hepatic and serum after chronic HBV-induced fibrosis
    • Huang, C. F. et al. miR-33a levels in hepatic and serum after chronic HBV-induced fibrosis. J Gastroenterol 50, 480-490 (2015).
    • (2015) J Gastroenterol , vol.50 , pp. 480-490
    • Huang, C.F.1
  • 32
    • 84921374864 scopus 로고    scopus 로고
    • Serum microRNA-124 is a novel biomarker for liver necroinflammation in patients with chronic hepatitis B virus infection
    • Wang, J. Y. et al. Serum microRNA-124 is a novel biomarker for liver necroinflammation in patients with chronic hepatitis B virus infection. J Viral Hepat 22, 128-136 (2015).
    • (2015) J Viral Hepat , vol.22 , pp. 128-136
    • Wang, J.Y.1
  • 33
    • 84893081987 scopus 로고    scopus 로고
    • Autophagy suppresses tumorigenesis of hepatitis B virus-associated hepatocellular carcinoma through degradation of microRNA-224
    • Lan, S. H. et al. Autophagy suppresses tumorigenesis of hepatitis B virus-associated hepatocellular carcinoma through degradation of microRNA-224. Hepatology 59, 505-517 (2014).
    • (2014) Hepatology , vol.59 , pp. 505-517
    • Lan, S.H.1
  • 34
    • 80555122819 scopus 로고    scopus 로고
    • MiR-146a suppresses the sensitivity to interferon-alpha in hepatocellular carcinoma cells
    • Tomokuni, A. et al. miR-146a suppresses the sensitivity to interferon-alpha in hepatocellular carcinoma cells. Biochem Biophys Res Commun 414, 675-680 (2011).
    • (2011) Biochem Biophys Res Commun , vol.414 , pp. 675-680
    • Tomokuni, A.1
  • 35
    • 84876467555 scopus 로고    scopus 로고
    • Association of a single-nucleotide polymorphism within the miR-146a gene with susceptibility for acute-on-chronic hepatitis B liver failure
    • Jiang, H. et al. Association of a single-nucleotide polymorphism within the miR-146a gene with susceptibility for acute-on-chronic hepatitis B liver failure. Immunogenetics 65, 257-263 (2013).
    • (2013) Immunogenetics , vol.65 , pp. 257-263
    • Jiang, H.1
  • 36
    • 84921280194 scopus 로고    scopus 로고
    • The RNA Sensor RIG-I Dually Functions as an Innate Sensor and Direct Antiviral Factor for Hepatitis B Virus
    • Sato, S. et al. The RNA Sensor RIG-I Dually Functions as an Innate Sensor and Direct Antiviral Factor for Hepatitis B Virus. Immunity 42, 123-132 (2015).
    • (2015) Immunity , vol.42 , pp. 123-132
    • Sato, S.1
  • 37
    • 79960434259 scopus 로고    scopus 로고
    • MicroRNA-146a downregulates NFkappaB activity via targeting TRAF6 and functions as a tumor suppressor having strong prognostic implications in NK/T cell lymphoma
    • Paik, J. H. et al. MicroRNA-146a downregulates NFkappaB activity via targeting TRAF6 and functions as a tumor suppressor having strong prognostic implications in NK/T cell lymphoma. Clin Cancer Res 17, 4761-4771 (2011).
    • (2011) Clin Cancer Res , vol.17 , pp. 4761-4771
    • Paik, J.H.1
  • 38
    • 80053330165 scopus 로고    scopus 로고
    • Reversal of hepatitis B virus-induced immune tolerance by an immunostimulatory 3p-HBxsiRNAs in a retinoic acid inducible gene I-dependent manner
    • Han, Q., Zhang, C., Zhang, J. & Tian, Z. Reversal of hepatitis B virus-induced immune tolerance by an immunostimulatory 3p-HBxsiRNAs in a retinoic acid inducible gene I-dependent manner. Hepatology 54, 1179-1189 (2011).
    • (2011) Hepatology , vol.54 , pp. 1179-1189
    • Han, Q.1    Zhang, C.2    Zhang, J.3    Tian, Z.4
  • 39
    • 79960561028 scopus 로고    scopus 로고
    • Ectopic expression of microRNA-155 enhances innate antiviral immunity against HBV infection in human hepatoma cells
    • Su, C. et al. Ectopic expression of microRNA-155 enhances innate antiviral immunity against HBV infection in human hepatoma cells. Virol J 8, 354 (2011).
    • (2011) Virol J , vol.8 , pp. 354
    • Su, C.1
  • 40
    • 46449092527 scopus 로고    scopus 로고
    • A three-step pathway comprising PLZF/miR-146a/CXCR4 controls megakaryopoiesis
    • Labbaye, C. et al. A three-step pathway comprising PLZF/miR-146a/CXCR4 controls megakaryopoiesis. Nat Cell Biol 10, 788-801 (2008).
    • (2008) Nat Cell Biol , vol.10 , pp. 788-801
    • Labbaye, C.1
  • 41
    • 84984548383 scopus 로고    scopus 로고
    • Hepatitis B virus X protein enhances androgen receptor-responsive gene expression depending on androgen level
    • Chiu, C. M. et al. Hepatitis B virus X protein enhances androgen receptor-responsive gene expression depending on androgen level. Proc Natl Acad Sci USA 104, 2571-2578 (2007).
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 2571-2578
    • Chiu, C.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.