Prognostic impact of immune response in resectable colorectal liver metastases treated by surgery alone or surgery with perioperative FOLFOX in the randomised EORTC study 40983

European Journal of Cancer

Volumn 51, Issue 17, 2015, Pages 2708-2717

  Tanis, Erik ^a,b   Julié, Catherine ^c   Emile, Jean Francois ^c   Mauer, Murielle ^a   Nordlinger, Bernard ^c   Aust, Daniela ^d   Roth, Arnaud ^e   Lutz, Manfred P ^f   Gruenberger, Thomas ^g   Wrba, Fritz ^g   Sorbye, Halfdan ^h   Bechstein, Wolf ⁱ   Schlag, Peter ^j   Fisseler, Annette ^k   Ruers, Theo ^b  

^a EORTC DATA CENTER   (Belgium)

^b ANTONI VAN LEEUWENHOEK HOSPITAL   (Netherlands)

^c HÔPITAL AMBROISE PARÉ   (France)

^d UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^e UNIVERSITY OF GENEVA   (Switzerland)

^f Caritas Klinikum   (Germany)

^g KRANKENANSTALT RUDOLFSTIFTUNG   (Austria)

^h HAUKELAND UNIVERSITY HOSPITAL   (Norway)

ⁱ UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^j CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^k DR HORST SCHMIDT KLINIKEN   (Germany)

more..

Author keywords

B lymphocytes; Chemotherapy response; Colorectal liver metastases; Immune profile; Macrophages; Mast cells; T lymphocytes

Indexed keywords

CD20 ANTIGEN; CD68 ANTIGEN; FLUOROURACIL; FOLINIC ACID; OXALIPLATIN; STEM CELL FACTOR RECEPTOR; ANTINEOPLASTIC AGENT; CD3 ANTIGEN; CD68 ANTIGEN, HUMAN; DIFFERENTIATION ANTIGEN; LEUKOCYTE ANTIGEN; PLATINUM COMPLEX;

ADJUVANT CHEMOTHERAPY; ADULT; AGED; ARTICLE; CANCER CHEMOTHERAPY; CANCER PROGNOSIS; CANCER SURVIVAL; CD3+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; COLORECTAL LIVER METASTASIS; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; IMMUNOHISTOCHEMISTRY; LYMPHOCYTE COUNT; MACROPHAGE; MAJOR CLINICAL STUDY; MALE; MAST CELL; MULTIMODALITY CANCER THERAPY; PERIOPERATIVE PERIOD; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; RETROSPECTIVE STUDY; SYSTEMIC THERAPY; TREATMENT RESPONSE; TUMOR REGRESSION; TUMOR VOLUME; B LYMPHOCYTE; CLINICAL TRIAL; COLORECTAL NEOPLASMS; CONTROLLED STUDY; DISEASE FREE SURVIVAL; DRUG EFFECTS; IMMUNE SYSTEM; LIVER NEOPLASMS; METABOLISM; MIDDLE AGED; MULTICENTER STUDY; PATHOLOGY; PHASE 3 CLINICAL TRIAL; PROCEDURES; PROGNOSIS; RANDOMIZED CONTROLLED TRIAL; SECONDARY; T LYMPHOCYTE; TREATMENT OUTCOME;

ADULT; AGED; ANTIGENS, CD; ANTIGENS, CD20; ANTIGENS, CD3; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; B-LYMPHOCYTES; CHEMOTHERAPY, ADJUVANT; COLORECTAL NEOPLASMS; COMBINED MODALITY THERAPY; DISEASE-FREE SURVIVAL; FEMALE; FLUOROURACIL; HUMANS; IMMUNE SYSTEM; LEUCOVORIN; LIVER NEOPLASMS; MACROPHAGES; MALE; MIDDLE AGED; ORGANOPLATINUM COMPOUNDS; PROGNOSIS; RETROSPECTIVE STUDIES; T-LYMPHOCYTES; TREATMENT OUTCOME;

EID: 84970984287     PISSN: 09598049     EISSN: 18790852     Source Type: Journal    
DOI: 10.1016/j.ejca.2015.08.014     Document Type: Article

References (35)

1. J. Ferlay, E. Steliarova-Foucher, J. Lortet-Tieulent, S. Rosso, J.W. Coebergh, H. Comber, and et al. Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012 Eur J Cancer 49 6 2013 1374 1403
2. G.P. Kanas, A. Taylor, J.N. Primrose, W.J. Langeberg, M.A. Kelsh, F.S. Mowat, and et al. Survival after liver resection in metastatic colorectal cancer: review and meta-analysis of prognostic factors Clin Epidemiol 4 2012 283 301
3. G. Veereman, J. Robays, L. Verleye, R. Leroy, C. Rolfo, E. Van Cutsem, and et al. Pooled analysis of the surgical treatment for colorectal cancer liver metastases Crit Rev Oncol Hematol 94 1 2015 122 135
4. A.K. House, and A.G. Watt Survival and the immune response in patients with carcinoma of the colorectum Gut 20 10 1979 868 874
5. K. Nosho, Y. Baba, N. Tanaka, and et al. Tumour-infiltrating T-cell subsets, molecular changes in colorectal cancer, and prognosis: cohort study and literature review J Pathol 222 4 2010 350 366
6. P. Salama, M. Phillips, F. Grieu, and et al. Tumour-infiltrating FOXP3+ T regulatory cells show strong prognostic significance in colorectal cancer J Clin Oncol 27 2 2009 186 192
7. S.C. Katz, and et al. Regulatory T cell infiltration predicts outcome following resection of colorectal cancer liver metastases Ann Surg Oncol. 20 3 2013 946 955
8. J. Galon, A. Costes, F. Sanchez-Cabo, and et al. Type, density, and location of immune cells within human colorectal tumours predict clinical outcome Science 313 5795 2006 1960 1964
9. N.R. Blatner, A. Bonertz, P. Beckhove, and et al. In colorectal cancer mast cells contribute to systemic regulatory T-cell dysfunction Proc Natl Acad Sci U S A 107 14 2010 6430 6435
10. M. Gulubova, and T. Vlaykova Prognostic significance of mast cell number and microvascular density for the survival of patients with primary colorectal cancer J Gastroenterol Hepatol 24 7 2009 1265 1275
11. J.C. Kang, J.S. Chen, C.H. Lee, J.J. Chang, and Y.S. Shieh Intratumoural macrophage counts correlate with tumour progression in colorectal cancer J Surg Oncol 102 3 2010 242 248
12. J. Forssell, A. Oberg, M.L. Henriksson, R. Stenling, A. Jung, and R. Palmqvist High macrophage infiltration along the tumour front correlates with improved survival in colon cancer Clin Cancer Res 13 5 2007 1472 1479
13. L. Zitvogel, L. Apetoh, F. Ghiringhelli, F. Andre, A. Tesniere, and G. Kroemer The anticancer immune response: indispensable for therapeutic success? J Clin Invest 118 6 2008 1991 2001
14. L. Zitvogel, L. Apetoh, F. Ghiringhelli, and G. Kroemer Immunological aspects of cancer chemotherapy Nat Rev Immunol 8 1 2008 59 73
15. A. Tesniere, F. Schlemmer, V. Boige, and et al. Immunogenic death of colon cancer cells treated with oxaliplatin Oncogene 29 4 2010 482 491
16. A. Galetto, S. Buttiglieri, S. Forno, F. Moro, A. Mussa, and L. Matera Drug- and cell-mediated antitumour cytotoxicities modulate cross-presentation of tumour antigens by myeloid dendritic cells Anticancer Drugs 14 10 2003 833 843
17. S.C. Katz, V. Pillarisetty, Z.M. Bamboat, and et al. T cell infiltrate predicts long-term survival following resection of colorectal cancer liver metastases Ann Surg Oncol 16 9 2009 2524 2530
18. P. Wagner, M. Koch, D. Nummer, and et al. Detection and functional analysis of tumour infiltrating T-lymphocytes (TIL) in liver metastases from colorectal cancer Ann Surg Oncol 15 8 2008 2310 2317
19. S.E. Giusca, F.E. Zugun, E. Tarcoveanu, E. Carasevici, C. Amalinei, and I.D. Caruntu Immunohistochemical study of colorectal cancer liver metastases: the immune/inflammatory infiltrate Rom J Morphol Embryol 51 1 2010 73 79
20. H.U. Kasper, U. Drebber, H.A. Zur, D. Stippel, H.P. Dienes, and V. Dries Dominance of CD4+ alpha/beta T-cells and inferior role of innate immune reaction in liver metastases Anticancer Res 23 4 2003 3175 3181
21. M. Gulubova, I. Manolova, D. Kyurkchiev, A. Julianov, and I. Altunkova Decrease in intrahepatic CD56+ lymphocytes in gastric and colorectal cancer patients with liver metastases APMIS 117 12 2009 870 879
22. N. Halama, S. Michel, M. Kloor, and et al. Localization and density of immune cells in the invasive margin of human colorectal cancer liver metastases are prognostic for response to chemotherapy Cancer Res 71 2011 5670 5677
23. S.A. Pugh, R.J. Harrison, J.N. Primrose, and S.I. Khakoo T cell but not NK cells are associated with favourable outcome for resected colorectal lover metastases BMC Cancer 14 2014 180
24. A. Meshcheryakova, D. Tamandl, E. Bajna, J. Stift, M. Mittlboeck, M. Svoboda, and et al. B cells and ectopic follicular structures: novel players in anti-tumor programming with prognostic power for patients with metastatic colorectal cancer PLoS One 9 6 2014 e99008
25. B. Nordlinger, H. Sorbye, B. Glimelius, and et al. Perioperative chemotherapy with FOLFOX4 and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC Intergroup trial 40983): a randomised controlled trial Lancet 371 9617 2008 1007 1016
26. L. Rubbia-Brandt, E. Giostra, C. Brezault, A.D. Roth, A. Andres, V. Audard, and et al. Importance of histological tumor response assessment in predicting the outcome in patients with colorectal liver metastases treated with neo-adjuvant chemotherapy followed by liver surgery Ann Oncol 18 2 2007 239 304
27. M.A. Allard, J.B. Bachet, A. Beauchet, C. Julie, R. Malafosse, C. Penna, and et al. Linear quantification of lymphoid infiltration of the tumor margin: a reproducible method, developed with colorectal cancer tissues, for assessing a highly variable prognostic factor Diagn Pathol 13 7 2012 156
28. F. Pages, A. Kirilovsky, B. Mlecnik, and et al. In situ cytotoxic and memory T cells predict outcome in patients with early-stage colorectal cancer J Clin Oncol 27 35 2009 5944 5951
29. J. Galon, B. Mlecnik, G. Bindea, and et al. Towards the introduction of the 'Immunoscore' in the classification of malignant tumours J Pathol 232 2014 199 209
30. F. Pages, A. Berger, M. Camus, and et al. Effector memory T cells, early metastasis, and survival in colorectal cancer N Engl J Med 353 25 2005 2654 2666
31. B. Mlecnik, M. Tosolini, A. Kirilovsky, and et al. Histopathologic-based prognostic factors of colorectal cancers are associated with the state of the local immune reaction J Clin Oncol 29 6 2011 610 618
32. G. Folprecht, T. Gruenberger, W.O. Bechstein, H.R. Raab, F. Lordick, J.T. Hartmann, and et al. Tumour response and secondary resectability of colorectal liver metastases following neoadjuvant chemotherapy with cetuximab: the CELIM randomised phase 2 trial Lancet Oncol 11 1 2010 38 47
33. H. Angell, and J. Galon From the immune contexture to the Immunoscore: the role of prognostic and predictive immune markers in cancer Curr Opin Immunol 25 2 2013 261 267
34. M.F. Acikalin, U. Oner, I. Topçu, B. Yaşar, H. Kiper, and E. Colak Tumour angiogenesis and mast cell density in the prognostic assessment of colorectal carcinomas Dig Liver Dis 37 3 2005 162 169
35. C.B. Westbury, A. Freeman, M. Rashid, A. Pearson, J.R. Yarnold, and S.C. Short Changes in mast cell number and stem cell factor expression in human skin after radiotherapy for breast cancer Radiother Oncol 111 2 2014 206 211