Immunohistochemical study of colorectal cancer liver metastases: The immune/inflammatory infiltrate

Romanian Journal of Morphology and Embryology

Volumn 51, Issue 1, 2010, Pages 73-79

  Giuşcǎ, Simona Eliza ^a   Eloae Zugun, Fl ^a   Tarcoveanu E ^a   Carasevici, E ^a   Amǎlinei, Cornelia ^a   Cǎruntu, Irina Draga ^a  

^a GRIGORE T POPA UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

Author keywords

Colorectal carcinoma; Immune inflammatory infiltrate; Liver metastasis

Indexed keywords

CD20 ANTIGEN; CD3 ANTIGEN; CD68 ANTIGEN, HUMAN; DIFFERENTIATION ANTIGEN; LEUKOCYTE ANTIGEN;

ARTICLE; CANCER INVASION; CARCINOMA; COLORECTAL TUMOR; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; INFLAMMATION; LIVER TUMOR; LYMPHOCYTE; MACROPHAGE; METABOLISM; METASTASIS; PATHOLOGY; LEUKEMIC INFILTRATION; SECONDARY;

ANTIGENS, CD; ANTIGENS, CD20; ANTIGENS, CD3; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; CARCINOMA; COLORECTAL NEOPLASMS; HUMANS; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LEUKEMIC INFILTRATION; LIVER NEOPLASMS; LYMPHOCYTES; MACROPHAGES;

EID: 77949407005     PISSN: 12200522     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Jemal A, Siegel R, Ward E, Murray T, Xu J, Thun MJ, Cancer statistics, 2007, CA Cancer J Clin, 2007, 57(1):43-66.
2. Scheele J, Stang R, Altendorf-Hofmann A, Paul M, Resection of colorectal liver metastases, World J Surg, 1995, 19(1):59-71.
3. Venook A, Critical evaluation of current treatments in meta-static colorectal cancer, Oncologist, 2005, 10(4):250-261.
4. Abdalla EK, Vauthey JN, Ellis LM, Ellis V, Pollock R, Broglio KR, Hess K, Curley SA, Recurrence and out-comes following hepatic resection, radiofrequency ablation, and combined resection/ablation for colorectal liver metastases, Ann Surg, 2004, 239(6): 818-825; discussion 825-827.
5. Kahlenberg MS, Sullivan JM, Witmer DD, Petrelli NJ, Molecular prognostics in colorectal cancer, Surg Oncol, 2003, 12(3):173-186.
6. Graziano F, Cascinu S, Prognostic molecular markers for planning adjuvant chemotherapy trials in Dukes' B colorectal cancer patients: how much evidence is enough?, Ann Oncol, 2003, 14(7):1026-1038.
7. Compton CC, Colorectal carcinoma: diagnostic, prognostic and molecular features, Mod Pathol, 2003, 16(4):376-388.
8. Anwar S, Frayling IM, Scott NA, Carlson GL, Systematic review of genetic influences on the prognosis of colorectal cancer, Br J Surg, 2004, 91(10):1275-1291.
9. Neal CP, Garcea G, Doucas H, Manson MM, Sutton CD, Dennison AR, Berry DP, Molecular prognostic markers in resectable colorectal liver metastases: a systematic review, Eur J Cancer, 2006, 42(12):1728-1743.
10. Aschele C, Debernardis D, Tunesi G, Maley F, Sobrero A, Thymidylate synthase protein expression in primary colorectal cancer compared with the corresponding distant metastases and relationship with the clinical response to 5-fluorouracil, Clin Cancer Res, 2000, 6(12):4797-4802.
11. Backus HH, Van Groeningen CJ, Vos W, Dukers DF, Bloemena E, Wouters D, Pinedo HM, Peters GJ, Differential expression of cell cycle and apoptosis related proteins in colorectal mucosa, primary colon tumours, and liver metastases, J Clin Pathol, 2002, 55(3):206-211.
12. Agui T, McConkey DJ, Tanigawa N, Comparative study of various biological parameters, including expression of survivin, between primary and metastatic human colonic adenocarcinomas, Anticancer Res, 2002, 22(3):1769-1776.
13. Scartozzi M, Bearzi I, Berardi R, Mandolesi A, Fabris G, Cascinu S, Epidermal growth factor receptor (EGFR) status in primary colorectal tumors does not correlate with EGFR expression in related metastatic sites: implications for treatment with EGFR-targeted monoclonal antibodies, Clin Oncol, 2004, 22(23):4772-4778.
14. Nordlinger B, Guiguet M, Vaillant JC, Balladur P, Boudjema K, Bachellier P, Jaeck D, Surgical resection of colorectal carcinoma metastases to the liver. A prognostic scoring system to improve case selection, based on 1568 patients. Association Française de Chirurgie, Cancer, 1996, 77(7):1254-1262.
15. Fong Y, Fortner J, Sun RL, Brennan MF, Blumgart LH, Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer: analysis of 1001 consecutive cases, Ann Surg, 1999, 230(3):309-318; discussion 318-321.
16. Smith DL, Soria JC, Morat L, Yang Q, Sabatier L, Liu DD, Nemr RA, Rashid A, Vauthey JN, Human telomerase reverse transcriptase (hTERT) and Ki-67 are better predictors of survival than established clinical indicators in patients undergoing curative hepatic resection for colorectal metastases, Ann Surg Oncol, 2004, 11(1):45-51.
17. Talmadge JE, Donkor M, Scholar E, Inflammatory cell infiltration of tumors: Jekyll or Hyde, Cancer Metastasis Rev, 2007, 26(3-4):373-400.
18. Svennevig JL, Lunde OC, Holter J, Bjørgsvik D, Lymphoid infiltration and prognosis in colorectal carcinoma, Br J Cancer, 1984, 49(3):375-377.
19. Carlon CA, Fabris G, Arslan-Pagnini C, Pluchinotta AM, Chinelli E, Carniato S, Prognostic correlations of operable carcinoma of the rectum, Dis Colon Rectum, 1985, 28(1):47-50.
20. Jass JR, Lymphocytic infiltration and survival in rectal cancer, J Clin Pathol, 1986, 39(6):585-589.
21. Ropponen KM, Eskelinen MJ, Lipponen PK, Alhava E, Kosma VM, Prognostic value of tumour-infiltrating lymphocytes (TILs) in colorectal cancer, J Pathol, 1997, 182(3):318-324.
22. Galon J, Fridman WH, Pagès F, The adaptive immunologic microenvironment in colorectal cancer: a novel perspective, Cancer Res, 2007, 67(5):1883-1886.
23. Jewell AP, Is the liver an important site for the development of immune tolerance to tumours?, Med Hypotheses, 2005, 64(4):751-754.
24. Canning C, O'Brian M, Hegarty J, O'Farrelly C, Liver immunity and tumour surveillance, Immunol Letters, 2006, 107(2):83-88.
25. Chattopadhyay S, Chakraborty NG, Mukherji B, Regulatory T cells and tumor immunity, Cancer Immunol Immunother, 2005, 54(12):1153-1161.
26. Dunn GP, Old LJ, Schreiber RD, The three Es of cancer immunoediting, Annu Rev Immunol, 2004, 22:329-360.
27. Harrrison JC, Dean PJ, el-Zeky F, Vander Zwaag R, Impact of the Crohn's-like lymphoid reaction on staging of right-sided colon cancer: results of multivariate analysis, Hum Pathol, 1995, 26(1):31-38.
28. Naito Y, Saito K, Shiiba K, Ohuchi A, Saigenji K, Nagura H, Ohtani H, CD8+ T-cells infiltrated within cancer cell nests as a prognostic factor in human colorectal cancer, Cancer Res, 1998, 58(16):3491-3494.
29. Dolcetti R, Viel A, Doglioni C, Russo A, Guidoboni M, Capozzi E, Vecchiato N, Macrì E, Fornasarig M, Boiocchi M, High prevalence of activated intraepithelial cytotoxic T lymphocytes and increased neoplastic cell apoptosis in colorectal carcinomas with microsatellite instability, Am J Pathol, 1999, 154(6):1805-1813.
30. Guidoboni M, Gafà R, Viel A, Doglioni C, Russo A, Santini A, Del Tin L, Macrì E, Lanza G, Boiocchi M, Dolcetti R, Microsatellite instability and high content of activated cytotoxic lymphocytes identify colon cancer pacients with a favorable prognosis, Am J Pathol, 2001, 159(1):297-304.
31. Menon AG, Janssen-Van Rhijn CM, Morreau H, Putter H, Tollenaar RA, van de Velde CJ, Fleuren GJ, Kuppen PJ, Immune system and prognosis in colorectal cancer: a detailed immunohistochemical analysis, Lab Invest, 2004, 84(4):493-501.
32. Jass JR, Whitehall VLJ, Young J, Leggett BA, Emerging concepts in colorectal neoplasia, Gastroenterology, 2002, 123(3):862-876.
33. Kopfstein L, Christofori G, Metastasis: cell-autonomous mechanisms versus contributions by the tumor microenvironment, Cell Mol Life Sci, 2006, 63(4):449-468.
34. Ohtani H, Focus on TILs: prognostic significance of tumor infiltrating lymphocytes in human colorectal cancer, Cancer Immun, 2007, 7:4-12.
35. Pagès F, Berger A, Camus M, Sanchez-Cabo F, Costes A, Molidor R, Mlecnik B, Kirilovsky A, Nilsson M, Damotte D, Meatchi T, Bruneval P, Cugnenc PH, Trajanoski Z, Fridman WH, Galon J, Effector memory T cells, early metastasis, and survival in colorectal cancer, N Engl J Med, 2005, 353(25):2654-2666.
36. Mantovani A, Sozzani S, Locati M, Allavena P, Sica A, Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes, Trends Immunol, 2002, 23(11):549-555.
37. Pollard JW, Tumour-educated macrophages promote tumour progression and metastasis, Nat Rev Cancer, 2004, 4(1):71-78.
38. Mantovani A, Sica A, Locati M, New vistas on macrophage differentiation and activation, Eur J Immunol, 2007, 37(1):14-16.