Blockade of GPR55 in the dorsolateral striatum impairs performance of rats in a T-maze paradigm

Behavioural Pharmacology

Volumn 27, Issue 4, 2016, Pages 393-396

  Marichal Cancino, Bruno A ^a   Sánchez Fuentes, Asai ^a   Méndez Díaz, Mónica ^a   Ruiz Contreras, Alejandra E ^a   Prospéro García, Oscar ^a  

^a UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

Author keywords

AM251; Dorsal striatum; GPR55; Noladin ether; Procedural memory

Indexed keywords

1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N (1 PIPERIDYL) 1H PYRAZOLE 3 CARBOXAMIDE; CANNABINOID 1 RECEPTOR; CANNABINOID RECEPTOR ANTAGONIST; CID 16020036; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 55; NOLADIN ETHER; UNCLASSIFIED DRUG; 4-(4-(3-HYDROXYPHENYL)-3-(4-METHYLPHENYL)-6-OXO-1H,4H,5H,6H-PYRROLO(3,4-C)PYRAZOL-5-YL)BENZOIC ACID; ACYLGLYCEROL; AZABICYCLO DERIVATIVE; BENZOIC ACID DERIVATIVE; CANNABINOID RECEPTOR; GPR55 PROTEIN, RAT; PIPERIDINE DERIVATIVE; PYRAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; DORSOLATERAL STRIATUM; LATENT PERIOD; LEARNING CURVE; LEARNING DISORDER; MALE; MOTOR COORDINATION; NONHUMAN; PROCEDURAL MEMORY; RAT; T-MAZE TEST; TREATMENT RESPONSE; ANIMAL; ANTAGONISTS AND INHIBITORS; COGNITION; CORPUS STRIATUM; DRUG EFFECTS; MAZE TEST; MEMORY; METABOLISM; PHYSIOLOGY; WISTAR RAT;

ANIMALS; AZABICYCLO COMPOUNDS; BENZOATES; COGNITION; CORPUS STRIATUM; GLYCERIDES; MALE; MAZE LEARNING; MEMORY; PIPERIDINES; PYRAZOLES; RATS; RATS, WISTAR; RECEPTORS, CANNABINOID; RECEPTORS, G-PROTEIN-COUPLED;

EID: 84970973807     PISSN: 09558810     EISSN: 14735849     Source Type: Journal    
DOI: 10.1097/FBP.0000000000000185     Document Type: Article

References (13)

1. Balenga NA, Henstridge CM, Kargl J, Waldhoer M (2011). Pharmacology, signaling and physiological relevance of the G protein-coupled receptor 55. Adv Pharmacol 62:251-277.
2. Balenga NA, Martínez-Pinilla E, Kargl J, Schröder R, Peinhaupt M, Platzer W, et al. (2014). Heteromerization of GPR55 and cannabinoid CB2 receptors modulates signalling. Br J Pharmacol 171:5387-5406.
3. Brighton PJ, McDonald J, Taylor AH, Challiss RA, Lambert DG, Konje JC, Willets JM (2009). Characterization of anandamide-stimulated cannabinoid receptor signaling in human ULTR myometrial smooth muscle cells. Mol Endocrinol 23:1415-1427.
4. Henstridge CM, Balenga NA, Schröder R, Kargl JK, Platzer W, Martini L, et al. (2010). GPR55 ligands promote receptor coupling to multiple signalling pathways. Br J Pharmacol 160:604-614.
5. Kargl J, Brown AJ, Andersen L, Dorn G, Schicho R, Waldhoer M, Heinemann A (2013). A selective antagonist reveals a potential role of G protein-coupled receptor 55 in platelet and endothelial cell function. J Pharmacol Exp Ther 346:54-66.
6. Marichal-Cancino BA, Manrique-Maldonado G, Altamirano-Espinoza AH, Ruiz-Salinas I, González-Hernández A, Maassenvandenbrink A, Villalón CM (2013). Analysis of anandamide- and lysophosphatidylinositol-induced inhibition of the vasopressor responses produced by sympathetic stimulation or noradrenaline in pithed rats. Eur J Pharmacol 721:168-177.
7. Paxinos G, Watson C (2007). The rat brain in stereotaxic coordinates, 6th ed. San Diego: Elsevier Academic Press.
8. Rueda-Orozco PE, Montes-Rodriguez CJ, Soria-Gomez E, Méndez-Díaz M, Prospéro-García O (2008a). Impairment of endocannabinoids activity in the dorsolateral striatum delays extinction of behavior in a procedural memory task in rats. Neuropharmacology 55:55-62.
9. Rueda-Orozco PE, Soria-Gomez E, Montes-Rodriguez CJ, Martínez-Vargas M, Galicia O, Navarro L, Prospero-García O (2008b). A potential function of endocannabinoids in the selection of a navigation strategy by rats. Psychopharmacology (Berl) 198:565-576.
10. Ryberg E, Larsson N, Sjögren S, Hjorth S, Hermansson N-O, Leonova J, et al. (2007). The orphan receptor GPR55 is a novel cannabinoid receptor. Br J Pharmacol 152:1092-1101.
11. Sharir H, Console-Bram L, Mundy C, Popoff SN, Kapur A, Abood ME (2012). The endocannabinoids anandamide and virodhamine modulate the activity of the candidate cannabinoid receptor GPR55. J Neuroimmune Pharmacol 7:856-865.
12. Waldeck-Weiermair M, Zoratti C, Osibow K, Balenga N, Goessnitzer E, Waldhoer M, et al. (2008). Integrin clustering enables anandamide-induced Ca2 + signaling in endothelial cells via GPR55 by protection against CB1-receptor-triggered repression. J Cell Sci 121:1704-1717.
13. Wu CS, Chen H, Sun H, Zhu J, Jew CP, Wager-Miller J, et al. (2013). GPR55, a G-protein coupled receptor for lysophosphatidylinositol, plays a role in motor coordination. PLoS One 8:e60314.