Identification of thioridazine, an antipsychotic drug, as an antiglioblastoma and anticancer stem cell agent using public gene expression data

Cell Death and Disease

Volumn 6, Issue 5, 2015, Pages

  Cheng, H W ^a   Liang, Y H ^a   Kuo, Y L ^b   Chuu, C P ^c   Lin, C Y ^c   Lee, M H ^a   Wu, A T H ^d   Yeh, C T ^e   Chen, Ei T ^a   Whang Peng, J ^f   Su, C L ^g   Huang, C Y F ^a,g  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^d TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^e TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^f TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^g NATIONAL TAIWAN NORMAL UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

8 AZAGUANINE; ACEPROMAZINE; AMIODARONE; AMOXAPINE; ANTIMYCIN A1; BEPRIDIL; CAMPTOTHECIN; CHLORPROMAZINE; CYCLOSERINE; DAUNORUBICIN; ELLIPTICINE; EMETINE; FLUPHENAZINE; FLUSPIRILENE; LUTEOLIN; PARTHENOLIDE; PERPHENAZINE; PHENOXYBENZAMINE; PROCHLORPERAZINE; PROMAZINE; PROPAFENONE; SULCONAZOLE; TANESPIMYCIN; THIOGUANOSINE; THIORIDAZINE; THIOSTREPTON; TRICHOSTATIN A; TRIFLUOPERAZINE; TYLOXAPOL; UNINDEXED DRUG; NEUROLEPTIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; AUTOPHAGY; CANCER STEM CELL; CARCINOGENESIS; CELL VIABILITY; CLONOGENIC ASSAY; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG SCREENING; GENE EXPRESSION; GLIOBLASTOMA; GLIOBLASTOMA CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION; ANIMAL; BRAIN NEOPLASMS; CELL SURVIVAL; DRUG EFFECTS; GENE EXPRESSION PROFILING; GENETICS; NONOBESE DIABETIC MOUSE; PATHOLOGY; PHYSIOLOGY; PROCEDURES; RANDOMIZATION; SCID MOUSE; TUMOR CELL LINE;

ANIMALS; ANTIPSYCHOTIC AGENTS; AUTOPHAGY; BRAIN NEOPLASMS; CELL LINE, TUMOR; CELL SURVIVAL; DRUG SCREENING ASSAYS, ANTITUMOR; GENE EXPRESSION PROFILING; GLIOBLASTOMA; HUMANS; MICE, INBRED NOD; MICE, SCID; NEOPLASTIC STEM CELLS; RANDOM ALLOCATION; THIORIDAZINE; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84970937471     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2015.77     Document Type: Article

References (36)

1. Kaza N, Kohli L, Roth KA. Autophagy in brain tumors: a new target for therapeutic intervention. Brain Pathol 2012; 22: 89-98.
2. Mason WP, Cairncross JG. Drug Insight: temozolomide as a treatment for malignant glioma- impact of a recent trial. Nat Clin Pract Neurol 2005; 1: 88-95.
3. Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJ et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 2005; 352: 987-996.
4. Chou FH, Tsai KY, Su CY, Lee CC. The incidence and relative risk factors for developing cancer among patients with schizophrenia: a nine-year follow-up study. Schizophr Res 2011; 129: 97-103.
5. Tabares-Seisdedos R, Rubenstein JL. Inverse cancer comorbidity: a serendipitous opportunity to gain insight into CNS disorders. Nat Rev 2013; 14: 293-304.
6. Sun L, Hui AM, Su Q, Vortmeyer A, Kotliarov Y, Pastorino S et al. Neuronal and gliomaderived stem cell factor induces angiogenesis within the brain. Cancer Cell 2006; 9: 287-300.
7. Murat A, Migliavacca E, Gorlia T, Lambiv WL, Shay T, Hamou MF et al. Stem cell-related 'self-renewal' signature and high epidermal growth factor receptor expression associated with resistance to concomitant chemoradiotherapy in glioblastoma. J Clin Oncol 2008; 26: 3015-3024.
8. Hodgson JG, Yeh RF, Ray A,Wang NJ, Smirnov I, Yu M et al. Comparative analyses of gene copy number and mRNA expression in glioblastoma multiforme tumors and xenografts. Neuro Oncol 2009; 11: 477-487.
9. Grzmil M, Morin P Jr., Lino MM, Merlo A, Frank S, Wang Y et al. MAP kinase-interacting kinase 1 regulates SMAD2-dependent TGF-beta signaling pathway in human glioblastoma. Cancer Res 2011; 71: 2392-2402.
10. Gravendeel LA, Kouwenhoven MC, Gevaert O, de Rooi JJ, Stubbs AP, Duijm JE et al. Intrinsic gene expression profiles of gliomas are a better predictor of survival than histology. Cancer Res 2009; 69: 9065-9072.
11. Shats I, Gatza ML, Chang JT, Mori S,Wang J, Rich J et al. Using a stem cell-based signature to guide therapeutic selection in cancer. Cancer Res 2011; 71: 1772-1780.
12. Suva ML, Riggi N, Janiszewska M, Radovanovic I, Provero P, Stehle JC et al. EZH2 is essential for glioblastoma cancer stem cell maintenance. Cancer Res 2009; 69: 9211-9218.
13. Wong DJ, Liu H, Ridky TW, Cassarino D, Segal E, Chang HY. Module map of stem cell genes guides creation of epithelial cancer stem cells. Cell Stem Cell 2008; 2: 333-344.
14. Krakstad C, Chekenya M. Survival signalling and apoptosis resistance in glioblastomas: opportunities for targeted therapeutics. Mol Cancer 2010; 9: 135.
15. Wick W, Weller M, Weiler M, Batchelor T, Yung AW, Platten M. Pathway inhibition: emerging molecular targets for treating glioblastoma. Neuro Oncol 2011; 13: 566-579.
16. Lino MM, Merlo A. PI3Kinase signaling in glioblastoma. J Neurooncol 2011; 103: 417-427.
17. Ciaccio MF, Wagner JP, Chuu CP, Lauffenburger DA, Jones RB. Systems analysis of EGF receptor signaling dynamics with microwestern arrays. Nat Methods 2010; 7: 148-155.
18. Takeuchi H, Kondo Y, Fujiwara K, Kanzawa T, Aoki H, Mills GB et al. Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase/protein kinase B inhibitors. Cancer Res 2005; 65: 3336-3346.
19. Filippi-Chiela EC, Villodre ES, Zamin LL, Lenz G. Autophagy interplay with apoptosis and cell cycle regulation in the growth inhibiting effect of resveratrol in glioma cells. PLoS ONE 2011; 6: e20849.
20. Fu J, Shao CJ, Chen FR, Ng HK, Chen ZP. Autophagy induced by valproic acid is associated with oxidative stress in glioma cell lines. Neuro Oncol 2010; 12: 328-340.
21. Song X, Kim SY, Zhang L, Tang D, Bartlett DL, Kwon YT et al. Role of AMP-activated protein kinase in cross-talk between apoptosis and autophagy in human colon cancer. Cell Death Dis 2014; 5: e1504.
22. Roach PJ. AMPK -4 ULK1 -4 autophagy. Mol Cell Biol 2011; 31: 3082-3084.
23. Tuynder M, Fiucci G, Prieur S, Lespagnol A, Géant A, Beaucourt S et al. Translationally controlled tumor protein is a target of tumor reversion. Proc Natl Acad Sci USA 2004; 101: 15364-15369.
24. Chen K, Huang C, Yuan J, Cheng H, Zhou R. Long-term artificial selection reveals a role of TCTP in autophagy in mammalian cells. Mol Biol Evol 2014; 31: 2194-2211.
25. Rinnerthaler M, Lejskova R, Grousl T, Stradalova V, Heeren G, Richter K et al. Mmi1, the yeast homologue of mammalian TCTP, associates with stress granules in heat-shocked cells and modulates proteasome activity. PLoS ONE 2013; 8: e77791.
26. Zungu M, Schisler JC, Essop MF, McCudden C, Patterson C, Willis MS. Regulation of AMPK by the ubiquitin proteasome system. Am J Pathol 2011; 178: 4-11.
27. Emdad L, Qadeer ZA, Bederson LB, Kothari HP, Uzzaman M, Germano IM. Is there a common upstream link for autophagic and apoptotic cell death in human high-grade gliomas? Neuro Oncol 2011; 13: 725-735.
28. Li J, Zhu S, Kozono D, Ng K, Futalan D, Shen Y et al. Genome-wide shRNA screen revealed integrated mitogenic signaling between dopamine receptor D2 (DRD2) and epidermal growth factor receptor (EGFR) in glioblastoma. Oncotarget 2014; 5: 882-893.
29. Burstein ES, Ma J, Wong S, Gao Y, Pham E, Knapp AE et al. Intrinsic efficacy of antipsychotics at human D2, D3, and D4 dopamine receptors: identification of the clozapine metabolite N-desmethylclozapine as a D2/D3 partial agonist. J Pharmacol Exp Ther 2005; 315: 1278-1287.
30. Weller M, Stupp R, Reifenberger G, Brandes AA, van den Bent MJ, Wick W et al. MGMT promoter methylation in malignant gliomas: ready for personalized medicine? Nat Rev Neurol 2010; 6: 39-51.
31. Riddick G, Fine HA. Integration and analysis of genome-scale data from gliomas. Nat Rev Neurol 2011; 7: 439-450.
32. Parsons DW, Jones S, Zhang X, Lin JC, Leary RJ, Angenendt P et al. An integrated genomic analysis of human glioblastoma multiforme. Science 2008; 321: 1807-1812.
33. Singh SK, Clarke ID, Terasaki M, Bonn VE, Hawkins C, Squire J et al. Identification of a cancer stem cell in human brain tumors. Cancer Res 2003; 63: 5821-5828.
34. Sachlos E, Risueno RM, Laronde S, Shapovalova Z, Lee JH, Russell J et al. Identification of drugs including a dopamine receptor antagonist that selectively target cancer stem cells. Cell 2012; 149: 1284-1297.
35. Gil-Ad I, Shtaif B, Levkovitz Y, Dayag M, Zeldich E, Weizman A et al. Characterization of phenothiazine-induced apoptosis in neuroblastoma and glioma cell lines: clinical relevance and possible application for brain-derived tumors. J Mol Neurosci 2004; 22: 189-198.
36. Traganos F, Darzynkiewicz Z. Lysosomal proton pump activity: supravital cell staining with acridine orange differentiates leukocyte subpopulations. Methods Cell Biol 1994; 41: 185-194.