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Volumn 24, Issue 13, 2016, Pages 3035-3042
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Identification, synthesis and evaluation of SARS-CoV and MERS-CoV 3C-like protease inhibitors
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Author keywords
3CLpro; Coronavirus; MERS CoV; Pyrazolone; SARS Cov
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Indexed keywords
2 [5 [(5 OXO 1,3 DIPHENYL 1,5 DIHYDRO 4H PYRAZOL 4 YLIDENE)METHYL]FURAN 2 YL]BENZOIC ACID;
2 [5 [[1 (3 CARBOXYPHENYL) 3 METHYL 5 OXO 1,5 DIHYDRO 4H PYRAZOL 4 YLIDENE]METHYL]FURAN 2 YL] 4 CHLOROBENZOIC ACID;
2 [5 [[1 (3 CARBOXYPHENYL) 5 OXO 3 (TRIFLUOROMETHYL) 1,5 DIHYDRO 4H PYRAZOL 4 YLIDENE]METHYL]FURAN 2 YL] 4 CHLOROBENZOIC ACID;
2 [5 [[1 (3 CARBOXYPHENYL) 5 OXO 3 (TRIFLUOROMETHYL) 1,5 DIHYDRO 4H PYRAZOL 4 YLIDENE]METHYL]FURAN 2 YL]BENZOIC ACID;
2 [5 [[1 (3 CARBOXYPHENYL) 5 OXO 3 PHENYL 1,5 DIHYDRO 4H PYRAZOL 4 YLIDENE]METHYL]FURAN 2 YL] 4 CHLOROBENZOIC ACID;
2 [5 [[1 (4 CYANOPHENYL) 5 OXO 3 PHENYL 1,5 DIHYDRO 4H PYRAZOL 4 YLIDENE]METHYL]FURAN 2 YL]BENZOIC ACID;
2 [5 [[1 (4 FLUOROPHENYL) 5 OXO 3 PHENYL 1,5 DIHYDRO 4H PYRAZOL 4 YLIDENE]METHYL]FURAN 2 YL]BENZOIC ACID;
2 [5 [[1 (4 METHOXYPHENYL) 5 OXO 3 PHENYL 1,5 DIHYDRO 4H PYRAZOL 4 YLIDENE]METHYL]FURAN 2 YL]BENZOIC ACID;
2 [5 [[1 [4 (TERT BUTYL)PHENYL] 5 OXO 3 PHENYL 1,5 DIHYDRO 4H PYRAZOL 4 YLIDENE]METHYL]FURAN 2 YL] 4 CHLOROBENZOIC ACID;
2 [5 [[1 [4 (TERT BUTYL)PHENYL] 5 OXO 3 PHENYL 1,5 DIHYDRO 4H PYRAZOL 4 YLIDENE]METHYL]FURAN 2 YL]BENZOIC ACID;
2,5 DIPHENYL 4 [(5 PHENYLFURAN 2 YL)METHYLENE] 2,4 DIHYDRO 3H PYRAZOL 3 ONE;
3 [3 METHYL 5 OXO 4 [(5 PHENYLFURAN 2 YL)METHYLENE] 4,5 DIHYDRO 1H PYRAZOL 1 YL]BENZOIC ACID;
3 [4 (FURAN 2 YLMETHYLENE) 5 OXO 3 PHENYL 4,5 DIHYDRO 1H PYRAZOL 1 YL]BENZOIC ACID;
3 [4 [(1,1' BIPHENYL) 4 YLMETHYLENE] 5 OXO 3 PHENYL 4,5 DIHYDRO 1H PYRAZOL 1 YL]BENZOIC ACID;
3 [4 [4 (BENZYLOXY)BENZYLIDENE] 5 OXO 3 PHENYL 4,5 DIHYDRO 1H PYRAZOL 1 YL]BENZOIC ACID;
3 [5 OXO 3 PHENYL 4 [(5 PHENYLFURAN 2 YL)METHYLENE] 4,5 DIHYDRO 1H PYRAZOL 1 YL]BENZOIC ACID;
3C LIKE PROTEASE;
4 CHLORO 2 [5 [(3 METHYL 5 OXO 1 PHENYL 1,5 DIHYDRO 4H PYRAZOL 4 YLIDENE)METHYL]FURAN 2 YL]BENZOIC ACID;
4 CHLORO 2 [5 [(5 OXO 1,3 DIPHENYL 1,5 DIHYDRO 4H PYRAZOL 4 YLIDENE)METHYL]FURAN 2 YL]BENZOIC ACID;
4 CHLORO 2 [5 [[1 (4 FLUOROPHENYL) 5 OXO 3 PHENYL 1,5 DIHYDRO 4H PYRAZOL 4 YLIDENE]METHYL]FURAN 2 YL]BENZOIC ACID;
4 CHLORO 2 [5 [[1 (4 ISOPROPYLPHENYL) 3 METHYL 5 OXO 1,5 DIHYDRO 4H PYRAZOL 4 YLIDENE]METHYL]FURAN 2 YL]BENZOIC ACID;
SIALIDASE INHIBITOR;
UNCLASSIFIED DRUG;
VIRUS PROTEIN;
VIRUS SIALIDASE;
ANTIVIRUS AGENT;
PEPTIDE HYDROLASE;
PROTEINASE INHIBITOR;
ARTICLE;
CARBON NUCLEAR MAGNETIC RESONANCE;
CONTROLLED STUDY;
DRUG IDENTIFICATION;
DRUG STRUCTURE;
DRUG SYNTHESIS;
ENZYME INHIBITION;
IC50;
MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS;
MOLECULAR DOCKING;
NONHUMAN;
PROTON NUCLEAR MAGNETIC RESONANCE;
SARS CORONAVIRUS;
CHEMISTRY;
DRUG EFFECTS;
ENZYME ACTIVATION;
ENZYMOLOGY;
HUMAN;
METABOLISM;
MOLECULAR MODEL;
SYNTHESIS;
ANTIVIRAL AGENTS;
ENZYME ACTIVATION;
HUMANS;
INHIBITORY CONCENTRATION 50;
MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS;
MODELS, MOLECULAR;
MOLECULAR DOCKING SIMULATION;
PEPTIDE HYDROLASES;
PROTEASE INHIBITORS;
SARS VIRUS;
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EID: 84969980357
PISSN: 09680896
EISSN: 14643391
Source Type: Journal
DOI: 10.1016/j.bmc.2016.05.013 Document Type: Article |
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Times cited : (84)
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References (30)
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