Vitamin D deficiency strongly predicts adverse medical outcome across different medical inpatient populations results from a prospective study

Medicine (United States)

Volumn 95, Issue 19, 2016, Pages

  Graedel, Lena ^a   Merker, Meret ^a   Felder, Susan ^a   Kutz, Alexander ^a   Haubitz, Sebastian ^a   Faessler, Lukas ^a   Kaeslin, Martha ^b   Huber, Andreas ^b   Mueller, Beat ^a   Schuetz, Philipp ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

^b CANTONAL HOSPITAL AARAU   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

25 HYDROXYVITAMIN D; 25-HYDROXYVITAMIN D; VITAMIN D;

ADULT; AGED; ARTICLE; BARTHEL INDEX; CONTROLLED STUDY; FALL RISK; FALLING; FEMALE; FOLLOW UP; HOSPITAL PATIENT; HUMAN; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MORTALITY; OUTCOME ASSESSMENT; PREVALENCE; PRIORITY JOURNAL; QUALITY OF LIFE; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY; VITAMIN SUPPLEMENTATION; ANALOGS AND DERIVATIVES; BLOOD; HOSPITALIZATION; MIDDLE AGED; PROSPECTIVE STUDY; PSYCHOLOGY; REGRESSION ANALYSIS; STATISTICS AND NUMERICAL DATA; TIME FACTOR;

ACCIDENTAL FALLS; AGED; FEMALE; HOSPITALIZATION; HUMANS; INPATIENTS; MALE; MIDDLE AGED; PATIENT OUTCOME ASSESSMENT; PREVALENCE; PROSPECTIVE STUDIES; QUALITY OF LIFE; REGRESSION ANALYSIS; TIME FACTORS; VITAMIN D; VITAMIN D DEFICIENCY;

EID: 84969940450     PISSN: 00257974     EISSN: 15365964     Source Type: Journal    
DOI: 10.1097/MD.0000000000003533     Document Type: Article

References (65)

1. Bouillon R, Bischoff-Ferrari H, Willett W. Vitamin D and health: perspectives from mice and man. J Bone Miner Res. 2008;23: 974-979.
2. Liu PT, Stenger S, Li H, et al. Toll-like receptor triggering of a Vitamin D-mediated human antimicrobial response. Science. 2006;311:1770-1773.
3. Nagpal S, Na S, Rathnachalam R. Noncalcemic actions of Vitamin D receptor ligands. Endocr Rev. 2005;26:662-687.
4. DeLuca HF. Overview of general physiologic features and functions of Vitamin D. Am J Clin Nutr. 2004;80(6 Suppl): 1689S-1696S.
5. Chowdhury R, Kunutsor S, Vitezova A, et al. Vitamin D and risk of cause specific death: systematic review and meta-analysis of observational cohort and randomised intervention studies. BMJ. 2014;348:g1903.
6. Garland CF, Kim JJ, Mohr SB, et al. Meta-analysis of all-cause mortality according to serum 25-hydroxyVitamin D. Am J Public health. 2014;104:e43-50.
7. Melamed ML, Michos ED, Post W, et al. 25-hydroxyVitamin D levels and the risk of mortality in the general population. Arch Inter Med. 2008;168:1629-1637.
8. Zittermann A, Prokop S. The role of Vitamin D for cardiovascular disease and overall mortality. Adv Exp Med Biol. 2014;810:106-119.
9. Ness RA, Miller DD, Li W. The role of Vitamin D in cancer prevention. Chin J Nat Med. 2015;13:481-497.
10. Zittermann A. Vitamin D and cardiovascular disease. Anticancer Res. 2014;34:4641-4648.
11. Nnoaham KE, Clarke A. Low serum Vitamin D levels and tuberculosis: A systematic review and meta-analysis. Int J Epidemiol. 2008;37:113-119.
12. Klassen KM, Fairley CK, Chen M, et al. Vitamin D deficiency may be associated with a more rapid decline in CD4 cell count to <350 cells/muL in untreated HIV-infected adults. Curr HIV Res. 2015;13:517-523.
13. Watkins RR, Lemonovich TL, Salata RA. An update on the association of Vitamin D deficiency with common infectious diseases. Can J Physiol Pharmacol. 2015;93:363-368.
14. Giovannucci E. Epidemiological evidence for Vitamin D and colorectal cancer. J Bone Miner Res. 2007;22(Suppl 2):V81-85.
15. Giovannucci E, Liu Y, Hollis BW, et al. 25-hydroxyVitamin D and risk of myocardial infarction in men: A prospective study. Arch Inter Med. 2008;168:1174-1180.
16. Dobnig H, Pilz S, Scharnagl H, et al. Independent association of low serum 25-hydroxyVitamin D and 1,25-dihydroxyVitamin D levels with all-cause and cardiovascular mortality. Arch Inter Med. 2008;168:1340-1349.
17. Forman JP, Giovannucci E, Holmes MD, et al. Plasma 25-hydroxyVitamin D levels and risk of incident hypertension. Hypertension. 2007;49:1063-1069.
18. Pilz S, Henry RM, Snijder MB, et al. 25-HydroxyVitamin D is not associated with carotid intima-media thickness in older men and women. Calcif Tissue Int. 2009;84:423-424.
19. Mithal A, Wahl DA, Bonjour JP, et al. Global Vitamin D status and determinants of hypovitaminosis D. Osteoporos Int. 2009;20: 1807-1820.
20. Bischoff-Ferrari HA. Empfehlungen der Eidgenössischen Ernaöhrungskommis-sion zur Vitamin-D-Zufuhr fuör die Schweizer Bevoölkerung. Swiss Med Forum. 2012;12:775-778.
21. MacLaughlin J, Holick MF. Aging decreases the capacity of human skin to produce Vitamin D3. J Clin Invest. 1985;76: 1536-1538.
22. Schuetz P, Hausfater P, Amin D, et al. Optimizing triage and hospitalization in adult general medical emergency patients: The triage project. BMC Emerg Med. 2013;13:12.
23. Kondrup J, Rasmussen HH, Hamberg O, et al. Nutritional risk screening (NRS 2002): A new method based on an analysis of controlled clinical trials. Clin Nutr. 2003;22:321-336.
24. Mahoney FI, Barthel DW. Functional evaluation: The Barthel index. MD State Med J. 1965;14:61-65.
25. EuroQol G. EuroQol-A new facility for the measurement of health-related quality of life. Health Policy. 1990;16:199-208.
26. Prevention and management of osteoporosis. World Health Organ Tech Rep Ser. 2003;921:1-164.
27. Thomas MK, Lloyd-Jones DM, Thadhani RI, et al. Hypovitaminosis D in medical inpatients. N Engl J Med. 1998;338:777-783.
28. Federal Commission for Nutrition: Vitamin D deficiency: Evidence, safety, and recommendations for the Swiss Population. Expert Report of the FCN. Zurich. Federal Office for Public Health. 2012.
29. Abdelfatah M, Nayfe R, Moftakhar B, et al. Low Vitamin D level and impact on severity and recurrence of Clostridium difficile infections. J Invest Med. 2015;63:17-21.
30. Anty R, Tonohouan M, Ferrari-Panaia P, et al. Low levels of 25-hydroxy Vitamin D are independently associated with the risk of bacterial infection in cirrhotic patients. Clin Transl Gastroenterol. 2014;5:e56.
31. Remmelts HH, van de Garde EM, Meijvis SC, et al. Addition of Vitamin D status to prognostic scores improves the prediction of outcome in community-acquired pneumonia. Clin Infect Dis. 2012;55:1488-1494.
32. Leow L, Simpson T, Cursons R, et al. Vitamin D, innate immunity and outcomes in community acquired pneumonia. Respirology. 2011;16:611-616.
33. Lange N, Litonjua AA, Gibbons FK, et al. Pre-hospital Vitamin D concentration, mortality, and bloodstream infection in a hospitalized patient population. Am J Med. 2013;126:640e619-e627.
34. Amrein K, Quraishi SA, Litonjua AA, et al. Evidence for a U-shaped relationship between prehospital Vitamin D status and mortality: A cohort study. J Clin Endocrinol Metab. 2014;99: 1461-1469.
35. Khalili H, Talasaz AH, Salarifar M. Serum Vitamin D concentration status and its correlation with early biomarkers of remodeling following acute myocardial infarction. Clin Res Cardiol. 2012;101:321-327.
36. Amrein K, Zajic P, Schnedl C, et al. Vitamin D status and its association with season, hospital and sepsis mortality in critical illness. Crit Care. 2014;18:R47.
37. Braun A, Chang D, Mahadevappa K, et al. Association of low serum 25-hydroxyVitamin D levels and mortality in the critically ill. Crit Care Med. 2011;39:671-677.
38. McKinney JD, Bailey BA, Garrett LH, et al. Relationship between Vitamin D status and ICU outcomes in veterans. J Am Med Dir Assoc. 2011;12:208-211.
39. Aygencel G, Turkoglu M, Tuncel AF, et al. Is Vitamin D insufficiency associated with mortality of critically ill patients? Crit Care Res Pract. 2013;2013:856747.
40. Hu J, Luo Z, Zhao X, et al. Changes in the calcium-parathyroid hormone-Vitamin D axis and prognosis for critically ill patients: A prospective observational study. PloS One. 2013;8:e75441.
41. Su LX, Jiang ZX, Cao LC, et al. Significance of low serum Vitamin D for infection risk, disease severity and mortality in critically ill patients. Chin Med J. 2013;126:2725-2730.
42. Venkatram S, Chilimuri S, Adrish M, et al. Vitamin D deficiency is associated with mortality in the medical intensive care unit. Crit Care. 2011;15:R292.
43. Pletz MW, Terkamp C, Schumacher U, et al. Vitamin D deficiency in community-acquired pneumonia: low levels of 1,25(OH)2 D are associated with disease severity. Respir Res. 2014;15:53.
44. Helard L, Mateus-Hamdan L, Beauchet O, et al. Hypovitaminosis D in geriatric acute care unit: A biomarker of longer length of stay. Dis Markers. 2013;35:525-529.
45. Beauchet O, Launay C, de Decker L, et al. Who is at risk of long hospital stay among patients admitted to geriatric acute care unit? Results from a prospective cohort study. J Nutr Health Aging. 2013;17:695-699.
46. Kiebzak GM, Moore NL, Margolis S, et al. Vitamin D status of patients admitted to a hospital rehabilitation unit: relationship to function and progress. Am J Phys Med Rehabil. 2007;86:435-445.
47. Pellicane AJ, Wysocki NM, Mallinson TR, et al. Prevalence of 25-hydroxyVitamin D deficiency in the acute inpatient rehabilitation population and its effect on function. Arch Phys Med Rehabil. 2011;92:705-711.
48. Higgins DM, Wischmeyer PE, Queensland KM, et al. Relationship of Vitamin D deficiency to clinical outcomes in critically ill patients. J Parent Enter Nutr. 2012;36:713-720.
49. Wang WJ, Gray S, Sison C, et al. Low Vitamin D level is an independent predictor of poor outcomes in Clostridium difficileassociated diarrhea. Ther Adv Gastroenterol. 2014;7:14-19.
50. van der Wilden GM, Fagenholz PJ, Velmahos GC, et al. Vitamin D status and severity of Clostridium difficile infections: A prospective cohort study in hospitalized adults. J Parent Enter Nutr. 2014.
51. Ginde AA, Camargo CA Jr, Shapiro NI. Vitamin D insufficiency and sepsis severity in emergency department patients with suspected infection. Acad Emerge Med. 2011;18:551-554.
52. Quraishi SA, Litonjua AA, Moromizato T, et al. Association between prehospital Vitamin D status and hospital-acquired bloodstream infections. Am J Clin Nutr. 2013;98:952-959.
53. Dahl B, Schiodt FV, Kiaer T, et al. Serum Gc-globulin in the early course of multiple trauma. Crit Care Med. 1998;26:285-289.
54. Krishnan A, Ochola J, Mundy J, et al. Acute fluid shifts influence the assessment of serum Vitamin D status in critically ill patients. Crit Care. 2010;14:R216.
55. Bikle DD, Gee E, Halloran B, et al. Assessment of the free fraction of 25-hydroxyVitamin D in serum and its regulation by albumin and the Vitamin D-binding protein. J Clin Endocrinol Metab. 1986;63:954-959.
56. Bikle DD, Halloran BP, Gee E, et al. Free 25-hydroxyVitamin D levels are normal in subjects with liver disease and reduced total 25-hydroxyVitamin D levels. J Clin Invest. 1986;78:748-752.
57. Premaor MO, Alves GV, Crossetti LB, et al. Hyperparathyroidism secondary to hypovitaminosis D in hypoalbuminemic is less intense than in normoalbuminemic patients: A prevalence study in medical inpatients in southern Brazil. Endocrine. 2004;24:47-53.
58. Chun RF, Liu PT, Modlin RL, et al. Impact of Vitamin D on immune function: lessons learned from genome-wide analysis. Front Physiol. 2014;5:151.
59. Guadarrama-Lopez AL, Valdes-Ramos R, Martinez-Carrillo BE. Type 2 diabetes, PUFAs, and Vitamin D: their relation to inflammation. J Immunol Res. 2014;2014:860703.
60. Bischoff-Ferrari HA, Dawson-Hughes B, Staehelin HB, et al. Fall prevention with supplemental and active forms of Vitamin D: A meta-analysis of randomised controlled trials. BMJ. 2009;339:b3692.
61. Bischoff-Ferrari HA, Willett WC, Wong JB, et al. Prevention of nonvertebral fractures with oral Vitamin D and dose dependency: A meta-analysis of randomized controlled trials. Arch Inter Med. 2009;169:551-561.
62. Hansen KE, Johnson RE, Chambers KR, et al. Treatment of Vitamin D insufficiency in postmenopausal women: A randomized clinical trial. JAMA Intern Med. 2015;175:1612-1621.
63. Bischoff-Ferrari HA, Dawson-Hughes B, Orav EJ, et al. Monthly high-dose Vitamin D treatment for the prevention of functional decline: A randomized clinical trial. JAMA Inter Med. 2016;176:175-183.
64. Snellman G, Melhus H, Gedeborg R, et al. Determining Vitamin D status: A comparison between commercially available assays. PloS One. 2010;5:e11555.
65. Zerwekh JE. Blood biomarkers of Vitamin D status. Am J Clin Nutr. 2008;87:1087S-1091S.