메뉴 건너뛰기




Volumn 6, Issue , 2016, Pages

DNA hypomethylation upregulates expression of the MGAT3 gene in HepG2 cells and leads to changes in N-glycosylation of secreted glycoproteins

Author keywords

[No Author keywords available]

Indexed keywords

BETA-1,4-MANNOSYL-GLYCOPROTEIN BETA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE; GLYCOPROTEIN; N ACETYLGLUCOSAMINYLTRANSFERASE;

EID: 84969862364     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep24363     Document Type: Article
Times cited : (27)

References (52)
  • 1
    • 84892754407 scopus 로고    scopus 로고
    • Emerging principles for the therapeutic exploitation of glycosylation
    • Dalziel, M., Crispin, M., Scanlan, C. N., Zitzmann, N. & Dwek, R. A. Emerging principles for the therapeutic exploitation of glycosylation. Science 3343, 1235681-1-1235681-8 (2014).
    • (2014) Science , vol.3343 , pp. 12356811-12356818
    • Dalziel, M.1    Crispin, M.2    Scanlan, C.N.3    Zitzmann, N.4    Dwek, R.A.5
  • 2
    • 84862728161 scopus 로고    scopus 로고
    • Vertebrate protein glycosylation: Diversity, synthesis and function
    • Moremen, K. W., Tiemeyer, M. & Nairn, A. V. Vertebrate protein glycosylation: diversity, synthesis and function. Nat. Rev. Mol. Cell Biol. 13, 448-462 (2012).
    • (2012) Nat. Rev. Mol. Cell Biol. , vol.13 , pp. 448-462
    • Moremen, K.W.1    Tiemeyer, M.2    Nairn, A.V.3
  • 3
    • 51049098987 scopus 로고    scopus 로고
    • A unified vision of the building blocks of life
    • Marth, J. D. A unified vision of the building blocks of life. Nat. Cell Biol. 10, 1015-1016 (2008).
    • (2008) Nat. Cell Biol. , vol.10 , pp. 1015-1016
    • Marth, J.D.1
  • 5
    • 84943637946 scopus 로고    scopus 로고
    • Complex genetics of protein glycosylation in
    • (eds Taniguchi, N., Endo, T., Hart, G. W., Seeberger, P. H. & Wong, C. H.) Ch. 8, (Springer Japan)
    • Krištić, J., Zoldoš, V. & Lauc, G. Complex genetics of protein glycosylation In Glycoscience: Biology and Medicine (eds Taniguchi, N., Endo, T., Hart, G. W., Seeberger, P. H. & Wong, C. H.) Ch. 8, 1303-1310 (Springer Japan, 2015).
    • (2015) Glycoscience: Biology and Medicine , pp. 1303-1310
    • Krištić, J.1    Zoldoš, V.2    Lauc, G.3
  • 6
    • 47749097124 scopus 로고    scopus 로고
    • Regulation of glycan structures in animal tissues: Transcript profiling of glycan-related genes
    • Nairn, A. V. et al. Regulation of glycan structures in animal tissues: transcript profiling of glycan-related genes. J. Biol. Chem. 283, 17298-17313 (2008).
    • (2008) J. Biol. Chem. , vol.283 , pp. 17298-17313
    • Nairn, A.V.1
  • 7
    • 78650712785 scopus 로고    scopus 로고
    • Identification of genes required for neural-specific glycosylation using functional genomics
    • Yamamoto-Hino, M. et al. Identification of genes required for neural-specific glycosylation using functional genomics. PLos Genet. 6, e1001254 (2010).
    • (2010) PLos Genet. , vol.6
    • Yamamoto-Hino, M.1
  • 8
    • 84873495247 scopus 로고    scopus 로고
    • Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers
    • Lauc, G. et al. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. PLos Genet. 9, e1003225 (2013).
    • (2013) PLos Genet. , vol.9
    • Lauc, G.1
  • 9
    • 84891958414 scopus 로고    scopus 로고
    • Glycosylation of immunoglobulin G: Role of genetic and epigenetic influences
    • Menni, C. et al. Glycosylation of immunoglobulin G: role of genetic and epigenetic influences. PLos One 8, e82558 (2013).
    • (2013) PLos One , vol.8
    • Menni, C.1
  • 10
    • 61849180382 scopus 로고    scopus 로고
    • Variability, heritability and environmental determinants of human plasma N-glycome
    • Knežević, A. et al. Variability, heritability and environmental determinants of human plasma N-glycome. J. Proteome Res. 8, 694-701 (2009).
    • (2009) J. Proteome Res. , vol.8 , pp. 694-701
    • Knežević, A.1
  • 11
    • 77954518174 scopus 로고    scopus 로고
    • Effects of aging, body mass index, plasma lipid profiles, and smoking on human plasma N-glycans
    • Knežević, A. et al. Effects of aging, body mass index, plasma lipid profiles, and smoking on human plasma N-glycans. Glycobiology 20, 959-969 (2010).
    • (2010) Glycobiology , vol.20 , pp. 959-969
    • Knežević, A.1
  • 14
    • 84922887966 scopus 로고    scopus 로고
    • Glycans in the immune system and the altered glycan theory of autoimmunity: A critical review
    • Maverakis, E. et al. Glycans in the immune system and the altered glycan theory of autoimmunity: a critical review. J. Autoimmun. 57, 1-13 (2015).
    • (2015) J. Autoimmun. , vol.57 , pp. 1-13
    • Maverakis, E.1
  • 15
    • 84856254596 scopus 로고    scopus 로고
    • Evolutional and clinical implications of epigenetic regulation of protein glycosylation
    • Horvat, T., Zoldoš, V. & Lauc, G. Evolutional and clinical implications of epigenetic regulation of protein glycosylation. Clin. Epigenetics 2, 425-432 (2011).
    • (2011) Clin. Epigenetics , vol.2 , pp. 425-432
    • Horvat, T.1    Zoldoš, V.2    Lauc, G.3
  • 16
  • 17
    • 80054016444 scopus 로고    scopus 로고
    • High throughput isolation and glycosylation analysis of IgG-variability and heritability of the IgG glycome in three isolated human populations
    • M111. 010090
    • Pucic, M. et al. High throughput isolation and glycosylation analysis of IgG-variability and heritability of the IgG glycome in three isolated human populations. Mol. Cell Proteomics 10, M111. 010090 (2011).
    • (2011) Mol. Cell Proteomics , vol.10
    • Pucic, M.1
  • 18
    • 71049118068 scopus 로고    scopus 로고
    • Stability of N-glycan profiles in human plasma
    • Gornik, O. et al. Stability of N-glycan profiles in human plasma. Glycobiology 19, 1547-1553 (2009).
    • (2009) Glycobiology , vol.19 , pp. 1547-1553
    • Gornik, O.1
  • 19
    • 84896320475 scopus 로고    scopus 로고
    • Changes in IgG and total plasma protein glycomes in acute systemic inflammation
    • 10.1038
    • Novokmet, M. et al. Changes in IgG and total plasma protein glycomes in acute systemic inflammation. Sci. Rep. 4, 4347, doi: 10.1038 (2014).
    • (2014) Sci. Rep. , vol.4 , pp. 4347
    • Novokmet, M.1
  • 20
    • 84959334370 scopus 로고    scopus 로고
    • The role of epigenetics in genetic and environmental epidemiology
    • Ladd-Acosta, C. & Fallin M. D. The role of epigenetics in genetic and environmental epidemiology. Epigenomics, doi: 10.2217/ epi.15.102 (2015).
    • (2015) Epigenomics
    • Ladd-Acosta, C.1    Fallin, M.D.2
  • 21
    • 84884992503 scopus 로고    scopus 로고
    • Epigenetic regulation of glycosylation is quantum mechanics of biology
    • Lauc, G., Vojta, A. & Zoldoš, V. Epigenetic regulation of glycosylation is quantum mechanics of biology. Biochim. Biophys. Acta 1840, 65-70 (2014).
    • (2014) Biochim. Biophys. Acta , vol.1840 , pp. 65-70
    • Lauc, G.1    Vojta, A.2    Zoldoš, V.3
  • 23
    • 84872384213 scopus 로고    scopus 로고
    • Reversibility of membrane N-glycome of HeLa cells upon treatment with epigenetic inhibitors
    • Horvat, T. et al. Reversibility of membrane N-glycome of HeLa cells upon treatment with epigenetic inhibitors. PLos ONE 8, e54672 (2013).
    • (2013) PLos ONE , vol.8
    • Horvat, T.1
  • 24
    • 84907200792 scopus 로고    scopus 로고
    • Specific glycosylation of membrane proteins in epithelial ovarian cancer cell lines: Glycan structures reflect gene expression and DNA methylation status
    • Anugraham, M. et al. Specific glycosylation of membrane proteins in epithelial ovarian cancer cell lines: Glycan structures reflect gene expression and DNA methylation status. Mol. Cell Proteomics 13, 2213-2232 (2014).
    • (2014) Mol. Cell Proteomics , vol.13 , pp. 2213-2232
    • Anugraham, M.1
  • 25
    • 81055154923 scopus 로고    scopus 로고
    • 5-AZA-2′-deoxycytidine induced demethylation influences N-glycosylation of secreted glycoproteins in ovarian cancer
    • Saldova, R. et al. 5-AZA-2′-deoxycytidine induced demethylation influences N-glycosylation of secreted glycoproteins in ovarian cancer. Epigenetics 6, 1362-1372 (2011).
    • (2011) Epigenetics , vol.6 , pp. 1362-1372
    • Saldova, R.1
  • 26
    • 84884652263 scopus 로고    scopus 로고
    • An epidermal microRNA regulates neuronal migration through control of the cellular glycosylation state
    • Pedersen, M. E. et al. An epidermal microRNA regulates neuronal migration through control of the cellular glycosylation state. Science 341, 1404-1408 (2013).
    • (2013) Science , vol.341 , pp. 1404-1408
    • Pedersen, M.E.1
  • 27
    • 84885121957 scopus 로고    scopus 로고
    • Effects of microRNAs on fucosyltransferase 8 (FUT8) expression in hepatocarcinoma cells
    • Bernardi, C., Soffientini, U., Piacente, F. & Tonetti, M. G. Effects of microRNAs on fucosyltransferase 8 (FUT8) expression in hepatocarcinoma cells. PLos ONE 8, e76540 (2013).
    • (2013) PLos ONE , vol.8
    • Bernardi, C.1    Soffientini, U.2    Piacente, F.3    Tonetti, M.G.4
  • 28
    • 84896536230 scopus 로고    scopus 로고
    • Mapping posttranscriptional regulation of the human glycome uncovers microRNA defining the glycocode
    • Agrawal, P. et al. Mapping posttranscriptional regulation of the human glycome uncovers microRNA defining the glycocode. Proc. Natl. Acad. Sci. USA 111, 4338-4343 (2014).
    • (2014) Proc. Natl. Acad. Sci. USA , vol.111 , pp. 4338-4343
    • Agrawal, P.1
  • 29
    • 46049085389 scopus 로고    scopus 로고
    • Aberrant expression of carbohydrate antigens in cancer: The role of genetic and epigenetic regulation
    • Kim, Y. S. & Deng, G. Aberrant expression of carbohydrate antigens in cancer: the role of genetic and epigenetic regulation. Gastroenterology 135, 305-309 (2008).
    • (2008) Gastroenterology , vol.135 , pp. 305-309
    • Kim, Y.S.1    Deng, G.2
  • 30
    • 84873589547 scopus 로고    scopus 로고
    • E-cadherin and adherens-junctions stability in gastric carcinoma: Functional implications of glycosyltransferases involving N-glycan branching biosynthesis, N-acetylglucosaminyltransferases III and v
    • Pinho, S. S. et al. E-cadherin and adherens-junctions stability in gastric carcinoma: functional implications of glycosyltransferases involving N-glycan branching biosynthesis, N-acetylglucosaminyltransferases III and V. Biochim. Biophys. Acta 1830, 2690-2700 (2013).
    • (2013) Biochim. Biophys. Acta , vol.1830 , pp. 2690-2700
    • Pinho, S.S.1
  • 31
    • 68249103612 scopus 로고    scopus 로고
    • Core fucose and bisecting GlcNAc, the direct modifiers of the N-glycan core: Their functions and target proteins
    • Takahashi, M., Kuroki, Y., Ohtsubo, K. & Taniguchi, N. Core fucose and bisecting GlcNAc, the direct modifiers of the N-glycan core: their functions and target proteins. Carbohydr. Res. 344, 1387-1390 (2009).
    • (2009) Carbohydr. Res. , vol.344 , pp. 1387-1390
    • Takahashi, M.1    Kuroki, Y.2    Ohtsubo, K.3    Taniguchi, N.4
  • 32
    • 84879101848 scopus 로고    scopus 로고
    • Identification of novel serum biomarkers of hepatocellular carcinoma using glycomic analysis
    • Kamiyama, T. et al. Identification of novel serum biomarkers of hepatocellular carcinoma using glycomic analysis. Hepatology 57, 2314-2325 (2013).
    • (2013) Hepatology , vol.57 , pp. 2314-2325
    • Kamiyama, T.1
  • 33
    • 33745913025 scopus 로고    scopus 로고
    • Profiling of glycans in serum for the discovery of potential biomarkers for ovarian cancer
    • An, H. J. et al. Profiling of glycans in serum for the discovery of potential biomarkers for ovarian cancer. J. Proteome Res. 5, 1626-1635 (2006).
    • (2006) J. Proteome Res. , vol.5 , pp. 1626-1635
    • An, H.J.1
  • 34
    • 33846542649 scopus 로고    scopus 로고
    • A serum glycomics approach to breast cancer biomarkers
    • Kirmiz, C. et al. A serum glycomics approach to breast cancer biomarkers. Mol. Cell Proteomics 6, 43-55 (2007).
    • (2007) Mol. Cell Proteomics , vol.6 , pp. 43-55
    • Kirmiz, C.1
  • 35
    • 84872171488 scopus 로고    scopus 로고
    • Fucosyltransferase 8 as a functional regulator of nonsmall cell lung cancer
    • Chen, C. Y. et al. Fucosyltransferase 8 as a functional regulator of nonsmall cell lung cancer. Proc. Natl. Acad. Sci. USA 110, 630-635 (2013).
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , pp. 630-635
    • Chen, C.Y.1
  • 36
    • 0029027831 scopus 로고
    • Suppression of lung metastasis of B16 mouse melanoma by N-acetylglucosaminyltransferase III gene transfection
    • Yoshimura, M., Nishikawa, A., Ihara, Y., Taniguchi, S. & Taniguchi, N. Suppression of lung metastasis of B16 mouse melanoma by N-acetylglucosaminyltransferase III gene transfection. Proc. Natl. Acad. Sci. USA 92, 8754-8758 (1995).
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 8754-8758
    • Yoshimura, M.1    Nishikawa, A.2    Ihara, Y.3    Taniguchi, S.4    Taniguchi, N.5
  • 37
    • 80052433997 scopus 로고    scopus 로고
    • Pathway to diabetes through attenuation of pancreatic beta cell glycosylation and glucose transport
    • Ohtsubo, K., Chen, M. Z., Olefsky, J. M. & Marth, J. D. Pathway to diabetes through attenuation of pancreatic beta cell glycosylation and glucose transport. Nat. Med. 17, 1067-1075 (2011).
    • (2011) Nat. Med. , vol.17 , pp. 1067-1075
    • Ohtsubo, K.1    Chen, M.Z.2    Olefsky, J.M.3    Marth, J.D.4
  • 38
    • 84879783987 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic analysis of 5-aza-2′-deoxycytidine (decitabine) in the design of its dose-schedule for cancer therapy
    • Karahoca, M. & Momparler, R. L. Pharmacokinetic and pharmacodynamic analysis of 5-aza-2′-deoxycytidine (decitabine) in the design of its dose-schedule for cancer therapy. Clin Epigenetics 5, 3 (2013).
    • (2013) Clin Epigenetics , vol.5 , pp. 3
    • Karahoca, M.1    Momparler, R.L.2
  • 39
    • 1242272932 scopus 로고    scopus 로고
    • The absence of p53 is critical for the induction of apoptosis by 5-aza-2′-deoxycytidine
    • Nieto, M. et al. The absence of p53 is critical for the induction of apoptosis by 5-aza-2′-deoxycytidine. Oncogene 23, 735-743 (2004).
    • (2004) Oncogene , vol.23 , pp. 735-743
    • Nieto, M.1
  • 40
    • 84857172895 scopus 로고    scopus 로고
    • Epigenetic silencing of HNF1A associates with changes in the composition of the human plasma N-glycome
    • Zoldos, V. et al. Epigenetic silencing of HNF1A associates with changes in the composition of the human plasma N-glycome. Epigenetics 7, 164-172 (2012).
    • (2012) Epigenetics , vol.7 , pp. 164-172
    • Zoldos, V.1
  • 41
    • 84875693400 scopus 로고    scopus 로고
    • A phenotype survey of 36 mutant mouse strains with gene-targeted defects in glycosyltransferases or glycan-binding proteins
    • Orr, S. L. et al. A phenotype survey of 36 mutant mouse strains with gene-targeted defects in glycosyltransferases or glycan-binding proteins. Glycobiology 23, 363-380 (2013).
    • (2013) Glycobiology , vol.23 , pp. 363-380
    • Orr, S.L.1
  • 42
    • 84899427302 scopus 로고    scopus 로고
    • The absence of core fucose up-regulates Gnt-III and Wnt target genes: A possible mechanism for an adaptive response in terms of glycan function
    • Kurimoto, A. et al. The absence of core fucose up-regulates Gnt-III and Wnt target genes: a possible mechanism for an adaptive response in terms of glycan function. J. Biol. Chem. 289, 11704-11714 (2014).
    • (2014) J. Biol. Chem. , vol.289 , pp. 11704-11714
    • Kurimoto, A.1
  • 43
    • 77952302417 scopus 로고    scopus 로고
    • Physiological and glycomic characterization of N-acetylglucosaminyltransferase-IVa and-IVb double deficient mice
    • Takamatsu, S. et al. Physiological and glycomic characterization of N-acetylglucosaminyltransferase-IVa and-IVb double deficient mice. Glycobiology 20, 485-497 (2010).
    • (2010) Glycobiology , vol.20 , pp. 485-497
    • Takamatsu, S.1
  • 44
    • 84956525817 scopus 로고    scopus 로고
    • Glyco-genes change expression in cancer through aberrant methylation
    • Vojta, A., Samarzija, I., Bockor, L. & Zoldos, V. Glyco-genes change expression in cancer through aberrant methylation. BBA Gen Subjects, doi: 10.1016/j.bbagen.2016.01.002.
    • BBA Gen Subjects
    • Vojta, A.1    Samarzija, I.2    Bockor, L.3    Zoldos, V.4
  • 45
    • 13144259662 scopus 로고    scopus 로고
    • Ectopic expression of N-acetylglucosaminyltrasferase III in transgenic hepatocytes disrupts apolipoprotein B secretion and induces aberrant cellular morphology with lipid storage
    • Ihara, Y. et al. Ectopic expression of N-acetylglucosaminyltrasferase III in transgenic hepatocytes disrupts apolipoprotein B secretion and induces aberrant cellular morphology with lipid storage. Proc. Natl. Acad. Sci. USA 95, 2526-2530 (1998).
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 2526-2530
    • Ihara, Y.1
  • 46
    • 0035980062 scopus 로고    scopus 로고
    • Down-regulation of the alpha-Gal epitope expression in N-glycans of swine endothelial cells by transfection with the N-acetylglucosaminyltransferase III gene. Modulation of the biosynthesis of terminal structures by a bisecting GlcNAc
    • Koyota, S. et al. Down-regulation of the alpha-Gal epitope expression in N-glycans of swine endothelial cells by transfection with the N-acetylglucosaminyltransferase III gene. Modulation of the biosynthesis of terminal structures by a bisecting GlcNAc. J. Biol. Chem. 276, 32867-32874 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 32867-32874
    • Koyota, S.1
  • 47
    • 20044377211 scopus 로고    scopus 로고
    • Use of targeted glycoproteomics to identify serum glycoproteins that correlate with liver cancer in woodchucks and humans
    • Block, T. M. et al. Use of targeted glycoproteomics to identify serum glycoproteins that correlate with liver cancer in woodchucks and humans. Proc. Natl. Acad. Sci. USA 102, 779-784 (2005).
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 779-784
    • Block, T.M.1
  • 48
    • 84894794252 scopus 로고    scopus 로고
    • Serum glycan as a prognostic marker in patients with advanced hepatocellular carcinoma treated with Sorafenib
    • Miyahara, K. et al. Serum glycan as a prognostic marker in patients with advanced hepatocellular carcinoma treated with Sorafenib. Hepatology 59, 355-356 (2014).
    • (2014) Hepatology , vol.59 , pp. 355-356
    • Miyahara, K.1
  • 49
    • 84907190416 scopus 로고    scopus 로고
    • The transcriptional profiling of glycogenes associated with hepatocellular carcinoma metastasis
    • Liu, T. et al. The transcriptional profiling of glycogenes associated with hepatocellular carcinoma metastasis. PLos ONE 9, e107941 (2014).
    • (2014) PLos ONE , vol.9
    • Liu, T.1
  • 50
    • 42449143890 scopus 로고    scopus 로고
    • Branched N-glycans regulate the biological functions of integrins and cadherins
    • Zhao, Y. et al. Branched N-glycans regulate the biological functions of integrins and cadherins. FEBS J. 275, 1939-1948 (2008).
    • (2008) FEBS J. , vol.275 , pp. 1939-1948
    • Zhao, Y.1
  • 51
    • 77955459115 scopus 로고    scopus 로고
    • Long-term stability of demethylation after transient exposure to 5-aza-2′-deoxycytidine correlates with sustained RNA polymerase II occupancy
    • Kagey, J. D., Kapoor-Vazirani, P., McCabe, M. T., Powell, D. R. & Vertino, P. M. Long-term stability of demethylation after transient exposure to 5-aza-2′-deoxycytidine correlates with sustained RNA polymerase II occupancy. Mol. Cancer Res. 8, 1048-1059 (2010).
    • (2010) Mol. Cancer Res. , vol.8 , pp. 1048-1059
    • Kagey, J.D.1    Kapoor-Vazirani, P.2    McCabe, M.T.3    Powell, D.R.4    Vertino, P.M.5
  • 52
    • 84874271270 scopus 로고    scopus 로고
    • NCBI GEO: Archive for functional genomics data sets-update
    • Barrett, T. et al. NCBI GEO: archive for functional genomics data sets-update. Nucleic Acids Res. 41, D991-5, doi: 10.1093/nar/ gks1193 (2013).
    • (2013) Nucleic Acids Res. , vol.41 , pp. D991-D995
    • Barrett, T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.