Piper nigrum ethanolic extract rich in piperamides causes ROS overproduction, oxidative damage in DNA leading to cell cycle arrest and apoptosis in cancer cells

Journal of Ethnopharmacology

Volumn 189, Issue , 2016, Pages 139-147

  De Souza Grinevicius, Valdelúcia Maria Alves ^a   Kviecinski, Maicon Roberto ^b   Santos Mota, Nádia Sandrini Ramos ^a   Ourique, Fabiana ^a   Porfirio Will Castro, Luiza Sheyla Evenni ^a   Andreguetti, Rafaela Rafognato ^a   Gomes Correia, João Francisco ^a   Filho, Danilo Wilhem ^a   Pich, Claus Tröger ^a   Pedrosa, Rozangela Curi ^a  

^a FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

^b UNIVERSITY OF SOUTHERN SANTA CATARINA   (Brazil)

Author keywords

Antitumor activity; Apoptosis; Cell cycle arrest; DNA damage; Piper nigrum; ROS overproduction

Indexed keywords

ALCOHOL; BLACK PEPPER EXTRACT; CARBONYL DERIVATIVE; CATALASE; CYCLIN A; DNA; DOXORUBICIN; GLUTATHIONE REDUCTASE; PIPERINE; PLASMID DNA; PROTEIN BAX; PROTEIN BCL XL; PROTEIN P53; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; ANTINEOPLASTIC AGENT; APOPTOSIS REGULATORY PROTEIN; CELL CYCLE PROTEIN; OXIDIZING AGENT; PIPERIDINE DERIVATIVE; PLANT EXTRACT; SOLVENT; TUMOR MARKER;

ABDOMINAL CIRCUMFERENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BLACK PEPPER; CANCER INHIBITION; CANCER SURVIVAL; CELL PROLIFERATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA CLEAVAGE; DNA FRAGMENTATION; DRUG CYTOTOXICITY; DRUG ISOLATION; DRUG SCREENING; EC50; EHRLICH ASCITES TUMOR; EHRLICH ASCITES TUMOR CELL; ELECTROSPRAY MASS SPECTROMETRY; ENZYME ACTIVITY; HT 29 CELL LINE; HUMAN; HUMAN CELL; LIPID PEROXIDATION; MALE; MCF 7 CELL LINE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PROTEIN CARBONYLATION; PROTEIN EXPRESSION; SURVIVAL TIME; TANDEM MASS SPECTROMETRY; THIN LAYER CHROMATOGRAPHY; ULTRAVIOLET SPECTROSCOPY; WAIST CIRCUMFERENCE; ANIMAL; BAGG ALBINO MOUSE; BREAST NEOPLASMS; CARCINOMA, EHRLICH TUMOR; CELL CYCLE CHECKPOINT; CHEMISTRY; DNA DAMAGE; DOSE RESPONSE; DRUG EFFECTS; FEMALE; GENETICS; HT-29 CELL LINE; ISOLATION AND PURIFICATION; MCF-7 CELL LINE; MEDICINAL PLANT; METABOLISM; PATHOLOGY; PHYTOTHERAPY; TIME FACTOR; TUMOR VOLUME; UPREGULATION;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BIOMARKERS, TUMOR; BREAST NEOPLASMS; CARCINOMA, EHRLICH TUMOR; CELL CYCLE CHECKPOINTS; CELL CYCLE PROTEINS; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHANOL; FEMALE; HT29 CELLS; HUMANS; LIPID PEROXIDATION; MALE; MCF-7 CELLS; MICE, INBRED BALB C; OXIDANTS; OXIDATIVE STRESS; PHYTOTHERAPY; PIPER NIGRUM; PIPERIDINES; PLANT EXTRACTS; PLANTS, MEDICINAL; PROTEIN CARBONYLATION; REACTIVE OXYGEN SPECIES; SOLVENTS; TIME FACTORS; TUMOR BURDEN; UP-REGULATION;

EID: 84969813072     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2016.05.020     Document Type: Article

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