메뉴 건너뛰기




Volumn 5, Issue 6, 2016, Pages 754-763

Mesenchymal stromal cell-derived extracellular vesicles protect the fetal brain after hypoxia-ischemia

Author keywords

Brain injury; Exosomes; Extracellular vesicles; Hypoxia ischemia; Mesenchymal stromal cells; Preterm

Indexed keywords

CASPASE 3;

EID: 84969790691     PISSN: 21576564     EISSN: 21576580     Source Type: Journal    
DOI: 10.5966/sctm.2015-0197     Document Type: Article
Times cited : (238)

References (56)
  • 1
    • 84925246443 scopus 로고    scopus 로고
    • Inflammation-induced sensitization of the brain in term infants
    • Fleiss B, Tann CJ, Degos V et al. Inflammation-induced sensitization of the brain in term infants. Dev Med Child Neurol 2015;57(suppl 3): 17-28.
    • (2015) Dev Med Child Neurol , vol.57 , pp. 17-28
    • Fleiss, B.1    Tann, C.J.2    Degos, V.3
  • 2
    • 74549131536 scopus 로고    scopus 로고
    • The worldwide incidence of preterm birth: A systematic review of maternal mortality and morbidity
    • Beck S, Wojdyla D, Say L et al. The worldwide incidence of preterm birth: A systematic review of maternal mortality and morbidity. Bull World Health Organ 2010;88:31-38.
    • (2010) Bull World Health Organ , vol.88 , pp. 31-38
    • Beck, S.1    Wojdyla, D.2    Say, L.3
  • 3
    • 84874816264 scopus 로고    scopus 로고
    • Coolingfor newborns with hypoxic ischaemic encepha-lopathy
    • Jacobs SE, Berg M, Hunt R et al. Coolingfor newborns with hypoxic ischaemic encepha-lopathy. Cochrane Database Syst Rev 2013; 1:CD003311.
    • (2013) Cochrane Database Syst Rev , vol.1
    • Jacobs, S.E.1    Berg, M.2    Hunt, R.3
  • 4
    • 0033777085 scopus 로고    scopus 로고
    • Pilot study of treatment with whole body hypothermia for neonatal encephalopathy
    • Azzopardi D, Robertson NJ, Cowan FM et al. Pilot study of treatment with whole body hypothermia for neonatal encephalopathy. Pediatrics 2000;106:684-694.
    • (2000) Pediatrics , vol.106 , pp. 684-694
    • Azzopardi, D.1    Robertson, N.J.2    Cowan, F.M.3
  • 5
    • 84875887836 scopus 로고    scopus 로고
    • EEG findings in cooled asphyxiated newborns and correlation with site and severity of brain damage
    • Briatore E, Ferrari F, Pomero G et al. EEG findings in cooled asphyxiated newborns and correlation with site and severity of brain damage. Brain Dev 2013;35:420-426.
    • (2013) Brain Dev , vol.35 , pp. 420-426
    • Briatore, E.1    Ferrari, F.2    Pomero, G.3
  • 6
    • 84883114502 scopus 로고    scopus 로고
    • Mesenchymal stem cells induce T-cell tolerance and protect the preterm brain after global hypoxia-ischemia
    • Jellema RK, Wolfs TG, Lima Passos V et al. Mesenchymal stem cells induce T-cell tolerance and protect the preterm brain after global hypoxia-ischemia. PLoS One 2013;8: e73031.
    • (2013) Plos One , pp. 8
    • Jellema, R.K.1    Wolfs, T.G.2    Lima Passos, V.3
  • 7
    • 67649171661 scopus 로고    scopus 로고
    • Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6
    • Lee RH, Pulin AA, Seo MJ et al. Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6. Cell Stem Cell 2009;5:54-63.
    • (2009) Cell Stem Cell , vol.5 , pp. 54-63
    • Lee, R.H.1    Pulin, A.A.2    Seo, M.J.3
  • 8
    • 84873567856 scopus 로고    scopus 로고
    • Encapsulated mesenchymal stem cells for in vivo immunomodulation
    • Zanotti L, Sarukhan A, Dander E et al. Encapsulated mesenchymal stem cells for in vivo immunomodulation. Leukemia 2013; 27:500-503.
    • (2013) Leukemia , vol.27 , pp. 500-503
    • Zanotti, L.1    Sarukhan, A.2    Dander, E.3
  • 9
    • 77952293014 scopus 로고    scopus 로고
    • Exosome secreted by MSC reduces myocardial ischemia/ reperfusion injury
    • Lai RC, Arslan F, Lee MM et al. Exosome secreted by MSC reduces myocardial ischemia/ reperfusion injury. Stem Cell Res (Amst) 2010; 4:214-222.
    • (2010) Stem Cell Res (Amst) , vol.4 , pp. 214-222
    • Lai, R.C.1    Arslan, F.2    Lee, M.M.3
  • 10
    • 44349134076 scopus 로고    scopus 로고
    • Reduction of myocardial infarct size by human mesen-chymal stem cell conditioned medium
    • Timmers L, Lim SK, Arslan F et al. Reduction of myocardial infarct size by human mesen-chymal stem cell conditioned medium. Stem Cell Res (Amst) 2007;1:129-137.
    • (2007) Stem Cell Res (Amst) , vol.1 , pp. 129-137
    • Timmers, L.1    Lim, S.K.2    Arslan, F.3
  • 11
    • 20244389882 scopus 로고    scopus 로고
    • Para-crine action accounts for marked protection of ischemic heart by Akt-modified mesenchy-mal stem cells
    • Gnecchi M, He H, Liang OD et al. Para-crine action accounts for marked protection of ischemic heart by Akt-modified mesenchy-mal stem cells. Nat Med 2005;11:367-368.
    • (2005) Nat Med , vol.11 , pp. 367-368
    • Gnecchi, M.1    He, H.2    Liang, O.D.3
  • 12
    • 33646252939 scopus 로고    scopus 로고
    • Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cell-mediated cardiac protection and functional improvement
    • Gnecchi M, He H, Noiseux N et al. Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cell-mediated cardiac protection and functional improvement. FASEB J 2006; 20:661-669.
    • (2006) FASEB J , vol.20 , pp. 661-669
    • Gnecchi, M.1    He, H.2    Noiseux, N.3
  • 13
    • 84878665716 scopus 로고    scopus 로고
    • The therapeutic potential of mesenchymal stem cell-derived extracellular vesicles
    • Katsuda T, Kosaka N, Takeshita F et al. The therapeutic potential of mesenchymal stem cell-derived extracellular vesicles. Proteo-mics 2013;13:1637-1653.
    • (2013) Proteo-Mics , vol.13 , pp. 1637-1653
    • Katsuda, T.1    Kosaka, N.2    Takeshita, F.3
  • 14
    • 84893803851 scopus 로고    scopus 로고
    • Stem cell therapy for neonatal brain injury
    • Fleiss B, Guillot PV, Titomanlio L et al. Stem cell therapy for neonatal brain injury. Clin Perinatol 2014;41:133-148.
    • (2014) Clin Perinatol , vol.41 , pp. 133-148
    • Fleiss, B.1    Guillot, P.V.2    Titomanlio, L.3
  • 15
    • 65649089130 scopus 로고    scopus 로고
    • Mesenchymal stem cell-derived microvesicles protect against acute tubular injury
    • Bruno S, Grange C, Deregibus MC et al. Mesenchymal stem cell-derived microvesicles protect against acute tubular injury. J Am Soc Nephrol 2009;20:1053-1067.
    • (2009) J am Soc Nephrol , vol.20 , pp. 1053-1067
    • Bruno, S.1    Grange, C.2    Deregibus, M.C.3
  • 16
    • 84887117028 scopus 로고    scopus 로고
    • Systemic administration of exosomes released from mesenchy-mal stromal cells promote functional recovery and neurovascular plasticity after stroke in rats
    • Xin H, Li Y, Cui Y et al. Systemic administration of exosomes released from mesenchy-mal stromal cells promote functional recovery and neurovascular plasticity after stroke in rats. J Cereb Blood Flow Metab 2013;33:1711-1715.
    • (2013) J Cereb Blood Flow Metab , vol.33 , pp. 1711-1715
    • Xin, H.1    Li, Y.2    Cui, Y.3
  • 17
    • 79955571241 scopus 로고    scopus 로고
    • Microvesicles derived from human adult mesen-chymal stem cells protect against ischaemia-reperfusion-induced acute and chronic kidney injury
    • Gatti S, Bruno S, Deregibus MC et al. Microvesicles derived from human adult mesen-chymal stem cells protect against ischaemia-reperfusion-induced acute and chronic kidney injury. Nephrol Dial Transplant 2011;26:1474-1483.
    • (2011) Nephrol Dial Transplant , vol.26 , pp. 1474-1483
    • Gatti, S.1    Bruno, S.2    Deregibus, M.C.3
  • 18
    • 84858185865 scopus 로고    scopus 로고
    • Micro-vesicles derived from mesenchymal stem cells enhance survival in a lethal model of acute kidney injury
    • Bruno S, Grange C, Collino F et al. Micro-vesicles derived from mesenchymal stem cells enhance survival in a lethal model of acute kidney injury. PLoS One 2012;7:e33115.
    • (2012) Plos One , pp. 7
    • Bruno, S.1    Grange, C.2    Collino, F.3
  • 19
    • 79960223740 scopus 로고    scopus 로고
    • Mesenchymal stem cell exosome: A novel stem cell-based therapy for cardiovascular disease
    • Lai RC, Chen TS, Lim SK. Mesenchymal stem cell exosome: A novel stem cell-based therapy for cardiovascular disease. Regen Med 2011; 6:481-492.
    • (2011) Regen Med , vol.6 , pp. 481-492
    • Lai, R.C.1    Chen, T.S.2    Lim, S.K.3
  • 20
    • 84964329540 scopus 로고    scopus 로고
    • Effect of exosomes derived from multipluripotent mes-enchymal stromal cells on functional recovery and neurovascular plasticity in rats after traumatic brain injury
    • Zhang Y, Chopp M, Meng Y et al. Effect of exosomes derived from multipluripotent mes-enchymal stromal cells on functional recovery and neurovascular plasticity in rats after traumatic brain injury. J Neurosurg 2015;122: 856-867.
    • (2015) J Neurosurg , vol.122 , pp. 856-867
    • Zhang, Y.1    Chopp, M.2    Meng, Y.3
  • 21
    • 84942162960 scopus 로고    scopus 로고
    • Extracellular vesicles improve post-stroke neuroregeneration and prevent postischemic immunosuppression
    • Doeppner TR, Herz J, Gorgens A et al. Extracellular vesicles improve post-stroke neuroregeneration and prevent postischemic immunosuppression. Stem Cells Translational Medicine 2015;4:1131-1143.
    • (2015) Stem Cells Translational Medicine , vol.4 , pp. 1131-1143
    • Doeppner, T.R.1    Herz, J.2    Gorgens, A.3
  • 22
    • 84898039042 scopus 로고    scopus 로고
    • MSC-derived exosomes: A novel tool to treat therapy-refractory graft-versus-host disease
    • Kordelas L, Rebmann V, Ludwig AK et al. MSC-derived exosomes: A novel tool to treat therapy-refractory graft-versus-host disease. Leukemia 2014;28:970-973.
    • (2014) Leukemia , vol.28 , pp. 970-973
    • Kordelas, L.1    Rebmann, V.2    Ludwig, A.K.3
  • 23
    • 84872679846 scopus 로고    scopus 로고
    • Cerebral inflammation and mobilization of the peripheral immune system following global hypoxia-ischemia in preterm sheep
    • Jellema RK, Lima Passos V, Zwanenburg A et al. Cerebral inflammation and mobilization of the peripheral immune system following global hypoxia-ischemia in preterm sheep. J Neuroin-flammation 2013;10:13.
    • (2013) J Neuroin-Flammation , vol.10 , pp. 13
    • Jellema, R.K.1    Lima Passos, V.2    Zwanenburg, A.3
  • 24
    • 84875677419 scopus 로고    scopus 로고
    • Heart rate-mediated blood pressure control in preterm f et al sheep under normal and hypoxic-ischemic conditions
    • Zwanenburg A, Jellema RK, Jennekens W et al. Heart rate-mediated blood pressure control in preterm f et al sheep under normal and hypoxic-ischemic conditions. Pediatr Res 2013;73:420-426.
    • (2013) Pediatr Res , vol.73 , pp. 420-426
    • Zwanenburg, A.1    Jellema, R.K.2    Jennekens, W.3
  • 25
    • 0037216408 scopus 로고    scopus 로고
    • Cardiovascular fluctuations and transfer function analysis in stable preterm infants
    • Andriessen P, Koolen AM, Berendsen RC et al. Cardiovascular fluctuations and transfer function analysis in stable preterm infants. Pediatr Res 2003;53:89-97.
    • (2003) Pediatr Res , vol.53 , pp. 89-97
    • Andriessen, P.1    Koolen, A.M.2    Berendsen, R.C.3
  • 26
    • 79959330841 scopus 로고    scopus 로고
    • Characterisation of exosomes derived from human cells by nanoparticle tracking analysis and scanning electron microscopy
    • Sokolova V, Ludwig AK, Hornung S et al. Characterisation of exosomes derived from human cells by nanoparticle tracking analysis and scanning electron microscopy. Colloids Surf B Biointerfaces 2011;87:146-150.
    • (2011) Colloids Surf B Biointerfaces , vol.87 , pp. 146-150
    • Sokolova, V.1    Ludwig, A.K.2    Hornung, S.3
  • 27
    • 84893007338 scopus 로고    scopus 로고
    • Effects of intra-amniotic lipopolysaccha-ride and maternal betamethasone on brain inflammation in f et al sheep
    • Kuypers E, Jellema RK, Ophelders DR et al. Effects of intra-amniotic lipopolysaccha-ride and maternal betamethasone on brain inflammation in f et al sheep. PLoS One 2013;8: e81644.
    • (2013) Plos One , pp. 8
    • Kuypers, E.1    Jellema, R.K.2    Ophelders, D.R.3
  • 28
    • 84886391856 scopus 로고    scopus 로고
    • Systemic G-CSF attenuates cerebral inflammation and hypomyelination but does not reduce seizure burden in preterm sheep exposed to global hypoxia-ischemia
    • Jellema RK, Lima Passos V, Ophelders DR et al. Systemic G-CSF attenuates cerebral inflammation and hypomyelination but does not reduce seizure burden in preterm sheep exposed to global hypoxia-ischemia. Exp Neu-rol 2013;250:293-303.
    • (2013) Exp Neu-Rol , vol.250 , pp. 293-303
    • Jellema, R.K.1    Lima Passos, V.2    Ophelders, D.R.3
  • 30
    • 48249100117 scopus 로고    scopus 로고
    • The spleen contributes to stroke-induced neurodegeneration
    • Ajmo CT Jr., Vernon DO, Collier L et al. The spleen contributes to stroke-induced neurodegeneration. J Neurosci Res 2008; 86:2227-2234.
    • (2008) J Neurosci Res , vol.86 , pp. 2227-2234
    • Ajmo, C.T.1    Vernon, D.O.2    Collier, L.3
  • 31
    • 13844321255 scopus 로고    scopus 로고
    • Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: Multicentre randomised trial
    • Gluckman PD, Wyatt JS, Azzopardi D et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial. Lancet 2005; 365:663-670.
    • (2005) Lancet , vol.365 , pp. 663-670
    • Gluckman, P.D.1    Wyatt, J.S.2    Azzopardi, D.3
  • 32
    • 69249216499 scopus 로고    scopus 로고
    • Clinical neonatal seizures are independently associated with outcome in infants at risk for hypoxic-ischemic brain injury
    • Glass HC, Glidden D, Jeremy RJ et al. Clinical neonatal seizures are independently associated with outcome in infants at risk for hypoxic-ischemic brain injury. J Pediatr 2009; 155:318-323.
    • (2009) J Pediatr , vol.155 , pp. 318-323
    • Glass, H.C.1    Glidden, D.2    Jeremy, R.J.3
  • 33
    • 0037176879 scopus 로고    scopus 로고
    • Seizure-associated brain injury in term new-borns with perinatal asphyxia
    • Miller SP, Weiss J, Barnwell A et al. Seizure-associated brain injury in term new-borns with perinatal asphyxia. Neurology 2002;58:542-548.
    • (2002) Neurology , vol.58 , pp. 542-548
    • Miller, S.P.1    Weiss, J.2    Barnwell, A.3
  • 34
    • 33748163533 scopus 로고    scopus 로고
    • Amplitude integrated electroencephalography in the full-term newborn
    • de Vries LS, Toet MC. Amplitude integrated electroencephalography in the full-term newborn. Clin Perinatol 2006;33:619-632.
    • (2006) Clin Perinatol , vol.33 , pp. 619-632
    • De Vries, L.S.1    Toet, M.C.2
  • 35
    • 70450253360 scopus 로고    scopus 로고
    • Therelationshipbetween systemic hemodynamic perturbations and periventricular-intraventricular hemorrhage-A historical perspective
    • Perlman JM. Therelationshipbetween systemic hemodynamic perturbations and periventricular-intraventricular hemorrhage-A historical perspective. Semin Pediatr Neurolo 2009;16:191-199.
    • (2009) Semin Pediatr Neurolo , vol.16 , pp. 191-199
    • Perlman, J.M.1
  • 36
    • 84902076967 scopus 로고    scopus 로고
    • The development of cardiovascular and cerebral vascular control in preterm infants
    • Fyfe KL, Yiallourou SR, Wong FY et al. The development of cardiovascular and cerebral vascular control in preterm infants. Sleep Med Rev 2014;18:299-310.
    • (2014) Sleep Med Rev , vol.18 , pp. 299-310
    • Fyfe, K.L.1    Yiallourou, S.R.2    Wong, F.Y.3
  • 37
    • 57149118216 scopus 로고    scopus 로고
    • Brain injury in premature infants: A complex amalgam of destructive and developmental disturbances
    • Volpe JJ. Brain injury in premature infants: A complex amalgam of destructive and developmental disturbances. Lancet Neurol 2009;8:110-124.
    • (2009) Lancet Neurol , vol.8 , pp. 110-124
    • Volpe, J.J.1
  • 38
    • 84866859990 scopus 로고    scopus 로고
    • Mesenchymal stromal cells: A key player in 'innate tolerance'?
    • Dazzi F, Lopes L, Weng L. Mesenchymal stromal cells: A key player in 'innate tolerance'? Immunology 2012;137:206-213.
    • (2012) Immunology , vol.137 , pp. 206-213
    • Dazzi, F.1    Lopes, L.2    Weng, L.3
  • 39
    • 77956420421 scopus 로고    scopus 로고
    • A new mesenchymal stem cell (MSC) paradigm: Polarization into a pro-inflammatory MSC1 or an Immunosuppressive MSC2 pheno-type
    • Waterman RS, Tomchuck SL, Henkle SL et al. A new mesenchymal stem cell (MSC) paradigm: Polarization into a pro-inflammatory MSC1 or an Immunosuppressive MSC2 pheno-type. PLoS One 2010;5:e10088.
    • (2010) Plos One , pp. 5
    • Waterman, R.S.1    Tomchuck, S.L.2    Henkle, S.L.3
  • 40
    • 84885099905 scopus 로고    scopus 로고
    • Mesenchymal stromal cells: Sensors and switchers of inflammation
    • Bernardo ME, Fibbe WE. Mesenchymal stromal cells: Sensors and switchers of inflammation. Cell Stem Cell 2013;13:392-402.
    • (2013) Cell Stem Cell , vol.13 , pp. 392-402
    • Bernardo, M.E.1    Fibbe, W.E.2
  • 41
    • 84865184497 scopus 로고    scopus 로고
    • Mesenchymal stem cells: A double-edged sword in regulating immune responses
    • Li W, Ren G, Huang Y et al. Mesenchymal stem cells: A double-edged sword in regulating immune responses. Cell Death Differ 2012;19: 1505-1513.
    • (2012) Cell Death Differ , vol.19 , pp. 1505-1513
    • Li, W.1    Ren, G.2    Huang, Y.3
  • 42
    • 77952944054 scopus 로고    scopus 로고
    • Interferon-gamma and tumor necrosis factor-alpha differentially affect cytokine expression and migration properties of mesenchymal stem cells
    • Hemeda H, Jakob M, Ludwig AK et al. Interferon-gamma and tumor necrosis factor-alpha differentially affect cytokine expression and migration properties of mesenchymal stem cells. Stem Cells Dev 2010;19:693-706.
    • (2010) Stem Cells Dev , vol.19 , pp. 693-706
    • Hemeda, H.1    Jakob, M.2    Ludwig, A.K.3
  • 43
    • 84857838864 scopus 로고    scopus 로고
    • Harnessing the mesenchymal stem cell secretome for the treatment of cardiovascular disease
    • Ranganath SH, Levy O, Inamdar MS et al. Harnessing the mesenchymal stem cell secretome for the treatment of cardiovascular disease. Cell Stem Cell 2012;10:244-258.
    • (2012) Cell Stem Cell , vol.10 , pp. 244-258
    • Ranganath, S.H.1    Levy, O.2    Inamdar, M.S.3
  • 45
    • 33645067071 scopus 로고    scopus 로고
    • Adult bone marrow stem/progenitor cells (MSCs) are preconditioned by microenvironmental" niches" in culture: A two-stage hypothesis for regulation of MSC fate
    • Gregory CA, Ylostalo J, Prockop DJ. Adult bone marrow stem/progenitor cells (MSCs) are preconditioned by microenvironmental" niches" in culture: A two-stage hypothesis for regulation of MSC fate. Sci STKE 2005;2005:p e37.
    • (2005) Sci STKE
    • Gregory, C.A.1    Ylostalo, J.2    Prockop, D.J.3
  • 46
    • 84879976839 scopus 로고    scopus 로고
    • Exosomal signaling during hypoxia mediates microvascular endothelial cell migration and vasculogenesis
    • Salomon C, Ryan J, Sobrevia L et al. Exosomal signaling during hypoxia mediates microvascular endothelial cell migration and vasculogenesis. PLoS One 2013;8:e68451.
    • (2013) Plos One , pp. 8
    • Salomon, C.1    Ryan, J.2    Sobrevia, L.3
  • 47
    • 84898461927 scopus 로고    scopus 로고
    • Extracellular vesicles derived from human bone marrow mesenchymal stem cells promote angiogenesis in a rat myocardial infarction model
    • Bian S, Zhang L, Duan L et al. Extracellular vesicles derived from human bone marrow mesenchymal stem cells promote angiogenesis in a rat myocardial infarction model. J Mol Med (Berl) 2014;92:387-397.
    • (2014) J Mol Med (Berl) , vol.92 , pp. 387-397
    • Bian, S.1    Zhang, L.2    Duan, L.3
  • 48
    • 84930424126 scopus 로고    scopus 로고
    • Human umbilical cord mesenchymal stem cell exosomes enhance angiogenesis through the Wnt4//3-catenin pathway
    • Zhang B, Wu X, Zhang X et al. Human umbilical cord mesenchymal stem cell exosomes enhance angiogenesis through the Wnt4//3-catenin pathway. Stem Cells Translational Medicine 2015;4:513-522.
    • (2015) Stem Cells Translational Medicine , vol.4 , pp. 513-522
    • Zhang, B.1    Wu, X.2    Zhang, X.3
  • 49
    • 84918536001 scopus 로고    scopus 로고
    • Proangio-genic compositions of microvesicles derived from human umbilical cord mesenchymal stem cells
    • Chen J, Liu Z, Hong MM et al. Proangio-genic compositions of microvesicles derived from human umbilical cord mesenchymal stem cells. PLoS One 2014;9:e115316.
    • (2014) Plos One , pp. 9
    • Chen, J.1    Liu, Z.2    Hong, M.M.3
  • 50
    • 84942162960 scopus 로고    scopus 로고
    • Extracellular vesicles improve post-stroke neuroregeneration and prevent post-ischemic immunosuppression
    • Doppner TR, Herz J, Gorgens A et al. Extracellular vesicles improve post-stroke neuroregeneration and prevent post-ischemic immunosuppression. Stem Cells Translational Medicine 2015;4:1131-1143.
    • (2015) Stem Cells Translational Medicine , vol.4 , pp. 1131-1143
    • Doppner, T.R.1    Herz, J.2    Gorgens, A.3
  • 51
    • 84907862127 scopus 로고    scopus 로고
    • Autograft-derived spinal cord mass following olfactory mucosal cell transplantation in a spinal cord injury patient: Case report
    • Dlouhy BJ, Awe O, Rao RC et al. Autograft-derived spinal cord mass following olfactory mucosal cell transplantation in a spinal cord injury patient: Case report. J Neurosurg Spine 2014;21:618-622.
    • (2014) J Neurosurg Spine , vol.21 , pp. 618-622
    • Dlouhy, B.J.1    Awe, O.2    Rao, R.C.3
  • 52
    • 84956943692 scopus 로고    scopus 로고
    • Applying extracellular vesicles based therapeutics in clinical trials-an ISEV position paper
    • Lener T, Gimona M, Aigner L et al. Applying extracellular vesicles based therapeutics in clinical trials-an ISEV position paper. J Extracell Vesicles 2015;4:30087.
    • (2015) J Extracell Vesicles , vol.4 , pp. 30087
    • Lener, T.1    Gimona, M.2    Aigner, L.3
  • 53
    • 84859723922 scopus 로고    scopus 로고
    • The instrumented f et al sheep as a model of cerebral white matter injury in the premature infant
    • Back SA, Riddle A, Dean J et al. The instrumented f et al sheep as a model of cerebral white matter injury in the premature infant. Neuro-therapeutics 2012;9:359-370.
    • (2012) Neuro-Therapeutics , vol.9 , pp. 359-370
    • Back, S.A.1    Riddle, A.2    Dean, J.3
  • 54
    • 69249249242 scopus 로고    scopus 로고
    • Hypoxia insults and patterns of brain injury: Insights from animal models
    • Gunn AJ, Bennet L.F et al hypoxia insults and patterns of brain injury: Insights from animal models. Clin Perinatol 2009;36:579-593.
    • (2009) Clin Perinatol , vol.36 , pp. 579-593
    • Gunn, A.J.1    Bennet, L.F.2
  • 55
    • 84862867271 scopus 로고    scopus 로고
    • Exosome-mediated transfer of miR-133b from multipotent mesenchymal stromal cells to neural cells contributes to neurite outgrowth
    • Xin H, Li Y, Buller B et al. Exosome-mediated transfer of miR-133b from multipotent mesenchymal stromal cells to neural cells contributes to neurite outgrowth. Stem Cells 2012;30:1556-1564.
    • (2012) Stem Cells , vol.30 , pp. 1556-1564
    • Xin, H.1    Li, Y.2    Buller, B.3
  • 56
    • 84876241933 scopus 로고    scopus 로고
    • Exosomes derived from human umbilical cord mesenchymal stem cells alleviate liver fibrosis
    • Li T, Yan Y, Wang B et al. Exosomes derived from human umbilical cord mesenchymal stem cells alleviate liver fibrosis. Stem Cells Dev 2013;22:845-854.
    • (2013) Stem Cells Dev , vol.22 , pp. 845-854
    • Li, T.1    Yan, Y.2    Wang, B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.