-
1
-
-
84924386749
-
Hes1 suppresses acute myeloid leukemia development through FLT3 repression
-
Kato T, Sakata-Yanagimoto M, Nishikii H, et al. Hes1 suppresses acute myeloid leukemia development through FLT3 repression. Leukemia. 2015;29:576-585.
-
(2015)
Leukemia
, vol.29
, pp. 576-585
-
-
Kato, T.1
Sakata-Yanagimoto, M.2
Nishikii, H.3
-
2
-
-
84927689722
-
The role of TLR8 signaling in acute myeloid leukemia differentiation
-
Ignatz-Hoover JJ, Wang H, Moreton SA, et al. The role of TLR8 signaling in acute myeloid leukemia differentiation. Leukemia. 2015;29:918-926.
-
(2015)
Leukemia
, vol.29
, pp. 918-926
-
-
Ignatz-Hoover, J.J.1
Wang, H.2
Moreton, S.A.3
-
3
-
-
33846230449
-
Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: Are we ready for a prognostically prioritized molecular classification?
-
Mrozek K, Marcucci G, Paschka P, et al. Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: are we ready for a prognostically prioritized molecular classification? Blood. 2007;109:431-448.
-
(2007)
Blood
, vol.109
, pp. 431-448
-
-
Mrozek, K.1
Marcucci, G.2
Paschka, P.3
-
4
-
-
84924599811
-
Prognostic and biologic significance of DNMT3B expression in older patients with cytogenetically normal primary acute myeloid leukemia
-
Niederwieser C, Kohlschmidt J, Volinia S, et al. Prognostic and biologic significance of DNMT3B expression in older patients with cytogenetically normal primary acute myeloid leukemia. Leukemia. 2015;29:567-575.
-
(2015)
Leukemia
, vol.29
, pp. 567-575
-
-
Niederwieser, C.1
Kohlschmidt, J.2
Volinia, S.3
-
6
-
-
84866551964
-
Genome-wide methylation profiling in decitabine-treated patients with acute myeloid leukemia
-
Yan P, Frankhouser D, Murphy M, et al. Genome-wide methylation profiling in decitabine-treated patients with acute myeloid leukemia. Blood. 2012;120:2466-2474.
-
(2012)
Blood
, vol.120
, pp. 2466-2474
-
-
Yan, P.1
Frankhouser, D.2
Murphy, M.3
-
7
-
-
84898679051
-
Epigenetics meets genetics in acute myeloid leukemia: Clinical impact of a novel seven-gene score
-
Marcucci G, Yan P, Maharry K, et al. Epigenetics meets genetics in acute myeloid leukemia: clinical impact of a novel seven-gene score. J Clin Oncol. 2014;32:548-556.
-
(2014)
J Clin Oncol
, vol.32
, pp. 548-556
-
-
Marcucci, G.1
Yan, P.2
Maharry, K.3
-
8
-
-
42949142189
-
Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia
-
Schlenk RF, Dohner K, Krauter J, et al. Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia. N Engl J Med. 2008;358:1909-1918.
-
(2008)
N Engl J Med
, vol.358
, pp. 1909-1918
-
-
Schlenk, R.F.1
Dohner, K.2
Krauter, J.3
-
9
-
-
84863393263
-
Prognostic relevance of integrated genetic profiling in acute myeloid leukemia
-
Patel JP, Gonen M, Figueroa ME, et al. Prognostic relevance of integrated genetic profiling in acute myeloid leukemia. N Engl J Med. 2012;366:1079-1089.
-
(2012)
N Engl J Med
, vol.366
, pp. 1079-1089
-
-
Patel, J.P.1
Gonen, M.2
Figueroa, M.E.3
-
10
-
-
84899809419
-
The de novo DNA methyltransferase DNMT3A in development and cancer
-
Chen BF, Chan WY. The de novo DNA methyltransferase DNMT3A in development and cancer. Epigenetics. 2014;9:669-677.
-
(2014)
Epigenetics
, vol.9
, pp. 669-677
-
-
Chen, B.F.1
Chan, W.Y.2
-
11
-
-
79953176952
-
Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia
-
Yan XJ, Xu J, Gu ZH, et al. Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia. Nat Genet. 2011;43:309-315.
-
(2011)
Nat Genet
, vol.43
, pp. 309-315
-
-
Yan, X.J.1
Xu, J.2
Gu, Z.H.3
-
12
-
-
84943587194
-
A tale of two siblings: Two cases of AML arising from a single pre-leukemic DNMT3A mutant clone
-
Hahn CN, Ross DM, Feng J, et al. A tale of two siblings: two cases of AML arising from a single pre-leukemic DNMT3A mutant clone. Leukemia. 2015;29:2101-2104.
-
(2015)
Leukemia
, vol.29
, pp. 2101-2104
-
-
Hahn, C.N.1
Ross, D.M.2
Feng, J.3
-
13
-
-
84879431557
-
Cooperating gene mutations in childhood acute myeloid leukemia with special reference on mutations of ASXL1, TET2, IDH1, IDH2, and DNMT3A
-
Liang DC, Liu HC, Yang CP, et al. Cooperating gene mutations in childhood acute myeloid leukemia with special reference on mutations of ASXL1, TET2, IDH1, IDH2, and DNMT3A. Blood. 2013;121:2988-2995.
-
(2013)
Blood
, vol.121
, pp. 2988-2995
-
-
Liang, D.C.1
Liu, H.C.2
Yang, C.P.3
-
14
-
-
78649906060
-
DNMT3A mutations in acute myeloid leukemia
-
Ley TJ, Ding L, Walter MJ, et al. DNMT3A mutations in acute myeloid leukemia. N Engl J Med. 2010;363:2424-2433.
-
(2010)
N Engl J Med
, vol.363
, pp. 2424-2433
-
-
Ley, T.J.1
Ding, L.2
Walter, M.J.3
-
15
-
-
79960735923
-
Incidence and prognostic influence of DNMT3A mutations in acute myeloid leukemia
-
Thol F, Damm F, Ludeking A, et al. Incidence and prognostic influence of DNMT3A mutations in acute myeloid leukemia. J Clin Oncol. 2011;29:2889-2896.
-
(2011)
J Clin Oncol
, vol.29
, pp. 2889-2896
-
-
Thol, F.1
Damm, F.2
Ludeking, A.3
-
16
-
-
84923762812
-
A new initiative on precision medicine
-
Collins FS, Varmus H. A new initiative on precision medicine. N Engl J Med. 2015;372:793-795.
-
(2015)
N Engl J Med
, vol.372
, pp. 793-795
-
-
Collins, F.S.1
Varmus, H.2
-
17
-
-
84975854830
-
Precision medicine initiative in the offing
-
Chun M. Precision medicine initiative in the offing. Cancer Discov. 2015;5:456.
-
(2015)
Cancer Discov
, vol.5
, pp. 456
-
-
Chun, M.1
-
18
-
-
84921468426
-
Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation
-
Mayle A, Yang L, Rodriguez B, et al. Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation. Blood. 2015;125:629-638.
-
(2015)
Blood
, vol.125
, pp. 629-638
-
-
Mayle, A.1
Yang, L.2
Rodriguez, B.3
-
19
-
-
84893437787
-
A DNMT3A mutation common in AML exhibits dominant-negative effects in murine ES cells
-
Kim SJ, Zhao H, Hardikar S, et al. A DNMT3A mutation common in AML exhibits dominant-negative effects in murine ES cells. Blood. 2013;122:4086-4089.
-
(2013)
Blood
, vol.122
, pp. 4086-4089
-
-
Kim, S.J.1
Zhao, H.2
Hardikar, S.3
-
20
-
-
84898545028
-
The R882H DNMT3A mutation associated with AML dominantly inhibits wildtype DNMT3A by blocking its ability to form active tetramers
-
Russler-Germain DA, Spencer DH, Young MA, et al. The R882H DNMT3A mutation associated with AML dominantly inhibits wildtype DNMT3A by blocking its ability to form active tetramers. Cancer Cell. 2014;25:442-454.
-
(2014)
Cancer Cell
, vol.25
, pp. 442-454
-
-
Russler-Germain, D.A.1
Spencer, D.H.2
Young, M.A.3
-
21
-
-
80055118997
-
Recurrent DNMT3A R882 mutations in Chinese patients with acute myeloid leukemia and myelodysplastic syndrome
-
Lin J, Yao DM, Qian J, et al. Recurrent DNMT3A R882 mutations in Chinese patients with acute myeloid leukemia and myelodysplastic syndrome. PLoS One. 2011;6:e26906.
-
(2011)
PLoS One
, vol.6
, pp. e26906
-
-
Lin, J.1
Yao, D.M.2
Qian, J.3
-
22
-
-
84908279899
-
DNMT3A and IDH mutations in acute myeloid leukemia and other myeloid malignancies: Associations with prognosis and potential treatment strategies
-
Im AP, Sehgal AR, Carroll MP, et al. DNMT3A and IDH mutations in acute myeloid leukemia and other myeloid malignancies: associations with prognosis and potential treatment strategies. Leukemia. 2014;28:1774-1783.
-
(2014)
Leukemia
, vol.28
, pp. 1774-1783
-
-
Im, A.P.1
Sehgal, A.R.2
Carroll, M.P.3
-
23
-
-
84862007674
-
Prognostic significance of DNA methyltransferase 3A mutations in cytogenetically normal acute myeloid leukemia: A study by the Acute Leukemia French Association
-
Renneville A, Boissel N, Nibourel O, et al. Prognostic significance of DNA methyltransferase 3A mutations in cytogenetically normal acute myeloid leukemia: a study by the Acute Leukemia French Association. Leukemia. 2012;26:1247-1254.
-
(2012)
Leukemia
, vol.26
, pp. 1247-1254
-
-
Renneville, A.1
Boissel, N.2
Nibourel, O.3
-
24
-
-
84881051116
-
Clinical impact of DNMT3A mutations in younger adult patients with acute myeloid leukemia: Results of the AML Study Group (AMLSG)
-
Gaidzik VI, Schlenk RF, Paschka P, et al. Clinical impact of DNMT3A mutations in younger adult patients with acute myeloid leukemia: results of the AML Study Group (AMLSG). Blood. 2013;121:4769-4777.
-
(2013)
Blood
, vol.121
, pp. 4769-4777
-
-
Gaidzik, V.I.1
Schlenk, R.F.2
Paschka, P.3
-
25
-
-
84947650028
-
Incidence and prognostic impact of DNMT3A mutations in Korean normal karyotype acute myeloid leukemia patients
-
Park SH, Choi JC, Kim SY, et al. Incidence and prognostic impact of DNMT3A mutations in Korean normal karyotype acute myeloid leukemia patients. Biomed Res Int. 2015;2015:723682.
-
(2015)
Biomed Res Int
, vol.2015
, pp. 723682
-
-
Park, S.H.1
Choi, J.C.2
Kim, S.Y.3
-
26
-
-
34547450763
-
Practical methods for incorporating summary time-to-event data into meta-analysis
-
Tierney JF, Stewart LA, Ghersi D, et al. Practical methods for incorporating summary time-to-event data into meta-analysis. Trials. 2007;8:16.
-
(2007)
Trials
, vol.8
, pp. 16
-
-
Tierney, J.F.1
Stewart, L.A.2
Ghersi, D.3
-
27
-
-
0032583387
-
Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints
-
Parmar MK, Torri V, Stewart L. Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints. Stat Med. 1998;17:2815-2834.
-
(1998)
Stat Med
, vol.17
, pp. 2815-2834
-
-
Parmar, M.K.1
Torri, V.2
Stewart, L.3
-
29
-
-
84903270849
-
Association between DNMT3A mutations and prognosis of adults with de novo acute myeloid leukemia: A systematic review and meta-analysis
-
Tie R, Zhang T, Fu H, et al. Association between DNMT3A mutations and prognosis of adults with de novo acute myeloid leukemia: a systematic review and meta-analysis. PLoS One. 2014;9:e93353.
-
(2014)
PLoS One
, vol.9
, pp. e93353
-
-
Tie, R.1
Zhang, T.2
Fu, H.3
-
30
-
-
33751267902
-
Acute myeloid leukaemia
-
Estey E, Dohner H. Acute myeloid leukaemia. Lancet. 2006;368:1894-1907.
-
(2006)
Lancet
, vol.368
, pp. 1894-1907
-
-
Estey, E.1
Dohner, H.2
-
31
-
-
84895467063
-
Acute myeloid leukaemia in Western Australia 1991-2005: A retrospective population-based study of 898 patients regarDing epidemiology, cytogenetics, treatment and outcome
-
Gangatharan SA, Grove CS, P'ng S, et al. Acute myeloid leukaemia in Western Australia 1991-2005: a retrospective population-based study of 898 patients regarDing epidemiology, cytogenetics, treatment and outcome. Intern Med J. 2013;43:903-911.
-
(2013)
Intern Med J
, vol.43
, pp. 903-911
-
-
Gangatharan, S.A.1
Grove, C.S.2
P'Ng, S.3
-
32
-
-
84905564511
-
Citrullination of DNMT3A by PADI4 regulates its stability and controls DNA methylation
-
Deplus R, Denis H, Putmans P, et al. Citrullination of DNMT3A by PADI4 regulates its stability and controls DNA methylation. Nucleic Acids Res. 2014;42:8285-8296.
-
(2014)
Nucleic Acids Res
, vol.42
, pp. 8285-8296
-
-
Deplus, R.1
Denis, H.2
Putmans, P.3
-
33
-
-
84923580247
-
DNMT3A in haematological malignancies
-
Yang L, Rau R, Goodell MA. DNMT3A in haematological malignancies. Nat Rev Cancer. 2015;15:152-165.
-
(2015)
Nat Rev Cancer
, vol.15
, pp. 152-165
-
-
Yang, L.1
Rau, R.2
Goodell, M.A.3
-
34
-
-
84900388467
-
Acute myeloid leukemia with DNMT3A mutations
-
Li Y, Zhu B. Acute myeloid leukemia with DNMT3A mutations. Leuk Lymphoma. 2014;55:2002-2012.
-
(2014)
Leuk Lymphoma
, vol.55
, pp. 2002-2012
-
-
Li, Y.1
Zhu, B.2
-
35
-
-
84863116398
-
Age-related prognostic impact of different types of DNMT3A mutations in adults with primary cytogenetically normal acute myeloid leukemia
-
Marcucci G, Metzeler KH, Schwind S, et al. Age-related prognostic impact of different types of DNMT3A mutations in adults with primary cytogenetically normal acute myeloid leukemia. J Clin Oncol. 2012;30:742-750.
-
(2012)
J Clin Oncol
, vol.30
, pp. 742-750
-
-
Marcucci, G.1
Metzeler, K.H.2
Schwind, S.3
-
36
-
-
84937576519
-
Simpson's paradox and the impact of different DNMT3A mutations on outcome in younger adults with acute myeloid leukemia
-
Gale RE, Lamb K, Allen C, et al. Simpson's paradox and the impact of different DNMT3A mutations on outcome in younger adults with acute myeloid leukemia. J Clin Oncol. 2015;33:2072-2083.
-
(2015)
J Clin Oncol
, vol.33
, pp. 2072-2083
-
-
Gale, R.E.1
Lamb, K.2
Allen, C.3
-
37
-
-
84862502902
-
Mutant DNMT3A: A marker of poor prognosis in acute myeloid leukemia
-
Ribeiro AF, Pratcorona M, Erpelinck-Verschueren C, et al. Mutant DNMT3A: a marker of poor prognosis in acute myeloid leukemia. Blood. 2012;119:5824-5831.
-
(2012)
Blood
, vol.119
, pp. 5824-5831
-
-
Ribeiro, A.F.1
Pratcorona, M.2
Erpelinck-Verschueren, C.3
-
38
-
-
84873580363
-
Acute myeloid leukaemia in adults
-
Ferrara F, Schiffer CA. Acute myeloid leukaemia in adults. Lancet. 2013;381:484-495.
-
(2013)
Lancet
, vol.381
, pp. 484-495
-
-
Ferrara, F.1
Schiffer, C.A.2
-
39
-
-
80055119130
-
Outcome of older adults with cytogenetically normal AML (CN-AML) and FLT3 mutations
-
Singh H, Asali S, Werner LL, et al. Outcome of older adults with cytogenetically normal AML (CN-AML) and FLT3 mutations. Leuk Res. 2011;35:1611-1615.
-
(2011)
Leuk Res
, vol.35
, pp. 1611-1615
-
-
Singh, H.1
Asali, S.2
Werner, L.L.3
-
40
-
-
0037114753
-
Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: Results from Cancer and Leukemia Group B (CALGB 8461)
-
Byrd JC, Mrozek K, Dodge RK, et al. Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: results from Cancer and Leukemia Group B (CALGB 8461). Blood. 2002;100:4325-4336.
-
(2002)
Blood
, vol.100
, pp. 4325-4336
-
-
Byrd, J.C.1
Mrozek, K.2
Dodge, R.K.3
|