Tumor-associated GM-CSF overexpression induces immunoinhibitory molecules via STAT3 in myeloid-suppressor cells infiltrating liver metastases

Cancer Gene Therapy

Volumn 23, Issue 6, 2016, Pages 188-198

  Thorn, M ^a   Guha, P ^a   Cunetta, M ^a   Espat, N J ^a,b   Miller, G ^c   Junghans, R P ^b   Katz, S C ^a,b  

^a ROGER WILLIAMS MEDICAL CENTER   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR RECEPTOR; INDOLEAMINE 2,3 DIOXYGENASE; JANUS KINASE 2; PROGRAMMED DEATH 1 LIGAND 1; STAT3 PROTEIN; BIOLOGICAL MARKER; PROTEIN BINDING;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GROWTH; CELL ISOLATION; CELL MATURATION; CONTROLLED STUDY; DIMERIZATION; GENE OVEREXPRESSION; IN VITRO STUDY; LIVER METASTASIS; MALE; MOUSE; MYELOID DERIVED SUPPRESSOR CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SUPPRESSOR CELL; TUMOR GROWTH; TUMOR IMMUNITY; UPREGULATION; ANIMAL; BIOLOGICAL MODEL; BONE MARROW CELL; DISEASE MODEL; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; IMMUNOMODULATION; IMMUNOPHENOTYPING; LIVER TUMOR; METABOLISM; PATHOLOGY; PROMOTER REGION; SECONDARY; SIGNAL TRANSDUCTION;

ANIMALS; ANTIGENS, CD274; BIOMARKERS; DISEASE MODELS, ANIMAL; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; IMMUNOMODULATION; IMMUNOPHENOTYPING; INDOLEAMINE-PYRROLE 2,3,-DIOXYGENASE; LIVER NEOPLASMS; MALE; MICE; MODELS, BIOLOGICAL; MYELOID CELLS; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR;

EID: 84969630979     PISSN: 09291903     EISSN: 14765500     Source Type: Journal    
DOI: 10.1038/cgt.2016.19     Document Type: Article

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