Knockdown of ApoL1 in zebrafish larvae affects the glomerular filtration barrier and the expression of nephrin

PLoS ONE

Volumn 11, Issue 5, 2016, Pages

  Kotb, Ahmed M ^a,c   Simon, Ole ^a   Blumenthal, Antje ^a   Vogelgesang, Silke ^a   Dombrowski, Frank ^a   Amann, Kerstin ^b   Zimmermann, Uwe ^a   Endlich, Karlhans ^a   Endlich, Nicole ^a  

^a UNIVERSITY MEDICINE GREIFSWALD   (Germany)

^b UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^c Assiut University   (Egypt)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN; APOLIPOPROTEIN L1; DEXTRAN; MESSENGER RNA; MORPHOLINO OLIGONUCLEOTIDE; NEPHRIN; UNCLASSIFIED DRUG; VITAMIN D BINDING PROTEIN; APOL1 PROTEIN, ZEBRAFISH; MEMBRANE PROTEIN; ZEBRAFISH PROTEIN;

ADULT; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EDEMA; EGG; EMBRYO; END STAGE RENAL DISEASE; GENE SILENCING; GLOMERULAR FILTRATION BARRIER; HUMAN; HUMAN TISSUE; LARVA; NONHUMAN; PHENOTYPE; PODOCYTE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN METABOLISM; ZEBRA FISH; ANIMAL; ANTIBODY SPECIFICITY; DEFICIENCY; ENDOTHELIUM; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PERICARDIUM;

ANIMALS; APOLIPOPROTEINS; EDEMA; ENDOTHELIUM; GENE EXPRESSION REGULATION; GLOMERULAR FILTRATION BARRIER; LARVA; MEMBRANE PROTEINS; ORGAN SPECIFICITY; PERICARDIUM; PODOCYTES; ZEBRAFISH; ZEBRAFISH PROTEINS;

EID: 84969542843     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0153768     Document Type: Article

References (26)

1. Genovese G, Friedman DJ, Ross MD, Lecordier L, Uzureau P, et al. (2010) Association of trypanolytic ApoL1 variants with kidney disease in African Americans. Science 329: 841-845. doi: 10.1126/science.1193032 PMID: 20647424
2. Pays E, Vanhollebeke B, Vanhamme L, Paturiaux-Hanocq F, Nolan DP, et al. (2006) The trypanolytic factor of human serum. Nat Rev Microbiol 4: 477-486. PMID: 16710327
3. Vanhamme L, Paturiaux-Hanocq F, Poelvoorde P, Nolan DP, Lins L, et al. (2003) Apolipoprotein L-I is the trypanosome lytic factor of human serum. Nature 422: 83-87. PMID: 12621437
4. Madhavan SM, O'Toole JF, Konieczkowski M, Ganesan S, Bruggeman LA, et al. (2011) APOL1 localization in normal kidney and nondiabetic kidney disease. J Am Soc Nephrol 22: 2119-2128. doi: 10.1681/ASN.2011010069 PMID: 21997392
5. Smith EE, Malik HS (2009) The apolipoprotein L family of programmed cell death and immunity genes rapidly evolved in primates at discrete sites of host-pathogen interactions. Genome Res 19: 850-858. doi: 10.1101/gr.085647.108 PMID: 19299565
6. Bollig F, Perner B, Besenbeck B, Kothe S, Ebert C, et al. (2009) A highly conserved retinoic acid responsive element controls wt1a expression in the zebrafish pronephros. Development 136: 2883-2892. doi: 10.1242/dev.031773 PMID: 19666820
7. Muller T, Rumpel E, Hradetzky S, Bollig F, Wegner H, et al. (2011) Non-muscle myosin IIA is required for the development of the zebrafish glomerulus. Kidney Int 80: 1055-1063. doi: 10.1038/ki.2011.256 PMID: 21849970
8. Kotb AM, Muller T, Xie J, Anand-Apte B, Endlich K, et al. (2014) Simultaneous assessment of glomerular filtration and barrier function in live zebrafish. Am J Physiol Renal Physiol 307: F1427-1434. doi: 10.1152/ajprenal.00029.2014 PMID: 25298528
9. Endlich N, Simon O, Gopferich A, Wegner H, Moeller MJ, et al. (2013) Two-Photon Microscopy Reveals Stationary Podocytes in Living Zebrafish Larvae. J Am Soc Nephrol.
10. Sato T (1968) A modified method for lead staining of thin sections. J Electron Microsc (Tokyo) 17: 158-159.
11. Price AL, Patterson N, Yu F, Cox DR, Waliszewska A, et al. (2007) A genomewide admixture map for Latino populations. Am J Hum Genet 80: 1024-1036. PMID: 17503322
12. Vanhollebeke B, Pays E (2006) The function of apolipoproteins L. Cell Mol Life Sci 63: 1937-1944. PMID: 16847577
13. Freedman BI, Kopp JB, Langefeld CD, Genovese G, Friedman DJ, et al. (2010) The apolipoprotein L1 (APOL1) gene and nondiabetic nephropathy in African Americans. J Am Soc Nephrol 21: 1422-1426. doi: 10.1681/ASN.2010070730 PMID: 20688934
14. Larsen CP, Beggs ML, Saeed M, Walker PD (2013) Apolipoprotein L1 risk variants associate with systemic lupus erythematosus-associated collapsing glomerulopathy. J Am Soc Nephrol 24: 722-725. doi: 10.1681/ASN.2012121180 PMID: 23520206
15. Behar DM, Rosset S, Tzur S, Selig S, Yudkovsky G, et al. (2010) African ancestry allelic variation at the MYH9 gene contributes to increased susceptibility to non-diabetic end-stage kidney disease in Hispanic Americans. Hum Mol Genet 19: 1816-1827. doi: 10.1093/hmg/ddq040 PMID: 20144966
16. Lan X, Jhaveri A, Cheng K, Wen H, Saleem MA, et al. (2014) APOL1 risk variants enhance podocyte necrosis through compromising lysosomal membrane permeability. Am J Physiol Renal Physiol 307: F326-336. doi: 10.1152/ajprenal.00647.2013 PMID: 24899058
17. Thomson R, Genovese G, Canon C, Kovacsics D, Higgins MK, et al. (2014) Evolution of the primate trypanolytic factor APOL1. Proc Natl Acad Sci U S A 111: E2130-2139. doi: 10.1073/pnas.1400699111 PMID: 24808134
18. Drummond IA, Majumdar A, Hentschel H, Elger M, Solnica-Krezel L, et al. (1998) Early development of the zebrafish pronephros and analysis of mutations affecting pronephric function. Development 125: 4655-4667. PMID: 9806915
19. Drummond IA (2000) The zebrafish pronephros: a genetic system for studies of kidney development. Pediatr Nephrol 14: 428-435. PMID: 10805474
20. Fukuyo Y, Nakamura T, Bubenshchikova E, Powell R, Tsuji T, et al. (2014) Nephrin and Podocin functions are highly conserved between the zebrafish pronephros and mammalian metanephros. Mol Med Rep 9: 457-465. doi: 10.3892/mmr.2013.1844 PMID: 24337247
21. Kramer-Zucker AG, Wiessner S, Jensen AM, Drummond IA (2005) Organization of the pronephric filtration apparatus in zebrafish requires Nephrin, Podocin and the FERM domain protein Mosaic eyes. Dev Biol 285: 316-329. PMID: 16102746
22. Putaala H, Soininen R, Kilpelainen P, Wartiovaara J, Tryggvason K (2001) The murine nephrin gene is specifically expressed in kidney, brain and pancreas: inactivation of the gene leads to massive proteinuria and neonatal death. Hum Mol Genet 10: 1-8. PMID: 11136707
23. Ma L, Shelness GS, Snipes JA, Murea M, Antinozzi PA, et al. (2015) Localization of APOL1 protein and mRNA in the human kidney: nondiseased tissue, primary cells, and immortalized cell lines. J Am Soc Nephrol 26: 339-348. doi: 10.1681/ASN.2013091017 PMID: 25012173
24. Anderson BR, Howell DN, Soldano K, Garrett ME, Katsanis N, et al. (2015) In vivo Modeling Implicates APOL1 in Nephropathy: Evidence for Dominant Negative Effects and Epistasis under Anemic Stress. PLoS Genet 11: e1005349. doi: 10.1371/journal.pgen.1005349 PMID: 26147622
25. Johnstone DB, Shegokar V, Nihalani D, Rathore YS, Mallik L, et al. (2012) APOL1 null alleles from a rural village in India do not correlate with glomerulosclerosis. PLoS One 7: e51546. doi: 10.1371/journal.pone.0051546 PMID: 23300552
26. Zhaorigetu S, Yang Z, Toma I, McCaffrey TA, Hu CA (2011) Apolipoprotein L6, induced in atherosclerotic lesions, promotes apoptosis and blocks Beclin 1-dependent autophagy in atherosclerotic cells. J Biol Chem 286: 27389-27398. doi: 10.1074/jbc.M110.210245 PMID: 21646352