In vivo Modeling Implicates APOL1 in Nephropathy: Evidence for Dominant Negative Effects and Epistasis under Anemic Stress

PLoS Genetics

Volumn 11, Issue 7, 2015, Pages

  Anderson, Blair R ^a   Howell, David N ^b   Soldano, Karen ^a   Garrett, Melanie E ^a   Katsanis, Nicholas ^a   Telen, Marilyn J ^a   Davis, Erica E ^a   Ashley Koch, Allison E ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN; APOLIPOPROTEIN L1; MESSENGER RNA; MYOSIN HEAVY CHAIN; PROTEIN MYH9; UNCLASSIFIED DRUG; APOL1 PROTEIN, HUMAN; HIGH DENSITY LIPOPROTEIN; MOLECULAR MOTOR; MORPHOLINO OLIGONUCLEOTIDE; MYH9 PROTEIN, HUMAN;

ALLELE; ANEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOL1 GENE; ARTICLE; CONTROLLED STUDY; EMBRYO; EPISTASIS; GENE EXPRESSION; GENE INTERACTION; GENE LOCUS; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GLOMERULUS FILTRATION; HAPLOTYPE; IN VIVO STUDY; KIDNEY DISEASE; MOLECULAR PATHOLOGY; MYH9 GENE; NONHUMAN; PODOCYTE; ZEBRA FISH; ANIMAL; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; EMBRYOLOGY; FLOW CYTOMETRY; GENE SILENCING; GENETIC PREDISPOSITION; GENETIC VARIATION; GENETICS; GLOMERULUS; GLOMERULUS FILTRATION RATE; GROWTH, DEVELOPMENT AND AGING; HUMAN; MEMBRANOUS GLOMERULONEPHRITIS; PATHOLOGY; TRANSMISSION ELECTRON MICROSCOPY;

DANIO RERIO;

ANIMALS; APOLIPOPROTEINS; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; FLOW CYTOMETRY; GENE KNOCKDOWN TECHNIQUES; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GLOMERULAR FILTRATION RATE; GLOMERULONEPHRITIS, MEMBRANOUS; HUMANS; KIDNEY GLOMERULUS; LIPOPROTEINS, HDL; MICROSCOPY, ELECTRON, TRANSMISSION; MOLECULAR MOTOR PROTEINS; MORPHOLINOS; MYOSIN HEAVY CHAINS; ZEBRAFISH;

EID: 84938781700     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1005349     Document Type: Article

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