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Volumn 4, Issue 2, 2009, Pages 76-85

Ototoxic effects of mefloquine in cochlear organotypic cultures

Author keywords

axon degeneration; inner hair cell; Mefloquine; neurons; Neuropathology; Ototoxicity; outer hair cell; spiral ganglion

Indexed keywords


EID: 84969300514     PISSN: None     EISSN: 16722930     Source Type: Journal    
DOI: 10.1016/S1672-2930(09)50018-9     Document Type: Article
Times cited : (7)

References (51)
  • 2
    • 4644348622 scopus 로고    scopus 로고
    • Prevention and treatment of malaria in young African children
    • Crawley, J., Nahlen, B., Prevention and treatment of malaria in young African children. Semin Pediatr Infect Dis 15 (2004), 169–180.
    • (2004) Semin Pediatr Infect Dis , vol.15 , pp. 169-180
    • Crawley, J.1    Nahlen, B.2
  • 3
    • 48749104463 scopus 로고    scopus 로고
    • International funding for malaria control in relation to populations at risk of stable Plasmodium falciparum transmission
    • Snow, R.W., Guerra, C.A., Mutheu, J.J., et al. International funding for malaria control in relation to populations at risk of stable Plasmodium falciparum transmission. PLoS Med, 5, 2008, e142.
    • (2008) PLoS Med , vol.5 , pp. e142
    • Snow, R.W.1    Guerra, C.A.2    Mutheu, J.J.3
  • 4
    • 0034858129 scopus 로고    scopus 로고
    • Serious adverse events of mefloquine in relation to blood level and gender
    • Schwartz, E., Potasman, I., Rotenberg, M., et al. Serious adverse events of mefloquine in relation to blood level and gender. Am J Trop Med Hyg 65 (2001), 189–192.
    • (2001) Am J Trop Med Hyg , vol.65 , pp. 189-192
    • Schwartz, E.1    Potasman, I.2    Rotenberg, M.3
  • 5
    • 0034685908 scopus 로고    scopus 로고
    • Mefloquine concentration profiles during prophylactic dose regimens
    • Kollaritsch, H., Karbwang, J., Wiedermann, G., et al. Mefloquine concentration profiles during prophylactic dose regimens. Wien Klin Wochenschr 112 (2000), 441–447.
    • (2000) Wien Klin Wochenschr , vol.112 , pp. 441-447
    • Kollaritsch, H.1    Karbwang, J.2    Wiedermann, G.3
  • 6
    • 0032749075 scopus 로고    scopus 로고
    • Population pharmacokinetics of mefloquine in patients with acute falciparum malaria
    • Simpson, J.A., Price, R., ter Kuile, F., et al. Population pharmacokinetics of mefloquine in patients with acute falciparum malaria. Clin Pharmacol Ther 66 (1999), 472–484.
    • (1999) Clin Pharmacol Ther , vol.66 , pp. 472-484
    • Simpson, J.A.1    Price, R.2    ter Kuile, F.3
  • 7
    • 0029063906 scopus 로고
    • CNS adverse events associated with antimalarial agents. Fact or fiction?
    • Phillips–Howard, P.A., ter Kuile, F.O., CNS adverse events associated with antimalarial agents. Fact or fiction?. Drug Saf 12 (1995), 370–383.
    • (1995) Drug Saf , vol.12 , pp. 370-383
    • Phillips–Howard, P.A.1    ter Kuile, F.O.2
  • 9
    • 33644655507 scopus 로고    scopus 로고
    • Mefloquine ind– uces dose–related neurological effects in a rat model
    • Dow, G.B.R., Caridha, D., Cabezas, M., et al. Mefloquine ind– uces dose–related neurological effects in a rat model. Antimicrobial Agents and Chemotherapy 50 (2006), 1045–1053.
    • (2006) Antimicrobial Agents and Chemotherapy , vol.50 , pp. 1045-1053
    • Dow, G.B.R.1    Caridha, D.2    Cabezas, M.3
  • 10
    • 0036153103 scopus 로고    scopus 로고
    • Unex–pected frequency, duration and spectrum of adverse events after therapeutic dose of mefloquine in healthy adults
    • Rendi–Wagner, P., Noedl, H., Wernsdorfer, W.H., et al. Unex–pected frequency, duration and spectrum of adverse events after therapeutic dose of mefloquine in healthy adults. Acta Trop 81 (2002), 167–173.
    • (2002) Acta Trop , vol.81 , pp. 167-173
    • Rendi–Wagner, P.1    Noedl, H.2    Wernsdorfer, W.H.3
  • 11
    • 0029814571 scopus 로고    scopus 로고
    • Comparison of adverse events associated with use of mefloquine and combination of chloroquine and proguanil as antimalarial prophylaxis: postal and telephone survey of travellers
    • Barrett, P.J., Emmins, P.D., Clarke, P.D., et al. Comparison of adverse events associated with use of mefloquine and combination of chloroquine and proguanil as antimalarial prophylaxis: postal and telephone survey of travellers. Bmj 313 (1996), 525–528.
    • (1996) Bmj , vol.313 , pp. 525-528
    • Barrett, P.J.1    Emmins, P.D.2    Clarke, P.D.3
  • 12
    • 0348066743 scopus 로고    scopus 로고
    • Neuropsychiatric reactions with mefloquine chemoprophylaxis
    • Croft, A.M., World, M.J., Neuropsychiatric reactions with mefloquine chemoprophylaxis. Lancet, 347, 1996, 326.
    • (1996) Lancet , vol.347 , pp. 326
    • Croft, A.M.1    World, M.J.2
  • 13
    • 0028113811 scopus 로고
    • Severe psychiatric side effects observed during prophylaxis and treatment with mefloquine
    • Hennequin, C., Bouree, P., Bazin, N., et al. Severe psychiatric side effects observed during prophylaxis and treatment with mefloquine. Arch Intern Med 154 (1994), 2360–2362.
    • (1994) Arch Intern Med , vol.154 , pp. 2360-2362
    • Hennequin, C.1    Bouree, P.2    Bazin, N.3
  • 14
    • 0029093625 scopus 로고
    • Mefloquine–induced grand mal seizure during malaria chemoprophylaxis in a non–epileptic subject
    • Pous, E., Gascon, J., Obach, J., et al. Mefloquine–induced grand mal seizure during malaria chemoprophylaxis in a non–epileptic subject. Trans R Soc Trop Med Hyg, 89, 1995, 434.
    • (1995) Trans R Soc Trop Med Hyg , vol.89 , pp. 434
    • Pous, E.1    Gascon, J.2    Obach, J.3
  • 15
    • 0025376020 scopus 로고
    • Neuropsychiatric side effects of mefloquine
    • Sturchler, D., Handschin, J., Kaiser, D., et al. Neuropsychiatric side effects of mefloquine. N Engl J Med 322 (1990), 1752–1753.
    • (1990) N Engl J Med , vol.322 , pp. 1752-1753
    • Sturchler, D.1    Handschin, J.2    Kaiser, D.3
  • 16
    • 0025819950 scopus 로고
    • Neuropsychiatric side effects after the use of mefloquine
    • Weinke, T., Trautmann, M., Held, T., et al. Neuropsychiatric side effects after the use of mefloquine. Am J Trop Med Hyg 45 (1991), 86–91.
    • (1991) Am J Trop Med Hyg , vol.45 , pp. 86-91
    • Weinke, T.1    Trautmann, M.2    Held, T.3
  • 17
    • 0033013280 scopus 로고    scopus 로고
    • Mefloquine for malaria chemoprophylaxis 1992–1998: a review
    • Schlagenhauf, P., Mefloquine for malaria chemoprophylaxis 1992–1998: a review. J Travel, Med 6 (1999), 122–133.
    • (1999) J Travel, Med , vol.6 , pp. 122-133
    • Schlagenhauf, P.1
  • 18
    • 0033398556 scopus 로고    scopus 로고
    • Mefloquine and ototoxicity: a report of 3 cases
    • Fusetti, M., Eibenstein, A., Corridore, V., et al. Mefloquine and ototoxicity: a report of 3 cases. Clin Ter 150 (1999), 379–382.
    • (1999) Clin Ter , vol.150 , pp. 379-382
    • Fusetti, M.1    Eibenstein, A.2    Corridore, V.3
  • 19
    • 0036212213 scopus 로고    scopus 로고
    • Leupeptin protects cochlear and vestibular hair cells from gentamicin ototoxicity
    • Ding, D., Stracher, A., Salvi, R.J., Leupeptin protects cochlear and vestibular hair cells from gentamicin ototoxicity. Hear Res 164 (2002), 115–126.
    • (2002) Hear Res , vol.164 , pp. 115-126
    • Ding, D.1    Stracher, A.2    Salvi, R.J.3
  • 20
    • 0037490192 scopus 로고    scopus 로고
    • Pifithrin–alpha suppresses p53 and protects cochlear and vestibular hair cells from cisplatin–induced apoptosis
    • Zhang, M., Liu, W., Ding, D., et al. Pifithrin–alpha suppresses p53 and protects cochlear and vestibular hair cells from cisplatin–induced apoptosis. Neuroscience 120 (2003), 191–205.
    • (2003) Neuroscience , vol.120 , pp. 191-205
    • Zhang, M.1    Liu, W.2    Ding, D.3
  • 21
    • 34249711395 scopus 로고    scopus 로고
    • Cell death after co–administration of cisplatin and ethacrynic acid
    • Ding, D., Jiang, H., Wang, P., et al. Cell death after co–administration of cisplatin and ethacrynic acid. Hear Res 226 (2007), 129–139.
    • (2007) Hear Res , vol.226 , pp. 129-139
    • Ding, D.1    Jiang, H.2    Wang, P.3
  • 22
    • 0034850207 scopus 로고    scopus 로고
    • Detection of caspase activation in situ by fluorochrome–labeled caspase inhibitors
    • 612, 614, passim.
    • Amstad, P.A., Yu, G., Johnson, G.L., et al. Detection of caspase activation in situ by fluorochrome–labeled caspase inhibitors. Biotechniques 31 (2001), 608–610 612, 614, passim.
    • (2001) Biotechniques , vol.31 , pp. 608-610
    • Amstad, P.A.1    Yu, G.2    Johnson, G.L.3
  • 23
    • 84979701851 scopus 로고    scopus 로고
    • Cochlear hair cell densities and inner ear staining techniques
    • J. Willott CRC Press Boca Raton
    • Ding, D., McFadden, S.L., Salvi, R.J., Cochlear hair cell densities and inner ear staining techniques. Willott, J., (eds.) The auditory psychobiology of the mouse, 2001, CRC Press, Boca Raton, 189–204.
    • (2001) The auditory psychobiology of the mouse , pp. 189-204
    • Ding, D.1    McFadden, S.L.2    Salvi, R.J.3
  • 24
    • 3042616941 scopus 로고    scopus 로고
    • The antimalarial potential of 4–quinolinecarbinolamines may be limited due to neurotoxicity and cross–resistance in mefloquine–resistant Plasmodium falciparum strains
    • Dow, G.S., Koenig, M.L., Wolf, L., et al. The antimalarial potential of 4–quinolinecarbinolamines may be limited due to neurotoxicity and cross–resistance in mefloquine–resistant Plasmodium falciparum strains. Antimicrob Agents Chem– other 48 (2004), 2624–2632.
    • (2004) Antimicrob Agents Chem– other , vol.48 , pp. 2624-2632
    • Dow, G.S.1    Koenig, M.L.2    Wolf, L.3
  • 25
    • 58549090904 scopus 로고    scopus 로고
    • Mefloquine neurotoxicity: a literature review
    • Toovey, S., Mefloquine neurotoxicity: a literature review. Travel Med Infect Dis 7 (2009), 2–6.
    • (2009) Travel Med Infect Dis , vol.7 , pp. 2-6
    • Toovey, S.1
  • 26
    • 0025163571 scopus 로고
    • Trimethyltin effects on auditory function and cochlear morphology
    • Crofton, K.M., Dean, K.F., Menache, M.G., et al. Trimethyltin effects on auditory function and cochlear morphology. Toxicol Appl Pharmacol 105 (1990), 123–132.
    • (1990) Toxicol Appl Pharmacol , vol.105 , pp. 123-132
    • Crofton, K.M.1    Dean, K.F.2    Menache, M.G.3
  • 27
    • 0023141511 scopus 로고
    • The species–specific nature of the ototoxicity of dihydrostreptomycin in the patas monkey
    • Stebbins, W.C., Moody, D.B., Hawkins, J.E., et al. The species–specific nature of the ototoxicity of dihydrostreptomycin in the patas monkey. Neurotoxicology 8 (1987), 33–44.
    • (1987) Neurotoxicology , vol.8 , pp. 33-44
    • Stebbins, W.C.1    Moody, D.B.2    Hawkins, J.E.3
  • 28
    • 0028867301 scopus 로고
    • Base–to–apex gradient of cell proliferation in the chick cochlea following kanamycin–induced hair cell loss
    • Hashino, E., TinHan, E.K., Salvi, R.J., Base–to–apex gradient of cell proliferation in the chick cochlea following kanamycin–induced hair cell loss. Hear Res 88 (1995), 156–168.
    • (1995) Hear Res , vol.88 , pp. 156-168
    • Hashino, E.1    TinHan, E.K.2    Salvi, R.J.3
  • 29
    • 0035033342 scopus 로고    scopus 로고
    • Differential vulnerability of basal and apical hair cells is based on intrinsic susceptibility to free radicals
    • Sha, S.H., Taylor, R., Forge, A., Schacht, J., Differential vulnerability of basal and apical hair cells is based on intrinsic susceptibility to free radicals. Hear Res 155 (2001), 1–8.
    • (2001) Hear Res , vol.155 , pp. 1-8
    • Sha, S.H.1    Taylor, R.2    Forge, A.3    Schacht, J.4
  • 30
    • 41749098046 scopus 로고    scopus 로고
    • Chloroquine–induced nitric oxide increase and cell death is dependent on cellular GSH depletion in A172 human glioblastoma cells
    • Park, B.C., Park, S.H., Paek, S.H., et al. Chloroquine–induced nitric oxide increase and cell death is dependent on cellular GSH depletion in A172 human glioblastoma cells. Toxicol Lett 178 (2008), 52–60.
    • (2008) Toxicol Lett , vol.178 , pp. 52-60
    • Park, B.C.1    Park, S.H.2    Paek, S.H.3
  • 31
    • 1842289274 scopus 로고    scopus 로고
    • Induction of apoptosis in peripheral blood lymphocytes following treatment in vitro with hydroxychloroquine
    • Meng, X.W., Feller, J.M., Ziegler, J.B., et al. Induction of apoptosis in peripheral blood lymphocytes following treatment in vitro with hydroxychloroquine. Arthritis Rheum 40 (1997), 927–935.
    • (1997) Arthritis Rheum , vol.40 , pp. 927-935
    • Meng, X.W.1    Feller, J.M.2    Ziegler, J.B.3
  • 32
    • 34447628307 scopus 로고    scopus 로고
    • Artesunate inhibits angiogenesis and downregulates vascular endothelial growth factor expression in chronic myeloid leukemia K562 cells
    • Zhou, H.J., Wang, W.Q., Wu, G.D., et al. Artesunate inhibits angiogenesis and downregulates vascular endothelial growth factor expression in chronic myeloid leukemia K562 cells. Vascul Pharmacol 47 (2007), 131–138.
    • (2007) Vascul Pharmacol , vol.47 , pp. 131-138
    • Zhou, H.J.1    Wang, W.Q.2    Wu, G.D.3
  • 33
    • 33746335995 scopus 로고    scopus 로고
    • Induction of cell cycle arrest and apoptosis in JAR trophoblast by antimalarial drugs
    • Nilkaeo, A., Bhuvanath, S., Praputbut, S., et al. Induction of cell cycle arrest and apoptosis in JAR trophoblast by antimalarial drugs. Biomed Res 27 (2006), 131–137.
    • (2006) Biomed Res , vol.27 , pp. 131-137
    • Nilkaeo, A.1    Bhuvanath, S.2    Praputbut, S.3
  • 34
    • 70249109669 scopus 로고    scopus 로고
    • Pro–apoptotic effects of antimalarial drugs do not affect mature human erythrocytes
    • Totino, P.R., Daniel–Ribeiro, C.T., Ferreira–da–Cruz, Mde F., Pro–apoptotic effects of antimalarial drugs do not affect mature human erythrocytes. Acta Trop 112 (2009), 236–238.
    • (2009) Acta Trop , vol.112 , pp. 236-238
    • Totino, P.R.1    Daniel–Ribeiro, C.T.2    Ferreira–da–Cruz, M.F.3
  • 35
    • 18144407551 scopus 로고    scopus 로고
    • Calpain mediates excitotoxic DNA fragmentation via mitochondrial pathways in adult brains: evidence from calpastatin mutant mice
    • Takano, J., Tomioka, M., Tsubuki, S., et al. Calpain mediates excitotoxic DNA fragmentation via mitochondrial pathways in adult brains: evidence from calpastatin mutant mice. J Biol Chem 280 (2005), 16175–16184.
    • (2005) J Biol Chem , vol.280 , pp. 16175-16184
    • Takano, J.1    Tomioka, M.2    Tsubuki, S.3
  • 36
    • 0029589516 scopus 로고
    • Ultrastructure of excitotoxic neuronal death in murine cortical culture
    • Regan, R.F., Panter, S.S., Witz, A., et al. Ultrastructure of excitotoxic neuronal death in murine cortical culture. Brain Res 705 (1995), 188–198.
    • (1995) Brain Res , vol.705 , pp. 188-198
    • Regan, R.F.1    Panter, S.S.2    Witz, A.3
  • 37
    • 0025012042 scopus 로고
    • Cell death via apoptosis and its relationship to growth, development and differentiation of both tumour and normal cells
    • Cotter, T.G., Lennon, S.V., Glynn, J.G., et al. Cell death via apoptosis and its relationship to growth, development and differentiation of both tumour and normal cells. Anticancer Res 10 (1990), 1153–1159.
    • (1990) Anticancer Res , vol.10 , pp. 1153-1159
    • Cotter, T.G.1    Lennon, S.V.2    Glynn, J.G.3
  • 38
    • 0035979998 scopus 로고    scopus 로고
    • Fas–associated death domain protein (FADD) and caspase–8 mediate up–regulation of c–Fos by Fas ligand and tumor necrosis factor–related apoptosis–inducing ligand (TRAIL) via a FLICE inhibitory protein (FLIP) –regulated pathway
    • Siegmund, D., Mauri, D., Peters, N., et al. Fas–associated death domain protein (FADD) and caspase–8 mediate up–regulation of c–Fos by Fas ligand and tumor necrosis factor–related apoptosis–inducing ligand (TRAIL) via a FLICE inhibitory protein (FLIP) –regulated pathway. J Biol Chem 276 (2001), 32585–32590.
    • (2001) J Biol Chem , vol.276 , pp. 32585-32590
    • Siegmund, D.1    Mauri, D.2    Peters, N.3
  • 39
    • 47349104351 scopus 로고    scopus 로고
    • Changes in FADD levels, distribution, and phosphorylation in TNFalpha–induced apoptosis in hepatocytes is caspase–3, caspase–8 and BID dependent
    • Zhang, X., Vallabhaneni, R., Loughran, P.A., et al. Changes in FADD levels, distribution, and phosphorylation in TNFalpha–induced apoptosis in hepatocytes is caspase–3, caspase–8 and BID dependent. Apoptosis 13 (2008), 983–992.
    • (2008) Apoptosis , vol.13 , pp. 983-992
    • Zhang, X.1    Vallabhaneni, R.2    Loughran, P.A.3
  • 40
    • 0033667778 scopus 로고    scopus 로고
    • FADD/MORT1 and caspase–8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2
    • Sprick, M.R., Weigand, M.A., Rieser, E., et al. FADD/MORT1 and caspase–8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2. Immunity 12 (2000), 599–609.
    • (2000) Immunity , vol.12 , pp. 599-609
    • Sprick, M.R.1    Weigand, M.A.2    Rieser, E.3
  • 41
    • 17644392418 scopus 로고    scopus 로고
    • Recruitment of TRADD, FADD, and caspase 8 to double–stranded RNA–triggered death inducing signaling complexes(dsRNA–DISCs)
    • Iordanov, M.S., Kirsch, J.D., Ryabinina, O.P., et al. Recruitment of TRADD, FADD, and caspase 8 to double–stranded RNA–triggered death inducing signaling complexes(dsRNA–DISCs). Apoptosis 10 (2005), 167–176.
    • (2005) Apoptosis , vol.10 , pp. 167-176
    • Iordanov, M.S.1    Kirsch, J.D.2    Ryabinina, O.P.3
  • 42
    • 2942692167 scopus 로고    scopus 로고
    • Overexpression of Bcl–2 prevents neomycin–induced hair cell death and caspase–9 activation in the adult mouse utricle in vitro
    • Cunningham, L.L., Matsui, J.I., Warchol, M.E., et al. Overexpression of Bcl–2 prevents neomycin–induced hair cell death and caspase–9 activation in the adult mouse utricle in vitro. J Neurobiol 60 (2004), 89–100.
    • (2004) J Neurobiol , vol.60 , pp. 89-100
    • Cunningham, L.L.1    Matsui, J.I.2    Warchol, M.E.3
  • 43
    • 3342956466 scopus 로고    scopus 로고
    • Caspase–9 regulation: an update
    • Johnson, C.R., Jarvis, W.D., Caspase–9 regulation: an update. Apoptosis 9 (2004), 423–427.
    • (2004) Apoptosis , vol.9 , pp. 423-427
    • Johnson, C.R.1    Jarvis, W.D.2
  • 44
    • 38049126036 scopus 로고    scopus 로고
    • Delineation of the caspase–9 signaling cascade
    • Guerrero, A.D., Chen, M., Wang, J., Delineation of the caspase–9 signaling cascade. Apoptosis 13 (2008), 177–186.
    • (2008) Apoptosis , vol.13 , pp. 177-186
    • Guerrero, A.D.1    Chen, M.2    Wang, J.3
  • 45
    • 0036299222 scopus 로고    scopus 로고
    • Calpain activation after mitochondrial permeability transition in microcystin–induced cell death in rat hepatocytes
    • Ding, W.X., Shen, H.M., Ong, C.N., Calpain activation after mitochondrial permeability transition in microcystin–induced cell death in rat hepatocytes. Biochem Biophys Res Commun 291 (2002), 321–331.
    • (2002) Biochem Biophys Res Commun , vol.291 , pp. 321-331
    • Ding, W.X.1    Shen, H.M.2    Ong, C.N.3
  • 46
    • 85044706202 scopus 로고    scopus 로고
    • The acute neurotoxicity of mefloquine may be mediated through a disruption of calcium homeostasis and ER function in vitro
    • Dow, G.S., Hudson, T.H., Vahey, M., et al. The acute neurotoxicity of mefloquine may be mediated through a disruption of calcium homeostasis and ER function in vitro. Malar J, 2, 2003, 14.
    • (2003) Malar J , vol.2 , pp. 14
    • Dow, G.S.1    Hudson, T.H.2    Vahey, M.3
  • 47
    • 33845337981 scopus 로고    scopus 로고
    • Calpain 10: a mitochondrial calpain and its role in calcium–induced mitochondrial dysfunction
    • Arrington, D.D., Van Vleet, T.R., Schnellmann, R.G., Calpain 10: a mitochondrial calpain and its role in calcium–induced mitochondrial dysfunction. Am J Physiol Cell Physiol 291 (2006), C1159–C1171.
    • (2006) Am J Physiol Cell Physiol , vol.291 , pp. C1159-C1171
    • Arrington, D.D.1    Van Vleet, T.R.2    Schnellmann, R.G.3
  • 48
    • 0037047326 scopus 로고    scopus 로고
    • Calpain and mitochondria in ischemia/reperfusion injury
    • Chen, M., Won, D.J., Krajewski, S., et al. Calpain and mitochondria in ischemia/reperfusion injury. J Biol Chem 277 (2002), 29181–29186.
    • (2002) J Biol Chem , vol.277 , pp. 29181-29186
    • Chen, M.1    Won, D.J.2    Krajewski, S.3
  • 49
    • 0029089779 scopus 로고
    • Calpain as a novel target for treating acute neurodegenerative disorders
    • Bartus, R.T., Elliott, P.J., Hayward, N.J., et al. Calpain as a novel target for treating acute neurodegenerative disorders. Neurol Res 17 (1995), 249–258.
    • (1995) Neurol Res , vol.17 , pp. 249-258
    • Bartus, R.T.1    Elliott, P.J.2    Hayward, N.J.3
  • 50
    • 0037972418 scopus 로고    scopus 로고
    • Expression of gap junction protein connexin43 in the adult rat cochlea: comparison with connexin26
    • Suzuki, T., Takamatsu, T., Oyamada, M., Expression of gap junction protein connexin43 in the adult rat cochlea: comparison with connexin26. J Histochem Cytochem 51 (2003), 903–912.
    • (2003) J Histochem Cytochem , vol.51 , pp. 903-912
    • Suzuki, T.1    Takamatsu, T.2    Oyamada, M.3
  • 51
    • 0031943736 scopus 로고    scopus 로고
    • Post–marketing surveillance of prophylactic mefloquine (Lariam) use in pregnancy
    • Vanhauwere, B., Maradit, H., Kerr, L., Post–marketing surveillance of prophylactic mefloquine (Lariam) use in pregnancy. Am J Trop Med Hyg 58 (1998), 17–21.
    • (1998) Am J Trop Med Hyg , vol.58 , pp. 17-21
    • Vanhauwere, B.1    Maradit, H.2    Kerr, L.3


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