Changes in FADD levels, distribution, and phosphorylation in TNFα-induced apoptosis in hepatocytes is caspase-3, caspase-8 and BID dependent

Apoptosis

Volumn 13, Issue 8, 2008, Pages 983-992

  Zhang, Xiaoying ^a   Vallabhaneni, Raghuveer ^a   Loughran, Patricia A ^a   Shapiro, Richard ^a   Yin, Xiao Min ^a   Yuan, Youzhong ^a   Billiar, Timothy R ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; BID; Caspase 8; Caspse 3; Dimerization; FADD; Hepatocytes; Nuclear cytoplasm translocation; Phosphorylation; TNF

Indexed keywords

CASPASE 3; CASPASE 8; FAS ASSOCIATED DEATH DOMAIN PROTEIN; PROTEIN BID; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOPLASM; ENZYME ACTIVATION; ENZYME ACTIVITY; LIVER CELL; MALE; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PHOSPHORYLATION;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; APOPTOSIS; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; CASPASE 3; CASPASE 8; CASPASES; CYTOPLASM; DACTINOMYCIN; DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS; FAS-ASSOCIATED DEATH DOMAIN PROTEIN; HEPATOCYTES; HUMANS; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 47349104351     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-008-0228-3     Document Type: Article

References (40)

1. T Patel 2000 Apoptosis in hepatic pathophysiology Clin Liver Dis 4 295 317 10.1016/S1089-3261(05)70112-4
2. JM Schattenberg PR Galle M Schuchmann 2006 Apoptosis in liver disease Liver Int 26 904 911 10.1111/j.1478-3231.2006.01324.x
3. W Schneider-Brachert V Tchikov J Neumeyer M Jakob 2004 Compartmentalization of TNF receptor 1 signaling: internalized TNF receptosomes as death signaling vesicles Immunity 21 415 428
4. BE Jones CR Lo H Liu 2000 Hepatocytes sensitized to tumor necrosis factor-alpha cytotoxicity undergo apoptosis through caspase-dependent and caspase-independent pathways J Biol Chem 275 705 712 10.1074/jbc.275.1.705
5. AM Chinnaiyan K O'Rourke M Tewari VM Dixit 1995 FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis Cell 81 505 512 10.1016/0092-8674(95)90071-3
6. MP Boldin EE Varfolomeev Z Pancer IL Mett JH Camonis D Wallach 1995 A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain J Biol Chem 270 7795 7798 10.1074/jbc.270.14.7795
7. PK Kim Y Wang A Gambotto 2002 Hepatocyte Fas-associating death domain protein/mediator of receptor-induced toxicity (FADD/MORT1) levels increase in response to pro-apoptotic stimuli J Biol Chem 277 38855 38862 10.1074/jbc.M203484200
8. Y Wang PK Kim X Peng 2006 Cyclic AMP and cyclic GMP suppress TNFalpha-induced hepatocyte apoptosis by inhibiting FADD up-regulation via a protein kinase A-dependent pathway Apoptosis 11 441 451 10.1007/s10495-005-4293- 6
9. C Scaffidi J Volkland I Blomberg I Hoffmann PH Krammer ME Peter 2000 Phosphorylation of FADD/ MORT1 at serine 194 and association with a 70-kDa cell cycle-regulated protein kinase J Immunol 164 1236 1242
10. RA Screaton S Kiessling OJ Sansom 2003 Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: a potential link between genome surveillance and apoptosis Proc Natl Acad Sci USA 100 5211 5216 10.1073/pnas.0431215100
11. M Eberstadt B Huang Z Chen 1998 NMR structure and mutagenesis of the FADD (Mort1) death-effector domain Nature 392 941 945 10.1038/31972
12. L Fan KW Freeman T Khan E Pham DM Spencer 1999 Improved artificial death switches based on caspases and FADD Hum Gene Ther 10 2273 2285 10.1089/10430349950016924
13. JR Muppidi AA Lobito M Ramaswamy 2006 Homotypic FADD interactions through a conserved RXDLL motif are required for death receptor-induced apoptosis Cell Death Differ 13 1641 1650 10.1038/sj.cdd.4401855
14. C Sandu G Morisawa I Wegorzewska T Huang AF Arechiga JM Hill 2006 FADD self-association is required for stable interaction with an activated death receptor Cell Death Differ 13 2052 2061 10.1038/sj.cdd.4401966
15. MS Sheikh Y Huang 2003 The FADD is going nuclear Cell Cycle 2 346 347
16. C Scaffidi J Volkland I Blomberg I Hoffmann PH Krammer ME Peter 2000 Phosphorylation of FADD/ MORT1 at serine 194 and association with a 70-kDa cell cycle-regulated protein kinase J Immunol 164 1236 1242
17. RM Siegel DA Martin L Zheng 1998 Death-effector filaments: novel cytoplasmic structures that recruit caspases and trigger apoptosis J Cell Biol 141 1243 1253 10.1083/jcb.141.5.1243
18. S Li Y Zhao X He 2002 Relief of extrinsic pathway inhibition by the Bid-dependent mitochondrial release of Smac in Fas-mediated hepatocyte apoptosis J Biol Chem 277 26912 26920 10.1074/jbc.M200726200
19. Sprott SC, Hammond KD, Savage N (1991) Subcellular fractionation of murine erythroleukemic cells: distribution of protein kinases. Anal Biochem 194:407-412. doi: 10.1074/jbc.M200726200
20. Cho HJ, Martin E, Xie QW, Sassa S, Nathan C (1995) Inducible nitric oxide synthase: identification of amino acid residues essential for dimerization and binding of tetrahydrobiopterin. Proc Natl Acad Sci USA 92:11514-11518. doi: 10.1073/pnas.92.25.11514
21. MS Bhojani G Chen BD Ross DG Beer A Rehemtulla 2005 Nuclear localized phosphorylated FADD induces cell proliferation and is associated with aggressive lung cancer Cell Cycle 4 1478 1481
22. G Chen MS Bhojani AC Heaford 2005 Phosphorylated FADD induces NF-kappaB, perturbs cell cycle, and is associated with poor outcome in lung adenocarcinomas Proc Natl Acad Sci USA 102 12507 12512 10.1073/pnas.0500397102
23. J Li CA Bombeck S Yang YM Kim TR Billiar 1999 Nitric oxide suppresses apoptosis via interrupting caspase activation and mitochondrial dysfunction in cultured hepatocytes J Biol Chem 274 17325 17333 10.1074/jbc.274.24.17325
24. ME Guicciardi GJ Gores 2004 Cheating death in the liver Nat Med 10 587 588 10.1038/nm0604-587
25. MP Boldin TM Goncharov YV Goltsev D Wallach 1996 Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death Cell 85 803 815 10.1016/S0092-8674(00)81265-9
26. M Muzio AM Chinnaiyan FC Kischkel 1996 FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex Cell 85 817 827 10.1016/S0092-8674(00)81266-0
27. M Gomez-Angelats JA Cidlowski 2003 Molecular evidence for the nuclear localization of FADD Cell Death Differ 10 791 797 10.1038/sj.cdd.4401237
28. PE Carrington C Sandu Y Wei 2006 The structure of FADD and its mode of interaction with procaspase-8 Mol Cell 22 599 610 10.1016/j.molcel.2006.04.018
29. N Werneburg ME Guicciardi XM Yin GJ Gores 2004 TNF-alpha-mediated lysosomal permeabilization is FAN and caspase 8/Bid dependent Am J Physiol Gastrointest Liver Physiol 287 G436 G443 10.1152/ajpgi.00019.2004
30. ME Guicciardi J Deussing H Miyoshi 2000 Cathepsin B contributes to TNF-a-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c J Clin Invest 106 1127 1137 10.1172/JCI9914
31. C Scaffidi S Fulda A Srinivasan C Friesen F Li KJ Tomaselli 1998 Two CD95 (APO-1/Fas) signaling pathways EMBO J 17 1675 1687 10.1093/emboj/17.6.1675
32. C Scaffidi I Schmitz J Zha SJ Korsmeyer PH Krammer ME Peter 1999 Differential modulation of apoptosis sensitivity in CD95 type I and type II cells J Biol Chem 274 22532 22538 10.1074/jbc.274.32.22532
33. E Bossy-Wetzel D Green 1999 Caspases induce cytochrome c release from mitochondria by activating cytosolic factors J Biol Chem 274 17484 17490 10.1074/jbc.274.25.17484
34. WX Ding HM Ni D DiFrancesca DB Stolz XM Yin 2004 Bid-dependent generation of oxygen radicals promotes death receptor activation-induced apoptosis in murine hepatocytes Hepatology 40 403 413 10.1002/hep.20310
35. EC Alappat J Volkland ME Peter 2003 Cell cycle effects by C-FADD depend on its C-terminal phosphorylation site J Biol Chem 278 41585 41588 10.1074/jbc.C300385200
36. EC Alappat C Feig B Boyerinas 2005 Phosphorylation of FADD at serine 194 by CKIalpha regulates its nonapoptotic activities Mol Cell 19 321 332 10.1016/j.molcel.2005.06.024
37. ZC Hua SJ Sohn C Kang D Cado A Winoto 2003 A function of Fas-associated death domain protein in cell cycle progression localized to a single amino acid at its C-terminal region Immunity 18 513 521 10.1016/S1074-7613(03)00083-9
38. K Shimada S Matsuyoshi M Nakamura E Ishida M Kishi N Konishi 2004 Phosphorylation of FADD is critical for sensitivity to anticancer drug-induced apoptosis Carcinogenesis 25 1089 1097 10.1093/carcin/bgh130
39. K Shimada M Nakamura E Ishida M Kishi S Yonehara N Konishi 2002 Phosphorylation of Fas-associated death domain contributes to enhancement of etoposide-induced apoptosis in prostate cancer cells Jpn J Cancer Res 93 1164 1174
40. K Izeradjene L Douglas AB Delaney JA Houghton 2004 Casein kinase I attenuates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by regulating the recruitment of fas-associated death domain and procaspase-8 to the death-inducing signaling complex Cancer Res 64 8036 8044 10.1158/0008-5472.CAN-04-0762