Saliva as a diagnostic tool for oral and systemic diseases

Journal of Oral Biology and Craniofacial Research

Volumn 6, Issue 1, 2016, Pages 67-76

  Javaid, Mohammad A ^a   Ahmed, Ahad S ^b   Durand, Robert ^c   Tran, Simon D ^b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

Diagnostics; Saliva; Salivary

Indexed keywords

EID: 84969142807     PISSN: 22124268     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jobcr.2015.08.006     Document Type: Review

References (71)

1. Holschneider C.H., Berek J.S. Ovarian cancer: epidemiology, biology, and prognostic factors. Semin Surg Oncol 2000, 19(1):3-10.
2. Crandall J.P., Knowler W.C., Kahn S.E., et al. The prevention of type 2 diabetes. Nat Clin Pract Endocrinol Metab 2008, 4(7):382-393.
3. Lee Y.H., Wong D.T. Saliva: an emerging biofluid for early detection of diseases. Am J Dent 2009, 22(4):241-248.
4. Anker P., Mulcahy H., Chen X.Q., Stroun M. Detection of circulating tumour DNA in the blood (plasma/serum) of cancer patients. Cancer Metastasis Rev 1999, 18(1):65-73.
5. Rieger-Christ K.M., Mourtzinos A., Lee P.J., et al. Identification of fibroblast growth factor receptor 3 mutations in urine sediment DNA samples complements cytology in bladder tumor detection. Cancer 2003, 98(4):737-744.
6. Wong L.J., Lueth M., Li X.N., Lau C.C., Vogel H. Detection of mitochondrial DNA mutations in the tumor and cerebrospinal fluid of medulloblastoma patients. Cancer Res 2003, 63(14):3866-3871.
7. Pfaffe T., Cooper-White J., Beyerlein P., Kostner K., Punyadeera C. Diagnostic potential of saliva: current state and future applications. Clin Chem 2011, 57(5):675-687.
8. Mandel I.D., Kutscher A., Denning C.R., Thompson R.H., Zegarelli E.V. Salivary studies in cystic fibrosis. Am J Dis Child 1967, 113(4):431-438.
9. Slavkin H.C. Toward molecularly based diagnostics for the oral cavity. J Am Dent Assoc 1998, 129(8):1138-1143.
10. Mandel I.D. A contemporary view of salivary research. Crit Rev Oral Biol Med 1993, 4(3-4):599-604.
11. Gröschl M. The physiological role of hormones in saliva. Bioessays 2009, 31(8):843-852.
12. Haeckel R., Hanecke P. The application of saliva, sweat and tear fluid for diagnostic purposes. Ann Biol Clin (Paris) 1993, 51(10-11):903-910.
13. Lima D.P., Diniz D.G., Moimaz S.A.S., Sumida D.H., Okamoto A.C. Saliva: reflection of the body. Intl J Infect Diseases 2010, 14(3):e184-e188.
14. Miller S.M. Saliva testing - a nontraditional diagnostic tool. Clin Lab Sci 1994, 7(1):39-44.
15. Tremblay M., Loucif Y., Methot J., Brisson D., Gaudet D. Salivary pH as a marker of plasma adiponectin concentrations in women. Diabetol Metab Syndr 2012, 4(4).
16. Chiappin S., Antonelli G., Gatti R., De Palo E.F. Saliva specimen: a new laboratory tool for diagnostic and basic investigation. Clin Chim Acta 2007, 383(1-2):30-40.
17. Daniels T.E. Sjogren's syndrome: clinical spectrum and current diagnostic controversies. Adv Dent Res 1996, 10(1):3-8.
18. Dirix P., Nuyts S., Vander Poorten V., Delaere P., Van den Bogaert W. Efficacy of the BioXtra dry mouth care system in the treatment of radiotherapy-induced xerostomia. Support Care Cancer 2007, 15(12):1429-1436.
19. Streckfus C.F., Bigler L.R. Saliva as a diagnostic fluid. Oral Dis 2002, 8(2):69-76.
20. Baldini C., Giusti L., Ciregia F., et al. Proteomic analysis of saliva: a unique tool to distinguish primary Sjogren's syndrome from secondary Sjogren's syndrome and other sicca syndromes. Arthritis Res Ther 2011, 13(6):R194.
21. Starosta V., Rietschel E., Paul K., Baumann U., Griese M. Oxidative changes of bronchoalveolar proteins in cystic fibrosis. Chest 2006, 129(2):431-437.
22. Khan T.Z., Wagener J.S., Bost T., Martinez J., Accurso F.J., Riches D.W. Early pulmonary inflammation in infants with cystic fibrosis. Am J Respir Crit Care Med 1995, 151(4):1075-1082.
23. Greabu M., Battino M., Mohora M., et al. Saliva - a diagnostic window to the body, both in health and in disease. J Med Life 2009, 2(2):124-132.
24. Goncalves A.C., Marson F.A., Mendonca R.M., et al. Saliva as a potential tool for cystic fibrosis diagnosis. Diagn Pathol 2013, 8:46.
25. Livnat G., Bentur L., Kuzmisnsky E., Nagler R.M. Salivary profile and oxidative stress in children and adolescents with cystic fibrosis. J Oral Pathol Med 2010, 39(1):16-21.
26. Public Health Agency of Canada Cardiovascular Disease Morbidity, Mortality and Risk Factors Surveillance Information 2009, [cited 2013-06-28]; Available from: http://www.phac-aspc.gc.ca/cd-mc/cvd-mcv/cvdmmrf-mmmcvfr-eng.php#1a.
27. Hansson G.K. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med 2005, 352(16):1685-1695.
28. Libby P., Ridker P.M., Maseri A. Inflammation and atherosclerosis. Circulation 2002, 105(9):1135-1143.
29. Khot U.N., Khot M.B., Bajzer C.T., et al. Prevalence of conventional risk factors in patients with coronary heart disease. JAMA 2003, 290(7):898-904.
30. Cushman M., Arnold A.M., Psaty B.M., et al. C-reactive protein and the 10-year incidence of coronary heart disease in older men and women The Cardiovascular Health Study. Circulation 2005, 112(1):25-31.
31. Wilson A.M., Ryan M.C., Boyle A.J. The novel role of C-reactive protein in cardiovascular disease: risk marker or pathogen. Int J Cardiol 2006, 106(3):291-297.
32. Out D., Hall R.J., Granger D.A., Page G.G., Woods S.J. Assessing salivary C-reactive protein: longitudinal associations with systemic inflammation and cardiovascular disease risk in women exposed to intimate partner violence. Brain Behav Immun 2012, 26(4):543-551.
33. Saunders J.T., Nambi V., de Lemos J.A., et al. Cardiac troponin T measured by a highly sensitive assay predicts coronary heart disease, heart failure, and mortality in the Atherosclerosis Risk in Communities Study. Circulation 2011, 123(13):1367-1376.
34. Mirzaii-Dizgah I., Riahi E. Salivary high-sensitivity cardiac troponin T levels in patients with acute myocardial infarction. Oral Dis 2012.
35. Public Health Agency of Canada Diabetes in Canada: Facts and figures from a public health perspective 2011, [cited 2013-06-28]; Available from: http://www.phac-aspc.gc.ca/cd-mc/publications/diabetes-diabete/facts-figures-faits-chiffres-2011/highlights-saillants-eng.php#chp1.
36. Border M.B., Schwartz S., Carlson J., et al. Exploring salivary proteomes in edentulous patients with type 2 diabetes. Mol Biosyst 2012, 8(4):1304-1310.
37. Rao P.V., Reddy A.P., Lu X., et al. Proteomic identification of salivary biomarkers of type-2 diabetes. J Proteome Res 2009, 8(1):239-245.
38. Kallings L.O. The first postmodern pandemic: 25 years of HIV/AIDS. J Intern Med 2008, 263(3):218-243.
39. Public Health Agency of Canada. At a Glance - HIV and AIDS in Canada: Surveillance Report to December 31st, 2011 [cited 2013-06-28]; Available from: . http://www.phac-aspc.gc.ca/aids-sida/publication/survreport/2011/dec/index-eng.php.
40. Food and Drug Administration (FDA) Evaluation of the safety and effectiveness of the OraQuick In-Home HIV Test. In: 102nd Meeting of the Blood Product Advisory Committee (BPAC) 2012, 15-16 May [cited 2013-06-28]; Available from: http://www.tinyurl.com/c9xwaeg.
41. Pant Pai N., Balram B., Shivkumar S., et al. Head-to-head comparison of accuracy of a rapid point-of-care HIV test with oral versus whole-blood specimens: a systematic review and meta-analysis. Lancet Infect Dis 2012, 12(5):373-380.
42. Speight P.M., Palmer S., Moles D.R., et al. The cost-effectiveness of screening for oral cancer in primary care. Health Technol Assess 2006, 10(14):1-144. iii-iv.
43. Patton L.L., Epstein J.B., Kerr A.R. Adjunctive techniques for oral cancer examination and lesion diagnosis: a systematic review of the literature. J Am Dent Assoc 2008, 139(7):896-905. quiz 93-4.
44. Franzmann E.J., Reategui E.P., Carraway K.L., Hamilton K.L., Weed D.T., Goodwin W.J. Salivary soluble CD44: a potential molecular marker for head and neck cancer. Cancer Epidemiol Biomarkers Prev 2005, 14(3):735-739.
45. Nagler R., Bahar G., Shpitzer T., Feinmesser R. Concomitant analysis of salivary tumor markers - a new diagnostic tool for oral cancer. Clin Cancer Res 2006, 12(13):3979-3984.
46. Li Y., St John M.A., Zhou X., et al. Salivary transcriptome diagnostics for oral cancer detection. Clin Cancer Res 2004, 10(24):8442-8450.
47. Elashoff D., Zhou H., Reiss J., et al. Prevalidation of salivary biomarkers for oral cancer detection. Cancer Epidemiol Biomarkers Prev 2012, 21(4):664-672.
48. Marur S., D'Souza G., Westra W.H., Forastiere A.A. HPV-associated head and neck cancer: a virus-related cancer epidemic. Lancet Oncol 2010, 11(8):781-789.
49. Report on the Findings of the Oral Health Component of the Canadian Health Measures Survey (2007-2009). 2010 [cited 2013-06-28]; Available from: . http://www.fptdwg.ca/English/e-chms.html.
50. Kutsch V.K., Young D.A. New directions in the etiology of dental caries disease. J Calif Dent Assoc 2011, 39(10):716-721.
51. Tanzer J.M., Livingston J., Thompson A.M. The microbiology of primary dental caries in humans. J Dent Educ 2001, 65(10):1028-1037.
52. Nishikawara F., Katsumura S., Ando A., et al. Correlation of cariogenic bacteria and dental caries in adults. J Oral Sci 2006, 48(4):245-251.
53. Teanpaisan R., Thitasomakul S., Piwat S., Thearmontree A., Pithpornchaiyakul W., Chankanka O. Longitudinal study of the presence of mutans streptococci and lactobacilli in relation to dental caries development in 3-24 month old Thai children. Int Dent J 2007, 57(6):445-451.
54. Hicks J., Garcia-Godoy F., Flaitz C. Biological factors in dental caries: role of saliva and dental plaque in the dynamic process of demineralization and remineralization (part 1). J Clin Pediatr Dent 2003, 28(1):47-52.
55. Carson S.J. Limited evidence for existing caries assessment systems. Evid Based Dent 2013, 14(1):10-11.
56. Eke P.I., Dye B.A., Wei L., Thornton-Evans G.O., Genco R.J. Cdc Periodontal Disease Surveillance workgroup: James Beck GDRP. Prevalence of periodontitis in adults in the United States: 2009 and 2010. J Dent Res 2012, 91(10):914-920.
57. Ong G. Periodontal disease and tooth loss. Int Dent J 1998, 48(3 Suppl 1):233-238.
58. Kaufman E., Lamster I.B. Analysis of saliva for periodontal diagnosis - a review. J Clin Periodontol 2000, 27(7):453-465.
59. Herr A.E., Hatch A.V., Throckmorton D.J., et al. Microfluidic immunoassays as rapid saliva-based clinical diagnostics. Proc Natl Acad Sci U S A 2007, 104(13):5268-5273.
60. Kinane D.F., Darby I.B., Said S., et al. Changes in gingival crevicular fluid matrix metalloproteinase-8 levels during periodontal treatment and maintenance. J Periodontal Res 2003, 38(4):400-404.
61. Prescher N., Maier K., Munjal S.K., et al. Rapid quantitative chairside test for active MMP-8 in gingival crevicular fluid: first clinical data. Ann N Y Acad Sci 2007, 1098:493-495.
62. Sorsa T., Hernandez M., Leppilahti J., Munjal S., Netuschil L., Mantyla P. Detection of gingival crevicular fluid MMP-8 levels with different laboratory and chair-side methods. Oral Dis 2010, 16(1):39-45.
63. Prakasam S., Srinivasan M. Evaluation of salivary biomarker profiles following non-surgical management of chronic periodontitis. Oral Dis 2013.
64. Kinney J.S., Morelli T., Braun T., et al. Saliva/pathogen biomarker signatures and periodontal disease progression. J Dent Res 2011, 90(6):752-758.
65. Saygun I., Nizam N., Keskiner I., et al. Salivary infectious agents and periodontal disease status. J Periodontal Res 2011, 46(2):235-239.
66. Karimbux N.Y., Saraiya V.M., Elangovan S., et al. Interleukin-1 gene polymorphisms and chronic periodontitis in adult whites: a systematic review and meta-analysis. J Periodontol 2012, 83(11):1407-1419.
67. Song G.G., Choi S.J., Ji J.D., Lee Y.H. Association between tumor necrosis factor-alpha promoter -308 A/G, -238 A/G, interleukin-6 -174 G/C and -572 G/C polymorphisms and periodontal disease: a meta-analysis. Mol Biol Rep 2013, 40(8):5191-5203.
68. Wong D.T. Salivaomics. J Am Dent Assoc 2012, 143(10 Suppl):19S-24S.
69. Tzioufas A.G., Kapsogeorgou E.K. Biomarkers: Saliva proteomics is a promising tool to study Sjögrens syndrome. Nat Rev Rheumatol 2015, 11:202-203.
70. Krishnamurthy S., Vasudeva S.B., Vijayasarathy S., et al. Salivary gland disorders: a comprehensive review. World J Stomatol 2015, 4(2):56-71.
71. Liljestrand J.M., Gursoy U.K., Hyvärinen K., et al. Combining salivary pathogen and serum antibody levels improves their diagnostic ability in detection of periodontitis. J Periodontol. 2014, 85(1):123-131.