The novel role of C-reactive protein in cardiovascular disease: Risk marker or pathogen

International Journal of Cardiology

Volumn 106, Issue 3, 2006, Pages 291-297

  Wilson, Andrew M ^a   Ryan, Marno C ^a   Boyle, Andrew J ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Atherosclerosis; C reactive protein; Inflammation

Indexed keywords

ACETYLSALICYLIC ACID; BIOLOGICAL MARKER; C REACTIVE PROTEIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR;

ACUTE HEART INFARCTION; ATHEROGENESIS; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CLINICAL TRIAL; HEART INFARCTION; HUMAN; IN-STENT RESTENOSIS; META ANALYSIS; METABOLIC DISORDER; OBESITY; PATHOGENESIS; PERCUTANEOUS CORONARY INTERVENTION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN LIPID INTERACTION; REVIEW; RHEUMATOID ARTHRITIS; SENSITIVITY AND SPECIFICITY; STROKE; SYSTEMATIC REVIEW;

ATHEROSCLEROSIS; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; CARDIOVASCULAR DISEASES; DEMENTIA; HUMANS; OBESITY; PREDICTIVE VALUE OF TESTS; RISK FACTORS;

EID: 28844475044     PISSN: 01675273     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijcard.2005.01.068     Document Type: Review

References (67)

1. P. Libby, P.M. Ridker, and A. Maseri Inflammation and atherosclerosis Circulation 105 2002 1135 1143
2. E.A. Bermudez, N. Rifai, J. Buring, J.E. Manson, and P.M. Ridker Interrelationships among circulating interleukin-6, C-reactive protein, and traditional cardiovascular risk factors in women Arterioscler Thromb Vasc Biol 22 2002 1668 1673
3. J. Hulthe, J. Wikstrand, L. Mattsson-Hulten, and B. Fagerberg Circulating ICAM-1 (intercellular cell-adhesion molecule 1) is associated with early stages of atherosclerosis development and with inflammatory cytokines in healthy 58-year-old men: the Atherosclerosis and Insulin Resistance (air) Study Clin Sci (Lond) 103 2002 123 129
4. T.W. Du Clos Function of C-reactive protein Ann Med 32 2000 274 278
5. S. Taskinen, P.T. Kovanen, H. Jarva, S. Meri, and M.O. Pentikainen Binding of C-reactive protein to modified low-density-lipoprotein particles: identification of cholesterol as a novel ligand for C-reactive protein Biochem J 367 2002 403 412
6. M.P. Stein, J.C. Edberg, and R.P. Kimberly C-reactive protein binding to fcgammariia on human monocytes and neutrophils is allele-specific J Clin Invest 105 2000 369 376
7. G.J. Blake, and P.M. Ridker C-reactive protein: a surrogate risk marker or mediator of atherothrombosis? Am J Physiol Regul Integr Comp Physiol 285 2003 R1250 R1252
8. K. Yasojima, C. Schwab, E.G. McGeer, and P.L. McGeer Generation of C-reactive protein and complement components in atherosclerotic plaques Am J Pathol 158 2001 1039 1051
9. N. Ouchi, S. Kihara, and T. Funahashi Reciprocal association of C-reactive protein with adiponectin in blood stream and adipose tissue Circulation 107 2003 671 674
10. K. Yasojima, C. Schwab, E.G. McGeer, and P.L. McGeer Human neurons generate C-reactive protein and amyloid P: upregulation in alzheimer's disease Brain Res 887 2000 80 89
11. S.J. Cleland, N. Sattar, J.R. Petrie, N.G. Forouhi, H.L. Elliott, and J.M. Connell Endothelial dysfunction as a possible link between C-reactive protein levels and cardiovascular disease Clin Sci (Lond) 98 2000 531 535
12. P. Libby Current concepts of the pathogenesis of the acute coronary syndromes Circulation 104 2001 365 372
13. M. Wong, L. Toh, and A. Wilson Reduced arterial elasticity in rheumatoid arthritis and the relationship to vascular disease risk factors and inflammation Arthritis Rheum 48 2003 81 89
14. T. Wu, M. Trevisan, R.J. Genco, J.P. Dorn, K.L. Falkner, and C.T. Sempos Periodontal disease and risk of cerebrovascular disease: the First National Health and Nutrition Examination Survey and its follow-up study Archives of Internal Medicine 160 2000 2749 2755
15. M.V. Kalayoglu, P. Libby, and G.I. Byrne Chlamydia pneumoniae as an emerging risk factor in cardiovascular disease JAMA 288 2002 2724 2731
16. C. Espinola-Klein, H.J. Rupprecht, and S. Blankenberg Impact of infectious burden on progression of carotid atherosclerosis Stroke 33 2002 2581 2586
17. S. Kiechl, P. Werner, and G. Egger Active and passive smoking, chronic infections, and the risk of carotid atherosclerosis: prospective results from the Bruneck study Stroke 33 2002 2170 2176
18. D. Sander, K. Winbeck, J. Klingelhofer, T. Etgen, and B. Conrad Reduced progression of early carotid atherosclerosis after antibiotic treatment and Chlamydia pneumoniae seropositivity Circulation 106 2002 2428 2433
19. L.A. Jackson, O. Yu, and S.R. Heckbert Influenza vaccination is not associated with a reduction in the risk of recurrent coronary events Am J Epidemiol 156 2002 634 640
20. M. Torzewski, C. Rist, and R.F. Mortensen C-reactive protein in the arterial intima: role of C-reactive protein receptor-dependent monocyte recruitment in atherogenesis Arterioscler Thromb Vasc Biol 20 2000 2094 2099
21. V. Pasceri, J.T. Willerson, and E.T. Yeh Direct proinflammatory effect of C-reactive protein on human endothelial cells Circulation 102 2000 2165 2168
22. J. Torzewski, M. Torzewski, and D.E. Bowyer C-reactive protein frequently colocalizes with the terminal complement complex in the intima of early atherosclerotic lesions of human coronary arteries Arterioscler Thromb Vasc Biol 18 1998 1386 1392
23. C.H. Wang, S.H. Li, and R.D. Weisel C-reactive protein upregulates angiotensin type 1 receptors in vascular smooth muscle Circulation 107 2003 1783 1790
24. S. Verma, S.H. Li, and M.V. Badiwala Endothelin antagonism and interleukin-6 inhibition attenuate the proatherogenic effects of C-reactive protein Circulation 105 2002 1890 1896
25. L. Li, N. Roumeliotis, T. Sawamura, and G. Renier C-reactive protein enhances lox-1 expression in human aortic endothelial cells: relevance of lox-1 to C-reactive protein-induced endothelial dysfunction Circ Res 95 2004 877 883
26. S. Devaraj, P.R. Kumaresan, and I. Jialal Effect of C-reactive protein on chemokine expression in human aortic endothelial cells J Mol Cell Cardiol 36 2004 405 410
27. H.D. Danenberg, A.J. Szalai, and R.V. Swaminathan Increased thrombosis after arterial injury in human C-reactive protein-transgenic mice Circulation 108 2003 512 515
28. U.N. Das Obesity, metabolic syndrome X, and inflammation Nutrition 18 2002 430 432
29. K. Esposito, A. Pontillo, and C. Di Palo Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: a randomized trial JAMA 289 2003 1799 1804
30. R.E. Banks, M.A. Forbes, and M. Storr The acute phase protein response in patients receiving subcutaneous IL-6 Clin Exp Immunol 102 1995 217 223
31. V. Mohamed-Ali, J.H. Pinkney, A. Panahloo, S. Goodrick, S.W. Coppack, and J.S. Yudkin Relationships between plasma leptin and insulin concentrations, but not insulin resistance, in non-insulin-dependent (type 2) diabetes mellitus Diabet Med 14 1997 376 380
32. J.C. Pickup, M.B. Mattock, G.D. Chusney, and D. Burt Niddm as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X Diabetologia 40 1997 1286 1292
33. E.S. Ford Body mass index, diabetes, and C-reactive protein among U.S. adults Diabetes Care 22 1999 1971 1977
34. J.C. Chambers, S. Eda, and P. Bassett C-reactive protein, insulin resistance, central obesity, and coronary heart disease risk in Indian Asians from the United Kingdom compared with European Whites Circulation 104 2001 145 150
35. P.M. Ridker, M. Cushman, M.J. Stampfer, R.P. Tracy, and C.H. Hennekens Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men N Engl J Med 336 1997 973 979
36. P.M. Ridker, C.H. Hennekens, J.E. Buring, and N. Rifai C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women N Engl J Med 342 2000 836 843
37. M. Schillinger, M. Exner, and J. Amighi Joint effects of C-reactive protein and glycated hemoglobin in predicting future cardiovascular events of patients with advanced atherosclerosis Circulation 108 2003 2323 2328
38. J.R. Burnett, G.F. Watts, and S.D. Vasikaran C-reactive protein: a new cardiovascular risk factor? Med J Aust 173 2000 117 118
39. P.M. Ridker, N. Rifai, L. Rose, J.E. Buring, and N.R. Cook Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events N Engl J Med 347 2002 1557 1565
40. P.M. Ridker Clinical application of C-reactive protein for cardiovascular disease detection and prevention Circulation 107 2003 363 369
41. J. Danesh, R. Collins, P. Appleby, and R. Peto Association of fibrinogen, C-reactive protein, albumin, or leukocyte count with coronary heart disease: meta-analyses of prospective studies JAMA 279 1998 1477 1482
42. G.J. Blake, N. Rifai, J.E. Buring, and P.M. Ridker Blood pressure, C-reactive protein, and risk of future cardiovascular events Circulation 108 2003 2993 2999
43. J.J. Cao, C. Thach, and T.A. Manolio C-reactive protein, carotid intima-media thickness, and incidence of ischemic stroke in the elderly: the cardiovascular health study Circulation 108 2003 166 170
44. J.D. Curb, R.D. Abbott, and B.L. Rodriguez C-reactive protein and the future risk of thromboembolic stroke in healthy men Circulation 107 2003 2016 2020
45. H. Hashimoto, K. Kitagawa, and H. Hougaku C-reactive protein is an independent predictor of the rate of increase in early carotid atherosclerosis Circulation 104 2001 63 67
46. P.M. Ridker, N. Rifai, and M.A. Pfeffer Inflammation, pravastatin, and the risk of coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events (care) Investigators Circulation 98 1998 839 844
47. J. Danesh, J.G. Wheeler, and G.M. Hirschfield C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease N Engl J Med 350 2004 1387 1397
48. M.T. Casl, B. Surina, and I. Glojnaric-Spasic Serum amyloid A protein in patients with acute myocardial infarction Ann Clin Biochem 32 Pt 2 1995 196 200
49. D.A. Morrow, N. Rifai, and E.M. Antman C-reactive protein is a potent predictor of mortality independently of and in combination with troponin T in acute coronary syndromes: a TIMI 11a Substudy. Thrombolysis in myocardial infarction J Am Coll Cardiol 31 1998 1460 1465
50. H. Toss, B. Lindahl, A. Siegbahn, and L. Wallentin Prognostic influence of increased fibrinogen and C-reactive protein levels in unstable coronary artery disease. Frisc Study Group. Fragmin during instability in coronary artery disease Circulation 96 1997 4204 4210
51. S.K. James, P. Armstrong, and E. Barnathan Troponin and C-reactive protein have different relations to subsequent mortality and myocardial infarction after acute coronary syndrome: a Gusto-IV substudy J Am Coll Cardiol 41 2003 916 924
52. E. Lindmark, E. Diderholm, L. Wallentin, and A. Siegbahn Relationship between interleukin 6 and mortality in patients with unstable coronary artery disease: effects of an early invasive or noninvasive strategy JAMA 286 2001 2107 2113
53. C. Mueller, H.J. Buettner, and J.M. Hodgson Inflammation and long-term mortality after non-ST elevation acute coronary syndrome treated with a very early invasive strategy in 1042 consecutive patients Circulation 105 2002 1412 1415
54. A. Gaspardone, F. Crea, and F. Versaci Predictive value of C-reactive protein after successful coronary-artery stenting in patients with stable angina Am J Cardiol 82 1998 515 518
55. B.D. Horne, J.B. Muhlestein, G.G. Strobel, J.F. Carlquist, T.L. Bair, and J.L. Anderson Greater pathogen burden but not elevated C-reactive protein increases the risk of clinical restenosis after percutaneous coronary intervention Am Heart J 144 2002 491 500
56. Y.F. Zhou, G. Csako, and J.T. Grayston Lack of association of restenosis following coronary angioplasty with elevated C-reactive protein levels or seropositivity to Chlamydia pneumoniae Am J Cardiol 84 1999 595 598 [A8]
57. A. Goldberg, O. Zinder, and A. Zdorovyak Diagnostic coronary angiography induces a systemic inflammatory response in patients with stable angina Am Heart J 146 2003 819 823
58. R. Schmidt, H. Schmidt, J.D. Curb, K. Masaki, L.R. White, and L.J. Launer Early inflammation and dementia: a 25-year follow-up of the Honolulu-Asia Aging Study Ann Neurol 52 2002 168 174
59. E.M. Balk, J. Lau, and L.C. Goudas Effects of statins on nonlipid serum markers associated with cardiovascular disease: a systematic review Ann Intern Med 139 2003 670 682
60. P.M. Ridker, C.P. Cannon, and D. Morrow C-reactive protein levels and outcomes after statin therapy N Engl J Med 352 2005 20 28
61. S.E. Nissen, E.M. Tuzcu, and P. Schoenhagen Statin therapy, LDL cholesterol, C-reactive protein, and coronary artery disease N Engl J Med 352 2005 29 38
62. M.R. Ehrenstein, E.C. Jury, and C. Mauri Statins for atherosclerosis-as good as it gets? N Engl J Med 352 2005 73 75
63. M Di Napoli, and F. Papa Angiotensin-converting enzyme inhibitor use is associated with reduced plasma concentration of C-reactive protein in patients with first-ever ischemic stroke Stroke 34 2003 2922 2929
64. S. Solheim, H. Arnesen, L. Eikvar, M. Hurlen, and I. Seljeflot Influence of aspirin on inflammatory markers in patients after acute myocardial infarction Am J Cardiol 92 2003 843 845
65. T.S. Church, C.E. Barlow, C.P. Earnest, J.B. Kampert, E.L. Priest, and S.N. Blair Associations between cardiorespiratory fitness and C-reactive protein in men Arterioscler Thromb Vasc Biol 22 2002 1869 1876
66. I.S. Ockene, C.E. Matthews, N. Rifai, P.M. Ridker, G. Reed, and E. Stanek Variability and classification accuracy of serial high-sensitivity C-reactive protein measurements in healthy adults Clin Chem 47 2001 444 450
67. T.A. Pearson, G.A. Mensah, and R.W. Alexander Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association Circulation 107 2003 499 511