1H NMR-based metabolite profiling workflow to reduce inter-sample chemical shift variations in urine samples for improved biomarker discovery

Analytical and Bioanalytical Chemistry

Volumn 408, Issue 17, 2016, Pages 4683-4691

  Gil, Ryan B ^a   Lehmann, Rainer ^b,c,d   Schmitt Kopplin, Philippe ^a,c,e   Heinzmann, Silke S ^a  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^c GERMAN CENTER FOR DIABETES RESEARCH DZD   (Germany)

^d UNIVERSITY OF TÜBINGEN   (Germany)

^e TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Biomarker discovery; Metabolomics; Multivariate data analysis; Non targeted; Nuclear magnetic resonance spectroscopy; Urine

Indexed keywords

BIOMARKERS; BIOMOLECULES; CHEMICAL ANALYSIS; CHEMICAL SHIFT; MAGNETIC RESONANCE SPECTROSCOPY; METABOLITES; MULTIVARIANT ANALYSIS; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SPECTROSCOPIC ANALYSIS; SPECTRUM ANALYSIS; STATISTICAL MECHANICS;

BIO-MARKER DISCOVERY; METABOLOMICS; MULTIVARIATE DATA ANALYSIS; NON-TARGETED; URINE;

BODY FLUIDS;

BIOLOGICAL MARKER;

METABOLOMICS; PH; PROCEDURES; PROTON NUCLEAR MAGNETIC RESONANCE; URINE;

BIOMARKERS; HYDROGEN-ION CONCENTRATION; METABOLOMICS; PROTON MAGNETIC RESONANCE SPECTROSCOPY;

EID: 84968583477     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-016-9552-6     Document Type: Article

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