메뉴 건너뛰기




Volumn 40, Issue 7, 2016, Pages 1043-1050

Pediatric obesity pharmacotherapy: Current state of the field, review of the literature and clinical trial considerations

Author keywords

[No Author keywords available]

Indexed keywords

EXENDIN 4; METFORMIN; TETRAHYDROLIPSTATIN; ANTIDIABETIC AGENT; ANTIOBESITY AGENT; PEPTIDE; VENOM;

EID: 84968538163     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/ijo.2016.69     Document Type: Review
Times cited : (54)

References (49)
  • 1
    • 84902155113 scopus 로고    scopus 로고
    • Prevalence and trends in obesity and severe obesity among children in the United States, 1999-2012
    • Skinner AC, Skelton JA. Prevalence and trends in obesity and severe obesity among children in the United States, 1999-2012. JAMA Pediatr 2014; 168: 561-566
    • (2014) JAMA Pediatr , vol.168 , pp. 561-566
    • Skinner, A.C.1    Skelton, J.A.2
  • 2
    • 84885843346 scopus 로고    scopus 로고
    • Severe obesity in children and adolescents: Identification, associated health risks, and treatment approaches: A scientific statement from the American Heart Association
    • Kelly AS, Barlow SE, Rao G, Inge TH, Hayman LL, Steinberger J, et al. Severe obesity in children and adolescents: identification, associated health risks, and treatment approaches: a scientific statement from the American Heart Association. Circulation 2013; 128: 1689-1712
    • (2013) Circulation , vol.128 , pp. 1689-1712
    • Kelly, A.S.1    Barlow, S.E.2    Rao, G.3    Inge, T.H.4    Hayman, L.L.5    Steinberger, J.6
  • 3
    • 84942857234 scopus 로고    scopus 로고
    • Cardiometabolic risks and severity of obesity in children and young adults
    • Skinner AC, Perrin EM, Moss LA, Skelton JA. Cardiometabolic risks and severity of obesity in children and young adults. N Engl J Med 2015; 373: 1307-1317
    • (2015) N Engl J Med , vol.373 , pp. 1307-1317
    • Skinner, A.C.1    Perrin, E.M.2    Moss, L.A.3    Skelton, J.A.4
  • 4
    • 84870655985 scopus 로고    scopus 로고
    • Response of severely obese children and adolescents to behavioral treatment
    • Danielsson P, Kowalski J, Ekblom O, Marcus C. Response of severely obese children and adolescents to behavioral treatment. Arch Pediatr Adolesc Med 2012; 166: 1103-1108
    • (2012) Arch Pediatr Adolesc Med , vol.166 , pp. 1103-1108
    • Danielsson, P.1    Kowalski, J.2    Ekblom, O.3    Marcus, C.4
  • 5
    • 84921635828 scopus 로고    scopus 로고
    • Extremely obese children respond better than extremely obese adolescents to lifestyle interventions
    • Knop C, Singer V, Uysal Y, Schaefer A, Wolters B, Reinehr T. Extremely obese children respond better than extremely obese adolescents to lifestyle interventions. Pediatr Obes 2015; 10: 7-14
    • (2015) Pediatr Obes , vol.10 , pp. 7-14
    • Knop, C.1    Singer, V.2    Uysal, Y.3    Schaefer, A.4    Wolters, B.5    Reinehr, T.6
  • 6
    • 79952574707 scopus 로고    scopus 로고
    • Smaller weight changes in standardized body mass index in response to treatment as weight classification increases
    • Johnston CA, Tyler C, Palcic JL, Stansberry SA, Gallagher MR, Foreyt JP. Smaller weight changes in standardized body mass index in response to treatment as weight classification increases. J Pediatr 2011; 158: 624-627
    • (2011) J Pediatr , vol.158 , pp. 624-627
    • Johnston, C.A.1    Tyler, C.2    Palcic, J.L.3    Stansberry, S.A.4    Gallagher, M.R.5    Foreyt, J.P.6
  • 8
    • 84925300900 scopus 로고    scopus 로고
    • Treating obesity seriously: When recommendations for lifestyle change confront biological adaptations
    • Ochner CN, Tsai AG, Kushner RF, Wadden TA. Treating obesity seriously: when recommendations for lifestyle change confront biological adaptations. Lancet Diabetes Endocrinol 2015; 3: 232-234
    • (2015) Lancet Diabetes Endocrinol , vol.3 , pp. 232-234
    • Ochner, C.N.1    Tsai, A.G.2    Kushner, R.F.3    Wadden, T.A.4
  • 9
    • 0028959193 scopus 로고
    • Changes in energy expenditure resulting from altered body weight
    • Leibel RL, Rosenbaum M, Hirsch J. Changes in energy expenditure resulting from altered body weight. N Engl J Med 1995; 332: 621-628
    • (1995) N Engl J Med , vol.332 , pp. 621-628
    • Leibel, R.L.1    Rosenbaum, M.2    Hirsch, J.3
  • 12
    • 84876059664 scopus 로고    scopus 로고
    • Clinical trials for adolescent obesity: Cooking up an alphabet stew of what to do
    • Schwimmer JB. Clinical trials for adolescent obesity: cooking up an alphabet stew of what to do. JAMA Pediatr 2013; 167: 391-393
    • (2013) JAMA Pediatr , vol.167 , pp. 391-393
    • Schwimmer, J.B.1
  • 14
    • 33846703082 scopus 로고    scopus 로고
    • Pharmacotherapy of childhood obesity: An evidence-based, conceptual approach
    • Freemark M. Pharmacotherapy of childhood obesity: an evidence-based, conceptual approach. Diabetes Care 2007; 30: 395-402
    • (2007) Diabetes Care , vol.30 , pp. 395-402
    • Freemark, M.1
  • 15
    • 84893470006 scopus 로고    scopus 로고
    • Systematic review of the benefits and risks of metformin in treating obesity in children aged 18 years and younger
    • McDonagh MS, Selph S, Ozpinar A, Foley C. Systematic review of the benefits and risks of metformin in treating obesity in children aged 18 years and younger. JAMA Pediatr 2014; 168: 178-184
    • (2014) JAMA Pediatr , vol.168 , pp. 178-184
    • McDonagh, M.S.1    Selph, S.2    Ozpinar, A.3    Foley, C.4
  • 16
    • 69549130779 scopus 로고    scopus 로고
    • Metformin for obesity in children and adolescents: A systematic review
    • Park MH, Kinra S, Ward KJ, White B, Viner RM. Metformin for obesity in children and adolescents: a systematic review. Diabetes Care 2009; 32: 1743-1745
    • (2009) Diabetes Care , vol.32 , pp. 1743-1745
    • Park, M.H.1    Kinra, S.2    Ward, K.J.3    White, B.4    Viner, R.M.5
  • 17
    • 77249087236 scopus 로고    scopus 로고
    • Pharmacotherapy and weight-loss supplements for treatment of paediatric obesity
    • Rogovik AL, Chanoine JP, Goldman RD. Pharmacotherapy and weight-loss supplements for treatment of paediatric obesity. Drugs 2010; 70: 335-346
    • (2010) Drugs , vol.70 , pp. 335-346
    • Rogovik, A.L.1    Chanoine, J.P.2    Goldman, R.D.3
  • 18
    • 84858275290 scopus 로고    scopus 로고
    • Metformin use in children with obesity and normal glucose tolerance-effects on cardiovascular markers and intrahepatic fat
    • Mauras N, DelGiorno C, Hossain J, Bird K, Killen K, Merinbaum D, et al. Metformin use in children with obesity and normal glucose tolerance-effects on cardiovascular markers and intrahepatic fat. J Pediatr Endocrinol Metab 2012; 25: 33-40
    • (2012) J Pediatr Endocrinol Metab , vol.25 , pp. 33-40
    • Mauras, N.1    DelGiorno, C.2    Hossain, J.3    Bird, K.4    Killen, K.5    Merinbaum, D.6
  • 20
    • 84876023362 scopus 로고    scopus 로고
    • The effect of glucagon-like Peptide-1 receptor agonist therapy on body mass index in adolescents with severe obesity: A randomized, placebo-controlled, clinical trial
    • Kelly AS, Rudser KD, Nathan BM, Fox CK, Metzig AM, Coombes BJ, et al. The effect of glucagon-like Peptide-1 receptor agonist therapy on body mass index in adolescents with severe obesity: a randomized, placebo-controlled, clinical trial. JAMA Pediatr 2013; 167: 355-360
    • (2013) JAMA Pediatr , vol.167 , pp. 355-360
    • Kelly, A.S.1    Rudser, K.D.2    Nathan, B.M.3    Fox, C.K.4    Metzig, A.M.5    Coombes, B.J.6
  • 21
    • 84891919414 scopus 로고    scopus 로고
    • Long-Term drug treatment for obesity: A systematic and clinical review
    • Yanovski SZ, Yanovski JA. Long-Term drug treatment for obesity: a systematic and clinical review. JAMA 2014; 311: 74-86
    • (2014) JAMA , vol.311 , pp. 74-86
    • Yanovski, S.Z.1    Yanovski, J.A.2
  • 24
    • 76049125309 scopus 로고    scopus 로고
    • Effectiveness of weight management interventions in children a Targeted Systematic Review for the USPSTF
    • Whitlock EP, O'Connor EA, Williams SB, Beil TL, Lutz KW. Effectiveness of weight management interventions in children: a Targeted Systematic Review for the USPSTF. Pediatrics 2010; 125: e396-e418
    • (2010) Pediatrics , vol.125 , pp. e396-e418
    • Whitlock, E.P.1    O'Connor, E.A.2    Williams, S.B.3    Beil, T.L.4    Lutz, K.W.5
  • 25
    • 35348866794 scopus 로고    scopus 로고
    • Efficacy of maintenance treatment approaches for childhood overweight: A randomized controlled trial
    • Wilfley DE, Stein RI, Saelens BE, Mockus DS, Matt GE, Hayden-Wade HA, et al. Efficacy of maintenance treatment approaches for childhood overweight: a randomized controlled trial. JAMA 2007; 298: 1661-1673
    • (2007) JAMA , vol.298 , pp. 1661-1673
    • Wilfley, D.E.1    Stein, R.I.2    Saelens, B.E.3    Mockus, D.S.4    Matt, G.E.5    Hayden-Wade, H.A.6
  • 28
    • 20444446770 scopus 로고    scopus 로고
    • Effect of orlistat on weight and body composition in obese adolescents: A randomized controlled trial
    • Chanoine JP, Hampl S, Jensen C, Boldrin M, Hauptman J. Effect of orlistat on weight and body composition in obese adolescents: a randomized controlled trial. JAMA 2005; 293: 2873-2883
    • (2005) JAMA , vol.293 , pp. 2873-2883
    • Chanoine, J.P.1    Hampl, S.2    Jensen, C.3    Boldrin, M.4    Hauptman, J.5
  • 29
    • 84860330219 scopus 로고    scopus 로고
    • Food and Drug Administration's obesity drug guidance document: A short history
    • Colman E. Food and Drug Administration's obesity drug guidance document: a short history. Circulation 2012; 125: 2156-2164
    • (2012) Circulation , vol.125 , pp. 2156-2164
    • Colman, E.1
  • 30
    • 70350651258 scopus 로고    scopus 로고
    • Using body mass index Z-score among severely obese adolescents: A cautionary note
    • Woo JG. Using body mass index Z-score among severely obese adolescents: a cautionary note. Int J Pediatr Obes 2009; 4: 405-410
    • (2009) Int J Pediatr Obes , vol.4 , pp. 405-410
    • Woo, J.G.1
  • 31
    • 70350650797 scopus 로고    scopus 로고
    • Characterizing extreme values of body mass index-for-Age by using the 2000 centers for disease control and prevention growth charts
    • Flegal KM, Wei R, Ogden CL, Freedman DS, Johnson CL, Curtin LR. Characterizing extreme values of body mass index-for-Age by using the 2000 Centers for Disease Control and Prevention growth charts. Am J Clin Nutr 2009; 90: 1314-1320
    • (2009) Am J Clin Nutr , vol.90 , pp. 1314-1320
    • Flegal, K.M.1    Wei, R.2    Ogden, C.L.3    Freedman, D.S.4    Johnson, C.L.5    Curtin, L.R.6
  • 32
    • 84870477814 scopus 로고    scopus 로고
    • Clinical tracking of severely obese children: A new growth chart
    • Gulati AK, Kaplan DW, Daniels SR. Clinical tracking of severely obese children: a new growth chart. Pediatrics 2012; 130: 1136-1140
    • (2012) Pediatrics , vol.130 , pp. 1136-1140
    • Gulati, A.K.1    Kaplan, D.W.2    Daniels, S.R.3
  • 33
    • 0034611996 scopus 로고    scopus 로고
    • Establishing a standard definition for child overweight and obesity worldwide: International survey
    • Cole TJ, Bellizzi MC, Flegal KM, Dietz WH. Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ 2000; 320: 1240-1243
    • (2000) BMJ , vol.320 , pp. 1240-1243
    • Cole, T.J.1    Bellizzi, M.C.2    Flegal, K.M.3    Dietz, W.H.4
  • 34
    • 15544363770 scopus 로고    scopus 로고
    • What is the best measure of adiposity change in growing children: BMI, BMI %, BMI z-score or BMI centile?
    • Cole TJ, Faith MS, Pietrobelli A, Heo M. What is the best measure of adiposity change in growing children: BMI, BMI %, BMI z-score or BMI centile?. Eur J Clin Nutr 2005; 59: 419-425
    • (2005) Eur J Clin Nutr , vol.59 , pp. 419-425
    • Cole, T.J.1    Faith, M.S.2    Pietrobelli, A.3    Heo, M.4
  • 35
    • 34447322555 scopus 로고    scopus 로고
    • Comparison of methods to evaluate changes in relative body mass index in pediatric weight control
    • Paluch RA, Epstein LH, Roemmich JN. Comparison of methods to evaluate changes in relative body mass index in pediatric weight control. Am J Hum Biol 2007; 19: 487-494
    • (2007) Am J Hum Biol , vol.19 , pp. 487-494
    • Paluch, R.A.1    Epstein, L.H.2    Roemmich, J.N.3
  • 36
    • 84939446625 scopus 로고    scopus 로고
    • Framework of outcome measures recommended for use in the evaluation of childhood obesity treatment interventions: The CoOR framework
    • Bryant M, Ashton L, Nixon J, Jebb S, Wright J, Roberts K, et al. Framework of outcome measures recommended for use in the evaluation of childhood obesity treatment interventions: the CoOR framework. Pediatr Obes 2014; 9: e116-e131
    • (2014) Pediatr Obes , vol.9 , pp. e116-e131
    • Bryant, M.1    Ashton, L.2    Nixon, J.3    Jebb, S.4    Wright, J.5    Roberts, K.6
  • 39
    • 78649638455 scopus 로고    scopus 로고
    • A randomized, triple masked, placebo-controlled clinical trial for controlling childhood obesity
    • Rezvanian H, Hashemipour M, Kelishadi R, Tavakoli N, Poursafa P. A randomized, triple masked, placebo-controlled clinical trial for controlling childhood obesity. World J Pediatr 2010; 6: 317-322
    • (2010) World J Pediatr , vol.6 , pp. 317-322
    • Rezvanian, H.1    Hashemipour, M.2    Kelishadi, R.3    Tavakoli, N.4    Poursafa, P.5
  • 40
    • 56649107790 scopus 로고    scopus 로고
    • Short-Term metabolic and cardiovascular effects of metformin in markedly obese adolescents with normal glucose tolerance
    • Burgert TS, Duran EJ, Goldberg-Gell R, Dziura J, Yeckel CW, Katz S, et al. Short-Term metabolic and cardiovascular effects of metformin in markedly obese adolescents with normal glucose tolerance. Pediatr Diabetes 2008; 9: 567-576
    • (2008) Pediatr Diabetes , vol.9 , pp. 567-576
    • Burgert, T.S.1    Duran, E.J.2    Goldberg-Gell, R.3    Dziura, J.4    Yeckel, C.W.5    Katz, S.6
  • 41
    • 0035321014 scopus 로고    scopus 로고
    • The effects of metformin on body mass index and glucose tolerance in obese adolescents with fasting hyperinsulinemia and a family history of type 2 diabetes
    • Freemark M, Bursey D. The effects of metformin on body mass index and glucose tolerance in obese adolescents with fasting hyperinsulinemia and a family history of type 2 diabetes. Pediatrics 2001; 107: E55
    • (2001) Pediatrics , vol.107 , pp. E55
    • Freemark, M.1    Bursey, D.2
  • 42
    • 43549109197 scopus 로고    scopus 로고
    • Addition of metformin to a lifestyle modification program in adolescents with insulin resistance
    • Love-Osborne K, Sheeder J, Zeitler P. Addition of metformin to a lifestyle modification program in adolescents with insulin resistance. J Pediatr 2008; 152: 817-822
    • (2008) J Pediatr , vol.152 , pp. 817-822
    • Love-Osborne, K.1    Sheeder, J.2    Zeitler, P.3
  • 43
    • 33744959061 scopus 로고    scopus 로고
    • Randomized, controlled trial of metformin for obesity and insulin resistance in children and adolescents: Improvement in body composition and fasting insulin
    • Srinivasan S, Ambler GR, Baur LA, Garnett SP, Tepsa M, Yap F, et al. Randomized, controlled trial of metformin for obesity and insulin resistance in children and adolescents: improvement in body composition and fasting insulin. J Clin Endocrinol Metab 2006; 91: 2074-2080
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 2074-2080
    • Srinivasan, S.1    Ambler, G.R.2    Baur, L.A.3    Garnett, S.P.4    Tepsa, M.5    Yap, F.6
  • 44
    • 77957117682 scopus 로고    scopus 로고
    • Metformin and placebo therapy both improve weight management and fasting insulin in obese insulin-resistant adolescents: A prospective, placebo-controlled, randomized study
    • Wiegand S, l'Allemand D, Hubel H, Krude H, Burmann M, Martus P, et al. Metformin and placebo therapy both improve weight management and fasting insulin in obese insulin-resistant adolescents: a prospective, placebo-controlled, randomized study. Eur J Endocrinol 2010; 163: 585-592
    • (2010) Eur J Endocrinol , vol.163 , pp. 585-592
    • Wiegand, S.1    L'Allemand, D.2    Hubel, H.3    Krude, H.4    Burmann, M.5    Martus, P.6
  • 45
    • 79551597310 scopus 로고    scopus 로고
    • Effects of metformin on body weight and body composition in obese insulinresistant children: A randomized clinical trial
    • Yanovski JA, Krakoff J, Salaita CG, McDuffie JR, Kozlosky M, Sebring NG, et al. Effects of metformin on body weight and body composition in obese insulinresistant children: a randomized clinical trial. Diabetes 2011; 60: 477-485
    • (2011) Diabetes , vol.60 , pp. 477-485
    • Yanovski, J.A.1    Krakoff, J.2    Salaita, C.G.3    McDuffie, J.R.4    Kozlosky, M.5    Sebring, N.G.6
  • 46
    • 79955446251 scopus 로고    scopus 로고
    • Effect of Vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: The TONIC randomized controlled trial
    • Lavine JE, Schwimmer JB, Van Natta ML, Molleston JP, Murray KF, Rosenthal P, et al. Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: the TONIC randomized controlled trial. JAMA 2011; 305: 1659-1668
    • (2011) JAMA , vol.305 , pp. 1659-1668
    • Lavine, J.E.1    Schwimmer, J.B.2    Van Natta, M.L.3    Molleston, J.P.4    Murray, K.F.5    Rosenthal, P.6
  • 47
    • 75849124826 scopus 로고    scopus 로고
    • Metformin extended release treatment of adolescent obesity: A 48-week randomized, double-blind, placebo-controlled trial with 48-week follow-up
    • Wilson DM, Abrams SH, Aye T, Lee PD, Lenders C, Lustig RH, et al. Metformin extended release treatment of adolescent obesity: a 48-week randomized, double-blind, placebo-controlled trial with 48-week follow-up. Arch Pediatr Adolesc Med 2010; 164: 116-123
    • (2010) Arch Pediatr Adolesc Med , vol.164 , pp. 116-123
    • Wilson, D.M.1    Abrams, S.H.2    Aye, T.3    Lee, P.D.4    Lenders, C.5    Lustig, R.H.6
  • 48
    • 33646842569 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled trial of orlistat for weight loss in adolescents
    • Maahs D, de Serna DG, Kolotkin RL, Ralston S, Sandate J, Qualls C, et al. Randomized, double-blind, placebo-controlled trial of orlistat for weight loss in adolescents. Endocr Pract 2006; 12: 18-28
    • (2006) Endocr Pract , vol.12 , pp. 18-28
    • Maahs, D.1    De Serna, D.G.2    Kolotkin, R.L.3    Ralston, S.4    Sandate, J.5    Qualls, C.6
  • 49
    • 84856242456 scopus 로고    scopus 로고
    • Exenatide as a weight-loss therapy in extreme pediatric obesity: A randomized, controlled pilot study
    • Kelly AS, Metzig AM, Rudser KD, Fitch AK, Fox CK, Nathan BM, et al. Exenatide as a weight-loss therapy in extreme pediatric obesity: a randomized, controlled pilot study. Obesity (Silver Spring) 2012; 20: 364-370
    • (2012) Obesity (Silver Spring) , vol.20 , pp. 364-370
    • Kelly, A.S.1    Metzig, A.M.2    Rudser, K.D.3    Fitch, A.K.4    Fox, C.K.5    Nathan, B.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.