Nutritional Immunity: Starving Pathogens of Trace Minerals

American Journal of Lifestyle Medicine

Volumn 10, Issue 3, 2016, Pages 170-173

  Hennigar, Stephen R ^a   McClung, James P ^a  

^a U S ARMY RESEARCH INSTITUTE OF ENVIRONMENTAL MEDICINE   (United States)

Author keywords

hepcidin; infection; inflammation; iron; zinc

Indexed keywords

EID: 84967322040     PISSN: 15598276     EISSN: 15598284     Source Type: Journal    
DOI: 10.1177/1559827616629117     Document Type: Review

References (36)

1. A.L.SchadeL.Caroline. Raw hen egg white and the role of iron in growth inhibition of Shigella dysenteriae, Staphylococcus aureus, Escherichia coli and Saccharomyces cerevisiae. Science. 1944;100:14-15.
2. A.L.SchadeL.Caroline. An iron-binding component in human blood plasma. Science. 1946;104:340.
3. E.D.Weinberg. Nutritional immunity. Host’s attempt to withhold iron from microbial invaders. JAMA. 1975;231:39-41.
4. T.E.Kehl-FieE.P.Skaar. Nutritional immunity beyond iron: a role for manganese and zinc. Curr Opin Chem Biol. 2010;14:218-224.
5. E.KemnaP.PickkersE.NemethH.van der HoevenD.Swinkels. Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS. Blood. 2005;106:1864-1866.
6. L.M.GaetkeC.J.McClainR.T.TalwalkarS.I.Shedlofsky. Effects of endotoxin on zinc metabolism in human volunteers. Am J Physiol. 1997;272:E952-E956.
7. A.KrauseS.NeitzH.J.MagertLEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity. FEBS Lett. 2000;480:147-150.
8. C.H.ParkE.V.ValoreA.J.WaringT.Ganz. Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem. 2001;276:7806-7810.
9. T.Ganz. Hepcidin and iron regulation, 10 years later. Blood. 2011;117:4425-4433.
10. M.Wessling-Resnick. Nramp1 and other transporters involved in metal withholding during infection. J Biol Chem. 2015;290:18984-18990.
11. Y.ValdezG.A.GrasslJ.A.GuttmanNramp1 drives an accelerated inflammatory response during Salmonella-induced colitis in mice. Cell Microbiol. 2009;11:351-362.
12. S.Soe-LinS.S.ApteB.AndriopoulosJrNramp1 promotes efficient macrophage recycling of iron following erythrophagocytosis in vivo. Proc Natl Acad Sci U S A. 2009;106:5960-5965.
13. J.P.LiuzziL.A.LichtenS.RiveraInterleukin-6 regulates the zinc transporter Zip14 in liver and contributes to the hypozincemia of the acute-phase response. Proc Natl Acad Sci U S A. 2005;102:6843-6848.
14. T.Beker AydemirS.M.ChangG.J.GuthrieZinc transporter ZIP14 functions in hepatic zinc, iron and glucose homeostasis during the innate immune response (endotoxemia). PLoS One. 2012;7:e48679.
15. B.D.CorbinE.H.SeeleyA.RaabMetal chelation and inhibition of bacterial growth in tissue abscesses. Science. 2008; 319:962-965.
16. D.J.MazzattiP.UciechowskiS.HebelEffects of long-term zinc supplementation and deprivation on gene expression in human THP-1 mononuclear cells. J Trace Elem Med Biol. 2008;22:325-336.
17. T.E.Kehl-FieS.ChitayatM.I.HoodNutrient metal sequestration by calprotectin inhibits bacterial superoxide defense, enhancing neutrophil killing of Staphylococcus aureus. Cell Host Microbe. 2011;10:158-164.
18. V.I.HoldenM.A.Bachman. Diverging roles of bacterial siderophores during infection. Metallomics. 2015;7:986-995.
19. J.E.PoseyF.C.Gherardini. Lack of a role for iron in the Lyme disease pathogen. Science. 2000;288:1651-1653.
20. A.S.Prasad. Discovery of human zinc deficiency: its impact on human health and disease. Adv Nutr. 2013;4:176-190.
21. M.I.HoodE.P.Skaar. Nutritional immunity: transition metals at the pathogen-host interface. Nat Rev Microbiol. 2012;10:525-537.
22. A.G.BobrovO.KirillinaJ.D.FetherstonM.C.MillerJ.A.BurlisonR.D.Perry. The Yersinia pestis siderophore, yersiniabactin, and the ZnuABC system both contribute to zinc acquisition and the development of lethal septicaemic plague in mice. Mol Microbiol. 2014;93:759-775.
23. J.Z.LiuS.JellbauerA.J.PoeZinc sequestration by the neutrophil protein calprotectin enhances Salmonella growth in the inflamed gut. Cell Host Microbe. 2012;11:227-239.
24. F.A.KhanM.A.FisherR.A.Khakoo. Association of hemochromatosis with infectious diseases: expanding spectrum. Int J Infect Dis. 2007;11:482-487.
25. S.J.Oppenheimer. Iron and its relation to immunity and infectious disease. J Nutr. 2001;131:616S-633S.
26. E.D.Weinberg. Iron availability and infection. Biochim Biophys Acta. 2009;1790:600-605.
27. J.P.McClungL.E.Murray-Kolb. Iron nutrition and premenopausal women: effects of poor iron status on physical and neuropsychological performance. Annu Rev Nutr. 2013;33:271-288.
28. J.P.McClungS.MartiniN.E.MurphyEffects of a 7-day military training exercise on inflammatory biomarkers, serum hepcidin, and iron status. Nutr J. 2013;12:141.
29. B.J.WenzelH.B.StultsJ.Mayer. Hypoferraemia in obese adolescents. Lancet. 1962;2:327-328.
30. C.C.SeltzerJ.Mayer. Serum iron and iron-binding capacity in adolescents. II. Comparison of obese and nonobese subjects. Am J Clin Nutr.1963;13:354-361.
31. R.L.AtkinsonW.T.DahmsG.A.BrayR.JacobH.H.Sandstead. Plasma zinc and copper in obesity and after intestinal bypass. Ann Intern Med. 1978;89:491-493.
32. R.K.ChandraK.M.Kutty. Immunocompetence in obesity. Acta Paediatr Scand. 1980;69:25-30.
33. A.S.LevineC.J.McClainB.S.HandwergerD.M.BrownJ.E.Morley. Tissue zinc status of genetically diabetic and streptozotocin-induced diabetic mice. Am J Clin Nutr. 1983;37:382-386.
34. L.Tussing-HumphreysC.PusatciogluE.NemethC.Braunschweig. Rethinking iron regulation and assessment in iron deficiency, anemia of chronic disease, and obesity: introducing hepcidin. J Acad Nutr Diet. 2012;112:391-400.
35. M.F.BarberN.C.Elde. Buried treasure: evolutionary perspectives on microbial iron piracy. Trends Genet. 2015;31:627-636.
36. E.DeriuJ.Z.LiuM.PezeshkiProbiotic bacteria reduce salmonella typhimurium intestinal colonization by competing for iron. Cell Host Microbe. 2013;14:26-37.